1. Survival of the Fattest: Evolutionary Trade-offs in Cellular Resource Storage
- Author
-
Vincent Danos, Andrea Y. Weiße, Guillaume Terradot, Andreea Beica, University of Edinburgh, Analyse Statique par Interprétation Abstraite (ANTIQUE), Département d'informatique - ENS Paris (DI-ENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria), Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), The research reported in this paper was partly funded by the ERC Project RULE/320823, Département d'informatique de l'École normale supérieure (DI-ENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL)
- Subjects
0301 basic medicine ,Resource (biology) ,General Computer Science ,Computer science ,Survival of the fittest ,[SDV]Life Sciences [q-bio] ,030106 microbiology ,Trade offs ,Biomass ,Storage ,Evolutionary strategies ,Theoretical Computer Science ,Gene regulation ,Mechanistic cell models ,03 medical and health sciences ,Variable (computer science) ,030104 developmental biology ,Cell physiology ,Metabolites ,Production (economics) ,[INFO]Computer Science [cs] ,Biochemical engineering - Abstract
International audience; Cells derive resources from their environments and use them to fuel the biosynthetic processes that determine cell growth. Depending on how responsive the biosynthetic processes are to the availability of intracellular resources, cells can build up different levels of resource storage. Here we use a recent mathematical model of the coarse-grained mechanisms that drive cellular growth to investigate the effects of cellular resource storage on growth. We show that, on the one hand, there is a cost associated with high levels of storage resulting from the loss of stored resources due to dilution. We further show that, on the other hand, high levels of storage can benefit cells in variable environments by increasing biomass production during transitions from one medium to another. Our results thus suggest that cells may face trade-offs in their maintenance of resource storage based on the frequency of environmental change.
- Published
- 2018