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1. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

Author

Walsh, R, Lahrouchi, N, Tadros, R, Kyndt, F, Glinge, C, Postema, P, Amin, A, Nannenberg, E, Ware, J, Whiffin, N, Mazzarotto, F, Skoric-Milosavljevic, D, Krijger, C, Arbelo, E, Babuty, D, Barajas-Martinez, H, Beckmann, B, Bezieau, S, Bos, J, Breckpot, J, Campuzano, O, Castelletti, S, Celen, C, Clauss, S, Corveleyn, A, Crotti, L, Dagradi, F, de Asmundis, C, Denjoy, I, Dittmann, S, Ellinor, P, Ortuno, C, Giustetto, C, Gourraud, J, Hazeki, D, Horie, M, Ishikawa, T, Itoh, H, Kaneko, Y, Kanters, J, Kimoto, H, Kotta, M, Krapels, I, Kurabayashi, M, Lazarte, J, Leenhardt, A, Loeys, B, Lundin, C, Makiyama, T, Mansourati, J, Martins, R, Mazzanti, A, Morner, S, Napolitano, C, Ohkubo, K, Papadakis, M, Rudic, B, Molina, M, Sacher, F, Sahin, H, Sarquella-Brugada, G, Sebastiano, R, Sharma, S, Sheppard, M, Shimamoto, K, Shoemaker, M, Stallmeyer, B, Steinfurt, J, Tanaka, Y, Tester, D, Usuda, K, van der Zwaag, P, Van Dooren, S, Van Laer, L, Winbo, A, Winkel, B, Yamagata, K, Zumhagen, S, Volders, P, Lubitz, S, Antzelevitch, C, Platonov, P, Odening, K, Roden, D, Roberts, J, Skinner, J, Tfelt-Hansen, J, van den Berg, M, Olesen, M, Lambiase, P, Borggrefe, M, Hayashi, K, Rydberg, A, Nakajima, T, Yoshinaga, M, Saenen, J, Kaab, S, Brugada, P, Robyns, T, Giachino, D, Ackerman, M, Brugada, R, Brugada, J, Gimeno, J, Hasdemir, C, Guicheney, P, Priori, S, Schulze-Bahr, E, Makita, N, Schwartz, P, Shimizu, W, Aiba, T, Schott, J, Redon, R, Ohno, S, Probst, V, Arnaout, A, Amelot, M, Anselme, F, Billon, O, Defaye, P, Dupuis, J, Jesel, L, Laurent, G, Maury, P, Pasquie, J, Wiart, F, Behr, E, Barc, J, Bezzina, C, Walsh R., Lahrouchi N., Tadros R., Kyndt F., Glinge C., Postema P. G., Amin A. S., Nannenberg E. A., Ware J. S., Whiffin N., Mazzarotto F., Skoric-Milosavljevic D., Krijger C., Arbelo E., Babuty D., Barajas-Martinez H., Beckmann B. M., Bezieau S., Bos J. M., Breckpot J., Campuzano O., Castelletti S., Celen C., Clauss S., Corveleyn A., Crotti L., Dagradi F., de Asmundis C., Denjoy I., Dittmann S., Ellinor P. T., Ortuno C. G., Giustetto C., Gourraud J. -B., Hazeki D., Horie M., Ishikawa T., Itoh H., Kaneko Y., Kanters J. K., Kimoto H., Kotta M. -C., Krapels I. P. C., Kurabayashi M., Lazarte J., Leenhardt A., Loeys B. L., Lundin C., Makiyama T., Mansourati J., Martins R. P., Mazzanti A., Morner S., Napolitano C., Ohkubo K., Papadakis M., Rudic B., Molina M. S., Sacher F., Sahin H., Sarquella-Brugada G., Sebastiano R., Sharma S., Sheppard M. N., Shimamoto K., Shoemaker M. B., Stallmeyer B., Steinfurt J., Tanaka Y., Tester D. J., Usuda K., van der Zwaag P. A., Van Dooren S., Van Laer L., Winbo A., Winkel B. G., Yamagata K., Zumhagen S., Volders P. G. A., Lubitz S. A., Antzelevitch C., Platonov P. G., Odening K. E., Roden D. M., Roberts J. D., Skinner J. R., Tfelt-Hansen J., van den Berg M. P., Olesen M. S., Lambiase P. D., Borggrefe M., Hayashi K., Rydberg A., Nakajima T., Yoshinaga M., Saenen J. B., Kaab S., Brugada P., Robyns T., Giachino D. F., Ackerman M. J., Brugada R., Brugada J., Gimeno J. R., Hasdemir C., Guicheney P., Priori S. G., Schulze-Bahr E., Makita N., Schwartz P. J., Shimizu W., Aiba T., Schott J. -J., Redon R., Ohno S., Probst V., Arnaout A. A., Amelot M., Anselme F., Billon O., Defaye P., Dupuis J. -M., Jesel L., Laurent G., Maury P., Pasquie J. -L., Wiart F., Behr E. R., Barc J., Bezzina C. R., Walsh, R, Lahrouchi, N, Tadros, R, Kyndt, F, Glinge, C, Postema, P, Amin, A, Nannenberg, E, Ware, J, Whiffin, N, Mazzarotto, F, Skoric-Milosavljevic, D, Krijger, C, Arbelo, E, Babuty, D, Barajas-Martinez, H, Beckmann, B, Bezieau, S, Bos, J, Breckpot, J, Campuzano, O, Castelletti, S, Celen, C, Clauss, S, Corveleyn, A, Crotti, L, Dagradi, F, de Asmundis, C, Denjoy, I, Dittmann, S, Ellinor, P, Ortuno, C, Giustetto, C, Gourraud, J, Hazeki, D, Horie, M, Ishikawa, T, Itoh, H, Kaneko, Y, Kanters, J, Kimoto, H, Kotta, M, Krapels, I, Kurabayashi, M, Lazarte, J, Leenhardt, A, Loeys, B, Lundin, C, Makiyama, T, Mansourati, J, Martins, R, Mazzanti, A, Morner, S, Napolitano, C, Ohkubo, K, Papadakis, M, Rudic, B, Molina, M, Sacher, F, Sahin, H, Sarquella-Brugada, G, Sebastiano, R, Sharma, S, Sheppard, M, Shimamoto, K, Shoemaker, M, Stallmeyer, B, Steinfurt, J, Tanaka, Y, Tester, D, Usuda, K, van der Zwaag, P, Van Dooren, S, Van Laer, L, Winbo, A, Winkel, B, Yamagata, K, Zumhagen, S, Volders, P, Lubitz, S, Antzelevitch, C, Platonov, P, Odening, K, Roden, D, Roberts, J, Skinner, J, Tfelt-Hansen, J, van den Berg, M, Olesen, M, Lambiase, P, Borggrefe, M, Hayashi, K, Rydberg, A, Nakajima, T, Yoshinaga, M, Saenen, J, Kaab, S, Brugada, P, Robyns, T, Giachino, D, Ackerman, M, Brugada, R, Brugada, J, Gimeno, J, Hasdemir, C, Guicheney, P, Priori, S, Schulze-Bahr, E, Makita, N, Schwartz, P, Shimizu, W, Aiba, T, Schott, J, Redon, R, Ohno, S, Probst, V, Arnaout, A, Amelot, M, Anselme, F, Billon, O, Defaye, P, Dupuis, J, Jesel, L, Laurent, G, Maury, P, Pasquie, J, Wiart, F, Behr, E, Barc, J, Bezzina, C, Walsh R., Lahrouchi N., Tadros R., Kyndt F., Glinge C., Postema P. G., Amin A. S., Nannenberg E. A., Ware J. S., Whiffin N., Mazzarotto F., Skoric-Milosavljevic D., Krijger C., Arbelo E., Babuty D., Barajas-Martinez H., Beckmann B. M., Bezieau S., Bos J. M., Breckpot J., Campuzano O., Castelletti S., Celen C., Clauss S., Corveleyn A., Crotti L., Dagradi F., de Asmundis C., Denjoy I., Dittmann S., Ellinor P. T., Ortuno C. G., Giustetto C., Gourraud J. -B., Hazeki D., Horie M., Ishikawa T., Itoh H., Kaneko Y., Kanters J. K., Kimoto H., Kotta M. -C., Krapels I. P. C., Kurabayashi M., Lazarte J., Leenhardt A., Loeys B. L., Lundin C., Makiyama T., Mansourati J., Martins R. P., Mazzanti A., Morner S., Napolitano C., Ohkubo K., Papadakis M., Rudic B., Molina M. S., Sacher F., Sahin H., Sarquella-Brugada G., Sebastiano R., Sharma S., Sheppard M. N., Shimamoto K., Shoemaker M. B., Stallmeyer B., Steinfurt J., Tanaka Y., Tester D. J., Usuda K., van der Zwaag P. A., Van Dooren S., Van Laer L., Winbo A., Winkel B. G., Yamagata K., Zumhagen S., Volders P. G. A., Lubitz S. A., Antzelevitch C., Platonov P. G., Odening K. E., Roden D. M., Roberts J. D., Skinner J. R., Tfelt-Hansen J., van den Berg M. P., Olesen M. S., Lambiase P. D., Borggrefe M., Hayashi K., Rydberg A., Nakajima T., Yoshinaga M., Saenen J. B., Kaab S., Brugada P., Robyns T., Giachino D. F., Ackerman M. J., Brugada R., Brugada J., Gimeno J. R., Hasdemir C., Guicheney P., Priori S. G., Schulze-Bahr E., Makita N., Schwartz P. J., Shimizu W., Aiba T., Schott J. -J., Redon R., Ohno S., Probst V., Arnaout A. A., Amelot M., Anselme F., Billon O., Defaye P., Dupuis J. -M., Jesel L., Laurent G., Maury P., Pasquie J. -L., Wiart F., Behr E. R., Barc J., and Bezzina C. R.

Abstract

Purpose: Stringent variant interpretation guidelines can lead to high rates of variants of uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS) and Brugada syndrome (BrS). Quantitative and disease-specific customization of American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) guidelines can address this false negative rate. Methods: We compared rare variant frequencies from 1847 LQTS (KCNQ1/KCNH2/SCN5A) and 3335 BrS (SCN5A) cases from the International LQTS/BrS Genetics Consortia to population-specific gnomAD data and developed disease-specific criteria for ACMG/AMP evidence classes—rarity (PM2/BS1 rules) and case enrichment of individual (PS4) and domain-specific (PM1) variants. Results: Rare SCN5A variant prevalence differed between European (20.8%) and Japanese (8.9%) BrS patients (p = 5.7 × 10−18) and diagnosis with spontaneous (28.7%) versus induced (15.8%) Brugada type 1 electrocardiogram (ECG) (p = 1.3 × 10−13). Ion channel transmembrane regions and specific N-terminus (KCNH2) and C-terminus (KCNQ1/KCNH2) domains were characterized by high enrichment of case variants and >95% probability of pathogenicity. Applying the customized rules, 17.4% of European BrS and 74.8% of European LQTS cases had (likely) pathogenic variants, compared with estimated diagnostic yields (case excess over gnomAD) of 19.2%/82.1%, reducing VUS prevalence to close to background rare variant frequency. Conclusion: Large case–control data sets enable quantitative implementation of ACMG/AMP guidelines and increased sensitivity for inherited arrhythmia genetic testing.

Published
2021

2. Edward Carmeliet (1930-2021) - Channelling scientific curiosity: A tribute from the ESC Working Group on Cardiac Cellular Electrophysiology

Author

Ravens, U, Gomez, A, Heijman, J, Remme, C, Dobrev, D, Smith, G, Volders, P, Cerbai, E, Eisner, D, Casadei, B, Zaza, A, Richard, S, Mugelli, A, Vassort, G, Brown, H, Sipido, K, Ravens U., Gomez A. M., Heijman J., Remme C. A., Dobrev D., Smith G., Volders P. G. A., Cerbai E., Eisner D. A., Casadei B., Zaza A., Richard S., Mugelli A., Vassort G., Brown H. F., Sipido K. R., Ravens, U, Gomez, A, Heijman, J, Remme, C, Dobrev, D, Smith, G, Volders, P, Cerbai, E, Eisner, D, Casadei, B, Zaza, A, Richard, S, Mugelli, A, Vassort, G, Brown, H, Sipido, K, Ravens U., Gomez A. M., Heijman J., Remme C. A., Dobrev D., Smith G., Volders P. G. A., Cerbai E., Eisner D. A., Casadei B., Zaza A., Richard S., Mugelli A., Vassort G., Brown H. F., and Sipido K. R.

Published
2021

3. Mutation location and IKsregulation in the arrhythmic risk of long QT syndrome type 1: The importance of the KCNQ1 S6 region

Author

Schwartz, P, Moreno, C, Kotta, M, Pedrazzini, M, Crotti, L, Dagradi, F, Castelletti, S, Haugaa, K, Denjoy, I, Shkolnikova, M, Brink, P, Heradien, M, Seyen, S, Spatjens, R, Spazzolini, C, Volders, P, Schwartz P. J., Moreno C., Kotta M. -C., Pedrazzini M., Crotti L., Dagradi F., Castelletti S., Haugaa K. H., Denjoy I., Shkolnikova M. A., Brink P. A., Heradien M. J., Seyen S. R. M., Spatjens R. L. H. M. G., Spazzolini C., Volders P. G. A., Schwartz, P, Moreno, C, Kotta, M, Pedrazzini, M, Crotti, L, Dagradi, F, Castelletti, S, Haugaa, K, Denjoy, I, Shkolnikova, M, Brink, P, Heradien, M, Seyen, S, Spatjens, R, Spazzolini, C, Volders, P, Schwartz P. J., Moreno C., Kotta M. -C., Pedrazzini M., Crotti L., Dagradi F., Castelletti S., Haugaa K. H., Denjoy I., Shkolnikova M. A., Brink P. A., Heradien M. J., Seyen S. R. M., Spatjens R. L. H. M. G., Spazzolini C., and Volders P. G. A.

Abstract

Aims: Mutation type, location, dominant-negative IKs reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent IKs stimulation via protein kinase A (PKA) influence the clinical severity of long QT syndrome type 1 (LQT1). Given the malignancy of KCNQ1-p.A341V, we assessed whether mutations neighbouring p.A341V in the S6 channel segment could also increase arrhythmic risk. Methods and results: Clinical and genetic data were obtained from 1316 LQT1 patients [450 families, 166 unique KCNQ1 mutations, including 277 p.A341V-positive subjects, 139 patients with p.A341-neighbouring mutations (91 missense, 48 non-missense), and 900 other LQT1 subjects]. A first cardiac event represented the primary endpoint. S6 segment missense variant characteristics, particularly cAMP stimulation responses, were analysed by cellular electrophysiology. p.A341-neighbouring mutation carriers had a QTc shorter than p.A341V carriers (477 ± 33 vs. 490 ± 44 ms) but longer than the remaining LQT1 patient population (467 ± 41 ms) (P < 0.05 for both). Similarly, the frequency of symptomatic subjects in the p.A341-neighbouring subgroup was intermediate between the other two groups (43% vs. 73% vs. 20%; P < 0.001). These differences in clinical severity can be explained, for p.A341V vs. p.A341-neighbouring mutations, by the p.A341V-specific impairment of IKs regulation. The differences between the p.A341-neighbouring subgroup and the rest of LQT1 mutations may be explained by the functional importance of the S6 segment for channel activation. Conclusion: KCNQ1 S6 segment mutations surrounding p.A341 increase arrhythmic risk. p.A341V-specific loss of PKA-dependent IKs enhancement correlates with its phenotypic severity. Cellular studies providing further insights into IKs-channel regulation and knowledge of structure-function relationships could improve risk stratification. These findings impact on clinical management.

Published
2021

4. Repolarization instability and arrhythmia by IKr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers

Author

Altrocchi, C, de Korte, T, Bernardi, J, Spatjens, R, Braam, S, Heijman, J, Zaza, A, Volders, P, Altrocchi C., de Korte T., Bernardi J., Spatjens R. L. H. M. G., Braam S. R., Heijman J., Zaza A., Volders P. G. A., Altrocchi, C, de Korte, T, Bernardi, J, Spatjens, R, Braam, S, Heijman, J, Zaza, A, Volders, P, Altrocchi C., de Korte T., Bernardi J., Spatjens R. L. H. M. G., Braam S. R., Heijman J., Zaza A., and Volders P. G. A.

Abstract

Aims Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have proven valuable for studies in drug discovery and safety, although limitations regarding their structural and electrophysiological characteristics persist. In this study, we investigated the electrophysiological properties of PluricyteVR CMs, a commercially available hiPSC-CMs line with a ventricular phenotype, and assessed arrhythmia incidence by IKr block at the single-cell and 2D monolayer level. Methods and Action potentials were measured at different pacing frequencies, using dynamic clamp. Through voltage-clamp results experiments, we determined the properties of INa, IKr, and ICaL. Intracellular Ca2þ measurements included Ca2þtransients at baseline and during caffeine perfusion. Effects of IKr block were assessed in single hiPSC-CMs and 2D monolayers (multi-electrode arrays). Action-potential duration (APD) and its rate dependence in PluricyteVR CMs were comparable to those reported for native human CMs. INa, IKr, and ICaL revealed amplitudes, kinetics, and voltage dependence of activation/inactivation similar to other hiPSC-CM lines and, to some extent, to native CMs. Near-physiological Ca2þ-induced Ca2þ release, response to caffeine and excitation-contraction coupling gain characterized the cellular Ca2þ-handling. Dofetilide prolonged the APD and field-potential duration, and induced early afterdepolarizations. Beat-to-beat variability of repolarization duration increased significantly before the first arrhythmic events in single PluricyteVR CMs and 2D monolayers, and predicted pending arrhythmias better than action-potential prolongation. Conclusion Taking their ion-current characteristics and Ca2þ handling into account, PluricyteVR CMs are suitable for in vitro studies on action potentials and field potentials. Beat-to-beat variability of repolarization duration proved useful to evaluate the dynamics of repolarization instability and demonstrated its significance as proarrhyt

Published
2020

5. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, T. A., Granite, S., Allessie, M. A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R. A. B., Cerbai, E., Chen, P. S., Delmar, M., DiFrancesco, D., Earm, Y. E., Efimov, I. R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M. R., Garny, A., Giles, W. R., Hannes, T., Harding, S. E., Hunter, P. J., Iribe, G., Jalife, J., Johnson, C. R., Kass, R. S., Kodama, I., Koren, G., Lord, P., Markhasin, V. S., Matsuoka, S., McCulloch, A. D., Mirams, G. R., Morley, G. E., Nattel, S., Noble, D., Olesen, S. P., Panfilov, A. V., Trayanova, N. A., Ravens, U., Richard, S., Rosenbaum, D. S., Rudy, Y., Sachs, F., Sachse, F. B., Saint, D. A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varro, A., Volders, P. G., Wang, K., Weiss, J. N., Wettwer, E., White, E., Wilders, R., Winslow, R. L., Kohl, P., Quinn, T. A., Granite, S., Allessie, M. A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R. A. B., Cerbai, E., Chen, P. S., Delmar, M., DiFrancesco, D., Earm, Y. E., Efimov, I. R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M. R., Garny, A., Giles, W. R., Hannes, T., Harding, S. E., Hunter, P. J., Iribe, G., Jalife, J., Johnson, C. R., Kass, R. S., Kodama, I., Koren, G., Lord, P., Markhasin, V. S., Matsuoka, S., McCulloch, A. D., Mirams, G. R., Morley, G. E., Nattel, S., Noble, D., Olesen, S. P., Panfilov, A. V., Trayanova, N. A., Ravens, U., Richard, S., Rosenbaum, D. S., Rudy, Y., Sachs, F., Sachse, F. B., Saint, D. A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varro, A., Volders, P. G., Wang, K., Weiss, J. N., Wettwer, E., White, E., Wilders, R., Winslow, R. L., and Kohl, P.

Published
2011

6. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE):standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, Kohl, P, Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, and Kohl, P

Abstract

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work.

Published
2011

7. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE):standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, Kohl, P, Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, and Kohl, P

Abstract

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work.

Published
2011

8. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE):standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, Kohl, P, Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, and Kohl, P

Abstract

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work.

Published
2011

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