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The patients diagnosed with coronavirus disease 2019 （COVID-19） produce IgM and IgG antibodies against severe acute respiratory syndrome coronavirus 2 （SARS-CoV-2）. However, the frequency and duration of antibody production still need to be fully understood. In the present study, we investigated the duration of antibody production after SARS-CoV-2 infection. The patients diagnosed with COVID-19 were monitored over twelve months for the production of SARS-CoV-2 IgM and IgG antibodies, and the characteristics of these patients were examined. Forty-five patients diagnosed with COVID-19 were enrolled, and thirty-four patients were followed up until they tested negative for SARS-CoV-2 IgM and IgG antibodies or up to twelve months after the date of a negative SARS-CoV-2 polymerase chain reaction （PCR） result. The positivity rates of SARS-CoV-2 IgM and IgG antibodies were 27.3％ and 68.2％ when SARS-CoV-2 PCR was negative, 20.6％ and 70.6％ after one month, 8.8％ and 52.9％ after three months, and 0.0％ and 14.7％ after six months, respectively. Moreover, we compared patients with milder conditions who did not require oxygen administration with those with severe conditions which required oxygen administration. The positivity rate of SARS-CoV-2 IgG antibodies was significantly higher in patients with severe conditions than in those with milder conditions on the date of a negative SARS-CoV-2 PCR result and after one month and three months, but not after six months. Patients with more severe COVID-19 produced more SARS-CoV-2 IgG antibodies. Moreover, it is suggested that the duration of IgG antibody production is independent of COVID-19 severity.

Takashi Abe,1,* Fumihiro Yamaguchi,1,* Shunsuke Sakakura,1 Yo Shiratori,1 Ayaka Mase,1 Toshitaka Funaki,1 Yoshito Kamio,2 Takashi Suzuki,2 Yusuke Shikama,1 Yasutaka Hoshino3 1Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan; 2Departments of Thoracic Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan; 3Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan*These authors contributed equally to this workCorrespondence: Fumihiro Yamaguchi, Department of Respiratory Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, 227-8501, Japan, Tel +81-45-971-1151, Email f_y@med.showa-u.ac.jpAbstract: Coccidioidomycosis is an endemic disease that is particularly prevalent in the United States. However, its geographic distribution is becoming widespread. Here, we present a Japanese male who resided in the United States for 1 year, where he was diagnosed with pulmonary coccidioidomycosis that was accompanied by cavity formation. He did not tolerate antifungal therapy and consequently underwent partial resection of the upper lobe of his left lung upon his return to Japan. The patient’s symptoms improved after surgery. The trend toward global networking and logistics means that a diagnosis of coccidioidomycosis should be considered in routine practice in nonendemic areas. Due to the rarity of surgical treatment for this disease, prolonged follow-up is necessary. During the last follow-up, the patient was symptom-free.Keywords: coccidioidomycosis, Coccidioides immitis, Coccidioides posadasii, endemic disease

Shunsuke Sakakura,1,* Fumihiro Yamaguchi,1,* Takashi Abe,1 Hidekazu Cho,1 Shohei Shimizu,1 Ayaka Mase,1 Yusuke Shikama,1 Haruhiko Maruyama2 1Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan; 2Division of Parasitology, Department of Infectious Diseases, Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan*These authors contributed equally to this workCorrespondence: Fumihiro Yamaguchi, Department of Respiratory Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, 227-8501, Japan, Tel +81-45-971-1151, Email f_y@med.showa-u.ac.jpAbstract: The Paragonimus westermani infection is a parasitic foodborne infection that induces systemic symptoms with eosinophilia in humans. Here, we described pneumothorax in addition to pulmonary opacities with eosinophilia in a man with a positive P. westermani serology. He was misdiagnosed with chronic eosinophilic pneumonia (CEP) during the initial phase. Paragonimiasis can share similar clinical findings with CEP in cases where the worm is confined to the lungs. The findings of the current study suggest that paragonimiasis and CEP can be distinguished from each other by the presence of various symptoms. Notably, eosinophilia with pneumothorax should be an important diagnostic factor for paragonimiasis.Keywords: Paragonimus westermani, chronic eosinophilic pneumonia, paragonimiasis, pneumothorax

Massive multiple-input multiple-output (MIMO) is a key technology used in fifth-generation wireless communication networks and beyond. Recently, various MIMO signal detectors based on deep learning have been proposed. Especially, deep unfolding (DU), which involves unrolling of an existing iterative algorithm and embedding of trainable parameters, has been applied with remarkable detection performance. Although DU has a lesser number of trainable parameters than conventional deep neural networks, the computational complexities related to training and execution have been problematic because DU-based MIMO detectors usually utilize matrix inversion to improve their detection performance. In this study, we attempted to construct a DU-based trainable MIMO detector with the simplest structure. The proposed detector based on the Hubbard--Stratonovich (HS) transformation and DU is called the trainable HS (THS) detector. It requires only $O(1)$ trainable parameters and its training and execution cost is $O(n^2)$ per iteration, where $n$ is the number of transmitting antennas. Numerical results show that the detection performance of the THS detector is better than that of existing algorithms of the same complexity and close to that of a DU-based detector, which has higher training and execution costs than the THS detector., 6 pages, 5 figures

In April-May of 2020 we conducted a cross-sectional survey of individuals who were previously engaged in resistance training behaviours, and who were impacted by government recommended/implemented measures to limit the spread of coronavirus (COVID-19). Now we follow up respondents to examine the longer terms effects of the COVID-19 pandemic upon training practices, in addition to perceptions and attitudes regarding training including motivation, goals, perceived effectiveness, enjoyment. The primary aim is descriptive and to examine the longitudinal characteristics of resistance training behaviours over time (i.e. prior to ‘lockdown’, during 'lockdown', and currently). Secondary aims are to explore how participant demographic characteristics impact changes in training practices over time, in addition to how training practices engaged in influence perceptions and attitudes towards training.

Purpose : To investigate whether or not the physiological brain and liver FDG uptake are decreased in patients with highly accelerated glycolysis lesions. Methods : We retrospectively analyzed 51 patients with malignant lymphoma. We compared the FDG uptake in the brain and liver of the patients with that in a control group. In 24 patients with a complete response (CR) or partial response (PR) to treatment, we compared the brain and liver uptake before and after treatment. Results : The maximum standardized uptake value (SUVmax) and total glycolytic volume (TGV) of the brain as well as the SUVmax and mean standardized uptake value (SUVmean) of the liver in malignant lymphoma patients were 13.1 ± 2.3, 7386.3 ± 1918.4, 3.2 ± 0.5, and 2.3 ± 0.4, respectively ; in the control group, these values were 14.9 ± 2.4, 8566.2 ± 1659.5, 3.4 ± 0.4, and 2.5 ± 0.3, respectively. The SUVmax and TGV of the brain and the SUVmean of the liver in malignant lymphoma patients were significantly lower than the control group. The SUVmax and TGV of the brain after treatment were significantly higher than before treatment. Both the SUVmax and SUVmean of liver after treatment were higher than before treatment, but not significant. Conclusion : A decreased physiological brain and liver FDG uptake is caused by highly accelerated lesion glycolysis.

Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women’s menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion.

In this study we explore how different levels of emotional intensity (Arousal) and pleasantness (Valence) are reflected in electroencephalographic (EEG) signals. We performed the experiments on EEG data of 32 subjects from the DEAP public dataset, where the subjects were stimulated using 60-s videos to elicitate different levels of Arousal/Valence and then self-reported the rating from 1 to 9 using the self-assessment Manikin (SAM). The EEG data was pre-processed and used as input to a convolutional neural network (CNN). First, the 32 EEG channels were used to compute the maximum accuracy level obtainable for each subject as well as for creating a single model using data from all the subjects. The experiment was repeated using one channel at a time, to see if specific channels contain more information to discriminate between low vs high arousal/valence. The results indicate than using one channel the accuracy is lower compared to using all the 32 channels. An optimization process for EEG channel selection is then designed with the Non-dominated Sorting Genetic Algorithm II (NSGA-II) with the objective to obtain optimal channel combinations with high accuracy recognition. The genetic algorithm evaluates all possible combinations using a chromosome representation for all the 32 channels, and the EEG data from each chromosome in the different populations are tested iteratively solving two unconstrained objectives; to maximize classification accuracy and to reduce the number of required EEG channels for the classification process. Best combinations obtained from a Pareto-front suggests that as few as 8–10 channels can fulfill this condition and provide the basis for a lighter design of EEG systems for emotion recognition. In the best case, the results show accuracies of up to 1.00 for low vs high arousal using eight EEG channels, and 1.00 for low vs high valence using only two EEG channels. These results are encouraging for research and healthcare applications that will require automatic emotion recognition with wearable EEG.

Additional file 1: Supplemental Fig. S1. Distribution map for AC+GT and GA+TC on all human chromosomes.Supplemental Fig. S2. Distribution map for CG on longest 3 scaffolds of 6 bats.Supplemental Fig. S3. Distribution map for Odds for CG on longest 3 scaffolds of 3 bats.Supplemental Fig. S4. Heatmaps of DegeTri BLSOM presented in Fig. 2A.Supplemental Fig. S5. Distribution map for GAA+TTC and GAC+GTC on all human chromosomes.Supplemental Fig. S6. Heatmaps of CG-containing DegePenta BLSOM presented in Fig. 3B.Supplemental Fig. S7. Distribution map for top 10 of CG-containing DegePenta on all human chromosomes.Supplemental Fig. S8. Distribution map for top 10 of CG-containing DegePenta on longest three scaffolds of 3 bats.Supplemental Fig. S9. Distribution map for top 10 of DegeHexa TFBSs on all human chromosomes.Supplemental Fig. S10. Distribution map for top 10 of DegeHexa TFBSs on longest 3 scaffolds of 6 bats.Supplemental Fig. S11. Heatmaps of human DegeHexa-TFBS BLSOM presented in Fig. 4B.

Additional file 2: Supplemental Table S1. Human DegeHexa TFBS sequences. Supplemental Table S2. List of Sz regions in each human chromosome.

Additional file 1

Additional file 1. Table S1 and Figures S1���S11.

Purpose : To compare data on brain tumors derived from intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) imaging with multiple parameters obtained on dynamic susceptibility contrast (DSC) perfusion MRI and to clarify the characteristics of IVIM and ASL perfusion data from the viewpoint of cerebral blood flow (CBF) analysis. Methods : ASL-CBF and IVIM techniques as well as DSC examination were performed in 24 patients with brain tumors. The IVIM data were analyzed with the two models. The relative blood flow (rBF), relative blood volume (rBV) corrected relative blood volume (crBV), mean transit time (MTT), and leakage coefficient (K2) were obtained from the DSC MRI data. Results : The ASL-CBF had the same tendency as the perfusion parameters derived from the DSC data, but the permeability from the vessels had less of an effect on the ASL-CBF. The diffusion coefficient of the fast component on IVIM contained more information on permeability than the f value. Conclusion : ASL-CBF is more suitable for the evaluation of perfusion in brain tumors than IVIM parameters. ASL-CBF and IVIM techniques should be carefully selected and the biological significance of each parameter should be understood for the correct comprehension of the pathological status of brain tumors.

Additional file 1: Supplemental Fig. 1. PFS of initial-TKIs according to T790M mutation positivity as assessed using ddPCR (T790M copy: ≥400 copies vs. T790M copy: 0.01–400 vs. T790M copy: negative).

令和元年度宇宙輸送シンポジウム（2020年1月16日-17日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)(ISAS)）, 相模原市, 神奈川県, Space Transportation Symposium FY2019 (January 16-17, 2020. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000147012, レポート番号: STCP-2019-012

Background: Currently there are no pharmacological therapies for patients with unruptured cerebral aneurysms. Elsewhere we showed that the mineralocorticoid receptor antagonist eplerenone prevented the formation of cerebral aneurysms in our ovariectomized hypertensive aneurysm rat model. The current pilot study evaluated whether it can be used to prevent the growth and rupture of cerebral aneurysms in hypertensive patients. Methods: Between August 2011 and May 2014, we enrolled 82 patients with 90 aneurysms in an open-label uncontrolled clinical trial. All provided prior informed consent for inclusion in this study, and all were treated with eplerenone (25-100 mg/d). The primary end points of our study were the rupture and enlargement of the cerebral aneurysms. Results: Of the 82 patients, 80 (88 unruptured aneurysms) were followed for a mean of 21.3 months (153.4 aneurysm-years); 12 patients (15.0%) permanently discontinued taking the drug. One month after the start of eplerenone administration and throughout the follow-up period, eplerenone kept the blood pressure within the normal range. Most notably, no aneurysms smaller than 9 mm ruptured or enlarged. However, of 2 large thrombosed aneurysms, 1 enlarged and the other ruptured. The overall annual rupture rate was .65%; it was 13.16% for aneurysms larger than 10 mm; the overall annual rate for reaching the primary end points was 1.30%. Conclusion: Our observations suggest that eplerenone may help to prevent the growth and rupture of unruptured cerebral aneurysms smaller than 9 mm. To assess its potential long-term clinical benefits, large clinical trials are needed.

学校と放課後等デイサービス（以下「デイ」とする）との情報交換・連携の取組について学校側に調査し，その全体像を明らかにした研究は見当たらない。そこで本研究は，千葉県内知的障害特別支援学校における取組の実態を明らかにするとともに，より良い情報交換・連携の在り方を検討した。第一研究（質問紙調査）では，学校による取組が進んでいる側面が明らかになった一方で，教員とデイ職員が児童生徒への支援について話し合う機会が少ないことが分かった。また，教員が感じる困難要因も明らかになった。この第一研究及び第二研究（聞き取り調査）の知見をもとに，第三研究ではX特別支援学校教員とデイD職員の連携会議を試行した。連携会議からは，児童生徒の相互理解が連携の基盤となることや，相互のニーズを事前に把握することの重要性が示唆された。以上の知見をふまえ，学校がデイとの連携推進の方策を検討する上で留意すべき点について提言を行った。

重度知的障害児へ本人主体の合理的配慮を提供するためには，人権の保護・促進を図ることを念頭に置き，本人の意思を推察・補充しながらその表明を補助することで，意思の表明に対する支援を行う必要がある。本研究では，自立活動とICFの視点に基づいた実態把握資料を作成・活用した意思の推察及び意思決定支援を行い，それを基にした合理的配慮の提供を実現する支援の在り方やプロセスを提案することを目的とした。事例研究を通じて提供した合理的配慮の適切性が評価されたことにより，作成した実態把握資料が事例児の意思を推察する上での根拠となり，情報を整理するツールとして機能し得ることが明らかになった。そして，意思の推察及び意思決定支援の有用性も示された。以上のことから，意思の推察及び本人・保護者との対話を要とし，意思の表明を補助することを目的とした意思決定支援，及びそれを起点とした合理的配慮提供のプロセスを提案する。, In order to provide reasonable accommodations to a person with severe mental retardation, we need to help his or her expression of wish. To help his or her expression, we need to infer his intention considering his human rights．The purpose of this study is to propose how to provide reasonable accommodations based on decision support, using assessment sheets from the viewpoint of Independent activities and ICF. In our case studies, we revealed the following: 1) The reasonable accommodations that we provided were appropriate. 2) The assessment sheets were effective for decision support. 3) The assessment sheets were effective information arranging tools. 4) The importance of decision support was suggested．From the above, we propose the effective process of the decision support and the reasonable accommodations through dialogs and the inference of intention.

筑波大学附属大塚特別支援学校教員と5附属連絡会議構成員による教材作成の共同研修，障害種を越えた実践を行った。本研修は附属大塚特別支援学校「教材・教具開発研究」部が企画し，附属大塚特別支援学校で使用している教材を本校教員と5附属連絡会議構成員が同じ場で作成した。研修後，「教材・教具開発研究」部の反省では5附属連絡会議と共同して研修をしたことに概ね良い評価があった。また，各附属で制作した教材を実際に使用していただき，フィードバックがあるとありがたいというような意見もあった。共同研修を終えた５附属連絡会議構成員には，感想用シートに作成した教材とその感想について記述してもらった。その感想から，勤務校で対象としている幼児・児童・生徒をイメージしながら作成していることや，その障害種の特徴を反映した教材の選択とその感想の記述が見られた。すでに本校では公開講座「特別支援教育における教材･教具の活用と製作」を実施しているが，そのような講座をより充実し，より広く情報発信していかなければならないと感じられた。

Accepted: 2017-06-29, 資料番号: SA1170151000

Introduction Arterial spin labeling (ASL) involves perfusion imaging using the inverted magnetization of arterial water. If the arterial arrival times are longer than the post-labeling delay, labeled spins are visible on ASL images as bright, high intra-arterial signals (IASs); such signals were found within occluded vessels of patients with acute ischemic stroke. The identification of the occluded segment in the internal carotid artery (ICA) is crucial for endovascular treatment. We tested our hypothesis that high IASs on ASL images can predict the occluded segment. Methods Our study included 13 patients with acute ICA occlusion who had undergone angiographic and ASL studies within 48 h of onset. We retrospectively identified the high IAS on ASL images and angiograms and recorded the occluded segment and the number of high IAS-positive slices on ASL images. The ICA segments were classified as cervical (C1), petrous (C2), cavernous (C3), and supraclinoid (C4). Results Of seven patients with intracranial ICA occlusion, five demonstrated high IASs at C1–C2, suggesting that high IASs could identify stagnant flow proximal to the occluded segment. Among six patients with extracranial ICA occlusion, five presented with high IASs at C3–C4, suggesting that signals could identify the collateral flow via the ophthalmic artery. None had high IASs at C1–C2. The mean number of high IAS-positive slices was significantly higher in patients with intra- than extracranial ICA occlusion. Conclusion High IASs on ASL images can identify slow stagnant and collateral flow through the ophthalmic artery in patients with acute ICA occlusion and help to predict the occlusion site.

Purpose : To determine whether differences in tumor volume between arterial spin labeling (ASL) and contrast-enhanced T1-weighted MR images (CE+T1WI) can help differentiate glioblastoma (GBM) from brain metastasis. Materials and methods : Patients with a diagnosis of GBM (n=25) or brain metastasis (n=13) were examined by both conventional and ASL MR imaging. Volumes of interest with high signal intensity on ASL and CE+T1WI were defined using three dimensional analysis software. Tumor volume difference (ASL-CE) and tumor volume ratio (ASL/CE) were obtained. Absolute maximal tumor blood flow (TBF) and TBF ratio (normalized to white matter) were also measured. The Mann-Whitney U test and receiver operating characteristic curve analysis were performed to compare measurements between the tumor groups. Results : Both tumor volume difference and tumor volume ratio were significantly higher in GBM than in metastasis. Both TBF and TBF ratio were higher for GBM than for metastasis, but the differences were not significant. Conclusion : The difference in tumor volume as measured by ASL high signal intensity and CE+T1WI might be useful for differentiating GBM from metastasis, whereas ASL-derived TBF is insufficient.

Purpose: T1-Cube (GE HealthCare) is a relatively new 3-dimensional (3D) fast spin-echo (FSE)-based magnetic resonance (MR) imaging sequence that uses a variable flip angle to acquire gap-free volume scans. We compared the gadolinium enhancement characteristics of a heterogeneous population of brain tumors imaged by T1-Cube and then 3D fast spoiled gradient recall acquisition in steady state (3D FSPGR) 3-tesla MR imaging to identify the superior modality for specific diagnostic purposes. Methods: We examined 61 lesions from 32 patients using the 2 sequences after administration of gadopentetic acid (Gd-DTPA; 0.1 mmol/kg). Two neuroradiologists independently measured each lesion twice using a region-of-interest (ROI) method. We measured the contrast-to-noise ratio (CNR), the difference in signal intensity (SI) between the tumor and normal white matter relative to the standard deviation (SD) of the SI within the lesion, for both post-contrast 3D FSPGR and post-contrast T1-Cube images of the same tumor and compared modality-specific CNRs for all tumors and in subgroups defined by tumor size, enhancement ratio, and histopathology. Results: The mean CNR was significantly higher on T1-Cube images than 3D FSPGR images for the total tumor population (1.85 ± 0.97 versus 1.12 ± 1.05, P < 0.01) and the histologic types, i.e., metastasis (P < 0.01) and lymphoma (P < 0.05). The difference in CNR was even larger for smaller tumors in the metastatic group (4.95 to 23.5 mm2) (P < 0.01). In contrast, mean CNRs did not differ between modalities for high grade glioma and meningioma. Conclusions: Gadolinium enhancement of brain tumors was generally higher when imaged by T1-Cube than 3D FSPGR, and T1-Cube with Gd enhancement may be superior to 3D FSPGR for detecting smaller metastatic tumors.

第46回流体力学講演会/第32回航空宇宙数値シミュレーション技術シンポジウム (2014年7月3日-4日. 弘前文化センター), 弘前市, 青森県, 46th Fluid Dynamics Conference / 32nd Aerospace Numerical Simulation Symposium (July 3-4, 2014. Hirosaki Bunka Center), Hirosaki, Aomori, Japan, A low ballistic coefficient atmospheric re-entry system, which applies a flexible membrane aeroshell to a spacecraft, attracts attention recently as a next-generation technology for space transportation. In order to realize this innovative technology, one of the important subjects is heating resistance evaluation of the membrane material for this flexible aeroshell. Therefore, inductively coupled plasma (ICP) heater was newly developed which has the ability to simulate the heating environment of the low-ballistic-coefficient re-entry. This ICP heater has 10kW electric power supply and Φ75mm glass tube. In this paper, the operating range of ICP heater and the result of heat flux distribution and dynamic pressure of air plasma flow are introduced. It is confirmed that the plasma flow produced by this ICP heater is axisymmetric and its core flow has a diameter of 40mm. Furthermore, the heat flux is controllable from almost 100kW/m2 to 250kW/m2, which is enough to evaluate the durability of the membrane material for the atmospheric entry vehicle., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA1530023004, レポート番号: JAXA-SP-14-010

第46回流体力学講演会/第32回航空宇宙数値シミュレーション技術シンポジウム (2014年7月3日-4日. 弘前文化センター), 弘前市, 青森県, 46th Fluid Dynamics Conference / 32nd Aerospace Numerical Simulation Symposium (July 3-4, 2014. Hirosaki Bunka Center), Hirosaki, Aomori, Japan, In the electrodynamic flow control, a weakly-ionized plasma flow behind the strong shock wave could be controlled by the applied magnetic field around a reentry vehicle. It could be an innovative technology for reentry vehicle design because it will realize an aerodynamic control device without moving part. To demonstrate this technology on the flight condition, a light-weight, compact, and strong magnetic field source must be required, which must be able to be magnetized tesla order. We have developed a prototype magnetic field source which contains a superconducting bulk magnet cooled by solid nitrogen and it was applied to some experiments including HIEST wind tunnel test. However, the prototype model has some problems for the magnetizing and cooling processes, which has significant impact on the flight operation. Therefore, the next model is planned to improve and ease the operation by using a Stirling refrigerator instead of liquid refrigerant., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA1530023011, レポート番号: JAXA-SP-14-010

第46回流体力学講演会/第32回航空宇宙数値シミュレーション技術シンポジウム (2014年7月3日-4日. 弘前文化センター), 弘前市, 青森県, 46th Fluid Dynamics Conference / 32nd Aerospace Numerical Simulation Symposium (July 3-4, 2014. Hirosaki Bunka Center), Hirosaki, Aomori, Japan, In the electrodynamic flow control, weakly-ionized plasma flow behind the strong shock wave could be controlled by the applied magnetic field around a reentry vehicle. To control the field, a very strong magnetic field is required and it could be applied by the superconducting magnet. However, the superconducting magnet system, including a superconducting magnetic coil, an electrical current source, a cooling mechanism, and refrigerant, is large and heavy for a reentry capsule such as the Hayabusa capsule. Thus, in this study, to avoid the use of the superconducting magnet, the electrodynamic effect by multiple weaker magnets such as permanent magnets is numerically investigated. According to the MHD simulation, the drag force can be also enhanced by the multiple magnets and it is clearly affected by the magnet array. Especially, the aerodynamic force part is significantly affected because the wall pressure is varied near the magnet. Therefore, the multiple magnet array might be as effective as the strong single magnet for the electrodynamic flow control., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA1530023006, レポート番号: JAXA-SP-14-010

第10回学際領域における分子イメージングフォーラム（2014年11月7日. 宇宙航空研究開発機構調布航空宇宙センター）, 調布市, 東京都, 10th Interdisciplinary Forum on Molecular Imaging (November 7, 2014. Chofu Aerospace Center, Japan Aerospace Exploration Agency (JAXA)), Chofu, Tokyo Japan, 形態: カラー図版あり, 形態: CD-ROM1枚, 主催: 宇宙航空研究開発機構(JAXA), Physical characteristics: Original contains color illustrations, Note: One CD-ROM, Meeting sponsor: Japan Aerospace Exploration Agency (JAXA), 資料番号: AA1630008019, レポート番号: JAXA-SP-15-020

平成29年度宇宙航行の力学シンポジウム（2017年12月7日-8日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)(ISAS)）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics: 2017 (December 7-8, 2017. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 著者人数: 13名, 資料番号: SA6000124002

平成29年度宇宙航行の力学シンポジウム（2017年12月7日-8日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)(ISAS)）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics: 2017 (December 7-8, 2017. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000124006

Supplemental figures. The powerpoint file contains Supplemental figures S1 through S3. These figures show composite images of agarose gel electrophoresis results from the marker-based assays, diagrams describing the location of the markers for chromosomes A02/C02 and A09/C09, and the IntroMap plots for Chromosomes C02 and C09 that resulted from the alignment of #174-12-26 reads to the B. oleracea reference genome, followed by analysis of the BAM file via IntroMap. (PPTX 1802 kb)

Maintaining human alertness and behavioral capability under conditions of sleep loss and circadian misalignment requires fatigue management technologies due to: (i) dynamic nonlinear modulation of performance capability by the interaction of sleep homeostatic drive and circadian regulation; (ii) large differences among people in neurobehavioral vulnerability to sleep loss; (iii) error in subjective estimates of fatigue on performance; and (iv) to inform people of the need for recovery sleep. Two promising areas of technology have emerged for managing fatigue risk in safety-sensitive occupations. The first involves preventing fatigue by optimizing work schedules using biomathematical models of performance changes associated with sleep homeostatic and circadian dynamics. Increasingly these mathematical models account for individual differences to achieve a more accurate estimate of the timing and magnitude of fatigue effects on individuals. The second area involves technologies for detecting transient fatigue from drowsiness. The Psychomotor Vigilance Test (PVT), which has been extensively validated to be sensitive to deficits in attention from sleep loss and circadian misalignment, is an example in this category. Two shorter-duration versions of the PVT recently have been developed for evaluating whether operators have sufficient behavioral alertness prior to or during work. Another example is online tracking the percent of slow eyelid closures (PERCLOS), which has been shown to reflect momentary fluctuations of vigilance. Technologies for predicting and detecting sleepiness/fatigue have the potential to predict and prevent operator errors and accidents in safety-sensitive occupations, as well as physiological and mental diseases due to inadequate sleep and circadian misalignment., 資料番号: PA1510087000

第45回流体力学講演会/航空宇宙数値シミュレーション技術シンポジウム2013 (2013年7月4日-5日. タワーホール船堀), 東京, 45th Fluid Dynamics Conference / Aerospace Numerical Simulation Symposium 2013 (July 4-5, 2013. Tower Hall Funabori), Tokyo, Japan, In the electrodynamic flow control, a weakly-ionized plasma flow behind the strong shock wave could be controlled by the applied magnetic field around a reentry vehicle. The magnetic field configuration is a controllable parameter, and then, the magnetic field can be inclined to the body axis to generate the asymmetric field. Recently, the influence of the inclined magnetic field was experimentally and numerically investigated. However, they didn’t agree qualitatively about the in-plane component of the side force based on the plane defined by the body axis and the magnetic pole. Meanwhile, when the magnetic field is inclined, the out-plane component of the side force acts on the body due to the Hall effect according to the MHD simulation, but it was not yet confirmed experimentally. Then, in this study, the side force acting on the magnetized body was investigated using the arcjet wind tunnel and the MHD simulation. As a result, we confirmed that the out-plane force is clearly measured and its direction agrees with the MHD simulation. The inclination angle dependency of the magnetic field on the in-plane force is significantly affected by the plume size. The experimental result is similar to the MHD simulation in which the finite plume size is considered like the experiment., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA0062268010, レポート番号: JAXA-SP-13-011

第45回流体力学講演会/航空宇宙数値シミュレーション技術シンポジウム2013 (2013年7月4日-5日. タワーホール船堀), 東京, 45th Fluid Dynamics Conference / Aerospace Numerical Simulation Symposium 2013 (July 4-5, 2013. Tower Hall Funabori), Tokyo, Japan, A reentry flight demonstration of an advanced reentry vehicle was carried out using JAXA S-310-41 sounding rocket. The vehicle was equipped with a flexible (membrane) aeroshell deployed by an inflatable torus structure and demonstrated deceleration at higher altitude. During the reentry flight, position, velocity and acceleration of the vehicle were measured by the global positioning system (GPS). Moreover, drag coefficient history was evaluated by the vehicle acceleration and the global reference atmospheric model (GRAM99). In the present study, flow field simulations around the reentry vehicle were conducted with numerical simulation methods. Aerodynamic force of the vehicle was investigated with the measured history through the supersonic and subsonic regions during the reentry. In the flow field simulation, it was found that the measured drag coefficient data shows a reasonable agreement with the predicted one in higher and lower altitudes. In addition, it was clarified that compressible effect in front of the vehicle appears in supersonic region, and a feature of vortex ring at the rear of the vehicle is formed in subsonic region., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA0062268019, レポート番号: JAXA-SP-13-011

資料番号: AC1500123000

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010028

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010023

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010036

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010033

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010035

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010032

平成24年度宇宙航行の力学シンポジウム（2012年12月13日-14日. 宇宙航空研究開発機構宇宙科学研究所）, 相模原市, 神奈川県, Symposium on Flight Mechanics and Astrodynamics 2012 (December 13-14, 2012. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000010024