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Coastal flood damage is primarily the result of extreme sea levels. Climate change is expected to drive an increase in these extremes. While proper estimation of changes in storm surges is essential to estimate changes in extreme sea levels, there remains low confidence in future trends of surge contribution to extreme sea levels. Alerting local populations of imminent extreme sea levels is also critical to protecting coastal populations. Both predicting and projecting extreme sea levels require reliable numerical prediction systems. The SurgeMIP (surge model intercomparison) community has been established to tackle such challenges. Efforts to intercompare storm surge prediction systems and coordinate the community's prediction and projection efforts are introduced. An overview of past and recent advances in storm surge science such as physical processes to consider and the recent development of global forecasting systems are briefly introduced. Selected historical events and drivers behind fast increasing service and knowledge requirements for emergency response to adaptation considerations are also discussed. The community's initial plans and recent progress are introduced. These include the establishment of an intercomparison project, the identification of research and development gaps, and the introduction of efforts to coordinate projections that span multiple climate scenarios.

Purpose: During the development process of the turbopump for a rocket engine, various problems of shaft vibration have been reported. Among them, vibration problems caused by dynamic fluid flow phenomena in the inducer, such as rotation cavitation (RC) and attached asymmetric cavitation (AAC), are known to be major factors that impair the stability of the system. The transition from RC to AAC was observed experimentally, however, there has been no analytical investigation of this transition phenomenon. The Purpose of this study is explaining the transition from RC to AAC in the inducer. Methods: The fluid flow phenomena in the inducer was modeled using a one-dimensional flow-path model of the inducer. The representation of pump dynamic characteristic coefficients (cavitation compliance and mass flow gain factor) in each flow path was proposed and investigated. Furthermore, a coupled analysis of the rotor and fluid systems was performed to investigate this transition from RC to AAC in the inducer. Results: The occurrence of this transition from RC to AAC in the inducer was observed and explained. It was evaluated by comparison with the experimental results. Conclusions: The key factor of transition from RC to AAC in the inducer was the signs of the pump dynamic characteristic coefficients (both cavitation compliance and mass flow gain factor). Transition occurred when both were set as negative. The results of the coupled analysis were qualitatively in good agreement with the experimental results obtained from the water tunnel test.

This study explores a new method in food development by utilizing AI including generative AI, aiming to craft products that delight the senses and resonate with consumers' emotions. The food ingredient recommendation approach used in this study can be considered as a form of multimodal generation in a broad sense, as it takes text as input and outputs food ingredient candidates. This Study focused on producing "Romance Bread," a collection of breads infused with flavors that reflect the nuances of a romantic Japanese television program. We analyzed conversations from TV programs and lyrics from songs featuring fruits and sweets to recommend ingredients that express romantic feelings. Based on these recommendations, the bread developers then considered the flavoring of the bread and developed new bread varieties. The research included a tasting evaluation involving 31 participants and interviews with the product developers. Findings indicate a notable correlation between tastes generated by AI and human preferences. This study validates the concept of using AI in food innovation and highlights the broad potential for developing unique consumer experiences that focus on emotional engagement through AI and human collaboration., Comment: Accepted to GenAICHI: CHI 2024 Workshop on Generative AI and HCI

Akio Onishi,1 Yayoi Matsumura-Kimoto,1,2 Shinsuke Mizutani,1 Taku Tsukamoto,1 Takahiro Fujino,1 Akihiro Miyashita,1,3 Daichi Nishiyama,4 Kazuho Shimura,5 Hiroto Kaneko,5 Eri Kawata,6 Ryoichi Takahashi,7 Tsutomu Kobayashi,1,8 Hitoji Uchiyama,8 Nobuhiko Uoshima,3 Yoko Nukui,9 Yuji Shimura,1 Tohru Inaba,9 Junya Kuroda1 1Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Department of Hematology, Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center, Kyoto, Japan; 3Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan; 4Department of Hematology, Fukuchiyama City Hospital, Fukuchiyama, Japan; 5Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan; 6Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan; 7Department of Hematology, Omihachiman Community Medical Center, Omihachiman, Japan; 8Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan; 9Division of Infection Control & Molecular Laboratory Medicine, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanCorrespondence: Junya Kuroda, Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan, Tel +81-75-251-5740, Fax +81-75-251-5743, Email junkuro@koto.kpu-m.ac.jpBackground and Purpose: Anti-CD20 monoclonal antibodies (MoAbs), rituximab (RIT), and obinutuzumab (OBZ) are the central components of immunochemotherapy for B-cell lymphoma (BCL). However, these agents potentially cause B-cell depletion, resulting in the impairment of antibody (Ab) production. During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the optimal prediction of Ab response against anti–SARS-CoV-2 vaccination is critically important in patients with BCL treated by B-cell depletion therapeutics to prevent coronavirus disease 2019

The 2022 Hunga Tonga-Hunga Ha’apai eruption generated tsunamis that propagated across the Pacific Ocean. Along the coast of Japan, nearshore amplification led to amplitudes of nearly 1 m at some locations, with varying peak tsunami occurrence times. The leading tsunami wave can generally be reproduced by Lamb waves, which are a type of air-pressure wave generated by an eruption. However, subsequent tsunamis that occurred several hours after the leading wave tended to be larger for unknown reasons. This study performs multi-scale numerical simulations to investigate subsequent tsunami waves in the vicinity of Japan induced by air pressure waves caused by the eruption. The atmospheric pressure field was created using a dispersion relation of atmospheric gravity wave and tuned by physical parameters based on observational records. The tsunami simulations used the adaptive mesh refinement method, incorporating detailed bathymetry and topography to solve the tsunami at various spatial scales. The simulations effectively reproduced the tsunami waveforms observed at numerous coastal locations, and results indicate that the factors contributing to the maximum tsunami amplitude differ by region. In particular, bay resonance plays a major role in determining the maximum amplitude at many sites along the east coast of Japan. However, large tsunami amplification at some west coast locations was not replicated, probably because it was caused by amplification during oceanic wave propagation rather than meteorological factors. These findings enhance our understanding of meteotsunami complexity and help distinguish tsunami amplification factors.

Tropical cyclones (TCs) cause severe coastal flooding in the middle latitudes. While the IPCC Fifth Assessment Reports (AR5, 2013) have focused on mean sea-level rise, recent advances (e.g., IPCC Sixth Assessment Reports, AR6, 2021) have shown the importance of storm surges and wave changes in extreme water levels causing coastal flooding. Both TC intensity and track changes are linked to future changes in extreme storm surges and wave climates in middle latitudes. This brief review summarizes historical and future long-term changes in extreme water levels, the contribution of increased storm surges, and wave height by the monitoring data and climate projections. In addition, several examples of impact assessment of storm surges and extreme wave changes are presented.

In this article, we give analysis for a structure-preserving finite difference scheme to the Cahn-Hilliard system coupled with elasticity in one space dimension. In the previous article [K. Shimura and S. Yoshikawa, Error estimate for structure-preserving finite difference schemes of the one-dimensional Cahn-Hilliard system coupled with viscoelasticity, Regularity and Asymptotic Analysis for Critical Cases of Partial Differential Equations, RIMS Kôkyûroku Bessatsu B82, Research Institute for Mathematical Sciences (RIMS), Kyoto 2020, 159-175], we studied the system coupled with viscoelasticity, where we proposed a conservative numerical scheme for the system which inherits the total energy conservation and momentum conservation laws, and showed the error estimate. However, the error estimate can not be applied to the system without viscosity, due to the fact that the proof relies on the viscous term. Here, we show the error estimate for the system without viscosity by proposing a new structure-preserving finite difference scheme for the system. In addition, we also give the proof of existence of solution for the scheme.

This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/acd1ca., While the formation of a GaOx interlayer is key to achieving SiO₂/GaN interfaces with low defect density, positive fixed charge is rather easily generated through the reduction of GaOx layer if the annealing conditions are not properly designed. In this study, we minimized the unstable GaOx layer by sputter SiO₂ deposition. Negligible GaOx growth was confirmed by synchrotron radiation X-ray photoelectron spectroscopy, even when post-deposition oxygen annealing up to 600℃ was performed. A MOS device with negligible capacitance–voltage hysteresis, stable flat-band voltage, and low leakage current was demonstrated by performing oxygen and forming gas annealing at temperatures of 600℃ and 400℃, respectively.

This is the Accepted Manuscript version of an article accepted for publication in Applied Physics Express. IOP Publishing Ltd are not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1882-0786/acc1bd., The effect of post-deposition annealing on the electrical characteristics of SiO₂/GaN MOS devices was investigated. While the key to the improvement was using oxygen annealing to form an interfacial GaOx layer and forming gas annealing to passivate the remaining defects, caution must be taken not to produce a fixed charge through reduction of the GaOx layer. By growing the GaOx layer with oxygen annealing at 800 ℃ and performing forming gas annealing at a low temperature of 200 ℃, it became possible to suppress the reduction of GaOx and to reduce the interface traps, oxide traps, and fixed charge simultaneously.

We report three cases of methotrexate (MTX) -induced oral erosions and ulcers mimicking Stevens-Johnson syndrome (SJS) in older women with rheumatoid arthritis, although they did not had conjunctivitis. Furthermore, age, dehydration, and renal dysfunction could trigger adverse reactions of MTX, but one patient underwent dialysis, which is a contraindication for MTX. It is sometimes very difficult to differentiate the toxicity of MTX from SJS. Learning from the three cases, we propose that oral mucosal erosions without conjunctive mucosal inflammation, leukopenia, and thrombocytopenia differentiate MTX toxicity from SJS. Furthermore, our patients nearly recovered from myelosuppression within seven days and recovered from mucosal erosions characteristic of MTX toxicity within 14 days. These clinical courses could also be characteristic for MTX toxicity rather than SJS, although quick recovery does not happen in all cases. Therefore, physicians who prescribe MTX must accurately know MTX-induced adverse reactions to recognize them early. Furthermore, as seen in our patients, oral mucosal erosions occur often. Therefore, dermatologists or others who examine these symptoms should consider that mucosal erosions mimicking SJS could be an adverse reaction of MTX, regardless of whether or not SJS/toxic epidermal necrolysis is suspected.

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11664-023-10309-w., We examined the fabrication process of uniaxial tensile-strained Ge wires in micro-bridge structures by utilizing the internal stresses in deposited metal thin films. This method enables strain control by adjusting film-deposition conditions, which is advantageous over previous methods that utilize internal stresses unintentionally applied to Ge-on-insulator substrates. We evaluated the internal stresses in W films formed by sputtering deposition methods. Tensile and compressive stresses were determined based on the Ar gas pressure during the deposition process. We applied tensile strain to Ge wires using 100-nm-thick W films, each with a tensile stress of 890 MPa, deposited in 1.5-Pa Ar gas. We confirmed that strains of up to 1.62% can be achieved and controlled by tuning the structural parameters of the bridge structure with the Ge wires. Photoluminescence peaks shifted to lower energies with increasing strain, in good agreement with theoretical predictions. We also used strained Ge wires to fabricate light-emitting diodes that exhibited clear electroluminescence peaks indicative of band structural modulation in the Ge wires.

We studied a high-speed Ge/Si electro-absorption optical modulator (EAM) evanescently coupled with a Si waveguide of a lateral p–n junction for a high-bandwidth optical interconnect over a wide range of temperatures from 25 °C to 85 °C. We demonstrated 56 Gbps high-speed operation at temperatures up to 85 °C. From the photoluminescence spectra, we confirmed that the bandgap energy dependence on temperature is relatively small, which is consistent with the shift in the operation wavelengths with increasing temperature for a Ge/Si EAM. We also demonstrated that the same device operates as a high-speed and high-efficiency Ge photodetector with the Franz-Keldysh (F-K) and avalanche-multiplication effects. These results demonstrate that the Ge/Si stacked structure is promising for both high-performance optical modulators and photodetectors integrated on Si platforms.

Purpose: There is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This study aimed to answer the following clinical questions: (1) how to use each hypnotic and non-pharmacological treatment differently depending on clinical situations and (2) how to reduce or stop benzodiazepine hypnotics using alternative pharmacological and nonpharmacological treatments. Methods: Experts were asked to evaluate treatment choices based on 10 clinical questions about insomnia disorder using a nine-point Likert scale (1 = “disagree” to 9 = “agree”). The responses of 196 experts were collected, and the answers were categorized into first-, second-, and third-line recommendations. Results: The primary pharmacological treatment, lemborexant (7.3 2.0), was categorized as a first-line recommendation for sleep initiation insomnia, and lemborexant (7.3 1.8) and suvorexant (6.8 1.8) were categorized as the first-line recommendations for sleep maintenance insomnia. Regarding nonpharmacological treatments for primary treatment, sleep hygiene education was categorized as the first-line recommendation for both sleep initiation (8.4 1.1) and maintenance insomnia (8.1 1.5), while multicomponent cognitive behavioral therapy for insomnia was categorized as the second-line treatment for both sleep initiation (5.6 2.3) and maintenance insomnia (5.7 2.4). When reducing or discontinuing benzodiazepine hypnotics by switching to other medications, lemborexant (7.5 1.8) and suvorexant (6.9 1.9) were categorized as first-line recommendations. Conclusion: Expert consensus indicates that orexin receptor antagonists and sleep hygiene education are recommended as first-line treatments in most clinical situations to treat insomnia disorder.

This is the Accepted Manuscript version of an article accepted for publication in Applied Physics Express. IOP Publishing Ltd are not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1882-0786/acfc95., A major challenge in GaN-based metal-oxide-semiconductor (MOS) devices is significant hole trapping near the oxide/GaN interface. In this study, we show that the density and energy level of the hole traps depends crucially on the concentration of magnesium (Mg) dopants in GaN layers. Although the surface potential of a conventional SiO₂/p-GaN MOS device is severely pinned by hole trapping, hole accumulation and very low interface state densities below 1011 cm−2 eV−1 are demonstrated for MOS capacitors on heavily Mg-doped GaN epilayers regardless of the degree of dopant activation. These findings indicate the decisive role of Mg atoms in defect passivation.

This is the Accepted Manuscript version of an article accepted for publication in Applied Physics Express. IOP Publishing Ltd are not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1882-0786/acc1bd., The effect of post-deposition annealing on the electrical characteristics of SiO₂/GaN MOS devices was investigated. While the key to the improvement was using oxygen annealing to form an interfacial GaOx layer and forming gas annealing to passivate the remaining defects, caution must be taken not to produce a fixed charge through reduction of the GaOx layer. By growing the GaOx layer with oxygen annealing at 800 ℃ and performing forming gas annealing at a low temperature of 200 ℃, it became possible to suppress the reduction of GaOx and to reduce the interface traps, oxide traps, and fixed charge simultaneously.

We report three cases of methotrexate (MTX) -induced oral erosions and ulcers mimicking Stevens-Johnson syndrome (SJS) in older women with rheumatoid arthritis, although they did not had conjunctivitis. Furthermore, age, dehydration, and renal dysfunction could trigger adverse reactions of MTX, but one patient underwent dialysis, which is a contraindication for MTX. It is sometimes very difficult to differentiate the toxicity of MTX from SJS. Learning from the three cases, we propose that oral mucosal erosions without conjunctive mucosal inflammation, leukopenia, and thrombocytopenia differentiate MTX toxicity from SJS. Furthermore, our patients nearly recovered from myelosuppression within seven days and recovered from mucosal erosions characteristic of MTX toxicity within 14 days. These clinical courses could also be characteristic for MTX toxicity rather than SJS, although quick recovery does not happen in all cases. Therefore, physicians who prescribe MTX must accurately know MTX-induced adverse reactions to recognize them early. Furthermore, as seen in our patients, oral mucosal erosions occur often. Therefore, dermatologists or others who examine these symptoms should consider that mucosal erosions mimicking SJS could be an adverse reaction of MTX, regardless of whether or not SJS/toxic epidermal necrolysis is suspected.

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11664-023-10309-w., We examined the fabrication process of uniaxial tensile-strained Ge wires in micro-bridge structures by utilizing the internal stresses in deposited metal thin films. This method enables strain control by adjusting film-deposition conditions, which is advantageous over previous methods that utilize internal stresses unintentionally applied to Ge-on-insulator substrates. We evaluated the internal stresses in W films formed by sputtering deposition methods. Tensile and compressive stresses were determined based on the Ar gas pressure during the deposition process. We applied tensile strain to Ge wires using 100-nm-thick W films, each with a tensile stress of 890 MPa, deposited in 1.5-Pa Ar gas. We confirmed that strains of up to 1.62% can be achieved and controlled by tuning the structural parameters of the bridge structure with the Ge wires. Photoluminescence peaks shifted to lower energies with increasing strain, in good agreement with theoretical predictions. We also used strained Ge wires to fabricate light-emitting diodes that exhibited clear electroluminescence peaks indicative of band structural modulation in the Ge wires.

This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/acd1ca., While the formation of a GaOx interlayer is key to achieving SiO₂/GaN interfaces with low defect density, positive fixed charge is rather easily generated through the reduction of GaOx layer if the annealing conditions are not properly designed. In this study, we minimized the unstable GaOx layer by sputter SiO₂ deposition. Negligible GaOx growth was confirmed by synchrotron radiation X-ray photoelectron spectroscopy, even when post-deposition oxygen annealing up to 600℃ was performed. A MOS device with negligible capacitance–voltage hysteresis, stable flat-band voltage, and low leakage current was demonstrated by performing oxygen and forming gas annealing at temperatures of 600℃ and 400℃, respectively.

We studied a high-speed Ge/Si electro-absorption optical modulator (EAM) evanescently coupled with a Si waveguide of a lateral p–n junction for a high-bandwidth optical interconnect over a wide range of temperatures from 25 °C to 85 °C. We demonstrated 56 Gbps high-speed operation at temperatures up to 85 °C. From the photoluminescence spectra, we confirmed that the bandgap energy dependence on temperature is relatively small, which is consistent with the shift in the operation wavelengths with increasing temperature for a Ge/Si EAM. We also demonstrated that the same device operates as a high-speed and high-efficiency Ge photodetector with the Franz-Keldysh (F-K) and avalanche-multiplication effects. These results demonstrate that the Ge/Si stacked structure is promising for both high-performance optical modulators and photodetectors integrated on Si platforms.

Purpose: There is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This study aimed to answer the following clinical questions: (1) how to use each hypnotic and non-pharmacological treatment differently depending on clinical situations and (2) how to reduce or stop benzodiazepine hypnotics using alternative pharmacological and nonpharmacological treatments. Methods: Experts were asked to evaluate treatment choices based on 10 clinical questions about insomnia disorder using a nine-point Likert scale (1 = “disagree” to 9 = “agree”). The responses of 196 experts were collected, and the answers were categorized into first-, second-, and third-line recommendations. Results: The primary pharmacological treatment, lemborexant (7.3 2.0), was categorized as a first-line recommendation for sleep initiation insomnia, and lemborexant (7.3 1.8) and suvorexant (6.8 1.8) were categorized as the first-line recommendations for sleep maintenance insomnia. Regarding nonpharmacological treatments for primary treatment, sleep hygiene education was categorized as the first-line recommendation for both sleep initiation (8.4 1.1) and maintenance insomnia (8.1 1.5), while multicomponent cognitive behavioral therapy for insomnia was categorized as the second-line treatment for both sleep initiation (5.6 2.3) and maintenance insomnia (5.7 2.4). When reducing or discontinuing benzodiazepine hypnotics by switching to other medications, lemborexant (7.5 1.8) and suvorexant (6.9 1.9) were categorized as first-line recommendations. Conclusion: Expert consensus indicates that orexin receptor antagonists and sleep hygiene education are recommended as first-line treatments in most clinical situations to treat insomnia disorder.

Shingo Ogawa, Hidetoshi Mizobata, Takuma Kobayashi, Takayoshi Shimura, Heiji Watanabe; Interface and oxide trap states of SiO2/GaN metal–oxide–semiconductor capacitors and their effects on electrical properties evaluated by deep level transient spectroscopy. J. Appl. Phys. 7 September 2023; 134 (9): 095704. https://doi.org/10.1063/5.0165894, The relationship between the electrical properties and the carrier trap properties of the SiO2/GaN metal–oxide–semiconductor (MOS) capacitors was investigated using electrical measurements and deep level transient spectroscopy (DLTS). The capacitance–voltage (C–V) measurement showed that the frequency dispersion of the C–V curves became smaller after an 800 °C annealing in O2 ambient. DLTS revealed that before the annealing, the interface trap states, in a broad energy range above the midgap of GaN, were detected with the higher interface state density at around 0.3 and 0.9 eV below the conduction band minimum (Ec) of GaN. Moreover, the oxide trap states were formed at around 0.1 eV below the Ec of GaN, plausibly indicating a slow electron trap with a tunneling process. Although both trap states affect the electrical reliability and insulating property of the SiO2/GaN MOS capacitors, they were found to drastically decrease after the annealing, leading to the improvement of the electrical properties.

Takato Nakanuma, Kosuke Tahara, Katsuhiro Kutsuki, Takayoshi Shimura, Heiji Watanabe, Takuma Kobayashi; Control on the density and optical properties of color centers at SiO2/SiC interfaces by oxidation and annealing. Appl. Phys. Lett. 4 September 2023; 123 (10): 102102. https://doi.org/10.1063/5.0166745, Color centers in solids can serve as single photon emitters (SPEs) those are important in many quantum applications. Silicon carbide (SiC) is a promising host for color centers because of its well-established crystal growth and device technologies. Although color centers with extremely high brightness were found at the silicon dioxide (SiO2)/SiC interface, controlling their density and optical properties remains a challenge. In this study, we demonstrate control over the color centers at the SiO2/SiC interface by designing the oxidation and annealing conditions. We report that post-oxidation CO2 annealing has the ability to reduce the color centers at the interface and form well-isolated SPEs with bright emission. We also discuss the correlation between the color centers and electrically active defects.

Delayed sleep–wake phase disorder (DSWPD) is a sleep disorder in which the habitual sleep–wake timing is delayed, resulting in difficulty in falling asleep and waking up at the desired time. Patients with DSWPD frequently experience fatigue, impaired concentration, sleep deprivation during weekdays, and problems of absenteeism, which may be further complicated by depressive symptoms. DSWPD is typically prevalent during adolescence and young adulthood. Although there are no studies comparing internationally, the prevalence of DSWPD is estimated to be approximately 3% with little racial differences between Caucasians and Asians. The presence of this disorder is associated with various physiological, genetic and psychological as well as behavioral factors. Furthermore, social factors are also involved in the mechanism of DSWPD. Recently, delayed sleep phase and prolonged sleep duration in the young generation have been reported during the period of COVID-19 pandemic-related behavioral restrictions. This phenomenon raises a concern about the risk of a mismatch between their sleep–wake phase and social life that may lead to the development of DSWPD after the removal of these restrictions. Although the typical feature of DSWPD is a delay in circadian rhythms, individuals with DSWPD without having misalignment of objectively measured circadian rhythm markers account for approximately 40% of the cases, wherein the psychological and behavioral characteristics of young people, such as truancy and academic or social troubles, are largely involved in the mechanism of this disorder. Recent studies have shown that DSWPD is frequently comorbid with psychiatric disorders, particularly mood and neurodevelopmental disorders, both of which have a bidirectional association with the pathophysiology of DSWPD. Additionally, patients with DSWPD have a strong tendency toward neuroticism and anxiety, which may result in the aggravation of insomnia symptoms. Therefore, future studies should a

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Hidetaka Noma, Kanako Yasuda, Ryota Nonaka, Shotaro Sasaki, Masahiko Shimura Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, JapanCorrespondence: Hidetaka Noma, Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tatemachi, Hachioji, Tokyo, 193-0998, Japan, Tel + 81-42-665-5611, Fax + 81-42-665-1796, Email nomahide1122@gmail.comPurpose: In branch retinal vein occlusion (BRVO), administering steroid injections to inhibit expression of inflammatory factors in the first phase of macular edema may reduce recurrence of the edema. The purpose of our study was to investigate the functional and morphological prognosis and frequency of recurrence after injection of an anti-vascular endothelial growth factor (VEGF) with and without initial steroid therapy to treat macular edema with BRVO.Patients and Methods: Patients with BRVO and macular edema (41 eyes) received intravitreal ranibizumab injection (IRI) alone (IRI group, 21 eyes) or subtenon triamcinolone (STTA) injection and IRI (combination group, 20 eyes). Patients in both groups with recurrent macular edema received further IRI as appropriate. A laser flare meter was used to assess aqueous flare values, and an optical coherence tomography device was used to measure central macular thickness (CMT). Before the first treatment, we obtained samples of aqueous humor and analyzed them by the suspension array method to evaluate VEGF, placental growth factor (PlGF), platelet-derived growth factor (PDGF)-AA, soluble intercellular adhesion molecule (sICAM)-1, monocyte chemoattractant protein 1 (MCP-1), interleukin (IL)-6, IL-8, and interferon-inducible 10-kDa protein (IP-10).Results: The two groups were not significantly different with regard to levels of VEGF, PlGF, PDGF-AA, sICAM-1, MCP-1, IL-6, IL-8, or IP-10. Best-corrected visual acuity, CMT, and aqueous flare value (IRI group, baseline 8.69 ± 4.55 photon counts/ms; combination group, baseline 9.21 ± 3

We analyzed tropical cyclones (TC) based on the theory of Maximum Potential Intensity (MPI) and Maximum Potential Surge (MPS) for a long-term assessment of extreme TC intensity and storm surge heights. We investigated future changes in the MPI fields and MPS for different global warming levels based on 150-year continuous scenario projections (HighResMIP) and large ensemble climate projections (d4PDF/d2PDF). Focusing on the Western North Pacific Ocean (WNP), we analyzed future changes in the MPI and found that it reached a maximum in the latitudinal range of 30–40°N in September. We also analyzed future changes in the MPS in major bays of East Asia and along the Pacific coast of Japan. Future changes in the MPS were projected, and it was confirmed that changes in the MPS are larger in bays where large storm surge events have occurred in the past.

Background: Little is known about the real-world survival benefits and safety profiles of carfilzomib-lenalidomide-dexamethasone (KRd) and carfilzomib-dexamethasone (Kd). Methods: We performed a retrospective analysis to evaluate their efficacy and safety in 157 patients registered in the Kansai Myeloma Forum database. Results: A total of 107 patients received KRd. Before KRd, 99% of patients had received bortezomib (54% were refractory disease), and 82% had received lenalidomide (57% were refractory disease). The overall response rate (ORR) was 68.2%. The median progression-free survival (PFS) and overall survival (OS) were 8.8 and 29.3 months, respectively. Multivariate analysis showed that reduction of the carfilzomib dose and non-IgG M protein were significantly associated with lower PFS and reduction of the carfilzomib dose and refractoriness to prior bortezomib-based regimens were significantly associated with lower OS. A total of 50 patients received Kd. Before Kd, 96% of patients had received bortezomib (54% were refractory disease). The ORR was 62.0%. The median PFS and OS were 7.1 and 20.9 months, respectively. Based on the multivariate analysis, reduction of the carfilzomib dose and International Staging System Stage III (ISS III) were significantly associated with lower PFS. Grade III or higher adverse events were observed in 48% of KRd cases and 54% of Kd cases. Cardiovascular events, cytopenia, and infections were frequent, and 4 KRd patients died due to heart failure, arrhythmia, cerebral hemorrhage, and pneumonia. Conclusion: Our analysis showed that an adequate dose of carfilzomib is important for achieving the best survival benefits in a real-world setting. Adverse effects after KRd and Kd therapy should also be considered.

Ocean surface wind and wave information is important in a wide variety of areas, such as coastal disaster reduction, offshore structure design, and atmosphere-ocean flux estimation. This study proposed a new method for ocean surface wind estimation from surface wave spectrum information measured by small global positioning system buoys. The concept of this method relies on the assumption that the high-frequency part of the ocean-wave spectrum is proportional to u* f⁻⁴ where u* is the friction velocity and urn:x-wiley:21699275:media:jgrc25175:jgrc25175-math-0003 is the frequency. The determination algorithm for the coefficient of f⁻⁴ was optimized in this study. The wind direction was determined by the wave cross-spectrum, assuming that the wind direction aligns the propagation direction of the high-frequency part of the wave. The proposed wind estimation method was applied to bay and open ocean observations, and the performance of the proposed wind estimation method was similar between the bay and the open ocean. The proposed method improves the wind estimation especially in coastal areas and at high wind speeds in the open ocean compared with the previous method. The performance of the method of the previous study differs between the bay and open ocean due to their spectral shape differences. High-quality wind and wave information can be obtained using the proposed method. If the mass deployment of small drifting buoys covered the global ocean, the information based on the proposed method could be considerably powerful, and could compensate for the weakness of satellite-based wind and wave estimations.

Hindcast experiments and pseudo-forecast experiments considering Typhoon Haishen (2020) were conducted using an atmospheric (WRF)-storm surge (GeoClaw) coupled model and a storm surge model with a parametric typhoon model. A series of simulations of the coupled model were used to quantify the error sources of the typhoon track and intensity in the forecast errors of storm surges. The results revealed that the typhoon track forecast had a larger error source for the storm surge forecast for the maximum surge height than the typhoon intensity. Furthermore, the parametric Holland typhoon model used in practice has an overestimation trend compared to the coupled model, and the parametric Holland typhoon model using WRF output was able to forecast the storm surge height near the typhoon (western Kyushu area) and its peak occurrence time accurately. However, the forecast accuracy tended to decrease as the distance from the typhoon to the target location increased. The pseudo-ensemble simulation of the storm surge forecast using forecast error information was conducted considering the uncertainty of the typhoon track forecast. The 20 ensemble forecast simulations revealed that the perturbed typhoon track simulation can increase the possibility of capturing the peak time of the storm surge.

Orchid seeds depend on colonization by orchid mycorrhizal (OM) fungi for their germination; therefore, the orchids and OM fungi have long maintained a close relationship (e.g., formation of the hyphal mass structure, peloton) during their evolution. In the present study, we isolated new partitiviruses from OM fungi; partitivirus were separately found in different subcultures from the same fungi. Partitiviruses have been believed to lack an RNA silencing suppressor (RSS), which is generally associated with viral pathogenicity, because most partitiviruses isolated so far are latent in both plants and fungi. However, we found that the coat protein (CP) of our partitiviruses indeed had RSS activity, which differed among the virus isolates from OM fungi; one CP showed RSS activity in both plants and fungi, while another CP showed no activity. The family Partitiviridae include viruses isolated from plants and fungi, and it has been suggested that these viruses may occasionally be transmitted between plant and fungal hosts. Given that there are several reports showing that viruses can adapt to nonhost using strong RSS, we here discussed the idea that partitiviruses may be better able to migrate between the orchid and fungus probably through the pelotons formed in the orchid cells, if host RNA silencing is suppressed by partitivirus RSS.

In Japan, the P1 protein (S-type) encoded by leek yel-low stripe virus (LYSV) isolates detected in Honshu and southward is shorter than the P1 (N-type) of LYSV isolates from garlic grown in Hokkaido due to a large deletion in the N-terminal half. In garlic fields in Hok-kaido, two types of LYSV isolate with N-and S-type P1s are sometimes found in mixed infections. In this study, we confirmed that N-and S-type P1 sequences were present in the same plant and that they belong to different evolutionary phylogenetic groups. To investi-gate how LYSV with S-type P1 (LYSV-S) could have invaded LYSV with N-type P1 (LYSV-N)-infected gar-lic, we examined wild Allium spp. plants in Hokkaido and found that LYSV was almost undetectable. On the other hand, in Honshu, LYSV-S was detected at a high frequency in Allium spp. other than garlic, suggesting that the LYSV-S can infect a wider host range of Al-liumspp. compared to LYSV-N. Because P1 proteins of potyviruses have been reported to promote RNA silenc-ing suppressor (RSS) activity of HC-Pro proteins, we analyzed whether the same was true for P1 of LYSV. In onion, contrary to expectation, the P1 protein itself had RSS activity. Moreover, the RSS activity of S-type P1 was considerably stronger than that of N-type P1, sug-gesting that LYSV P1 may be able to enhance its RSS activity when the deletion is in the N-terminal half and that acquiring S-type P1 may have enabled LYSV to expand its host range.

Author summaryRNA silencing, a small RNA (sRNA)-mediated sequence-specific mechanism, is a primary antiviral response of host plants against viral infection. Argonaute 1 (AGO1), an effector protein of RNA silencing, associates with sRNAs to degrade viral RNAs or silence the genes involved in biotic stresses in cytoplasm; such functions are promoted by its translocation between the nucleus and cytoplasm. To survive host RNA silencing, cucumber mosaic virus (CMV) encodes an RNA silencing suppressor (RSS), 2b protein (2b). 2b plays multiple roles in suppressing RNA silencing by binding to either sRNAs or AGOs, in the nucleus and the cytoplasm. However, several previous reports suggest that 2b exerts its RSS activity mainly when it is in the cytoplasm. Here, we found that the serine residue at position 28 is phosphorylated, and its phosphorylation negatively regulated the RSS activity of 2b by regulating 2b's nuclear/nucleolar localization. Furthermore, we also found that 2bs were dephosphorylated in the nucleus and exported to the cytoplasm in an exportin-dependent manner. Because 2b's transport between the nucleus and cytoplasm is similar to that of AGOs, 2b seems to work in cells as if it is manipulating its nucleocytoplasmic trafficking to track down its targets in the RNA silencing pathway. The 2b protein (2b) of cucumber mosaic virus (CMV), an RNA-silencing suppressor (RSS), is a major pathogenicity determinant of CMV. 2b is localized in the nucleus and cytoplasm, and its nuclear import is determined by two nuclear localization signals (NLSs); a carrier protein (importin [IMP alpha]) is predicted to be involved in 2b's nuclear transport. Cytoplasmic 2bs play a role in suppression of RNA silencing by binding to small RNAs and AGO proteins. A putative nuclear export signal (NES) motif was also found in 2b, but has not been proved to function. Here, we identified a leucine-rich motif in 2b's C-terminal half as an NES. We then showed that NES-deficient 2b accumulated