1. The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial
- Author
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Wen,Tao, Liu,Xuan, Pang,Tao, Li,Mingming, Jiao,Guangyang, Fan,Xiangcheng, Tang,Jigui, Zhang,Ciâan, Wang,Zhipeng, Yue,Xiaoqiang, Chen,Wansheng, Zhang,Feng, Wen,Tao, Liu,Xuan, Pang,Tao, Li,Mingming, Jiao,Guangyang, Fan,Xiangcheng, Tang,Jigui, Zhang,Ciâan, Wang,Zhipeng, Yue,Xiaoqiang, Chen,Wansheng, and Zhang,Feng
- Abstract
Tao Wen,1,* Xuan Liu,2,* Tao Pang,1,* Mingming Li,1 Guangyang Jiao,3 Xiangcheng Fan,1 Jigui Tang,4 Ciâan Zhang,4 Zhipeng Wang,1 Xiaoqiang Yue,4,* Wansheng Chen,1,3,5 Feng Zhang1,5 1Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai, Peopleâs Republic of China; 2Oncology-Department, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai, Peopleâs Republic of China; 3The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleâs Republic of China; 4Department of Traditional Chinese Medicine, Changzheng Hospital, Naval Medical University, Shanghai, Peopleâs Republic of China; 5Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Feng Zhang; Wansheng Chen, Changzheng Hospital, Naval Medical University, No. 415, Fengyang Road, Shanghai, 200003, Peopleâs Republic of China, Email fengzhang@smmu.edu.cn; chenwansheng@smmu.edu.cnPurpose: The aim of this study was to verify the effectiveness and explore the mechanism of Chaihu-Guizhi-Ganjiang decoction (CGGD) in the treatment of chronic non-atrophic gastritis (CNAG) with gallbladder heat and spleen cold syndrome (GHSC) by metabolomics based on UHPLC-Q-TOF/MS.Patients and Methods: An observational controlled before-after study was conducted to verify the effectiveness of CGGD in the treatment of CNAG with GHSC from January to June 2023, enrolling 27 patients, who took CGGD for 28 days. 30 healthy volunteers were enrolled as the controls. The efficacy was evaluated by comparing the traditional Chinese medicine (TCM) syndrome and CNAG scores, and clinical parameters before and after treatment. The plasma levels of hormones related to gastrointestinal function were collected by ELISA. The mechanisms of
- Published
- 2024