Search

Your search keyword '"Reinhard, Christoph"' showing total 32 results
Start Over Author "Reinhard, Christoph" Database OAIster
32 results on '"Reinhard, Christoph"'

1. Precision oncology beyond genomics: the future is here - it is just not evenly distributed

Author

Pfohl, Ulrike, Pflaume, Alina, Regenbrecht, Manuela, Finkler, Sabine, Adelmann, Quirin Graf, Reinhard, Christoph, Regenbrecht, Christian René Alexander, Wedeken, Lena, Pfohl, Ulrike, Pflaume, Alina, Regenbrecht, Manuela, Finkler, Sabine, Adelmann, Quirin Graf, Reinhard, Christoph, Regenbrecht, Christian René Alexander, and Wedeken, Lena

Abstract

Cancer is a multifactorial disease with increasing incidence. There are more than 100 different cancer types, defined by location, cell of origin, and genomic alterations that influence oncogenesis and therapeutic response. This heterogeneity between tumors of different patients and also the heterogeneity within the same patient’s tumor pose an enormous challenge to cancer treatment. In this review, we explore tumor heterogeneity on the longitudinal and the latitudinal axis, reviewing current and future approaches to study this heterogeneity and their potential to support oncologists in tailoring a patient’s treatment regimen. We highlight how the ideal of precision oncology is reaching far beyond the knowledge of genetic variants to inform clinical practice and discuss the technologies and strategies already available to improve our understanding and management of heterogeneity in cancer treatment. We will focus on integrating multi-omics technologies with suitable in vitro models and their proficiency in mimicking endogenous tumor heterogeneity.

Published
2021

2. Applying a Process Organization Perspective in the Context of Corporate Sustainability

Author

Königstorfer, Jörg (Prof. Dr.), Belz, Frank-Martin (Prof. Dr.), Jungnik Freiherr von Wittken, Reinhard Christoph, Königstorfer, Jörg (Prof. Dr.), Belz, Frank-Martin (Prof. Dr.), and Jungnik Freiherr von Wittken, Reinhard Christoph

Abstract

This dissertation applies a process organization perspective to various phenomena which are of particular importance in the context of corporate sustainability. The first essay elaborates on the role of organizational products in the evolution of organizational identity. The second essay investigates how organizations can navigate the paradox of authenticity and market commercialization over time. The third essay critically discusses how organizations can translate the inherently processual character of sustainable development from the societal level to the organizational level in corporate sustainability accounting., Diese Dissertation wendet eine Process Organization Perspective auf verschiedene Phänomene an, die im Kontext unternehmerischer Nachhaltigkeit von besonderer Bedeutung sind. Das erste Essay richtet den Fokus auf die Rolle organisationaler Produkte in der Entwicklung organisationaler Identität. Das zweite Essay untersucht, wie Organisationen über die Zeit hinweg mit dem Paradox zwischen organisationaler Authentizität und Marktkommerzialisierung umgehen können. Das dritte Essay diskutiert kritisch, wie Organisationen im Nachhaltigkeitsaccounting das prozessuale Verständnis Nachhaltiger Entwicklung von der gesellschaftlichen auf die organisationale Ebene übertragen können.

Published
2020

3. Applying a Process Organization Perspective in the Context of Corporate Sustainability

Author

Belz, Frank-Martin (Prof. Dr.), Belz, Frank-Martin (Prof. Dr.);Königstorfer, Jörg (Prof. Dr.), Jungnik Freiherr von Wittken, Reinhard Christoph, Belz, Frank-Martin (Prof. Dr.), Belz, Frank-Martin (Prof. Dr.);Königstorfer, Jörg (Prof. Dr.), and Jungnik Freiherr von Wittken, Reinhard Christoph

Abstract

This dissertation applies a process organization perspective to various phenomena which are of particular importance in the context of corporate sustainability. The first essay elaborates on the role of organizational products in the evolution of organizational identity. The second essay investigates how organizations can navigate the paradox of authenticity and market commercialization over time. The third essay critically discusses how organizations can translate the inherently processual character of sustainable development from the societal level to the organizational level in corporate sustainability accounting., Diese Dissertation wendet eine Process Organization Perspective auf verschiedene Phänomene an, die im Kontext unternehmerischer Nachhaltigkeit von besonderer Bedeutung sind. Das erste Essay richtet den Fokus auf die Rolle organisationaler Produkte in der Entwicklung organisationaler Identität. Das zweite Essay untersucht, wie Organisationen über die Zeit hinweg mit dem Paradox zwischen organisationaler Authentizität und Marktkommerzialisierung umgehen können. Das dritte Essay diskutiert kritisch, wie Organisationen im Nachhaltigkeitsaccounting das prozessuale Verständnis Nachhaltiger Entwicklung von der gesellschaftlichen auf die organisationale Ebene übertragen können.

Published
2020

4. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Author

Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure, Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, and Yaspo, Marie-Laure

Abstract

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

Published
2017
Full Text
View/download PDF

5. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Author

Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure, Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, and Yaspo, Marie-Laure

Abstract

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

Published
2017
Full Text
View/download PDF

6. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Author

Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure, Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, and Yaspo, Marie-Laure

Abstract

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

Published
2017
Full Text
View/download PDF

7. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Author

Schütte, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Jörg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schäfer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure, Schütte, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Jörg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schäfer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, and Yaspo, Marie-Laure

Abstract

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

Published
2017
Full Text
View/download PDF

8. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Author

Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure, Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, and Yaspo, Marie-Laure

Abstract

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

Published
2017
Full Text
View/download PDF

9. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Author

Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure, Schuette, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildirimman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans-Joerg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schaefer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, and Yaspo, Marie-Laure

Abstract

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

Published
2017
Full Text
View/download PDF

10. Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Author

Chen, Kexin, Chen, Kexin, Yang, Da, Li, Xiangchun, Sun, Baocun, Song, Fengju, Cao, Wenfeng, Brat, Daniel J, Gao, Zhibo, Li, Haixin, Liang, Han, Zhao, Yanrui, Zheng, Hong, Li, Miao, Buckner, Jan, Patterson, Scott D, Ye, Xiang, Reinhard, Christoph, Bhathena, Anahita, Joshi, Deepa, Mischel, Paul S, Croce, Carlo M, Wang, Yi Michael, Raghavakaimal, Sreekumar, Li, Hui, Lu, Xin, Pan, Yang, Chang, Han, Ba, Sujuan, Luo, Longhai, Cavenee, Webster K, Zhang, Wei, Hao, Xishan, Chen, Kexin, Chen, Kexin, Yang, Da, Li, Xiangchun, Sun, Baocun, Song, Fengju, Cao, Wenfeng, Brat, Daniel J, Gao, Zhibo, Li, Haixin, Liang, Han, Zhao, Yanrui, Zheng, Hong, Li, Miao, Buckner, Jan, Patterson, Scott D, Ye, Xiang, Reinhard, Christoph, Bhathena, Anahita, Joshi, Deepa, Mischel, Paul S, Croce, Carlo M, Wang, Yi Michael, Raghavakaimal, Sreekumar, Li, Hui, Lu, Xin, Pan, Yang, Chang, Han, Ba, Sujuan, Luo, Longhai, Cavenee, Webster K, Zhang, Wei, and Hao, Xishan

Abstract

Gastric cancer (GC) is a highly heterogeneous disease. To identify potential clinically actionable therapeutic targets that may inform individualized treatment strategies, we performed whole-exome sequencing on 78 GCs of differing histologies and anatomic locations, as well as whole-genome sequencing on two GC cases, each with three primary tumors and two matching lymph node metastases. The data showed two distinct GC subtypes with either high-clonality (HiC) or low-clonality (LoC). The HiC subtype of intratumoral heterogeneity was associated with older age, TP53 (tumor protein P53) mutation, enriched C > G transition, and significantly shorter survival, whereas the LoC subtype was associated with younger age, ARID1A (AT rich interactive domain 1A) mutation, and significantly longer survival. Phylogenetic tree analysis of whole-genome sequencing data from multiple samples of two patients supported the clonal evolution of GC metastasis and revealed the accumulation of genetic defects that necessitate combination therapeutics. The most recurrently mutated genes, which were validated in a separate cohort of 216 cases by targeted sequencing, were members of the homologous recombination DNA repair, Wnt, and PI3K-ERBB pathways. Notably, the drugable NRG1 (neuregulin-1) and ERBB4 (V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 4) ligand-receptor pair were mutated in 10% of GC cases. Mutations of the BRCA2 (breast cancer 2, early onset) gene, found in 8% of our cohort and validated in The Cancer Genome Atlas GC cohort, were associated with significantly longer survivals. These data define distinct clinicogenetic forms of GC in the Chinese population that are characterized by specific mutation sets that can be investigated for efficacy of single and combination therapies.

Published
2015

11. Mutational landscape of gastric adenocarcinoma in Chinese:implications for prognosis and therapy

Author

Chen, Kexin, Yang, Da, Li, Xiangchun, Sun, Baocun, Song, Fengju, Cao, Wenfeng, Brat, Daniel J., Gao, Zhibo, Li, Haixin, Liang, Han, Zhao, Yanrui, Zheng, Hong, Li, Miao, Buckner, Jan, Patterson, Scott D., Ye, Xiang, Reinhard, Christoph, Bhathena, Anahita, Joshi, Deepa, Mischel, Paul S., Croce, Carlo M., Wang, Yi Michael, Raghavakaimal, Sreekumar, Li, Hui, Lu, Xin, Pan, Yang, Chang, Han, Ba, Sujuan, Luo, Longhai, Cavenee, Webster K., Zhang, Wei, Hao, Xishan, Chen, Kexin, Yang, Da, Li, Xiangchun, Sun, Baocun, Song, Fengju, Cao, Wenfeng, Brat, Daniel J., Gao, Zhibo, Li, Haixin, Liang, Han, Zhao, Yanrui, Zheng, Hong, Li, Miao, Buckner, Jan, Patterson, Scott D., Ye, Xiang, Reinhard, Christoph, Bhathena, Anahita, Joshi, Deepa, Mischel, Paul S., Croce, Carlo M., Wang, Yi Michael, Raghavakaimal, Sreekumar, Li, Hui, Lu, Xin, Pan, Yang, Chang, Han, Ba, Sujuan, Luo, Longhai, Cavenee, Webster K., Zhang, Wei, and Hao, Xishan

Published
2015

12. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

Author

Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., Mao, Mao, Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., and Mao, Mao

Published
2013

13. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

Author

Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., Mao, Mao, Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., and Mao, Mao

Published
2013

14. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

Author

Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., Mao, Mao, Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., and Mao, Mao

Published
2013

15. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

Author

Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., Mao, Mao, Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., and Mao, Mao

Published
2013

16. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

Author

Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus H., Wong, Kwong F., Liu, Angela M., Poon, Ronnie T., Fan, Sheung Tat, Chan, Kwong L., Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas D., Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, Luk, John M., Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus H., Wong, Kwong F., Liu, Angela M., Poon, Ronnie T., Fan, Sheung Tat, Chan, Kwong L., Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas D., Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, and Luk, John M.

Abstract

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival.

Published
2012
Full Text
View/download PDF

17. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

Author

Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus, Wong, Kwong, Liu, Angela, Poon, Ronnie, Fan, Sheung, Chan, Kwong, Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas, Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, Luk, John, Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus, Wong, Kwong, Liu, Angela, Poon, Ronnie, Fan, Sheung, Chan, Kwong, Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas, Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, and Luk, John

Abstract

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥ 4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival.

Published
2012

18. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

Author

Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus H., Wong, Kwong F., Liu, Angela M., Poon, Ronnie T., Fan, Sheung Tat, Chan, Kwong L., Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas D., Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, Luk, John M., Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus H., Wong, Kwong F., Liu, Angela M., Poon, Ronnie T., Fan, Sheung Tat, Chan, Kwong L., Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas D., Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, and Luk, John M.

Abstract

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival.

Published
2012
Full Text
View/download PDF

19. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

Author

Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus, Wong, Kwong, Liu, Angela, Poon, Ronnie, Fan, Sheung, Chan, Kwong, Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas, Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, Luk, John, Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P., Lee, Wah H., Ariyaratne, Pramila N., Tennakoon, Chandana, Mulawadi, Fabianus, Wong, Kwong, Liu, Angela, Poon, Ronnie, Fan, Sheung, Chan, Kwong, Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas, Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, and Luk, John

Abstract

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥ 4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival.

Published
2012

20. Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast.

Author

Fendt, Sarah-Maria, Oliveira, Ana Paula, Christen, Stefan, Picotti, Paola, Dechant, Reinhard Christoph, Sauer, Uwe, Fendt, Sarah-Maria, Oliveira, Ana Paula, Christen, Stefan, Picotti, Paola, Dechant, Reinhard Christoph, and Sauer, Uwe

Abstract

Which transcription factors control the distribution of metabolic fluxes under a given condition? We address this question by systematically quantifying metabolic fluxes in 119 transcription factor deletion mutants of Saccharomyces cerevisiae under five growth conditions. While most knockouts did not affect fluxes, we identified 42 condition-dependent interactions that were mediated by a total of 23 transcription factors that control almost exclusively the cellular decision between respiration and fermentation. This relatively sparse, condition-specific network of active metabolic control contrasts with the much larger gene regulation network inferred from expression and DNA binding data. Based on protein and transcript analyses in key mutants, we identified three enzymes in the tricarboxylic acid cycle as the key targets of this transcriptional control. For the transcription factor Gcn4, we demonstrate that this control is mediated through the PKA and Snf1 signaling cascade. The discrepancy between flux response predictions, based on the known regulatory network architecture and our functional (13)C-data, demonstrates the importance of identifying and quantifying the extent to which regulatory effectors alter cellular functions.

Published
2010

21. Petri Mülleri U.I.D. & In Academ. Ienensi Profess. ad Tit. Dig. Ult. De Regulis Iuris Antiqui Collegium Publicum; in duas partes distributum; Ubi Singulae leges per Exempla, adiectis Limitationibus & Notabilibus perspicue explicantur

Author

Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, Müller, Peter, Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, and Müller, Peter

22. Petri Mülleri U.I.D. & In Academ. Ienensi Profess. ad Tit. Dig. Ult. De Regulis Iuris Antiqui Collegium Publicum; in duas partes distributum; Ubi Singulae leges per Exempla, adiectis Limitationibus & Notabilibus perspicue explicantur

Author

Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, Müller, Peter, Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, and Müller, Peter

23. Petri Mülleri U.I.D. & In Academ. Ienensi Profess. ad Tit. Dig. Ult. De Regulis Iuris Antiqui Collegium Publicum; in duas partes distributum; Ubi Singulae leges per Exempla, adiectis Limitationibus & Notabilibus perspicue explicantur

Author

Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, Müller, Peter, Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, and Müller, Peter

24. Petri Mülleri U.I.D. & In Academ. Ienensi Profess. ad Tit. Dig. Ult. De Regulis Iuris Antiqui Collegium Publicum; in duas partes distributum; Ubi Singulae leges per Exempla, adiectis Limitationibus & Notabilibus perspicue explicantur

Author

Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, Müller, Peter, Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, and Müller, Peter

25. Petri Mülleri U.I.D. & In Academ. Ienensi Profess. ad Tit. Dig. Ult. De Regulis Iuris Antiqui Collegium Publicum; in duas partes distributum; Ubi Singulae leges per Exempla, adiectis Limitationibus & Notabilibus perspicue explicantur

Author

Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, Müller, Peter, Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, and Müller, Peter

26. Petri Mülleri U.I.D. & In Academ. Ienensi Profess. ad Tit. Dig. Ult. De Regulis Iuris Antiqui Collegium Publicum; in duas partes distributum; Ubi Singulae leges per Exempla, adiectis Limitationibus & Notabilibus perspicue explicantur

Author

Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, Müller, Peter, Luedeke, Jacob Heinrich, Pleetz, Andreas, Drachstedt, Augustus, Brem, Johann-Georg, Rhode, David Rudolphus, Donauer, Wolffgang Christoph, Söhlen, Friedrich Ulrich, Gerikens, Sebastianus, Mollenbec, Bernhard Ludwig, Carstens, Christoph Hermann, Gerbet, Georg, Mencke, Lüder, Rabe, Wolfgang Georg, Reutter, Matthaeus, Nicolai, Johann Philipp, Planckenauer, Joh. Christophorus, Brendel, Johann Caspar, Oernster, Philip Jacob, Reichhelm, Sigismund Siegfried, Becht, Johann Georg, Schönfeld, Johann Benjamin, Creutzing, Kaspar, Bötticher, Heinrich Günther, Bötticher, Johann Philipp, Reinhard, Christoph, Oelsner, Christian Conrad, Klesch, Christoph Daniel, Wedekind, Johann Ernst, Magen, Benjamin, Meisner, Joh. Chr., Redel, Carl Adolph, Fischer, Johann Caspar, Dresde, Elias, Bohsius, Joh. Andreas, Behrmann, Georg Adam, Schneider, Batholomaeus, and Müller, Peter

27. Als Der Edle, Groß-Achtbare und Wohlgelahrte Herr, Herr Johann Caspar Krause, Von Roßwein aus Meissen, Der Heil. Schrifft eifrigst Beflieszner, Die Höchste Ehre Der Welt-Weiszheit, Den 17. Octobr. 1705. Auf dem Welt-berühmten Elb-Athen Rühmlichst erhielte, Wolten aus Vetterlicher Schuldigkeit Von Hertzen gratuliren Christoph Ludewig Reinhard, und Johann Benjamin Reinhard

Author

Reinhard, Christoph Ludwig, Reinhard, Johann Benjamin, Reinhard, Christoph Ludwig, and Reinhard, Johann Benjamin

Abstract

Vorlageform des Erscheinungsvermerks: Dreßden, druckts Joh. Friedrich Schrödel.

28. Gymnasii Novi Reipublicae Liberae-Imperialis Mulhusinae Constitutio Et Lectionum Atque Exercitationum Ordo Pro Semestri Hyberno An. MDCXXVI. Amplissimi Ac Prudentissimi Senatus Decreto P. P. Rectore & Gymnasiarcha Georg. Andrea Fabricio Philos. Mag. ...

Author

Reinhard, Christoph., Starck, Benjamin, Fabricius, Georg Andreas, Reinhard, Christoph., Starck, Benjamin, and Fabricius, Georg Andreas

Abstract

Schlüsselseiten aus dem Exemplar der ULB Halle: Pon Yd 2343 n (9), Alle Seiten mit Zierrahmen

29. Ein Unvergeßliches Denck- Danck- und Ehren-Mahl der von GOtt überkom[m]enen dreyfachen herrlichen Siegs- Ehr- und Lebens-Crone, Solte und wolte, Alß der Hochgebohrne Graff und Herr, Herr Curt Reinicke, Des Heil. Röm. Reichs Graff von Callenberg, Herr der freyen Standes- und Erb-Herrschafft Mußkau in Ober-Laußitz, auch uf Wettesingen, Westheimb und Alt-Lübel. [et]c. Sein im Leben Gnädigster Graff und Herr, Dero rühmligst geführtes Leben im 58. Jahr Ihres Alters, den 20. April. 1709. In der Königl. und Chur-Sächs. Residentz-Stadt Dreßden ... Hochseligst beschlossen ... eyligst entwerffen, [Und Der Hochgebohrnen Gräffin und Frauen, Frauen Ursul Reginen, Wittben, Des Heil. Röm. Reichs Gräffin von Callenberg, gebohrner Reichs-Gräffin von Frießin, Frauen der freyen Standes- und Erb-Herrschafft Mußkau, auch uf Wettesingen, Westheimb und Alt-Lübel, ingleichen, Jemblitz, Mertz- und Neudorff [et]c. [et]c. [et]c. ... Wie auch Denen Hochgebohrnen Graffen und Herren, Herrn Heinrichen, Herrn Carl Otten, Herrn Friedrich Maximilian, Herrn August Heinrich Gottloben, Herrn Johann Alexander, Allerseits Graffen von Callenberg, Ingleichen Denen Hochgeb. Gräffinnen und Frauen, auch Conteßinnen, Frauen Margarethen, Vermählter Reichs-Gräffin von Schönburg-Lichtenstein [et]c. Conteßin Marien Charlottin, Conteßin Loysen Amalien, Conteßin Christianen Sophien, Seinen allerseits Gnädigsten Graffen, und Conteßinnen, gehorsambst übersenden und dediciren, Dero vormahliger Ampts-Secretarius zu Mußkau, und itziger würcklicher Rath von Hauß aus, Christoff Reinhard, Advoc. Hallens.]

Author

Reinhard, Christoph and Reinhard, Christoph

Abstract

Trauerschrift auf Curt Reinicke Graf von Calenberg, +20. April 1709, Vorlageform des Erscheinungsvermerks: Halle, den 14. Mäy 1709. als am Tage Coronæ. Druckts, Johann Grunert, Univ. Buchdr.

30. Ein Unvergeßliches Denck- Danck- und Ehren-Mahl der von GOtt überkom[m]enen dreyfachen herrlichen Siegs- Ehr- und Lebens-Crone, Solte und wolte, Alß der Hochgebohrne Graff und Herr, Herr Curt Reinicke, Des Heil. Röm. Reichs Graff von Callenberg, Herr der freyen Standes- und Erb-Herrschafft Mußkau in Ober-Laußitz, auch uf Wettesingen, Westheimb und Alt-Lübel. [et]c. Sein im Leben Gnädigster Graff und Herr, Dero rühmligst geführtes Leben im 58. Jahr Ihres Alters, den 20. April. 1709. In der Königl. und Chur-Sächs. Residentz-Stadt Dreßden ... Hochseligst beschlossen ... eyligst entwerffen, [Und Der Hochgebohrnen Gräffin und Frauen, Frauen Ursul Reginen, Wittben, Des Heil. Röm. Reichs Gräffin von Callenberg, gebohrner Reichs-Gräffin von Frießin, Frauen der freyen Standes- und Erb-Herrschafft Mußkau, auch uf Wettesingen, Westheimb und Alt-Lübel, ingleichen, Jemblitz, Mertz- und Neudorff [et]c. [et]c. [et]c. ... Wie auch Denen Hochgebohrnen Graffen und Herren, Herrn Heinrichen, Herrn Carl Otten, Herrn Friedrich Maximilian, Herrn August Heinrich Gottloben, Herrn Johann Alexander, Allerseits Graffen von Callenberg, Ingleichen Denen Hochgeb. Gräffinnen und Frauen, auch Conteßinnen, Frauen Margarethen, Vermählter Reichs-Gräffin von Schönburg-Lichtenstein [et]c. Conteßin Marien Charlottin, Conteßin Loysen Amalien, Conteßin Christianen Sophien, Seinen allerseits Gnädigsten Graffen, und Conteßinnen, gehorsambst übersenden und dediciren, Dero vormahliger Ampts-Secretarius zu Mußkau, und itziger würcklicher Rath von Hauß aus, Christoff Reinhard, Advoc. Hallens.]

Author

Reinhard, Christoph and Reinhard, Christoph

Abstract

Trauerschrift auf Curt Reinicke Graf von Calenberg, +20. April 1709, Vorlageform des Erscheinungsvermerks: Halle, den 14. Mäy 1709. als am Tage Coronæ. Druckts, Johann Grunert, Univ. Buchdr.

31. Als Der Edle, Groß-Achtbare und Wohlgelahrte Herr, Herr Johann Caspar Krause, Von Roßwein aus Meissen, Der Heil. Schrifft eifrigst Beflieszner, Die Höchste Ehre Der Welt-Weiszheit, Den 17. Octobr. 1705. Auf dem Welt-berühmten Elb-Athen Rühmlichst erhielte, Wolten aus Vetterlicher Schuldigkeit Von Hertzen gratuliren Christoph Ludewig Reinhard, und Johann Benjamin Reinhard

Author

Reinhard, Christoph Ludwig, Reinhard, Johann Benjamin, Reinhard, Christoph Ludwig, and Reinhard, Johann Benjamin

Abstract

Vorlageform des Erscheinungsvermerks: Dreßden, druckts Joh. Friedrich Schrödel.

32. Gymnasii Novi Reipublicae Liberae-Imperialis Mulhusinae Constitutio Et Lectionum Atque Exercitationum Ordo Pro Semestri Hyberno An. MDCXXVI. Amplissimi Ac Prudentissimi Senatus Decreto P. P. Rectore & Gymnasiarcha Georg. Andrea Fabricio Philos. Mag. ...

Author

Reinhard, Christoph., Starck, Benjamin, Fabricius, Georg Andreas, Reinhard, Christoph., Starck, Benjamin, and Fabricius, Georg Andreas

Abstract

Schlüsselseiten aus dem Exemplar der ULB Halle: Pon Yd 2343 n (9), Alle Seiten mit Zierrahmen

Catalog

Books, media, physical & digital resources
See catalog results