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21 results on '"Skerka C"'

7. Complement signaling at the RPE

Author

Strauß, O, Busch, C, Genewsky, A, Huber, C, Skerka, C, Zipfel, P, Rohrer, B, Strauß, O, Busch, C, Genewsky, A, Huber, C, Skerka, C, Zipfel, P, and Rohrer, B

Published
2015

10. Complement signaling at the RPE

Author

Strauß, O, Busch, C, Genewsky, A, Huber, C, Skerka, C, Zipfel, P, Rohrer, B, Strauß, O, Busch, C, Genewsky, A, Huber, C, Skerka, C, Zipfel, P, and Rohrer, B

Published
2015

13. Mechanism of complement evasion by malaria parasites

Author

Rosa, TFA, Ngwa, CJ, Simon, N, Kuehn, A, Lasonder, E, Agarwal, V, Blom, A, Zipfel, PF, Skerka, C, Pradel, G, Rosa, TFA, Ngwa, CJ, Simon, N, Kuehn, A, Lasonder, E, Agarwal, V, Blom, A, Zipfel, PF, Skerka, C, and Pradel, G

Published
2014

14. Mechanism of complement evasion by malaria parasites

Author

Rosa, TFA, Ngwa, CJ, Simon, N, Kuehn, A, Lasonder, E, Agarwal, V, Blom, A, Zipfel, PF, Skerka, C, Pradel, G, Rosa, TFA, Ngwa, CJ, Simon, N, Kuehn, A, Lasonder, E, Agarwal, V, Blom, A, Zipfel, PF, Skerka, C, and Pradel, G

Published
2014

15. Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Author

Moore, Anthony, Moore, Anthony, Ansari, M, McKeigue, PM, Skerka, C, Hayward, C, Rudan, I, Vitart, V, Polasek, O, Armbrecht, A-M, Yates, JRW, Vatavuk, Z, Moore, Anthony, Moore, Anthony, Ansari, M, McKeigue, PM, Skerka, C, Hayward, C, Rudan, I, Vitart, V, Polasek, O, Armbrecht, A-M, Yates, JRW, and Vatavuk, Z

Abstract

It is a longstanding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associated with age-related macular degeneration (AMD) than functional coding variants that directly influence the alternative complement pathway. T

Published
2013

16. Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Author

Moore, Anthony, Moore, Anthony, Ansari, M, McKeigue, PM, Skerka, C, Hayward, C, Rudan, I, Vitart, V, Polasek, O, Armbrecht, A-M, Yates, JRW, Vatavuk, Z, Moore, Anthony, Moore, Anthony, Ansari, M, McKeigue, PM, Skerka, C, Hayward, C, Rudan, I, Vitart, V, Polasek, O, Armbrecht, A-M, Yates, JRW, and Vatavuk, Z

Abstract

It is a longstanding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associated with age-related macular degeneration (AMD) than functional coding variants that directly influence the alternative complement pathway. T

Published
2013

17. Liver-kidney transplantation to cure atypical hemolytic uremic syndrome

Author

Saland, J, Ruggenenti, P, Remuzzi, G, Bekassy, Z, Bensman, A, Bresin, E, Colledan, M, Camilla, R, Coppo, R, Cruzado-Garrit, J, Daina, E, Fremeaux-Bacchi, V, Goodship, T, Gridelli, B, Hugo, C, Karpman, D, Jalanko, H, Loirat, C, Hijosa, M, Mc Kiernan, P, Noris, M, De Cordoba, S, Rota, G, Sanchez-Corral, P, Skerka, C, Tartufari, A, Zipfel, P, Saland, JM, Cruzado-Garrit, JM, Goodship, TJ, Hijosa, MM, Mc Kiernan, PJ, De Cordoba, SR, Zipfel, PF, Saland, J, Ruggenenti, P, Remuzzi, G, Bekassy, Z, Bensman, A, Bresin, E, Colledan, M, Camilla, R, Coppo, R, Cruzado-Garrit, J, Daina, E, Fremeaux-Bacchi, V, Goodship, T, Gridelli, B, Hugo, C, Karpman, D, Jalanko, H, Loirat, C, Hijosa, M, Mc Kiernan, P, Noris, M, De Cordoba, S, Rota, G, Sanchez-Corral, P, Skerka, C, Tartufari, A, Zipfel, P, Saland, JM, Cruzado-Garrit, JM, Goodship, TJ, Hijosa, MM, Mc Kiernan, PJ, De Cordoba, SR, and Zipfel, PF

Abstract

Atypical hemolytic uremic syndrome is often associated with mutations in genes encoding complement regulatory proteins and secondary disorders of complement regulation. Progression to kidney failure and recurrence with graft loss after kidney transplantation are frequent. The most common mutation is in the gene encoding complement factor H. Combined liver-kidney transplantation may correct this complement abnormality and prevent recurrence when the defect involves genes encoding circulating proteins that are synthesized in the liver, such as factor H or I. Good outcomes have been reported when surgery is associated with intensified plasma therapy. A consensus conference to establish treatment guidelines for atypical hemolytic uremic syndrome was held in Bergamo in December 2007. The recommendations in this article are the result of combined clinical experience, shared research expertise, and a review of the literature and registry information. This statement defines groups in which isolated kidney transplantation is extremely unlikely to be successful and a combined liver-kidney transplant is recommended and also defines those for whom kidney transplant remains a viable option. Although combined liver-kidney or isolated liver transplantation is the preferred therapeutic option in many cases, the gravity of risk associated with the procedure has not been eliminated completely, and assessment of risk and benefit requires careful and individual attention. Copyright © 2009 by the American Society of Nephrology.

Published
2009

18. Intravitreale Spiegel des Komplementfaktors H (CFH)

Author

Weinberger,, AWA, Skerka, C, Zipfel, PF, Weber, BHF, Becker, J, Carstesen, D, Jung, C, Keilhauer, C, Walter, P, Weinberger,, AWA, Skerka, C, Zipfel, PF, Weber, BHF, Becker, J, Carstesen, D, Jung, C, Keilhauer, C, and Walter, P

Published
2006

21. Intravitreale Spiegel des Komplementfaktors H (CFH)

Author

Weinberger,, AWA, Skerka, C, Zipfel, PF, Weber, BHF, Becker, J, Carstesen, D, Jung, C, Keilhauer, C, Walter, P, Weinberger,, AWA, Skerka, C, Zipfel, PF, Weber, BHF, Becker, J, Carstesen, D, Jung, C, Keilhauer, C, and Walter, P

Published
2006

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