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31 results on '"Tsilidis, Kostas K."'

1. Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Author: Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, Zheng, Wei, Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, and Zheng, Wei
Abstract: Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
Published: 2024
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2. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Author: Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J., Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J.
Abstract: Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Published: 2023
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3. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer.
Published: 2023
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4. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Author: Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J., Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J.
Abstract: Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Published: 2023
Full Text: View/download PDF

5. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer.
Published: 2023
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6. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Author: Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J., Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J.
Abstract: Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Published: 2023
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7. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer.
Published: 2023
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8. Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Author: Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D.T., Brenner, Hermann, Budiarto, Arif, Carreras-Torres, Robert, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gsur, Andrea, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jordahl, Kristina, Kawaguchi, Eric, Keku, Temitope O., Larsson, Susanna C., Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John, Newcomb, Polly A., Newton, Christina C., Obon-Santacana, Mireia, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D.P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Scacheri, Peter C., Schoen, Robert E., Su, Yu Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J.B., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, White, Emily, Wolk, Alicja, Woods, Michael O., Qu, Conghui, Kundaje, Anshul, Hsu, Li, Gauderman, W.J., Gunter, Marc J., Peters, Ulrike, Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D.T., Brenner, Hermann, Budiarto, Arif, Carreras-Torres, Robert, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gsur, Andrea, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jordahl, Kristina, Kawaguchi, Eric, Keku, Temitope O., Larsson, Susanna C., Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John, Newcomb, Polly A., Newton, Christina C., Obon-Santacana, Mireia, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D.P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Scacheri, Peter C., Schoen, Robert E., Su, Yu Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J.B., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, White, Emily, Wolk, Alicja, Woods, Michael O., Qu, Conghui, Kundaje, Anshul, Hsu, Li, Gauderman, W.J., Gunter, Marc J., and Peters, Ulrike
Abstract: Background: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. Methods: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test). Results: Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 – ORAA: 1.62, 95% CI: 1.34–1.96; ORAG: 1.41, 95% CI: 1.30–1.54; ORGG: 1.22, 95% CI: 1.13–1.31; p-value3-d.f.: 5.46 × 10−11) and 13q14.13 (rs9526201, LRCH1 – ORGG: 2.11, 95% CI: 1.56–2.83; ORGA: 1.52, 95% CI: 1.38–1.68; ORAA: 1.13, 95% CI: 1.06–1.21; p-value2-d.f.: 7.84 × 10−09). Discussion: These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
Published: 2023

9. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries:results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and, Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of m
Published: 2023

10. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer.
Published: 2023
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11. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer.
Published: 2023
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12. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Author: Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J., Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J.
Abstract: Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Published: 2023
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13. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Author: Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J., Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J.
Abstract: Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Published: 2023
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14. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Author: Epi Kanker Team B, Cancer, MS MDL 1, Rothwell, Joseph A, Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J, Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C, Nøst, Therese Haugdahl, Sandanger, Torkjel M, Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K, Eichelmann, Fabian, Schulze, Matthias B, van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W G, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J, Epi Kanker Team B, Cancer, MS MDL 1, Rothwell, Joseph A, Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J, Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C, Nøst, Therese Haugdahl, Sandanger, Torkjel M, Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K, Eichelmann, Fabian, Schulze, Matthias B, van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W G, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J
Published: 2023

15. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries:results from the EPIC cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
Abstract: Background The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and, Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of m
Published: 2023

16. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022
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17. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022
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18. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022
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19. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022

20. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022

21. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022
Full Text: View/download PDF

22. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

Author: Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
Abstract: Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022
Full Text: View/download PDF

23. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., Gunter, Marc J., Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
Abstract: Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results In sex-specific MR analyses, higher BMI (per 4.2 kg/m(2)) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m(2)) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P <= 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative
Published: 2020
Full Text: View/download PDF

24. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., Gunter, Marc J., Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
Abstract: Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results In sex-specific MR analyses, higher BMI (per 4.2 kg/m(2)) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m(2)) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P <= 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative
Published: 2020
Full Text: View/download PDF

25. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., Gunter, Marc J., Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
Abstract: Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results In sex-specific MR analyses, higher BMI (per 4.2 kg/m(2)) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m(2)) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P <= 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative
Published: 2020
Full Text: View/download PDF

26. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J, Bell, Joshua A, Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J, Banbury, Barbara L, Albanes, Demetrius, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Cross, Amanda J, de la Chapelle, Albert, Figueiredo, Jane C, Gallinger, Steven J, Gapstur, Susan M, Giles, Graham G, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A, Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R, Jenkins, Mark A, Joshu, Corinne E, Keku, Temitope O, Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M, Milne, Roger L, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Qu, Conghui, Quirós, J Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C, Schafmayer, Clemens, Schoen, Robert E, Slattery, Martha L, Tangen, Catherine M, Tsilidis, Kostas K, Ulrich, Cornelia M, van Duijnhoven, Fränzel J B, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Zheng, Wei, Peters, Ulrike, Vincent, Emma E, Gunter, Marc J, Bull, Caroline J, Bell, Joshua A, Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J, Banbury, Barbara L, Albanes, Demetrius, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Cross, Amanda J, de la Chapelle, Albert, Figueiredo, Jane C, Gallinger, Steven J, Gapstur, Susan M, Giles, Graham G, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A, Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R, Jenkins, Mark A, Joshu, Corinne E, Keku, Temitope O, Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M, Milne, Roger L, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Qu, Conghui, Quirós, J Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C, Schafmayer, Clemens, Schoen, Robert E, Slattery, Martha L, Tangen, Catherine M, Tsilidis, Kostas K, Ulrich, Cornelia M, van Duijnhoven, Fränzel J B, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Zheng, Wei, Peters, Ulrike, Vincent, Emma E, and Gunter, Marc J
Abstract: BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. METHODS: We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. RESULTS: In sex-specific MR analyses, higher BMI (per 4.2 kg/m2) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m2) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P ≤ 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative meta
Published: 2020
Full Text: View/download PDF

27. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., Gunter, Marc J., Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
Abstract: Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results In sex-specific MR analyses, higher BMI (per 4.2 kg/m(2)) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m(2)) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P <= 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative
Published: 2020
Full Text: View/download PDF

28. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kühn, Tilman, Kweon, Sun Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quirós, José Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Fränzel J.B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., Gunter, Marc J., Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kühn, Tilman, Kweon, Sun Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quirós, José Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Fränzel J.B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
Abstract: Background: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods: We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results: In sex-specific MR analyses, higher BMI (per 4.2 kg/m2) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m2) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P ≤ 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative meta
Published: 2020

29. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

Author: Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., Gunter, Marc J., Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bezieau, Stephane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellvi-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kuhn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martin, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quiros, J. Ramon, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
Abstract: Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results In sex-specific MR analyses, higher BMI (per 4.2 kg/m(2)) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m(2)) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P <= 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative
Published: 2020
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30. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Author: CMM Groep Burgering, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Bull, Caroline J, Bell, Joshua A, Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J, Banbury, Barbara L, Albanes, Demetrius, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Cross, Amanda J, de la Chapelle, Albert, Figueiredo, Jane C, Gallinger, Steven J, Gapstur, Susan M, Giles, Graham G, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A, Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R, Jenkins, Mark A, Joshu, Corinne E, Keku, Temitope O, Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M, Milne, Roger L, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Qu, Conghui, Quirós, J Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C, Schafmayer, Clemens, Schoen, Robert E, Slattery, Martha L, Tangen, Catherine M, Tsilidis, Kostas K, Ulrich, Cornelia M, van Duijnhoven, Fränzel J B, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Zheng, Wei, Peters, Ulrike, Vincent, Emma E, Gunter, Marc J, CMM Groep Burgering, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Bull, Caroline J, Bell, Joshua A, Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J, Banbury, Barbara L, Albanes, Demetrius, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Cross, Amanda J, de la Chapelle, Albert, Figueiredo, Jane C, Gallinger, Steven J, Gapstur, Susan M, Giles, Graham G, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A, Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R, Jenkins, Mark A, Joshu, Corinne E, Keku, Temitope O, Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M, Milne, Roger L, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Qu, Conghui, Quirós, J Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C, Schafmayer, Clemens, Schoen, Robert E, Slattery, Martha L, Tangen, Catherine M, Tsilidis, Kostas K, Ulrich, Cornelia M, van Duijnhoven, Fränzel J B, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Zheng, Wei, Peters, Ulrike, Vincent, Emma E, and Gunter, Marc J
Published: 2020

31. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author: van Duijnhoven, Fränzel J B, Bueno-De-Mesquita, H Bas, Calligaro, Miriam, Jenab, Mazda, Pischon, Tobias, Jansen, Eugène H J M, Frohlich, Jiri, Ayyobi, Amir, Overvad, Kim, Toft-Petersen, Anne Pernille, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Cottet, Vanessa, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Kaaks, Rudolf, Teucher, Birgit, Boeing, Heiner, Drogan, Dagmar, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Peeters, Petra H M, Siersema, Peter D, Rodríguez, Laudina, González, Carlos A, Molina-Montes, Esther, Dorronsoro, Miren, Tormo, Maria-Jose, Barricarte, Aurelio, Palmqvist, Richard, Hallmans, Göran, Khaw, Kay-Tee, Tsilidis, Kostas K, Crowe, Francesca L, Chajes, Veronique, Fedirko, Veronika, Rinaldi, Sabina, Norat, Teresa, Riboli, Elio, van Duijnhoven, Fränzel J B, Bueno-De-Mesquita, H Bas, Calligaro, Miriam, Jenab, Mazda, Pischon, Tobias, Jansen, Eugène H J M, Frohlich, Jiri, Ayyobi, Amir, Overvad, Kim, Toft-Petersen, Anne Pernille, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Cottet, Vanessa, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Kaaks, Rudolf, Teucher, Birgit, Boeing, Heiner, Drogan, Dagmar, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Peeters, Petra H M, Siersema, Peter D, Rodríguez, Laudina, González, Carlos A, Molina-Montes, Esther, Dorronsoro, Miren, Tormo, Maria-Jose, Barricarte, Aurelio, Palmqvist, Richard, Hallmans, Göran, Khaw, Kay-Tee, Tsilidis, Kostas K, Crowe, Francesca L, Chajes, Veronique, Fedirko, Veronika, Rinaldi, Sabina, Norat, Teresa, and Riboli, Elio
Abstract: OBJECTIVE: To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC). DESIGN: Nested case-control study. SETTING: The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520,000 participants from 10 western European countries. PARTICIPANTS: 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status. MAIN OUTCOME MEASURES: Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy. RESULTS: After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer. CONCLUSIONS: These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.
Published: 2011
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31 results on '"Tsilidis, Kostas K."'

1. Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

2. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

3. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

4. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

5. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

6. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

7. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

8. Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

9. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries:results from the EPIC cohort study

10. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

11. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries : results from the EPIC cohort study

12. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

13. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

14. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

15. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries:results from the EPIC cohort study

16. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

17. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

18. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

19. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

20. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

21. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

22. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

23. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

24. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

25. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

26. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

27. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

28. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

29. Adiposity, metabolites, and colorectal cancer risk : Mendelian randomization study

30. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

31. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition

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31 results on '"Tsilidis, Kostas K."'

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