1. Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
- Author
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Timothy C. Zhu, Mary Potasek, Michele M. Kim, Karl W. Beeson, and Evgueni Parilov
- Subjects
Paper ,solid cancer therapy ,Medical device ,Porphyrins ,medicine.medical_treatment ,Monte Carlo method ,Biomedical Engineering ,Photodynamic therapy ,01 natural sciences ,010309 optics ,Biomaterials ,chemistry.chemical_compound ,Mice ,Nuclear magnetic resonance ,0103 physical sciences ,medicine ,polycyclic compounds ,Animals ,Computer Simulation ,Benzoporphyrin derivative ,General ,Mice, Inbred C3H ,Photosensitizing Agents ,Singlet Oxygen ,Singlet oxygen ,medical device ,Reproducibility of Results ,Equipment Design ,Atomic and Molecular Physics, and Optics ,3. Good health ,Electronic, Optical and Magnetic Materials ,Light dose ,chemistry ,Tissue optics ,photodynamic therapy ,Photochemotherapy ,Correlation analysis ,Female ,Monte Carlo Method - Abstract
We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosie™, that calculates light transport and photokinetics for PDT in near real-time. The two sets of results are consistent and validate the use of the device in PDT treatment planning to predict BPD-mediated PDT outcomes in mice animal studies based on singlet oxygen dose, which showed a much better correlation with the cure index than the conventional light dose.
- Published
- 2019