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4 results on '"post-transplant"'

1. Relationship of Post-Transplant Lymphoproliferative Disorders (PTLD) Subtypes and Clinical Outcome in Pediatric Heart Transplant Recipients: A Retrospective Single Institutional Analysis/Experience of 558 Patients.

Author

Liu, Yan, Liu, Yan, Wang, Billy C, Zuppan, Craig W, Chau, Peter, Fitts, James, Chinnock, Richard, Wang, Jun, Liu, Yan, Liu, Yan, Wang, Billy C, Zuppan, Craig W, Chau, Peter, Fitts, James, Chinnock, Richard, and Wang, Jun

Abstract

Post-transplant lymphoproliferative disorders (PTLD) are heterogenous lymphoproliferative disorders that develop as a consequence of immunosuppression in transplant recipients. We sought to determine if subtypes of PTLD correlated with different outcomes. We performed a retrospective review of PTLD occurring in pediatric heart transplant recipients. A total of 558 children and infants underwent cardiac transplantation at our institution between 1985 and 2019 and were followed until March 2021. Forty-nine of 558 patients developed PTLD (8.8%). As compared to older children (>one year of age), infant recipients (p = 0.04). Although not reaching statistical significance, patients with a shorter time to PTLD diagnosis showed a trend toward higher rates of M-PTLD or cHL. As expected, the overall survival (OS) of patients with M-PTLD or cHL was significantly lower than patients with non-destructive or polymorphic PTLD.

Published
2023

2. Novel Mechanisms for Post-Transplant Maintenance Therapy in Acute Myeloid Leukemia

Author

Manobianco, Steven A, Rakiewicz, Tara, Wilde, Lindsay, Palmisiano, Neil D, Manobianco, Steven A, Rakiewicz, Tara, Wilde, Lindsay, and Palmisiano, Neil D

Abstract

Allogeneic stem cell transplantation has improved survival for patients with acute myeloid leukemia (AML), especially for patients with disease at high risk of relapse. However, relapse remains the most common cause of treatment failure and death in the post-transplant period. Maintenance therapy, an extended course of treatment after achieving remission to reduce the rate of relapse, is an important component of the treatment of various hematologic malignancies; however, its role in the treatment of AML is far less well-defined. Recently, there has been significant interest in the use of novel therapeutic agents as maintenance therapy after allogeneic stem cell transplant, utilizing new mechanisms of treatment and more favorable toxicity profiles. In this review, we will discuss the mechanistic and clinical data for post-transplant maintenance therapies in AML. Then, we will review several emergent and current clinical trials which aim to incorporate novel agents into maintenance therapy regimens.

Published
2022

4. S-metolachlor phytotoxicity in sweetpotato

Author

Abukari, Issah Alidu and Abukari, Issah Alidu

Abstract

S-metolachlor is an effective herbicide used to control/suppress annual grasses, nutsedges and several broadleaf weeds in sweet potato. However, a decline in storage root quality and yield has been reported under certain environmental conditions. Information is limited on the effect of S-metolachlor application followed immediately by rainfall on sweet potato growth and development under different temperatures, as well as the optimum application time. Therefore, the objectives of this study were to evaluate sweet potato responses to interactive effects of S-metolachlor, temperature and rainfall, and to determine S-metolachlor optimum application time. A sunlit, controlled environment experiment was conducted to investigate sweet potato response to S-metolachlor and rainfall immediately after application under different temperatures. Sweet potato slips were transplanted into sandy soil filled pots. Treatment combinations included five levels of S-metolachlor, 0.00, 0.86, 1.72, 2.58 and 3.44 kg ha-1, two levels of rainfall, 0 and 38 mm and three temperatures, 25/17, 30/22 and 35/27 °C, day/night. After POST application of S-metolachlor and rainfall, all plants were transferred to sunlit growth chambers that were maintained at their respective temperatures and ambient CO2 concentration for 60 days. In another experiment, S-metolachlor application time was varied to investigate sweet potato growth and development. Two levels of S-metolachlor 0.0 and 1.0 kg ha-1 and three application times 0, 5 and 10 days after transplanting (DAT) were used and plants were harvested five times, 5, 10, 15, 20 and 80 DAT to estimate plant growth and development. Shoot, root and total plant biomass yields declined with increasing concentration of S-metolachlor across temperatures. In addition, storage root yield and quality decline was S-metolachlor rate dependent and aggravated by rainfall immediately after herbicide treatment across temperatures. S-metolachlor was more injurious on most plant component parameters in the optimum and high temperatures where plant growth was vigorous than in the low temperatures. S-metolachlor application at 0 and 5 days affected sweet potato growth, including storage roots, but delaying until 10 days minimized the injury. These results can be used to weigh the risk of crop injury against the weed control benefits of S-metolachlor when making management decisions, and to determine application time based on weather information.

Published
2014

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