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The neuoroendocrine cancer of the bladder is a rare tumour, and from this entity the well-differentiated tumours with favourable prognosis, the paraganglioma with unfavourable prognosis, small and large cell types of tumours should be emphasised. From the methods of the anticancer therapies’ operation can be eligible by itself in the first group but in the second group should form only the part of the multimodal treatment. Radiotherapy plays a role only in the treatment of the small and large cell tumours, and during the treatment of these tumours, the administration of the cytostatic drugs is also essential (mainly platina derivates). Somatostatin analogues, immune checkpoint inhibitors could be beneficial in special cases and some tumour agnostic treatment can be useful as well. Moreover, the palliative treatment should represent an important modality even in the early treatment period, but it should also be provided when no other treatment options are left.