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Background: A better understanding of food-related behaviour and its determinants can be achieved through harmonisation and linking of the various data-sources and knowledge platforms. Scope: We describe the key decision-making in the development of a prototype of the Determinants and Intake Platform (DI Platform), a data platform that aims to harmonise and link data on consumer food behaviour. It will be part of the Food Nutrition Health Research Infrastructure (FNH-RI) that will facilitate health, social and food sciences. Approach: The decision-making was based on the evidence of user needs and data characteristics that guided the specification of the key building blocks of the DI Platform. Eight studies were carried out, including consumer online survey; interview studies of key DI Platform stakeholders; desk research and workshops. Key findings: Consumers were most willing to share data with universities, then industry and government. Trust, risk perception and altruism predicted willingness to share. For most other stakeholders non-proprietary data was most likely to be shared. Lack of data standards, and incentives for sharing were the main barriers for sharing data among the key stakeholders. The value of various data types would hugely increase if linked with other sources. Finding the right balance between optimizing data sharing and minimizing ethical and legal risks was considered a key challenge. Conclusions: The development of DI Platform is based on careful balancing of the user, technical, business, legal and ethical requirements, following the FAIR principles and the need for financial sustainability, technical flexibility, transparency and multi-layered organisational governance.

Background: Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an opportunistic infection across the tropics. Here, we provide a systematic overview of imported human cases in a non-endemic country over a 25-year period. Methods: All 55

Het Interdepartementale Beleidsonderzoek (IBO) Agrosector heeft behoefte aan inzicht in de werking van de fiscale faciliteiten voor de agrosector en in de effecten van mogelijke aanpassingen daarvan. Doelstelling van dit project is om de IBO-werkgroep Agrosector inzicht te bieden in de effecten van het draaien aan knoppen van de fiscale regelingen, met name het afschaffen ervan. Door dit inzicht is de werkgroep beter in staat om onderbouwde beleidsaanbevelingen te doen.

Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs in TLR2 and TLR4 and their associations with the level and change over time of both FEV1 and sputum inflammatory cells in moderate-to-severe COPD. Nine TLR2 SNPs and 17 TLR4 SNPs were genotyped in 110 COPD patients. Associations of SNPs with lung function and inflammatory cells in induced sputum were analyzed cross-sectionally with linear regression and longitudinally with linear mixed-effect models. Two SNPs in TLR2 (rs1898830 and rs11938228) were associated with a lower level of FEV1 and accelerated decline of FEV1 and higher numbers of sputum inflammatory cells. None of the TLR4 SNPs was associated with FEV1 level. Eleven out of 17 SNPs were associated with FEV1 decline, including rs12377632 and rs10759931, which were additionally associated with higher numbers of sputum inflammatory cells at baseline and with increase over time. This is the first longitudinal study showing that tagging SNPs in TLR2 and TLR4 are associated with the level and decline of lung function as well as with inflammatory cell numbers in induced sputum in COPD patients, suggesting a role in the severity and progression of COPD.

In dit rapport is voor drie varianten van vestigingssteun het effect op de financiële positie na de bedrijfsovername onderzocht. De financiële positie na bedrijfsovername is zeer verschillend tussen bedrijven. Deze uitgangssituatie na overname is van essentieel belang voor de levensvatbaarheid. Voor de analyse van de drie varianten is een rekenmodel gemaakt. Van de drie varianten komt de variant zoals die door het Nederlands Agrarisch Jongeren Kontakt is voorgesteld het beste naar voren: het 'Next Generation Fund'. De opvolger ontvangt bij bedrijfsovername 50.000 gulden, die na 10 jaar moet worden terugbetaald. Dit is met name gunstig voor de liquiditeitspositie van de opvolger. Het effect van vestigingssteun op de levensvatbaarheid valt in het niet vergeleken met de effecten van de verschillen in uitgangssituatie.

Applied Sciences