Search

Your search keyword '"Veerabhadrappa, Praveen"' showing total 11 results
Start Over Author "Veerabhadrappa, Praveen" Database OAIster
11 results on '"Veerabhadrappa, Praveen"'

1. Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, Maciej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, Maciej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024
Full Text
View/download PDF

2. Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, Maciej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, Maciej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024
Full Text
View/download PDF

3. Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F., Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R.C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, MacIej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F., Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R.C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, MacIej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024

4. Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F., Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R.C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, MacIej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F., Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R.C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, MacIej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024

5. Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, Maciej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, Maciej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024
Full Text
View/download PDF

6. Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, Maciej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, Maciej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024
Full Text
View/download PDF

8. Council for high blood pressure research/InterAmerican society of hypertension/International society of hypertension : first new investigators symposium at the high blood pressure research 2011 scientific sessions

Author

Veerabhadrappa, Praveen, Burger, Dylan, Charchar, Fadi, Tomaszewski, Maciej, Carlberg, Bo, Harrap, Stephen, Touyz, Rhian M, Veerabhadrappa, Praveen, Burger, Dylan, Charchar, Fadi, Tomaszewski, Maciej, Carlberg, Bo, Harrap, Stephen, and Touyz, Rhian M

Abstract

For the very first time, the International Society of Hypertension (ISH) sponsored the ISH New Investigators Symposium on September 21, 2011, in Orlando, FL, entitled, “A Global Hypertension Initiative: Trainee/New Investigator Session” as part of the High Blood Pressure Research 2011 Scientific Sessions. This symposium was cosponsored by ISH, the InterAmerican Society of Hypertension, the American Heart Association's Council for High Blood Pressure Research and the Council on the Kidney in Cardiovascular Disease, and was organized entirely by the newly formed ISH New Investigators Committee (NIC; Figure 1) and young/new investigators (students, postdoctoral fellows, and early career scientists) in hypertension research.1 The symposium consisted of a half-day event with both oral and poster presentations of highly rated abstracts highlighting the most recent advances in hypertension research by young researchers. The scientific program was abstract based with >100 abstracts reviewed by new investigators as assigned by NIC. Top-scoring abstracts received an invitation for either oral or poster presentation based on their scientific merit. The program provided an opportunity for learning, networking, and socializing among budding scientists from around the world. More than 50 new investigators across 5 continents presented their research at the session, making it a truly “global” hypertension initiative, which was targeted toward young researchers.

Published
2012
Full Text
View/download PDF

11. Racial differences in tumor necrosis factor-α-induced endothelial microparticles and interleukin-6 production

Author

Brown,Michael, Feairheller,Deborah L, Thakkar,Sunny, Veerabhadrappa,Praveen, Park,Joon-Young, Brown,Michael, Feairheller,Deborah L, Thakkar,Sunny, Veerabhadrappa,Praveen, and Park,Joon-Young

Abstract

Michael D Brown1,3, Deborah L Feairheller1, Sunny Thakkar1, Praveen Veerabhadrappa1, Joon-Young Park21Hypertension, Molecular and Applied Physiology Laboratory, 2Cardiovascular Genomics Laboratory, Department of Kinesiology, 3Cardiovascular Research Center, School of Medicine, Temple University, Philadelphia, PA, USAAbstract: African Americans (AA) tend to have heightened systemic inflammation and endothelial dysfunction. Endothelial microparticles (EMP) are released from activated/apoptotic endothelial cells (EC) when stimulated by inflammation. The purpose of our study was to assess EMP responses to inflammatory cytokine (TNF-α) and antioxidant (superoxide dismutase, SOD) conditions in human umbilical vein ECs (HUVECs) obtained from AA and Caucasians. EMPs were measured under four conditions: control (basal), TNF-α, SOD, and TNF-α + SOD. Culture supernatant was collected for EMP analysis by flow cytometry and IL-6 assay by ELISA. IL-6 protein expression was assessed by Western blot. AA HUVECs had greater EMP levels under the TNF- α condition compared to the Caucasian HUVECs (6.8 ± 1.1 vs 4.7% ± 0.4%, P = 0.04). The EMP level increased by 89% from basal levels in the AA HUVECs under the TNF-α condition (P = 0.01) compared to an 8% increase in the Caucasian HUVECs (P = 0.70). Compared to the EMP level under the TNF-α condition, the EMP level in the AA HUVECs was lower under the SOD only condition (2.9% ± 0.3%, P = 0.005) and under the TNF-α + SOD condition (2.1% ± 0.4%, P = 0.001). Basal IL-6 concentrations were 56.1 ± 8.8 pg/mL/µg in the AA and 30.9 ± 14.9 pg/mL/µg in the Caucasian HUVECs (P = 0.17), while basal IL-6 protein expression was significantly greater (P < 0.05) in the AA HUVECs. These preliminary observational results suggest that AA HUVECs may be more susceptible to the injurious effects of th

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results