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Background: Up-to-date and hospital-specific knowledge of prognoses for horses with various forms of colic is essential for helping to guide owners’ decisions on costly treatments, and for assessing the continuous development of standards of care in the hospital. This study aimed to determine the short-term survival rates of horses admitted with colic to the University Hospital for Large Animals (UHLA), University of Copenhagen, Denmark, from 2010 to 2018, and to compare these to a previous local study as well as recent, comparable international studies. Short-term survival rates were calculated for horses grouped by treatment (surgical, medical) and diseases. Results were compared to the selected studies using Chi-square tests. Results: A total of 1752 horses were admitted with colic during the period, of which 355 were excluded for reasons such as economic restrictions or immediate euthanasia. Short-term survival of the remaining 1397 cases was significantly higher (83.0% (95% CI 81.1–85.0%)) than a previous local study (76%) and a recent Dutch study (80%). Medical treatment was carried out in 77.1% of cases, and surgery in 22.9% of the cases. Short-term survival for medically (89.7%) and surgically (60.6%) treated horses was significantly higher in the present study compared to the previous study (87% and 42%, respectively), but was similar to that found in the Dutch study. Significantly fewer horses were euthanised during surgery than in the previous study (17.2 vs. 40%), and significantly more horses recovered from surgery (79.1 vs. 56%). Short-term survival rate of surgically treated horses (60.6%) did not differ from other European studies (55–62%). Conclusions: Short-term survival rates have increased since the previous study at UHLA, mainly due to a decrease in intraoperative euthanasia. Survival rates in this study are similar to those found in recent comparable colic studies.

Background: Up-to-date and hospital-specific knowledge of prognoses for horses with various forms of colic is essential for helping to guide owners’ decisions on costly treatments, and for assessing the continuous development of standards of care in the hospital. This study aimed to determine the short-term survival rates of horses admitted with colic to the University Hospital for Large Animals (UHLA), University of Copenhagen, Denmark, from 2010 to 2018, and to compare these to a previous local study as well as recent, comparable international studies. Short-term survival rates were calculated for horses grouped by treatment (surgical, medical) and diseases. Results were compared to the selected studies using Chi-square tests. Results: A total of 1752 horses were admitted with colic during the period, of which 355 were excluded for reasons such as economic restrictions or immediate euthanasia. Short-term survival of the remaining 1397 cases was significantly higher (83.0% (95% CI 81.1–85.0%)) than a previous local study (76%) and a recent Dutch study (80%). Medical treatment was carried out in 77.1% of cases, and surgery in 22.9% of the cases. Short-term survival for medically (89.7%) and surgically (60.6%) treated horses was significantly higher in the present study compared to the previous study (87% and 42%, respectively), but was similar to that found in the Dutch study. Significantly fewer horses were euthanised during surgery than in the previous study (17.2 vs. 40%), and significantly more horses recovered from surgery (79.1 vs. 56%). Short-term survival rate of surgically treated horses (60.6%) did not differ from other European studies (55–62%). Conclusions: Short-term survival rates have increased since the previous study at UHLA, mainly due to a decrease in intraoperative euthanasia. Survival rates in this study are similar to those found in recent comparable colic studies.

Background: Currently, radiation-oncologists generally evaluate a single treatment plan for each patient that is possibly adapted by the planner prior to final appr

This thesis describes research on the personalization of treatment of gastro-intestinal cancers by use of pharmacokinetic and pharmacogenetic principles.

Data are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum (n = 46, 44.2%), small intestines except terminal ileum (n = 36, 34.6%), colon (n = 29, 27.8%), stomach (n = 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and M. tuberculosis was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy, n = 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery., SCOPUS: ar.j, info:eu-repo/semantics/published

peer-reviewed, Zn is essential for growth and development. The bioavailability of Zn is affected by several factors such as other food components. It is therefore of interest, to understand uptake mechanisms of Zn delivering compounds to identify ways to bypass the inhibitory effects of these factors. Here, we studied the effect of Zn amino acid conjugates (ZnAAs) on the bioavailabilty of Zn. We used Caco-2 cells and enterocytes differentiated from human induced pluripotent stem cells from a control and Acroder- matitis enteropathica (AE) patient, and performed fluorescence based assays, protein biochemistry and atomic absorption spectrometry to characterize cellular uptake and absorption of ZnAAs. The results show that ZnAAs are taken up by AA transporters, leading to an intracellular enrichment of Zn mostly uninhibited by Zn uptake antagonists. Enterocytes from AE patients were unable to gain significant Zn through exposure to ZnCl2 but did not show differences with respect to ZnAAs. We conclude that ZnAAs may possess an advantage over classical Zn supplements such as Zn salts, as they may be able to increase bioavailability of Zn, and may be more efficient in patients with AE., PUBLISHED, peer-reviewed

Background. The food- and waterborne disease situation in Russia requires special attention. Poor quality of centralized water supplies and sewage systems, biological and chemical contamination of drinking water, as well as contamination of food products, promote widespread infectious diseases, significantly exceeding nationwide rates in the population living in the two-thirds of Russian northern territories.Objectives. The general aim was to assess the levels of food- and waterborne diseases in selected regions of Russian Arctic, Siberia and the Far East (for the period 2000ￜ2011), and to compare disease levels among regions and with national levels in Russia.Study design and methods. This study is the first comparative assessment of the morbidity in these fields of the population of 18 selected regions of Russian Arctic, Siberia and the Far East, using official statistical sources. The incidences of infectious and parasitic food- and waterborne diseases among the general population (including indigenous peoples) have been analyzed in selected regions (per 100,000 of population, averaged for 2000ￜ2011).Results. Among compulsory registered infectious and parasitic diseases, there were high rates and widespread incidences in selected regions of shigellosis, yersiniosis, hepatitis A, tularaemia, giardiasis, enterobiasis, ascariasis, diphyllobothriasis, opistorchiasis, echinococcosis and trichinellosis.Conclusion. Incidences of infectious and parasitic food- and waterborne diseases in the general population of selected regions of the Russian Arctic, Siberia and the Far East (2000ￜ2011) are alarmingly high. Parallel solutions must be on the agenda, including improvement of sanitary conditions of cities and settlements in the regions, modernization of the water supply and of the sewage system. Provision and monitoring of the quality of the drinking water, a reform of the general healthcare system and the epidemiological surveillance (including gender-divided statis

Background. The food- and waterborne disease situation in Russia requires special attention. Poor quality of centralized water supplies and sewage systems, biological and chemical contamination of drinking water, as well as contamination of food products, promote widespread infectious diseases, significantly exceeding nationwide rates in the population living in the two-thirds of Russian northern territories.Objectives. The general aim was to assess the levels of food- and waterborne diseases in selected regions of Russian Arctic, Siberia and the Far East (for the period 2000ￜ2011), and to compare disease levels among regions and with national levels in Russia.Study design and methods. This study is the first comparative assessment of the morbidity in these fields of the population of 18 selected regions of Russian Arctic, Siberia and the Far East, using official statistical sources. The incidences of infectious and parasitic food- and waterborne diseases among the general population (including indigenous peoples) have been analyzed in selected regions (per 100,000 of population, averaged for 2000ￜ2011).Results. Among compulsory registered infectious and parasitic diseases, there were high rates and widespread incidences in selected regions of shigellosis, yersiniosis, hepatitis A, tularaemia, giardiasis, enterobiasis, ascariasis, diphyllobothriasis, opistorchiasis, echinococcosis and trichinellosis.Conclusion. Incidences of infectious and parasitic food- and waterborne diseases in the general population of selected regions of the Russian Arctic, Siberia and the Far East (2000ￜ2011) are alarmingly high. Parallel solutions must be on the agenda, including improvement of sanitary conditions of cities and settlements in the regions, modernization of the water supply and of the sewage system. Provision and monitoring of the quality of the drinking water, a reform of the general healthcare system and the epidemiological surveillance (including gender-divided statis

Background. The food- and waterborne disease situation in Russia requires special attention. Poor quality of centralized water supplies and sewage systems, biological and chemical contamination of drinking water, as well as contamination of food products, promote widespread infectious diseases, significantly exceeding nationwide rates in the population living in the two-thirds of Russian northern territories.Objectives. The general aim was to assess the levels of food- and waterborne diseases in selected regions of Russian Arctic, Siberia and the Far East (for the period 2000ￜ2011), and to compare disease levels among regions and with national levels in Russia.Study design and methods. This study is the first comparative assessment of the morbidity in these fields of the population of 18 selected regions of Russian Arctic, Siberia and the Far East, using official statistical sources. The incidences of infectious and parasitic food- and waterborne diseases among the general population (including indigenous peoples) have been analyzed in selected regions (per 100,000 of population, averaged for 2000ￜ2011).Results. Among compulsory registered infectious and parasitic diseases, there were high rates and widespread incidences in selected regions of shigellosis, yersiniosis, hepatitis A, tularaemia, giardiasis, enterobiasis, ascariasis, diphyllobothriasis, opistorchiasis, echinococcosis and trichinellosis.Conclusion. Incidences of infectious and parasitic food- and waterborne diseases in the general population of selected regions of the Russian Arctic, Siberia and the Far East (2000ￜ2011) are alarmingly high. Parallel solutions must be on the agenda, including improvement of sanitary conditions of cities and settlements in the regions, modernization of the water supply and of the sewage system. Provision and monitoring of the quality of the drinking water, a reform of the general healthcare system and the epidemiological surveillance (including gender-divided statis

Background. The food- and waterborne disease situation in Russia requires special attention. Poor quality of centralized water supplies and sewage systems, biological and chemical contamination of drinking water, as well as contamination of food products, promote widespread infectious diseases, significantly exceeding nationwide rates in the population living in the two-thirds of Russian northern territories.Objectives. The general aim was to assess the levels of food- and waterborne diseases in selected regions of Russian Arctic, Siberia and the Far East (for the period 2000ￜ2011), and to compare disease levels among regions and with national levels in Russia.Study design and methods. This study is the first comparative assessment of the morbidity in these fields of the population of 18 selected regions of Russian Arctic, Siberia and the Far East, using official statistical sources. The incidences of infectious and parasitic food- and waterborne diseases among the general population (including indigenous peoples) have been analyzed in selected regions (per 100,000 of population, averaged for 2000ￜ2011).Results. Among compulsory registered infectious and parasitic diseases, there were high rates and widespread incidences in selected regions of shigellosis, yersiniosis, hepatitis A, tularaemia, giardiasis, enterobiasis, ascariasis, diphyllobothriasis, opistorchiasis, echinococcosis and trichinellosis.Conclusion. Incidences of infectious and parasitic food- and waterborne diseases in the general population of selected regions of the Russian Arctic, Siberia and the Far East (2000ￜ2011) are alarmingly high. Parallel solutions must be on the agenda, including improvement of sanitary conditions of cities and settlements in the regions, modernization of the water supply and of the sewage system. Provision and monitoring of the quality of the drinking water, a reform of the general healthcare system and the epidemiological surveillance (including gender-divided statis

Background. The food- and waterborne disease situation in Russia requires special attention. Poor quality of centralized water supplies and sewage systems, biological and chemical contamination of drinking water, as well as contamination of food products, promote widespread infectious diseases, significantly exceeding nationwide rates in the population living in the two-thirds of Russian northern territories.Objectives. The general aim was to assess the levels of food- and waterborne diseases in selected regions of Russian Arctic, Siberia and the Far East (for the period 2000ￜ2011), and to compare disease levels among regions and with national levels in Russia.Study design and methods. This study is the first comparative assessment of the morbidity in these fields of the population of 18 selected regions of Russian Arctic, Siberia and the Far East, using official statistical sources. The incidences of infectious and parasitic food- and waterborne diseases among the general population (including indigenous peoples) have been analyzed in selected regions (per 100,000 of population, averaged for 2000ￜ2011).Results. Among compulsory registered infectious and parasitic diseases, there were high rates and widespread incidences in selected regions of shigellosis, yersiniosis, hepatitis A, tularaemia, giardiasis, enterobiasis, ascariasis, diphyllobothriasis, opistorchiasis, echinococcosis and trichinellosis.Conclusion. Incidences of infectious and parasitic food- and waterborne diseases in the general population of selected regions of the Russian Arctic, Siberia and the Far East (2000ￜ2011) are alarmingly high. Parallel solutions must be on the agenda, including improvement of sanitary conditions of cities and settlements in the regions, modernization of the water supply and of the sewage system. Provision and monitoring of the quality of the drinking water, a reform of the general healthcare system and the epidemiological surveillance (including gender-divided statis

A group of 13,698 patients from 127 gastro-intestinal clinical trials, conducted in 13 countries was included in the analyses. All adverse events reported were included in the evaluation. The general adverse event reporting rate, the mean number of adverse events reported, the serious adverse event reporting rate and the mean number of serious adverse events reported were calculated for each country. In addition, the pattern of adverse events reported in each country was studied. The general adverse event reporting rate varied between 17% and 68% with a mean of 47% and the serious adverse event reporting rate varied between 1% and 20% with a mean of 8%. The mean number of adverse events, reported by patients reporting adverse events, varied between 1.5 and 2.7 with a mean of 2.1 and the mean number of serious adverse events, reported by patients reporting serious adverse events, varied between 1.1 and 1.7 with a mean of 1.4. In addition to these differences, patients/investigators had a tendency to put emphasis on different kinds of adverse events in different countries.

Entendemos con este nombre un vivísimo dolor que tiene su sitio en la cavidad abdominal y que se manifiesta con movimientos del animal muy característicos y además desordenados y anormales.Los cólicos rio representan, por consiguiente, una enfermedad, sino la manifestación externa de diferentes alteraciones del tubo digestivo (verdaderos cólicos) o de otros órganos de la cavidad abdominal, como el hígado, los riñones, la vejiga o la matriz (falsos cólicos).El cólico verdadero o gastro-intestinal, es la manifestación morbosa nás frecuente de los caballos. También se presenta con frecuencia en os bóvidos, pero es en ellos menos peligrosa, sin duda, que en el caballo.De cien caballos que se enferman puede afirmarse que cincuenta están atacados de cólico, y de cien caballos que mueren, cincuenta a lo menos deben la muerte a un cólico.

Entendemos con este nombre un vivísimo dolor que tiene su sitio en la cavidad abdominal y que se manifiesta con movimientos del animal muy característicos y además desordenados y anormales.Los cólicos rio representan, por consiguiente, una enfermedad, sino la manifestación externa de diferentes alteraciones del tubo digestivo (verdaderos cólicos) o de otros órganos de la cavidad abdominal, como el hígado, los riñones, la vejiga o la matriz (falsos cólicos).El cólico verdadero o gastro-intestinal, es la manifestación morbosa nás frecuente de los caballos. También se presenta con frecuencia en os bóvidos, pero es en ellos menos peligrosa, sin duda, que en el caballo.De cien caballos que se enferman puede afirmarse que cincuenta están atacados de cólico, y de cien caballos que mueren, cincuenta a lo menos deben la muerte a un cólico.

Entendemos con este nombre un vivísimo dolor que tiene su sitio en la cavidad abdominal y que se manifiesta con movimientos del animal muy característicos y además desordenados y anormales.Los cólicos rio representan, por consiguiente, una enfermedad, sino la manifestación externa de diferentes alteraciones del tubo digestivo (verdaderos cólicos) o de otros órganos de la cavidad abdominal, como el hígado, los riñones, la vejiga o la matriz (falsos cólicos).El cólico verdadero o gastro-intestinal, es la manifestación morbosa nás frecuente de los caballos. También se presenta con frecuencia en os bóvidos, pero es en ellos menos peligrosa, sin duda, que en el caballo.De cien caballos que se enferman puede afirmarse que cincuenta están atacados de cólico, y de cien caballos que mueren, cincuenta a lo menos deben la muerte a un cólico.