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The present study deals with the phytochemical screening and evaluation of antiasthmatic activity of methanolic extract of Trigonella foenumgraecum on experimental models of bronchial asthma and anaphylaxis. The antiasthmatic activity was studied on histamine-induced bronchospasm in guinea pig (Dunkey-Hartley) for respiratory parameters such as maximum airflow, minimum airflow, tidal volume, respiratory rate, minute volume, specific airway resistance determination on double chambered whole body plethysmography on un-anesthetized guinea pigs, for mast cell degranulation by compound 48/80 (in vitro) was done using rat (Albino Wistar) peritoneal fluid. Trigonella foenum graecum treated result indicated significant protection against histamine-induced bronchospasm in guinea pigs at highest dose i.e. 400mg/kg. The bronchodilatory effect of Trigonella foenum graecum was found comparable to the protection offered by the standard drug Salbutamol on respiratory parameters in double chambered whole body plethysmography, Treatment with Trigonella foenum graecum at a dose of 400mg/kg showed a significant decrease in degranulation rate of actively and passively sensitized mast cells of sensitized rats when challenged with antigen. Trigonella foenum graecum. Possess significant anti-asthmatic activity due to its potential anti inflammatory, antioxidant and the antihistaminic activity, which reflects as anti-degranulating effect on mast cells and on respiratory parameters. Keywords: Trigonella foenum graecum; asthma; mast cell; compound 48/80; histamine

The present study deals with the phytochemical screening and evaluation of antiasthmatic activity of methanolic extract of Trigonella foenumgraecum on experimental models of bronchial asthma and anaphylaxis. The antiasthmatic activity was studied on histamine-induced bronchospasm in guinea pig (Dunkey-Hartley) for respiratory parameters such as maximum airflow, minimum airflow, tidal volume, respiratory rate, minute volume, specific airway resistance determination on double chambered whole body plethysmography on un-anesthetized guinea pigs, for mast cell degranulation by compound 48/80 (in vitro) was done using rat (Albino Wistar) peritoneal fluid. Trigonella foenum graecum treated result indicated significant protection against histamine-induced bronchospasm in guinea pigs at highest dose i.e. 400mg/kg. The bronchodilatory effect of Trigonella foenum graecum was found comparable to the protection offered by the standard drug Salbutamol on respiratory parameters in double chambered whole body plethysmography, Treatment with Trigonella foenum graecum at a dose of 400mg/kg showed a significant decrease in degranulation rate of actively and passively sensitized mast cells of sensitized rats when challenged with antigen. Trigonella foenum graecum. Possess significant anti-asthmatic activity due to its potential anti inflammatory, antioxidant and the antihistaminic activity, which reflects as anti-degranulating effect on mast cells and on respiratory parameters. Keywords: Trigonella foenum graecum; asthma; mast cell; compound 48/80; histamine

The aqueous (100 mg/kg p.o.), methanolic (100 mg/kg p.o.) and petroleum ether (50 mg/kg p.o.) extracts of the flowers of Cassia auriculata linn, (Caesalpinaceae) were tested for their hepatoprotective activity against paracetamol induced hepatotoxicity in albino rats. Silymarin at a dose of 25 mg/kg i.p. was used as standard. The degree of protection was measured by using biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALP), direct bilirubin and total bilirubin. The histopathological studies were also conducted. The aqueous and methanolic extracts of the flowers showed a significant hepatoprotective activity comparable with those of Silymarin.

The aqueous (100 mg/kg p.o.), methanolic (100 mg/kg p.o.) and petroleum ether (50 mg/kg p.o.) extracts of the flowers of Cassia auriculata linn, (Caesalpinaceae) were tested for their hepatoprotective activity against paracetamol induced hepatotoxicity in albino rats. Silymarin at a dose of 25 mg/kg i.p. was used as standard. The degree of protection was measured by using biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALP), direct bilirubin and total bilirubin. The histopathological studies were also conducted. The aqueous and methanolic extracts of the flowers showed a significant hepatoprotective activity comparable with those of Silymarin.