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12 results on '"Smoot, Rory L."'

1. Perception versus reality: A National Cohort Analysis of the surgery‐first approach for resectable pancreatic cancer

Author

Bergquist, John R., Thiels, Cornelius A., Shubert, Christopher R., Ivanics, Tommy, Habermann, Elizabeth B., Vege, Santhi S., Grotz, Travis E., Cleary, Sean P., Smoot, Rory L., Kendrick, Michael L., Nagorney, David M., Truty, Mark J., Bergquist, John R., Thiels, Cornelius A., Shubert, Christopher R., Ivanics, Tommy, Habermann, Elizabeth B., Vege, Santhi S., Grotz, Travis E., Cleary, Sean P., Smoot, Rory L., Kendrick, Michael L., Nagorney, David M., and Truty, Mark J.

Published
2021
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2. Symptom relief and quality of life after combined partial hepatectomy and cyst fenestration in highly symptomatic polycystic liver disease

Author

Bernts, L.H.P., Neijenhuis, M.K., Edwards, M.E., Sloan, J.A., Fischer, Jenna, Smoot, Rory L., Drenth, J.P.H., Hogan, Marie C., Bernts, L.H.P., Neijenhuis, M.K., Edwards, M.E., Sloan, J.A., Fischer, Jenna, Smoot, Rory L., Drenth, J.P.H., and Hogan, Marie C.

Abstract

Contains fulltext : 220354.pdf (Publisher’s version ) (Closed access)

Published
2020

3. Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine

Author

Leiting, Jennifer L., Murphy, Stephen J., Bergquist, John R., Hernandez, Matthew C., Ivanics, Tommy, Abdelrahman, Amro M., Yang, Lin, Lynch, Isaac, Smadbeck, James B., Cleary, Sean P., Nagorney, David M., Torbenson, Michael S., Graham, Rondell P., Roberts, Lewis R., Gores, Gregory J., Smoot, Rory L., Truty, Mark J., Leiting, Jennifer L., Murphy, Stephen J., Bergquist, John R., Hernandez, Matthew C., Ivanics, Tommy, Abdelrahman, Amro M., Yang, Lin, Lynch, Isaac, Smadbeck, James B., Cleary, Sean P., Nagorney, David M., Torbenson, Michael S., Graham, Rondell P., Roberts, Lewis R., Gores, Gregory J., Smoot, Rory L., and Truty, Mark J.

Published
2020
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4. Symptom relief and quality of life after combined partial hepatectomy and cyst fenestration in highly symptomatic polycystic liver disease

Author

Bernts, L.H.P., Neijenhuis, M.K., Edwards, M.E., Sloan, J.A., Fischer, Jenna, Smoot, Rory L., Drenth, J.P.H., Hogan, Marie C., Bernts, L.H.P., Neijenhuis, M.K., Edwards, M.E., Sloan, J.A., Fischer, Jenna, Smoot, Rory L., Drenth, J.P.H., and Hogan, Marie C.

Abstract

Contains fulltext : 220354.pdf (Publisher’s version ) (Closed access)

Published
2020

5. Symptom relief and quality of life after combined partial hepatectomy and cyst fenestration in highly symptomatic polycystic liver disease

Author

Bernts, L.H.P., Neijenhuis, M.K., Edwards, M.E., Sloan, J.A., Fischer, Jenna, Smoot, Rory L., Drenth, J.P.H., Hogan, Marie C., Bernts, L.H.P., Neijenhuis, M.K., Edwards, M.E., Sloan, J.A., Fischer, Jenna, Smoot, Rory L., Drenth, J.P.H., and Hogan, Marie C.

Abstract

Contains fulltext : 220354.pdf (Publisher’s version ) (Closed access)

Published
2020

7. Adjuvant systemic therapy after resection of node positive gallbladder cancer: Time for a well-designed trial? (Results of a US-national retrospective cohort study)

Author

Bergquist, John R., Shah, Harsh N., Habermann, Elizabeth B., Hernandez, Matthew C., Ivanics, Tommy, Kendrick, Michael L., Smoot, Rory L., Nagorney, David M., Borad, Mitesh J., McWilliams, Robert R., Truty, Mark J., Bergquist, John R., Shah, Harsh N., Habermann, Elizabeth B., Hernandez, Matthew C., Ivanics, Tommy, Kendrick, Michael L., Smoot, Rory L., Nagorney, David M., Borad, Mitesh J., McWilliams, Robert R., and Truty, Mark J.

Published
2018
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8. Type of Resection (Whipple vs. Distal) Does Not Affect the National Failure to Provide Post-resection Adjuvant Chemotherapy in Localized Pancreatic Cancer

Author

Bergquist, John R., Ivanics, Tommy, Shubert, Christopher R., Habermann, Elizabeth B., Smoot, Rory L., Kendrick, Michael L., Nagorney, David M., Farnell, Michael B., Truty, Mark J., Bergquist, John R., Ivanics, Tommy, Shubert, Christopher R., Habermann, Elizabeth B., Smoot, Rory L., Kendrick, Michael L., Nagorney, David M., Farnell, Michael B., and Truty, Mark J.

Published
2017
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9. Mixed hepatocellular and cholangiocarcinoma: a rare tumor with a mix of parent phenotypic characteristics

Author

Bergquist, John R., Groeschl, Ryan T., Ivanics, Tommy, Shubert, Christopher R., Habermann, Elizabeth B., Kendrick, Michael L., Farnell, Michael B., Nagorney, David M., Truty, Mark J., Smoot, Rory L., Bergquist, John R., Groeschl, Ryan T., Ivanics, Tommy, Shubert, Christopher R., Habermann, Elizabeth B., Kendrick, Michael L., Farnell, Michael B., Nagorney, David M., Truty, Mark J., and Smoot, Rory L.

Published
2016
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10. Implications of CA19-9 elevation for survival, staging, and treatment sequencing in intrahepatic cholangiocarcinoma: A national cohort analysis

Author

Bergquist, John R., Ivanics, Tommy, Storlie, Curtis B., Groeschl, Ryan T., Tee, May C., Habermann, Elizabeth B., Smoot, Rory L., Kendrick, Michael L., Farnell, Michael B., Roberts, Lewis R., Gores, Gregory J., Nagorney, David M., Truty, Mark J., Bergquist, John R., Ivanics, Tommy, Storlie, Curtis B., Groeschl, Ryan T., Tee, May C., Habermann, Elizabeth B., Smoot, Rory L., Kendrick, Michael L., Farnell, Michael B., Roberts, Lewis R., Gores, Gregory J., Nagorney, David M., and Truty, Mark J.

Published
2016
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11. Small Cell Carcinoma of the Pancreas

Author

Ivanics, Tommy, Bergquist, John R., Shubert, Christopher R., Smoot, Rory L., Habermann, Elizabeth B., Truty, Mark J., Ivanics, Tommy, Bergquist, John R., Shubert, Christopher R., Smoot, Rory L., Habermann, Elizabeth B., and Truty, Mark J.

Published
2016
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12. Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma

Author

Mertens, Joachim C, Fingas, Christian D, Christensen, John D, Smoot, Rory L, Bronk, Steven F, Werneburg, Nathan W, Gustafson, Michael P, Dietz, Allan B, Roberts, Lewis R, Sirica, Alphonse E, Gores, Gregory J, Mertens, Joachim C, Fingas, Christian D, Christensen, John D, Smoot, Rory L, Bronk, Steven F, Werneburg, Nathan W, Gustafson, Michael P, Dietz, Allan B, Roberts, Lewis R, Sirica, Alphonse E, and Gores, Gregory J

Abstract

Cancer-associated fibroblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progression. CAFs are "activated" and as such may be uniquely susceptible to apoptosis. Using cholangiocarcinoma as a desmoplastic tumor model, we investigated the sensitivity of liver CAFs to the cytotoxic drug navitoclax, a BH3 mimetic. Navitoclax induced apoptosis in CAF and in myofibroblastic human hepatic stellate cells but lacked similar effects in quiescent fibroblasts or cholangiocarcinoma cells. Unlike cholangiocarcinoma cells, neither CAF nor quiescent fibroblasts expressed Mcl-1, a known resistance factor for navitoclax cytotoxicity. Explaining this paradox, we found that mitochondria isolated from CAFs or cells treated with navitoclax both released the apoptogenic factors Smac and cytochrome c, suggesting that they are primed for cell death. Such death priming in CAFs appeared to be due, in part, to upregulation of the proapoptotic protein Bax. Short hairpin RNA-mediated attenuation of Bax repressed navitoclax-mediated mitochondrial dysfunction, release of apoptogenic factors, and apoptotic cell death. In a syngeneic rat model of cholangiocarcinoma, navitoclax treatment triggered CAF apoptosis, diminishing expression of the desmoplastic extracellular matrix protein tenascin C, suppressing tumor outgrowth, and improving host survival. Together, our findings argue that navitoclax may be useful for destroying CAFs in the tumor microenvironment as a general strategy to attack solid tumors.

Published
2013

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