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Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.

Neurodegenerative diseases such as Alzheimer's disease (AD) have become very important in recent years due to the increase in the number of cases worldwide, becoming a major problem for Public Health. This has been due to an increase in life expectancy, which translates into a greater number of elderly people at risk of suffering from chronic and degenerative diseases. AD is the most common type of dementia assuming cognitive decline that ultimately leads to a decrease and loss of patient autonomy. It is characterized by the loss of the neuronal synapse due to the presence of senile plaques (PS) formed by the accumulation of ?-amyloid peptides at the extracellular level, and aggregates of the hyperphosphorylated tau protein at the intracellular level, giving rise to neurofibrillary tangles (ONFs). ). This entails an increase in oxidative stress and inflammatory processes that ultimately produce neuronal apoptosis. Currently, there is no pharmacological treatment capable of reversing this pathology, so one of the strategies being used is intervention at the level of modifiable risk factors that have been associated with the development of AD, such as example, cardiovascular disease. Lifestyle, especially dietary habits and physical activity seem to play an important role in preventing the onset of AD and other neurodegenerative diseases. The Mediterranean diet and the Japanese diet are considered worldwide as prudent, healthy and nutritionally balanced diets. Therefore, the analysis of both diets in the context of the decreased risk of developing AD is of great interest. The objective of this work is to carry out a bibliographic review on the current evidence about the association of these diets with cognitive function and AD. Both the Mediterranean and Japanese diets seem to help minimize the likelihood of AD. The high content of antioxidant and anti-inflammatory substances seems to be the reason. The main foods and nutrients responsible for these actions are: polyp, Las enfermedades neurodegenerativas como la enfermedad de Alzheimer (EA) han cobrado gran importancia en los últimos años debido al aumento del número de casos a nivel mundial, convirtiéndose en un gran problema para la Salud Pública. Esto se ha debido a un incremento de la esperanza de vida, lo que se traduce en un mayor número de personas ancianas en riesgo de padecer enfermedades crónicas y degenerativas. La EA es el tipo de demencia más común suponiendo un deterioro cognitivo que, en última instancia, lleva a una disminución y pérdida de la autonomía del paciente. Se caracteriza por la pérdida de la sinapsis neuronal debido a la presencia de placas seniles (PS) formadas por la acumulación de péptidos ß- amiloide a nivel extracelular, y agregados de la proteína tau hiperfosforilada a nivel intracelular dando lugar a los ovillos neurofibrilares (ONFs). Esto conlleva un aumento del estrés oxidativo y de procesos inflamatorios que producen, finalmente, la apoptosis neuronal. Actualmente, no existe ningún tratamiento farmacológico capaz de revertir dicha patología por lo que, una de las estrategias a las que se está recurriendo, es la intervención a nivel de los factores de riesgo modificables que se han asociado al desarrollo de la EA como, por ejemplo, las enfermedades cardiovasculares. El estilo de vida, especialmente los hábitos dietéticos y la realización de actividad física parecen jugar un papel importante en la prevención de la aparición de la EA y otras enfermedades neurodegenerativas. La dieta Mediterránea y la dieta japonesa son consideradas mundialmente como dietas prudentes, saludables y nutricionalmente equilibradas. Por ello, el análisis de ambas dietas en el contexto de la disminución del riesgo de desarrollar la EA es de gran interés. El objetivo de este trabajo es llevar a cabo una revisión bibliográfica sobre la evidencia actual acerca de la asociación de dichas dietas con la función cognitiva y la EA. Tanto la dieta Mediterránea como