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Functionalized cages encapsulating xenon atoms enable highly sensitive, background-free molecular imaging through a technique known as HyperCEST ¹²⁹Xe MRI. Here, we introduce a class of potential biosensor cage structures based on two resorcinarene macrocycles bridged either by aliphatic carbon chains or piperazines. First-principles-based modeling predicts a high chemical shift (about 345 ppm) outside the typical experimental observation window for ¹²⁹Xe encapsulated by the aliphatically bridged cage and two ¹²⁹Xe resonances for the piperazine-bridged cages corresponding to single and double loading. Based on the computational predictions as well as ¹²⁹Xe chemical exchange saturation transfer (CEST) and T₂ relaxation nuclear magnetic resonance experiments, we confirm Xe encapsulation in the aliphatically bridged and double encapsulation in the piperazine-bridged resorcinarene in methanol. The cages show fast Xe exchange rates (12,000–49,000 s⁻¹), resulting in a high CEST response regardless of the relatively low binding constant (0.09–3 M⁻¹).

We have designed a low-cost radio telescope system named the Bose Horn Antenna Radio Telescope (BHARAT) to detect the 21 cm hydrogen line emission from our Galaxy. The system is being used at the Radio Physics Laboratory (RPL), Inter-University Centre for Astronomy and Astrophysics (IUCAA), India, for laboratory sessions and training students and teachers. It is also a part of the laboratory curriculum at several universities and colleges. Here, we present the design of a highly efficient, easy to build, and cost-effective dual-mode conical horn used as a radio telescope and describe the calibration procedure. We also present some model observation data acquired using the telescope for facilitating easy incorporation of this experiment in the laboratory curriculum of undergraduate or post-graduate programs. We have named the antenna after Acharya Jagadish Chandra Bose, honoring a pioneer in radio-wave science and an outstanding teacher, who inspired several world renowned scientists., Comment: Accepted for publication in American Journal of Physics. 22 pages, 16 figures, and 1 table. Comments are welcome

Solitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn’s disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Computed Tomography (CT) demonstrated mucosal thickening of the middescending colon, consistent with fibrosing stricture. Surgical excision revealed an unusual, 5 cm mass originating in the subserosa. Histopathology of the lesion was notable for a proliferation of cells with spindle and stellate-shaped nuclei and no appreciable mitotic figures, which extended into the muscularis and submucosa. Immunohistochemistry was STAT6 nuclear positive and cytoplasmic CD34 positive, diagnostic for solitary fibrous tumor (SFT). In this case, the SFT infiltrating into the muscularis propria and subserosa caused the stricture and bowel obstruction. This illustrates that while fibrosing strictures are usually the etiology of bowel obstruction in the setting of Crohn’s disease, other rare possible causes should be considered.

Solitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn’s disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Computed Tomography (CT) demonstrated mucosal thickening of the middescending colon, consistent with fibrosing stricture. Surgical excision revealed an unusual, 5 cm mass originating in the subserosa. Histopathology of the lesion was notable for a proliferation of cells with spindle and stellate-shaped nuclei and no appreciable mitotic figures, which extended into the muscularis and submucosa. Immunohistochemistry was STAT6 nuclear positive and cytoplasmic CD34 positive, diagnostic for solitary fibrous tumor (SFT). In this case, the SFT infiltrating into the muscularis propria and subserosa caused the stricture and bowel obstruction. This illustrates that while fibrosing strictures are usually the etiology of bowel obstruction in the setting of Crohn’s disease, other rare possible causes should be considered.

Solitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn’s disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Computed Tomography (CT) demonstrated mucosal thickening of the middescending colon, consistent with fibrosing stricture. Surgical excision revealed an unusual, 5 cm mass originating in the subserosa. Histopathology of the lesion was notable for a proliferation of cells with spindle and stellate-shaped nuclei and no appreciable mitotic figures, which extended into the muscularis and submucosa. Immunohistochemistry was STAT6 nuclear positive and cytoplasmic CD34 positive, diagnostic for solitary fibrous tumor (SFT). In this case, the SFT infiltrating into the muscularis propria and subserosa caused the stricture and bowel obstruction. This illustrates that while fibrosing strictures are usually the etiology of bowel obstruction in the setting of Crohn’s disease, other rare possible causes should be considered.

Dimethyl sulfide (DMS), emitted from the oceans, is the most abundant biological source of sulfur to the marine atmosphere. Atmospheric DMS is oxidized to condensable products that form secondary aerosols that affect Earth's radiative balance by scattering solar radiation and serving as cloud condensation nuclei. We report the atmospheric discovery of a previously unquantified DMS oxidation product, hydroperoxymethyl thioformate (HPMTF, HOOCH2SCHO), identified through global-scale airborne observations that demonstrate it to be a major reservoir of marine sulfur. Observationally constrained model results show that more than 30% of oceanic DMS emitted to the atmosphere forms HPMTF. Coincident particle measurements suggest a strong link between HPMTF concentration and new particle formation and growth. Analyses of these observations show that HPMTF chemistry must be included in atmospheric models to improve representation of key linkages between the biogeochemistry of the ocean, marine aerosol formation and growth, and their combined effects on climate.

Dimethyl sulfide (DMS), emitted from the oceans, is the most abundant biological source of sulfur to the marine atmosphere. Atmospheric DMS is oxidized to condensable products that form secondary aerosols that affect Earth’s radiative balance by scattering solar radiation and serving as cloud condensation nuclei. We report the atmospheric discovery of a previously unquantified DMS oxidation product, hydroperoxymethyl thioformate (HPMTF, HOOCH2SCHO), identified through global-scale airborne observations that demonstrate it to be a major reservoir of marine sulfur. Observationally constrained model results show that more than 30% of oceanic DMS emitted to the atmosphere forms HPMTF. Coincident particle measurements suggest a strong link between HPMTF concentration and new particle formation and growth. Analyses of these observations show that HPMTF chemistry must be included in atmospheric models to improve representation of key linkages between the biogeochemistry of the ocean, marine aerosol formation and growth, and their combined effects on climate.

Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone presentation reveals MR and GR co-occupy DNA only at the peaks of glucocorticoid oscillations, allowing interaction. GR DNA occupancy was pulsatile, while MR DNA occupancy was prolonged through the inter-pulse interval. In mouse mammary 3617 cells MR-GR interacted in the nucleus and at a chromatin-associated DNA binding site. Interactions occurred irrespective of ligand type and receptors formed complexes of higher order than heterodimers. We also detected MR-GR interactions ex-vivo in rat hippocampus. An expanded range of MR-GR interactions predicts structural allostery allowing a variety of transcriptional outcomes and is applicable to the multiple tissue types that co-express both receptors in the same cells whether activated by the same or different hormones., Biotechnology and Biological Sciences Research Council (BBSRC); Neuroendocrinology Charitable Trust; BBSRC Alert 13 Capital Grant; Intramural Research Program of the NIH; National Cancer Institute; Center for Cancer Research (USA); Society for Endocrinology Early Career Grant; Biotechnology and Biological Sciences Research Council International Scientific Interchange Scheme Award; British Society for Neuroendocrinology Project Support Grant

The Community Coordinated Modeling Center has been leading community-wide space science and space weather model validation projects for many years. These efforts have been broadened and extended via the newly launched International Forum for Space Weather Modeling Capabilities Assessment (https://ccmc.gsfc.nasa.gov/assessment/). Its objective is to track space weather models' progress and performance over time, a capability that is critically needed in space weather operations and different user communities in general. The Space Radiation and Plasma Effects Working Team of the aforementioned International Forum works on one of the many focused evaluation topics and deals with five different subtopics (https://ccmc.gsfc.nasa.gov/assessment/topics/radiation-all.php) and varieties of particle populations: Surface Charging from tens of eV to 50-keV electrons and internal charging due to energetic electrons from hundreds keV to several MeVs. Single-event effects from solar energetic particles and galactic cosmic rays (several MeV to TeV), total dose due to accumulation of doses from electrons (>100 keV) and protons (>1 MeV) in a broad energy range, and radiation effects from solar energetic particles and galactic cosmic rays at aviation altitudes. A unique aspect of the Space Radiation and Plasma Effects focus area is that it bridges the space environments, engineering, and user communities. The intent of the paper is to provide an overview of the current status and to suggest a guide for how to best validate space environment models for operational/engineering use, which includes selection of essential space environment and effect quantities and appropriate metrics.

The Community Coordinated Modeling Center has been leading community-wide space science and space weather model validation projects for many years. These efforts have been broadened and extended via the newly launched International Forum for Space Weather Modeling Capabilities Assessment (https://ccmc.gsfc.nasa.gov/assessment/). Its objective is to track space weather models' progress and performance over time, a capability that is critically needed in space weather operations and different user communities in general. The Space Radiation and Plasma Effects Working Team of the aforementioned International Forum works on one of the many focused evaluation topics and deals with five different subtopics (https://ccmc.gsfc.nasa.gov/assessment/topics/radiation-all.php) and varieties of particle populations: Surface Charging from tens of eV to 50-keV electrons and internal charging due to energetic electrons from hundreds keV to several MeVs. Single-event effects from solar energetic particles and galactic cosmic rays (several MeV to TeV), total dose due to accumulation of doses from electrons (>100 keV) and protons (>1 MeV) in a broad energy range, and radiation effects from solar energetic particles and galactic cosmic rays at aviation altitudes. A unique aspect of the Space Radiation and Plasma Effects focus area is that it bridges the space environments, engineering, and user communities. The intent of the paper is to provide an overview of the current status and to suggest a guide for how to best validate space environment models for operational/engineering use, which includes selection of essential space environment and effect quantities and appropriate metrics.

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

We have investigated the role of a few prominent excitation mechanisms viz. collisional excitation, recombination, continuum fluorescence and Lyman beta fluorescence on the OI line spectra in Herbig Ae/Be stars. The aim is to understand which of them is the central mechanism that explains the observed OI line strengths. The study is based on an analysis of the observed optical spectra of 62 Herbig Ae/Be stars and near-infrared spectra of 17 Herbig Ae/Be stars. The strong correlation observed between the line fluxes of OI $\lambda$8446 and OI $\lambda$11287, as well as a high positive correlation between the line strengths of OI $\lambda$8446 and H$\alpha$ suggest that Lyman beta fluorescence is the dominant excitation mechanism for the formation of OI emission lines in Herbig Ae/Be stars. Further, from an analysis of the emission line fluxes of OI $\lambda\lambda$7774, 8446, and comparing the line ratios with those predicted by theoretical models, we assessed the contribution of collisional excitation in the formation of OI emission lines., Comment: 13 pages, 2 tables, 6 figures, accepted for publication in ApJ

Participants of the 2017 European Space Weather Week in Ostend, Belgium, discussed the stakeholder requirements for space weather related models. It was emphasized that stakeholders show an increased interest in space weather related models. Participants of the meeting discussed particular prediction indicators that can provide first order estimates of the impact of space weather on engineering systems.

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

We have investigated the role of a few prominent excitation mechanisms viz. collisional excitation, recombination, continuum fluorescence and Lyman beta fluorescence on the OI line spectra in Herbig Ae/Be stars. The aim is to understand which of them is the central mechanism that explains the observed OI line strengths. The study is based on an analysis of the observed optical spectra of 62 Herbig Ae/Be stars and near-infrared spectra of 17 Herbig Ae/Be stars. The strong correlation observed between the line fluxes of OI $\lambda$8446 and OI $\lambda$11287, as well as a high positive correlation between the line strengths of OI $\lambda$8446 and H$\alpha$ suggest that Lyman beta fluorescence is the dominant excitation mechanism for the formation of OI emission lines in Herbig Ae/Be stars. Further, from an analysis of the emission line fluxes of OI $\lambda\lambda$7774, 8446, and comparing the line ratios with those predicted by theoretical models, we assessed the contribution of collisional excitation in the formation of OI emission lines., Comment: 13 pages, 2 tables, 6 figures, accepted for publication in ApJ

Participants of the 2017 European Space Weather Week in Ostend, Belgium, discussed the stakeholder requirements for space weather related models. It was emphasized that stakeholders show an increased interest in space weather related models. Participants of the meeting discussed particular prediction indicators that can provide first order estimates of the impact of space weather on engineering systems.

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

type:Journal Article, We evaluate and compare the performance and potential of GaAs and of wide and extreme bandgap semiconductors (SiC, GaN, Ga2O3, diamond), relative to silicon, for power electronics applications. We examine their device structures and associated materials/process technologies and selectively review the recent experimental demonstrations of high voltage power devices and IC structures of these semiconductors. We discuss the technical obstacles that still need to be addressed and overcome before large-scale commercialization commences., source:http://ieeexplore.ieee.org/document/7851006

Tarkastelen pro gradu -tutkielmassani sitä, millä tavoin mennä ja tulla -verbien ilmaiseman muuttujan reitti ikkunoidaan suomen kielessä. Muuttuja reitin voi käsitteistää ikään kuin liikepolkuna, joka sisältää sekä alku-, keski- että loppuosan riippuen siitä, mitä osia polusta nostetaan huomion ikkunaan. Huomion ikkunointi on kielitieteilijä Leonard Talmyn kehittämä teoria, ja hän on käyttänyt seuraavaa esimerkkilausetta liikepolun havainnollistamiseen: laatikko, joka oli lentokoneen lastiruumassa, putosi koneesta ilman halki mereen. Lauseessa muuttujana toimii putoava laatikko, ja tämän alkupisteeksi määrittyy erosijainen paikan adverbiaali koneesta. Itse ilmalento määrittyy puolestaan polun keskikohdaksi (ilman halki), ja päätepisteeksi kuvatussa tapahtumassa hahmottuu meri, johon laatikko lopulta putoaa. Liikepolun kaikkien osien nostaminen huomion ikkunaan on kuitenkin harvinaista, koska pyrimme yleensä valikoimaan tuottamaamme informaatioon vain itsemme mielestä kaikista olennaisimman osan. Jos edellisestä esimerkkilauseesta nostettaisiin huomion ikkunaan ainoastaan sen loppuosa, esiintyisi se siis muodossa laatikko, joka oli lentokoneen lastiruumassa, putosi mereen. Tutkimukseni perusteella pelkästään polun loppuosan nostaminen huomion ikkunaan onkin kaikista yleisin tapa esittää liikepolku; kaikkiaan 400 esimerkkilauseesta tai -virkkeestä koostuvasta aineistostani 237 tapausta edusti kyseistä ikkunointityyppiä. Maksimaalista, kaikki liikepolun osat huomion ikkunaan nostavaa ikkunointityyppiä edusti aineistossani ainoastaan 14 lausetta tai virkettä. Loput tapaukset edustivat muita mahdollisia ikkunointitapoja. Liikepolun alku-, keski- ja loppuosat voivat esiintyä lauseessa yhteensä seitsemällä eri tavalla riippuen siitä, mitä osia siihen sisällyttää ja mitä siitä jättää pois. Tilastoinnin lisäksi olen kiinnittänyt huomiota siihen, millaisia keinoja huomion ikkunoimiseen käytetään ja sitä, millä tavoin konkreettinen ja abstraktinen liike eroavat toisistaan huom

With aircraft-mounted in situ and remote sensing instruments for dynamical, thermal, and chemical measurements we studied two cases of tropopause folding. In both folds we found Kelvin-Helmholtz billows with horizontal wavelength of ∼900 m and thickness of ∼120 m. In one case the instability was effectively mixing the bottomside of the fold, leading to the transfer of stratospheric air into the troposphere. Also, we discovered in both cases small-scale secondary ozone maxima shortly after the aircraft ascended past the topside of the fold that corresponded to regions of convective instability. We interpreted this phenomenon as convectively breaking gravity waves. Therefore we posit that convectively breaking gravity waves acting on tropopause folds must be added to the list of important irreversible mixing mechanisms leading to stratosphere-troposphere exchange., United States. National Aeronautics and Space Administration (Grant NAG2-1105), United States. National Aeronautics and Space Administration (Grant NAGl-1758), United States. National Aeronautics and Space Administration (Grant NAGl-1901)

Huldrych Zwingli is the father of Reformed Protestantism. Although that movement has been equated with and often restricted to “Calvinism,” especially in the English-speaking world, Reformed Protestantism undeniably owes its fundamental design to this Zürich Reformer. BECOMING A REFORMER Ulrich Zwingli (who would later adopt the name “Huldrych,” “rich in grace”) was born on January 1, 1484, in Wildhaus, in eastern Switzerland. His father belonged to the rural elite and held political office as Landammann, the chief local magistrate. Exposed to local politics from an early age, Zwingli developed a particular interest in political concerns – a trait that would be very evident in the later life of the Swiss Reformer. After grammar school, Zwingli was sent by his parents first to Bern and then to the University of Vienna. He subsequently attended the university in Basel, from 1502 to 1506, where, having completed his Master's examination, he studied theology for one semester. During these years of study, he received a scholastic education and became familiar with the philosophical tradition of the via antiqua. It is more than likely that Thomas Wyttenbach (ca. 1472–1526), who was professor in Basel and pastor in Biel, introduced Zwingli to the writings of Thomas Aquinas and Peter Lombard and to the commentaries on Lombard's Sentences by Duns Scotus. After leaving Basel, Zwingli worked as a pastor in Glarus, in central Switzerland, for ten years and then, from 1516 to 1518, served as a preacher at the pilgrimage site of Einsiedeln. These years were marked by diligent private study. Zwingli's remarkable education included studying the Bible in its original languages, reading the Church Fathers, and pursuing an interest in classical antiquity and poetry. During these years, Zwingli also became increasingly aware of clerical and political abuses, which were a cause of injustice and a source of grievance within the Swiss Confederation. His criticism targeted ecclesial superf

Background: Health literacy is an important predictor of healthcare outcomes, but research on this topic has largely been absent from the emergency medicine literature.Objectives: We measured the prevalence of health literacy in parents or guardians of pediatric patients seen in the emergency department (ED).Methods: This was an observational study conducted in a Midwestern urban, university-based, tertiary, Level 1 trauma center ED with 33,000 visits/year. Using convenience sampling during a three-month period, English-speaking parents or guardians of pediatric patients (< 19 yrs.) were asked to complete the short version of the Test of Functional Health Literacy for Adults (s-TOFHLA). Parents/guardians were excluded if they had uncorrected visual impairment, required an interpreter, had altered mental status, or if the patients they accompanied were the subjects of a medical or trauma activation.Results: Of the 188 parents or guardians approached, six did not consent or withdrew, one was excluded, leaving 181 (96.3%) in the study. Of these, 19 (10.5%) had either "marginal" or "inadequate" health literacy, while 162 (89.5%, 95% CI: 84.1%, 93.6%) had "adequate" health literacy.Conclusions: A large majority (89.5%) of English-speaking parents or guardians of pediatric patients evaluated in the ED have adequate health literacy. This data may prompt ED professionals to adjust their communication styles in the evaluation of children. Future multi-center studies are needed to confirm the findings in this pilot study. [WestJEM.2008:9:130-134]

The field of development economics has evolved since volume 3 of the Handbook of Development Economics was published more than a decade ago. Volume 4 takes stock of some of the newer trends and their implications for research in the field and our understanding of economic development. The handbook is divided into four sections which reflect these developments, of which the first deals with agricultural and rural development. Section two is concerned with developments in the theory and evidence regarding public goods and political economy. The third section is focused on the behavior of households and individuals regarding various aspects of human capital investments, in the face of the various constraints, particularly market incentives and public goods. The final section contains papers that describe the different methods now available, both experimental and non-experimental, to conduct program evaluations, as well as describing papers that implement these methods. The authors of the chapters are all experts in the fields they survey and extend, and this volume promises to be an invaluable addition to the Handbooks in Economics series and a useful reference to graduate students, researchers and professionals in the field of development economics. * Presents an accurate, self-contained survey of the current state of the field. * Summarizes the most recent discussions in journals, and elucidates new developments. * Although original material is also included, the main aim is the provision of comprehensive and accessible surveys.

Background: Health literacy is an important predictor of healthcare outcomes, but research on this topic has largely been absent from the emergency medicine literature.Objectives: We measured the prevalence of health literacy in parents or guardians of pediatric patients seen in the emergency department (ED).Methods: This was an observational study conducted in a Midwestern urban, university-based, tertiary, Level 1 trauma center ED with 33,000 visits/year. Using convenience sampling during a three-month period, English-speaking parents or guardians of pediatric patients (< 19 yrs.) were asked to complete the short version of the Test of Functional Health Literacy for Adults (s-TOFHLA). Parents/guardians were excluded if they had uncorrected visual impairment, required an interpreter, had altered mental status, or if the patients they accompanied were the subjects of a medical or trauma activation.Results: Of the 188 parents or guardians approached, six did not consent or withdrew, one was excluded, leaving 181 (96.3%) in the study. Of these, 19 (10.5%) had either "marginal" or "inadequate" health literacy, while 162 (89.5%, 95% CI: 84.1%, 93.6%) had "adequate" health literacy.Conclusions: A large majority (89.5%) of English-speaking parents or guardians of pediatric patients evaluated in the ED have adequate health literacy. This data may prompt ED professionals to adjust their communication styles in the evaluation of children. Future multi-center studies are needed to confirm the findings in this pilot study. [WestJEM.2008:9:130-134]

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. We recognize that much progress has been made and continues to be made with a powerful suite of research observatories on the ground and in space, forming the basis of a Sun Earth system observatory. But the domain of space weather is vast extending from deep within the Sun to far outside the planetary orbits and the physics complex including couplings between various types of physical processes that link scales and domains from the microscopic to large parts of the solar system. Consequently, advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun Earth system, (2) on forecasts more than 12 h ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on deve

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. We recognize that much progress has been made and continues to be made with a powerful suite of research observatories on the ground and in space, forming the basis of a Sun Earth system observatory. But the domain of space weather is vast extending from deep within the Sun to far outside the planetary orbits and the physics complex including couplings between various types of physical processes that link scales and domains from the microscopic to large parts of the solar system. Consequently, advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun Earth system, (2) on forecasts more than 12 h ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on deve

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. We recognize that much progress has been made and continues to be made with a powerful suite of research observatories on the ground and in space, forming the basis of a Sun Earth system observatory. But the domain of space weather is vast extending from deep within the Sun to far outside the planetary orbits and the physics complex including couplings between various types of physical processes that link scales and domains from the microscopic to large parts of the solar system. Consequently, advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun Earth system, (2) on forecasts more than 12 h ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on deve

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. [...] advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun-Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun-Earth system, (2) on forecasts more than 12 hrs ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on developing a comprehensive specification of space climate, including the characterization of extreme space storms to guide resilient and robust engineering of technological infrastructures. The roadmap clusters its implementation recommendations by formulating three action pathways, and outlines needed instrumentation and research programs and infrastructure for each of these. [...], Comment: In press for Advances of Space Research: an international roadmap on the science of space weather, commissioned by COSPAR and ILWS (63 pages and 4 figures)

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. We recognize that much progress has been made and continues to be made with a powerful suite of research observatories on the ground and in space, forming the basis of a Sun Earth system observatory. But the domain of space weather is vast extending from deep within the Sun to far outside the planetary orbits and the physics complex including couplings between various types of physical processes that link scales and domains from the microscopic to large parts of the solar system. Consequently, advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun Earth system, (2) on forecasts more than 12 h ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on deve

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. [...] advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun-Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun-Earth system, (2) on forecasts more than 12 hrs ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on developing a comprehensive specification of space climate, including the characterization of extreme space storms to guide resilient and robust engineering of technological infrastructures. The roadmap clusters its implementation recommendations by formulating three action pathways, and outlines needed instrumentation and research programs and infrastructure for each of these. [...], Comment: In press for Advances of Space Research: an international roadmap on the science of space weather, commissioned by COSPAR and ILWS (63 pages and 4 figures)

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. We recognize that much progress has been made and continues to be made with a powerful suite of research observatories on the ground and in space, forming the basis of a Sun Earth system observatory. But the domain of space weather is vast extending from deep within the Sun to far outside the planetary orbits and the physics complex including couplings between various types of physical processes that link scales and domains from the microscopic to large parts of the solar system. Consequently, advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun Earth system, (2) on forecasts more than 12 h ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on deve

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Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000., Includes bibliographical references (p. 61)., by Paul T. Czerniak., M.Eng.and S.B.

Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000., Includes bibliographical references (p. 61)., by Paul T. Czerniak., M.Eng.and S.B.

Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000., Includes bibliographical references (p. 61)., by Paul T. Czerniak., M.Eng.and S.B.

Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000., Includes bibliographical references (p. 61)., by Paul T. Czerniak., M.Eng.and S.B.

Energetic proton flux maps of the differential flux intensity in the medium-Earth orbit (MEO) regime (altitudes ~ 7000-15,000 km) are developed from measurements taken by detectors aboard the Combined Release and Radiation Effects Satellite (CRRES), HEO-F1, HEO-F3 and ICO satellites. Measurement errors have been estimated by cross-calibrating to a standard sensor aboard the GOES satellite during solar proton events. Spectral inversion techniques were employed to derive differential flux spectra from the HEO and ICO integral channel dosimeters. Two methods for combining the four different satellite data sets on a standard energy and coordinate grid are presented and the ramifications due to limited spatial and temporal coverage are explored. Comparison to the NASA AP-8 models shows the new model median flux maps to be of approximately equivalent or lower magnitude in the slot region while new model 95th percentile maps are always higher. Implications for the proton dose received by MEO satellites are discussed., United States. Air Force (Contract FA8721-10-C-0007)