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Dental caries is among the most prevalent chronic diseases of childhood, affecting larger part of children and adults. Non-treated enamel caries can lead to destruction and then spreads into the underlying softer and sensitive dentine layer. Dental restorative materials are applied to treat and reconstruct damaged teeth clinically and recover their functions. Currently, there are various dental restorative materials available, and many appropriate materials are used to restore dental carious teeth. The applicability of biomimetic principles can elicit innovations in restorative dentistry for tooth conservation and preservation. There are three types of materials commonly used in dental restorations: resin, alloys, and ceramic. During the past decade, zirconia-based ceramics have been successfully introduced into the clinic due to acceptable biocompatibility, lower price compared with gold restorations, and better appearance than traditional metal-ceramic restorations. Recently, zirconia restoration is an acceptable treatment option in restorative dentistry and a developing trend in esthetic dentistry.

The most efficient way to prevent caries is by using fluoridated dental products. Fluoride can reduce enamel demineralization and promote enamel remineralization. In terms of prevention, the topical application of fluoride is accessible, which includes fluoride toothpaste, fluoride varnish, fluoride gel, and mouth rinse. Besides, the application of fluoride is systematical. In some countries, fluoride is added into water, salt, or milk. Fluoride is also used for the medical treatment of early dental caries. However, fluoride is a double-edged sword. Excessive fluoride intake will cause toxic reactions, and dental fluorosis is caused by a high intake of fluorides during tooth development.