1. Is there significant improvement in neonatal outcome after treating pPROM mothers with amnio-infusion?
- Author
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De Carolis, Maria Pia, Romagnoli, Costantino, De Santis, Marco, Piersigilli, F, Vento, Giovanni, Caruso, Alessandro, De Carolis, Maria Pia (ORCID:0000-0003-2054-8228), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), De Santis, Marco (ORCID:0000-0002-1388-0014), Vento, Giovanni (ORCID:0000-0002-8132-5127), Caruso, Alessandro (ORCID:0000-0002-4749-3207), De Carolis, Maria Pia, Romagnoli, Costantino, De Santis, Marco, Piersigilli, F, Vento, Giovanni, Caruso, Alessandro, De Carolis, Maria Pia (ORCID:0000-0003-2054-8228), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), De Santis, Marco (ORCID:0000-0002-1388-0014), Vento, Giovanni (ORCID:0000-0002-8132-5127), and Caruso, Alessandro (ORCID:0000-0002-4749-3207)
- Abstract
The aim of this study was to determine the effects of amnio-infusion treatment on fetal and neonatal mortality and neonatal pulmonary development in women with singleton pregnancies and premature rupture of the membranes occurring at a gestational age of <26 weeks and who had severe oligohydramnios. The treated group of 45 consenting women received serial amnio-infusion and was compared with the control group of 44 women who underwent waiting treatment. Our study confirmed a higher number of live births in the treated group, especially in cases with a gestational age at rupture (GAR) of <20 weeks. Furthermore, even if GAR is an important factor for predicting pulmonary hypoplasia, amnio-infusion treatment reduces the probability of pulmonary hypoplasia. In fact, over 20 weeks, amnio-infusion treatment significantly reduces the risk of pulmonary hypoplasia even if normal lung development cannot be guaranteed.
- Published
- 2004