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Topik® One is a novel, selective herbicide for the control of grasses and broadleaf weeds in soft and durum wheat. The efficacy of the product is based on the combination of two active ingredients (AI), piroxsulam and clodinafop-propargyl. In this study we present the results of field trials conducted over a period of three years (2011-2013) in Italy. Data implies that Topik One has very good efficacy against Alopecurus myosuroides, Avena spp., Bromus spp., Lolium spp. and a wide range of broadleaf weeds like Galium spp., Matricaria spp. and Sinapis spp.. Topik One is safe for use in durum and soft wheat when applied between BBCH 13-32 at different environmental conditions. Due to the combination of two complementary active ingredients with very strong grass weed activity, a relatively low dose of 0.25 kg/ha already provides sufficient control. In addition, combining two different modes of action (MoA) in the same product and applying it only once a year, keeps the agronomic risk of a resistance development low.