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The object of this study was to determine the importance and relevance of DNA damage in sulfur-mustard(H)-induced skin lesions. It was found that caffeine, proflavine, and acriflavine, three DNA repair inhibitors, significantly potentiated the vesicant action of sulfur mustard. Biochemical evidence obtained from biopsied sections of rabbit skin indicated that H caused approximately a 95 percent inhibition of normal semiconservative DNA replication and initiated DNA repair replication. The DNA repair inhibitors were also found to be effective in this system. It was concluded that: (a) The vesicant action of H is due to an initial damage to DNA; (b) rabbit skin possesses an active but inhibitable DNA repair capability; and (c) the failure to repair DNA results in a more severe skin lesion following an almost uneventful latent period; and (d) cellular breakdown products stimulate reproduction of basal and hair follicle cells. (Author)

The present paper sheds light on one of the possible mechanisms of interaction between the typical aromatic dye proflavine and the carbon nanotube surface, namely, π-stacking between aromatic rings of these compounds. To investigate such a complexation, a qualitative analysis was performed by means of ultraviolet visible, infrared, and nuclear magnetic resonance spectroscopy. The data obtained suggest that π-stacking brings the major contribution to the stabilization of the complex between proflavine and the carbon nanotube

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[No abstract available]