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Microscaled modeling of laboratory experiments, which needs adaptation a number of parameters of numerical model of a composite kern building, uses for the applying results of flowing laboratory experiments in sector and full hydrodynamic models of occurrences. Adaptation of parameters of numerical kern model shall be carried out at reproduction measured variables of flowing experiments. Moreover, there are uncertainties of filtration and capacitance properties related to heterogeneity of kern samples and instability of heated polymer’ displacement front. Iteration algorithm is developed and implemented in this article. Algorithm provides adapting of series synthetic hydrodynamic models of laboratory experiments. At the first adapting step the whole range of uncertainties of a series of laboratory experiments is taken into account. Minimization of number of variable parameters and model’ adaptation error realizes on all iteration steps. To increase the reliability of adaptation, the spectrum of 1D models is supplements with synthetic 3D models with stochastic distribution of heterogeneity in porosity and permeability. This process allows take processes of filtration in polymer adsorption conditions and heterogeneity of collector properties into account more fully while modeling. In addition, it can help to specify variable parameters with scaling on different numerical grids. Developed algorithm tested on heated polymer’ displacement experiments, determination of the relative phase permeability as a function of temperature. Decreased uncertainties of variable parameters, which are relative phase permeability as a function of concentration of polymer solution, residual resistance factor, dependence of the viscosity of the polymer solution on the shear rate, is the results of method’s application. Then these results transfers to the adaptation process of sector and full hydrodynamic models.

The safety of biological products derived from animal cells is associated with the properties of the cells themselves or their components, as well as with the possible presence of contaminants of microbial and viral origin. The suitability of cell substrate for production of prophylactic preparations is often determined by the features of the production process, which allows to benefit/risk ratio of the product. One of the common contaminants of cell substrates are mycoplasmas, type Mollicutes. As distinguished from other microorganisms they don’t have cell membranes, and parasitize a wide range of animals and plants, on the surface or inside the cells. Some mycoplasma species of are potentially pathogenic to humans, they compete for nutrients with cells in vitro , cause chromosomal aberrations, interfere with normal cell metabolism. The detection of mycoplasma contamination in cell substrates when manufacturing prophylactic preparations is required by regulatory documents.

Hepatitis A (HA) is an acute infectious disease of the liver caused by the hepatitis A virus (HAV). HA disease incidence rate is closely linked to the social and economical development. The results of seroepidemiologic studies show that the prevalence of anti-HAV antibodies in population ranges from 15 to almost 100% in various countries of the world. The only reliable way to prevent hepatitis A virus (HAV) for today is the specific prophylactic vaccination. Recently developed inactivated vaccines against HAV have been successfully used in many countries. Vaccines authorized in Russia are safe, possess low reactogenicity and high immunogenicity. Practical experience in using vaccines during the outbreaks of HAV has shown that they possess epidemiological efficacy and provide necessary protection of the population in extreme conditions. This is clearly confirmed by single administration of vaccines to patients in epidemic focus of HAV. Constant regular monitoring of the duration of protection induced by one and two doses of the vaccine is required. The article considers WHO’s position on the use of vaccines for the prevention of HA. It describes the prospects of the further use of vaccines to control the spread of HA.

Objective of the study is to conduct epidemiological analysis of official statistical data on brucellosis morbidity rates over the period of 2005–2014 in different constituent entities of the Russian Federation, using Wald method. Materials and methods. Utilized were recording and reporting documents of the Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, FBHI “Federal Center of Hygiene and Epidemiology” of the Rospotrebnadzor, and WHO information resources. Results and conclusions. Studies of peculiarities of epidemic process development over the long-term period have allowed for identification of entities that are the most affected by the diseases. The results obtained on the morbidity rates in the Russian Federation over the period of 2005–2014 testify to the fact that first comes North Caucasian Federal District (NCFD) (62 %), next go Siberian (SbFD) (16 %) and Southern (SFD) (13 %) Federal Districts, second and third lines of the list respectively. Other regions account for 9 % of the load. The largest share of morbidity in NCFD entities belongs to the Republic of Dagestan – 62 %. Thereat, annual increment rate is 5.54 cases, which points to stabilization and some downward trend. Application of this morbidity rate prediction tool provides for in-time planning of clinical-diagnostic, prophylactic, and anti-epidemic measures in brucellosis foci. Wald method for forecasting of morbidity can be used for other infectious diseases too.

The localization of oil reserves in water-flooded areas is considered. Despite a high watercut of 90% or more well production, individual regions of the reservoir can retain recoverable oil. These reserves may have rather high (up to initial) oil saturations. Developing these reserves even partly will deliver a valuable incremental field production. Oil field development experience shows that recovery factor can be comparatively low, even at the late development stage. The issue of additional recovery is illustrated by the Bavly oil field experiment which ran for 30 years. This experiment included high watercut wells that were shut-in for a long time and subsequently brought back into production, and some of the wells yielded tens of thousands of tons of crude. Moreover it was established that remaining reserves can be located in certain areas. So, the problem of finding the location of such areas needs to be solved without resort to large-scale experiments like this. If we could do this, the scope of late stage infill drilling could be reduced thus preventing wells being drilled in swept zones. Currently the issue of finding high oil saturation zones is generally solved through reservoir modeling. The issue of the accuracy of modeling oil saturation distribution is of primary importance for a reservoir engineer. There are a variety of numerical methods for modeling oil and gas field development processes widely in use, but are not sufficiently reasonable for this goal. In the general case, heterogeneous media cannot be described by averaged equations with scientifically based pseudorelative permeabilities. The inconsistency of using pseudo relative permeabilities for simulation of the heterogeneous reservoir development is illustrated by numerical experiment. The pseudo relative permeabilities technique enables forecasting the field production and injection rates and cumulatives only. The reliability of the prediction of the oil saturation distribution turned to be unsatisfactory. This means that currently used pseudo relative permeabilities techniques do not allow reliable detection of bypassed oil. At the moment, the only efficient method of locating unrecovered oil reserves is integration of advanced reservoir study methods combined with geological modeling and reservoir simulation.

To solve the problem of unfavorable sanitary and epidemiological situation in diseases of respiratory organs in one of the organized groups in the Moscow region, a preparation prepared from a group of curative vaccines, IRS 19, was used. For controlling the effectiveness of its prophylactic action two groups of 250 persons were formed. As a result, morbidity rate in respiratory diseases decreased 2.5-3 times. In 1.5 months after the use of the preparation was started the coefficient of protection against the whole group of diseases of respiratory organs was 70%.

The article deals with the shortcomings of the existing system of the in-hospital infections' control. The authors regard the international provisions and classification rules on in-hospital infections as mandatory for implementation elsewhere.