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3 results on '"Shouval, R."'

1. Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Bazarbachi, A., Bug, G. (Gesine), Baron, F. (Frederic), Brissot, E, Ciceri, F, Abou Dalle, I., Döhner, H. (Hartmut), Esteve, J. (Jordi), Floisand, Y., Giebel, S. (Sebastian), Gilleece, M., Gorin, N.C., Jabbour, J. (Jason), Aljurf, M, Kantarjian, H. (Hagop), Kharfan-Dabaja, M., Labopin, M. (Myriam), Lanza, F. (Francesco), Malard, F, Peric, Z., Prebet, T. (Thomas), Ravandi, F, Ruggeri, A. (Annelisa), Sanz, J. (Jaime), Schmid, C. (Christoph), Shouval, R, Spyridonidis, A., Versluis, J., Vey, N. (Norbert), Savani, BN, Nagler, A. (Arnon), Mohty, M. (Mohamad), Bazarbachi, A., Bug, G. (Gesine), Baron, F. (Frederic), Brissot, E, Ciceri, F, Abou Dalle, I., Döhner, H. (Hartmut), Esteve, J. (Jordi), Floisand, Y., Giebel, S. (Sebastian), Gilleece, M., Gorin, N.C., Jabbour, J. (Jason), Aljurf, M, Kantarjian, H. (Hagop), Kharfan-Dabaja, M., Labopin, M. (Myriam), Lanza, F. (Francesco), Malard, F, Peric, Z., Prebet, T. (Thomas), Ravandi, F, Ruggeri, A. (Annelisa), Sanz, J. (Jaime), Schmid, C. (Christoph), Shouval, R, Spyridonidis, A., Versluis, J., Vey, N. (Norbert), Savani, BN, Nagler, A. (Arnon), and Mohty, M. (Mohamad)

Abstract

The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal tandem duplication mutated AML, allogeneic hematopoietic stem-cell transplantation (SCT) was commonly performed in first complete remission. Remarkable progress has been made in frontline treatments with the incorporation of FLT3 inhibitors and the development of highly sensitive minimal/measurable residual disease assays. Similarly, recent progress in allogeneic hematopoietic SCT includes improvement of transplant techniques, the use of haplo-identical donors in patients lacking an HLA matched donor, and the introduction of FLT3 inhibitors as post-transplant maintenance therapy. Nevertheless, current transplant strategies vary between centers and differ in terms of transplant indications based on the internal tandem duplication allelic ratio and concomitant nucleophosmin-1 mutation, as well as in terms of post-transplant maintenance/consolidation. This review generated by international leukemia or transplant experts, mostly from the European Society for Blood and Marrow Transplantation, attempts to develop a position statement on best approaches for allogeneic hematopoietic SCT for AML with FLT3-internal tandem duplication including indications for and modalities of such transplants and on the potential optimization of post-transplant maintenance with FLT inhibitors.

Published
2020
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2. Deconstructing tumor heterogeneity : The stromal perspective

Author

Vickman, R. E., Faget, D. V., Beachy, P., Beebe, D., Bhowmick, N. A., Cukierman, E., Deng, W. -M, Granneman, J. G., Hildesheim, J., Kalluri, R., Lau, K. S., Lengyel, E., Lundeberg, Joakim, Moscat, J., Nelson, P. S., Pietras, K., Politi, K., Puré, E., Scherz-Shouval, R., Sherman, M. H., Tuveson, D., Weeraratna, A. T., White, R. M., Wong, M. H., Woodhouse, E. C., Zheng, Y., Hayward, S. W., Stewart, S. A., Vickman, R. E., Faget, D. V., Beachy, P., Beebe, D., Bhowmick, N. A., Cukierman, E., Deng, W. -M, Granneman, J. G., Hildesheim, J., Kalluri, R., Lau, K. S., Lengyel, E., Lundeberg, Joakim, Moscat, J., Nelson, P. S., Pietras, K., Politi, K., Puré, E., Scherz-Shouval, R., Sherman, M. H., Tuveson, D., Weeraratna, A. T., White, R. M., Wong, M. H., Woodhouse, E. C., Zheng, Y., Hayward, S. W., and Stewart, S. A.

Abstract

Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field. Copyright, QC 20210330

Published
2020
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3. Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Bazarbachi, A, Bug, G, Baron, F, Brissot, E, Ciceri, F, Abou Dalle, I, Dohner, H, Esteve, J, Floisand, Y, Giebel, S, Gilleece, M, Gorin, NC, Jabbour, E, Aljurf, M, Kantarjian, H, Kharfan-Dabaja, M, Labopin, M, Lanza, F, Malard, F, Peric, Z, Prebet, T, Ravandi, F, Ruggeri, A, Sanz, J, Schmid, C, Shouval, R, Spyridonidis, A, Versluis, Jurjen, Vey, N, Savani, BN, Nagler, A, Mohty, M, Bazarbachi, A, Bug, G, Baron, F, Brissot, E, Ciceri, F, Abou Dalle, I, Dohner, H, Esteve, J, Floisand, Y, Giebel, S, Gilleece, M, Gorin, NC, Jabbour, E, Aljurf, M, Kantarjian, H, Kharfan-Dabaja, M, Labopin, M, Lanza, F, Malard, F, Peric, Z, Prebet, T, Ravandi, F, Ruggeri, A, Sanz, J, Schmid, C, Shouval, R, Spyridonidis, A, Versluis, Jurjen, Vey, N, Savani, BN, Nagler, A, and Mohty, M

Published
2020

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