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1. Correction: ERas and COLorectal endoscopic surgery: an Italian society for endoscopic surgery and new technologies (SICE) national report (Surgical Endoscopy, (2022), 10.1007/s00464-022-09212-y)

Author

Milone M., Elmore U., Manigrasso M., Ortenzi M., Botteri E., Arezzo A., Silecchia G., Guerrieri M., De Palma G. D., Agresta F., Pizza F., D'Antonio D., Amalfitano F., Selvaggi F., Sciaudone G., Selvaggi L., Prando D., Cavallo F., Lezoche G., Cuccurullo D., Tartaglia E., Sagnelli C., Coratti A., Tribuzi A., Di Marino M., Anania G., Bombardini C., Zago M. P., Tagliabue F., Burati M., Di Saverio S., Colombo S., El Adla S., De Luca M., Zese M., Parini D., Prosperi P., Alemanno G., Martellucci J., Olmi S., Oldani A., Uccelli M., Bono D., Scaglione D., Saracco R., Podda M., Pisanu A., Murzi V., Agrusa A., Buscemi S., Muttillo I. A., Picardi B., Muttillo E. M., Solaini L., Cavaliere D., Ercolani G., Corcione F., Peltrini R., Bracale U., Lucchi A., Vittori L., Grassia M., Porcu A., Perra T., Feo C., Angelini P., Izzo D., Ricciardelli L., Trompetto M., Gallo G., Luc A. R., Muratore A., Calabro M., Cuzzola B., Barberis A., Costanzo F., Angelini G., Ceccarelli G., Rondelli F., De Rosa M., Cassinotti E., Boni L., Baldari L., Bianchi P. P., Formisano G., Giuliani G., Ceretti A. A. P., Mariani N. M., Giovenzana M., Farfaglia R., Marciano P., Arizzi V., Piccoli M., Pecchini F., Pattacini G. C., Vettoretto N., Guarnieri C., Laface L., Abate E., Casati M., Fabri N., Pesce A., Maida P., Marte G., Abete R., Casali L., Marchignoli A., Dall'Aglio M., Scabini S., Pertile D., Aprile A., Andreuccetti J., Di Leo A., Crepaz L., Maione F., Vertaldi S., Chini A., Rosati R., Puccetti F., Maggi G., Cossu A., Sartori A., Piatto G., Perrotta N., Celiento M., Scorzelli M., Pilone V., Tramontano S., Calabrese P., Sechi R., Cillara N., Putzu G., Podda M. G., Montuori M., Pinotti E., Sica G., Franceschilli M., Sensi B., Degiuli M., Reddavid R., Puca L., Farsi M., Minuzzo A., Gia E., Baiocchi G. L., Ranieri V., Celotti A., Bianco F., Grassia S., Novi A., Milone M., Elmore U., Manigrasso M., Ortenzi M., Botteri E., Arezzo A., Silecchia G., Guerrieri M., De Palma G.D., Agresta F., Pizza F., D'Antonio D., Amalfitano F., Selvaggi F., Sciaudone G., Selvaggi L., Prando D., Cavallo F., Lezoche G., Cuccurullo D., Tartaglia E., Sagnelli C., Coratti A., Tribuzi A., Di Marino M., Anania G., Bombardini C., Zago M.P., Tagliabue F., Burati M., Di Saverio S., Colombo S., El Adla S., De Luca M., Zese M., Parini D., Prosperi P., Alemanno G., Martellucci J., Olmi S., Oldani A., Uccelli M., Bono D., Scaglione D., Saracco R., Podda M., Pisanu A., Murzi V., Agrusa A., Buscemi S., Muttillo I.A., Picardi B., Muttillo E.M., Solaini L., Cavaliere D., Ercolani G., Corcione F., Peltrini R., Bracale U., Lucchi A., Vittori L., Grassia M., Porcu A., Perra T., Feo C., Angelini P., Izzo D., Ricciardelli L., Trompetto M., Gallo G., Luc A.R., Muratore A., Calabro M., Cuzzola B., Barberis A., Costanzo F., Angelini G., Ceccarelli G., Rondelli F., De Rosa M., Cassinotti E., Boni L., Baldari L., Bianchi P.P., Formisano G., Giuliani G., Ceretti A.A.P., Mariani N.M., Giovenzana M., Farfaglia R., Marciano P., Arizzi V., Piccoli M., Pecchini F., Pattacini G.C., Vettoretto N., Guarnieri C., Laface L., Abate E., Casati M., Fabri N., Pesce A., Maida P., Marte G., Abete R., Casali L., Marchignoli A., Dall'Aglio M., Scabini S., Pertile D., Aprile A., Andreuccetti J., Di Leo A., Crepaz L., Maione F., Vertaldi S., Chini A., Rosati R., Puccetti F., Maggi G., Cossu A., Sartori A., Piatto G., Perrotta N., Celiento M., Scorzelli M., Pilone V., Tramontano S., Calabrese P., Sechi R., Cillara N., Putzu G., Podda M.G., Montuori M., Pinotti E., Sica G., Franceschilli M., Sensi B., Degiuli M., Reddavid R., Puca L., Farsi M., Minuzzo A., Gia E., Baiocchi G.L., Ranieri V., Celotti A., Bianco F., Grassia S., and Novi A.

Subjects
Settore MED/18 - Chirurgia Generale, Colorectal ERAS ·Enhanced Recovery Minimally invasive
Abstract

This article was updated to correct Nicolò Fabbri's name in the listing of the ERCOLE Study Group (in Acknowledgments).

Published
2022

2. Correction: ERas and COLorectal endoscopic surgery: an Italian society for endoscopic surgery and new technologies (SICE) national report (Surgical Endoscopy, (2022), 36, 10, (7619-7627), 10.1007/s00464-022-09212-y)

Author

Milone M., Elmore U., Manigrasso M., Ortenzi M., Botteri E., Arezzo A., Silecchia G., Guerrieri M., De Palma G. D., Agresta F., Pizza F., D'Antonio D., Amalfitano F., Selvaggi F., Sciaudone G., Selvaggi L., Prando D., Cavallo F., Lezoche G., Cuccurullo D., Tartaglia E., Sagnelli C., Coratti A., Tribuzi A., Di Marino M., Anania G., Bombardini C., Zago M. P., Tagliabue F., Burati M., Di Saverio S., Colombo S., El Adla S., De Luca M., Zese M., Parini D., Prosperi P., Alemanno G., Martellucci J., Olmi S., Oldani A., Uccelli M., Bono D., Scaglione D., Saracco R., Podda M., Pisanu A., Murzi V., Agrusa A., Buscemi S., Muttillo I. A., Picardi B., Muttillo E. M., Solaini L., Cavaliere D., Ercolani G., Corcione F., Peltrini R., Bracale U., Lucchi A., Vittori L., Grassia M., Porcu A., Perra T., Feo C., Angelini P., Izzo D., Ricciardelli L., Trompetto M., Gallo G., Luc A. R., Muratore A., Calabro M., Cuzzola B., Barberis A., Costanzo F., Angelini G., Ceccarelli G., Rondelli F., De Rosa M., Cassinotti E., Boni L., Baldari L., Bianchi P. P., Formisano G., Giuliani G., Ceretti A. A. P., Mariani N. M., Giovenzana M., Farfaglia R., Marciano P., Arizzi V., Piccoli M., Pecchini F., Pattacini G. C., Vettoretto N., Guarnieri C., Laface L., Abate E., Casati M., Fabri N., Pesce A., Maida P., Marte G., Abete R., Casali L., Marchignoli A., Dall'Aglio M., Scabini S., Pertile D., Aprile A., Andreuccetti J., Di Leo A., Crepaz L., Maione F., Vertaldi S., Chini A., Rosati R., Puccetti F., Maggi G., Cossu A., Sartori A., Piatto G., Perrotta N., Celiento M., Scorzelli M., Pilone V., Tramontano S., Calabrese P., Sechi R., Cillara N., Putzu G., Podda M. G., Montuori M., Pinotti E., Sica G., Franceschilli M., Sensi B., Degiuli M., Reddavid R., Puca L., Farsi M., Minuzzo A., Gia E., Baiocchi G. L., Ranieri V., Celotti A., Bianco F., Grassia S., Novi A., Milone, M., Elmore, U., Manigrasso, M., Ortenzi, M., Botteri, E., Arezzo, A., Silecchia, G., Guerrieri, M., De Palma, G. D., Agresta, F., Pizza, F., D'Antonio, D., Amalfitano, F., Selvaggi, F., Sciaudone, G., Selvaggi, L., Prando, D., Cavallo, F., Lezoche, G., Cuccurullo, D., Tartaglia, E., Sagnelli, C., Coratti, A., Tribuzi, A., Di Marino, M., Anania, G., Bombardini, C., Zago, M. P., Tagliabue, F., Burati, M., Di Saverio, S., Colombo, S., El Adla, S., De Luca, M., Zese, M., Parini, D., Prosperi, P., Alemanno, G., Martellucci, J., Olmi, S., Oldani, A., Uccelli, M., Bono, D., Scaglione, D., Saracco, R., Podda, M., Pisanu, A., Murzi, V., Agrusa, A., Buscemi, S., Muttillo, I. A., Picardi, B., Muttillo, E. M., Solaini, L., Cavaliere, D., Ercolani, G., Corcione, F., Peltrini, R., Bracale, U., Lucchi, A., Vittori, L., Grassia, M., Porcu, A., Perra, T., Feo, C., Angelini, P., Izzo, D., Ricciardelli, L., Trompetto, M., Gallo, G., Luc, A. R., Muratore, A., Calabro, M., Cuzzola, B., Barberis, A., Costanzo, F., Angelini, G., Ceccarelli, G., Rondelli, F., De Rosa, M., Cassinotti, E., Boni, L., Baldari, L., Bianchi, P. P., Formisano, G., Giuliani, G., Ceretti, A. A. P., Mariani, N. M., Giovenzana, M., Farfaglia, R., Marciano, P., Arizzi, V., Piccoli, M., Pecchini, F., Pattacini, G. C., Vettoretto, N., Guarnieri, C., Laface, L., Abate, E., Casati, M., Fabri, N., Pesce, A., Maida, P., Marte, G., Abete, R., Casali, L., Marchignoli, A., Dall'Aglio, M., Scabini, S., Pertile, D., Aprile, A., Andreuccetti, J., Di Leo, A., Crepaz, L., Maione, F., Vertaldi, S., Chini, A., Rosati, R., Puccetti, F., Maggi, G., Cossu, A., Sartori, A., Piatto, G., Perrotta, N., Celiento, M., Scorzelli, M., Pilone, V., Tramontano, S., Calabrese, P., Sechi, R., Cillara, N., Putzu, G., Podda, M. G., Montuori, M., Pinotti, E., Sica, G., Franceschilli, M., Sensi, B., Degiuli, M., Reddavid, R., Puca, L., Farsi, M., Minuzzo, A., Gia, E., Baiocchi, G. L., Ranieri, V., Celotti, A., Bianco, F., Grassia, S., and Novi, A.

Abstract

This article was updated to correct Nicolò Fabbri's name in the listing of the ERCOLE Study Group (in Acknowledgments).

Published
2022

3. Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry

Author

Salzano, A, D'Assante, R, Iacoviello, M, Triggiani, V, Rengo, G, Cacciatore, F, Maiello, C, Limongelli, G, Masarone, D, Sciacqua, A, Perrone Filardi, P, Mancini, A, Volterrani, M, Vriz, O, Castello, R, Passantino, A, Campo, M, Modesti, Pa, De Giorgi, A, Arcopinto, M, Gargiulo, P, Perticone, M, Colao, A, Milano, S, Garavaglia, A, Napoli, R, Suzuki, T, Bossone, E, Marra, Am, Cittadini, A, Saccà, L, Monti, Mg, Matarazzo, M, Stagnaro, Fm, Piccioli, L, Lombardi, A, Panicara, V, Flora, M, Golia, L, Faga, V, Ruocco, A, Della Polla, D, Franco, R, Schiavo, A, Gigante, A, Spina, E, Sicuranza, M, Monaco, F, Apicella, M, Miele, C, Campanino, Ag, Mazza, L, Abete, R, Farro, A, Luciano, F, Polizzi, R, Ferrillo, G, De Luca, M, Crisci, G, Giardino, F, Barbato, M, Ranieri, B, Ferrara, F, Russo, V, Malinconico, M, Citro, R, Guastalamacchia, E, Leone, M, Giagulli, Va, Amarelli, C, Mattucci, I, Calabrò, P, Calabrò, R, D'Andrea, A, Maddaloni, V, Pacileo, G, Scarafile, R, Belfiore, A, Cimellaro, A, Casaretti, L, Paolillo, S, Favuzzi, Amr, Di Segni, C, Bruno, C, Vergani, E, Massaro, R, Grimaldi, F, Frigo, A, Sorrentino, Mr, Malandrino, D, Manfredini, R, Fabbian, F, Puzzo, A, Ragusa, L, Caliendo, L, Carbone, L, Frigiola, A, Generali, T, Giacomazzi, F, De Vincentiis, C, Ballotta, A, Garofalo, P, Malizia, G, Misiano, G, Israr, Mz, Bernieh, D, Cassambai, S, Yazaki, Y, Heaney, Lm, Eagle, Ka, Ventura, Ho, Bruzzese, D, Salzano, Andrea, D'Assante, Roberta, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Sciacqua, Angela, Filardi, Pasquale Perrone, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A, De Giorgi, Alfredo, Arcopinto, Michele, Gargiulo, Paola, Perticone, Maria, Colao, Annamaria, Milano, Salvatore, Garavaglia, Agnese, Napoli, Raffaele, Suzuki, Toru, Bossone, Eduardo, Marra, Alberto M, Cittadini, Antonio, and Misiano, Gabriella

Subjects
Registrie, Heart Failure, Endocrinology, Diabetes and Metabolism, Ventricular Dysfunction, Right, Diabetes, Insulins, Socio-culturale, Stroke Volume, Insulin resistance, Diabete, Cardiopulmonary exercise test, Chronic heart failure, Diabetes, Insulin resistance, Right ventricle, TOSCA Registry, Chronic heart failure, Diabetes Mellitus, Type 2, TOSCA Registry, Exercise Test, Ventricular Function, Right, Humans, Insulin, Right ventricle, Registries, Cardiology and Cardiovascular Medicine, Cardiopulmonary exercise test, TOSCA, Human, LS4_7
Abstract

Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance—IR or diabetes mellitus—T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF. Methods Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairment: euglycemic without IR (EU), euglycemic with IR (IR), and T2D. Results Compared with EU and IR, T2D was associated with increased filling pressures (E/e′ratio: 15.9 ± 8.9, 12.0 ± 6.5, and 14.5 ± 8.1 respectively, p 2) in TD2 vs EU and IR patients was recorded (respectively, 15.8 ± 3.8 ml/Kg/min, 18.4 ± 4.3 ml/Kg/min and 16.5 ± 4.3 ml/Kg/min, p 2 in the T2D group (+ 13% increase in RV dimension, − 21% decline in TAPSE/PAPS ratio and − 20% decrease in peak VO2). Conclusion The higher risk of death and CV hospitalizations exhibited by HF-T2D patients in the T.O.S.CA. Registry is associated with progressive RV ventricular dysfunction and exercise impairment when compared to euglycemic CHF patients, supporting the pivotal importance of hyperglycaemia and right chambers in HF prognosis. Trial registration ClinicalTrials.gov identifier: NCT023358017

Published
2022
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4. Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry

Author

Cittadini A., Salzano A., Iacoviello M., Triggiani V., Rengo G., Cacciatore F., Maiello C., Limongelli G., Masarone D., Perticone F., Cimellaro A., Filardi P. P., Paolillo S., Mancini A., Volterrani M., Vriz O., Castello R., Passantino A., Campo M., Modesti P. A., de Giorgi A., Monte I. P., Puzzo A., Ballotta A., D'Assante R., Arcopinto M., Gargiulo P., Sciacqua A., Bruzzese D., Colao A., Napoli R., Suzuki T., Eagle K. A., Ventura H. O., Marra A. M., Bossone E., Sacca L., Monti M. G., Matarazzo M., Stagnaro F. M., Piccioli L., Lombardi A., Panicara V., Flora M., Golia L., Faga V., Ruocco A., della Polla D., Franco R., Schiavo A., Gigante A., Spina E., Sicuranza M., Monaco F., Apicella M., Miele C., Campanino A. G., Mazza L., Abete R., Farro A., Luciano F., Polizzi R., Ferrillo G., de Luca M., Crisci G., Giardino F., Barbato M., Ranieri B., Ferrara F., Russo V., Malinconico M., Citro R., Guastalamacchia E., Leone M., Giagulli V. A., Amarelli C., Mattucci I., Calabro P., Calabro R., D'Andrea A., Maddaloni V., Pacileo G., Scarafile R., Belfiore A., Casaretti L., Favuzzi A. M. R., Di Segni C., Bruno C., Vergani E., Massaro R., Grimaldi F., Frigo A., Campo M. R., Sorrentino M. R., Malandrino D., Manfredini R., Fabbian F., Ragusa L., Caliendo L., Carbone L., Frigiola A., Generali T., Giacomazzi F., de Vincentiis C., Garofalo P., Malizia G., Milano S., Misiano G., Israr M. Z., Bernieh D., Cassambai S., Yazaki Y., Heaney L. M., Cittadini, Antonio, Salzano, Andrea, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Perticone, Francesco, Cimellaro, Antonio, Perrone Filardi, Pasquale, Paolillo, Stefania, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A, De Giorgi, Alfredo, Monte, Ines P, Puzzo, Alfonso, Ballotta, Andrea, D'Assante, Roberta, Arcopinto, Michele, Gargiulo, Paola, Sciacqua, Angela, Bruzzese, Dario, Colao, Annamaria, Napoli, Raffaele, Suzuki, Toru, Eagle, Kim A, Ventura, Hector O, Marra, Alberto M, Bossone, Eduardo, Cittadini, A., Salzano, A., Iacoviello, M., Triggiani, V., Rengo, G., Cacciatore, F., Maiello, C., Limongelli, G., Masarone, D., Perticone, F., Cimellaro, A., Filardi, P. P., Paolillo, S., Mancini, A., Volterrani, M., Vriz, O., Castello, R., Passantino, A., Campo, M., Modesti, P. A., de Giorgi, A., Monte, I. P., Puzzo, A., Ballotta, A., D'Assante, R., Arcopinto, M., Gargiulo, P., Sciacqua, A., Bruzzese, D., Colao, A., Napoli, R., Suzuki, T., Eagle, K. A., Ventura, H. O., Marra, A. M., Bossone, E., Sacca, L., Monti, M. G., Matarazzo, M., Stagnaro, F. M., Piccioli, L., Lombardi, A., Panicara, V., Flora, M., Golia, L., Faga, V., Ruocco, A., della Polla, D., Franco, R., Schiavo, A., Gigante, A., Spina, E., Sicuranza, M., Monaco, F., Apicella, M., Miele, C., Campanino, A. G., Mazza, L., Abete, R., Farro, A., Luciano, F., Polizzi, R., Ferrillo, G., de Luca, M., Crisci, G., Giardino, F., Barbato, M., Ranieri, B., Ferrara, F., Russo, V., Malinconico, M., Citro, R., Guastalamacchia, E., Leone, M., Giagulli, V. A., Amarelli, C., Mattucci, I., Calabro, P., Calabro, R., D'Andrea, A., Maddaloni, V., Pacileo, G., Scarafile, R., Belfiore, A., Casaretti, L., Favuzzi, A. M. R., Di Segni, C., Bruno, C., Vergani, E., Massaro, R., Grimaldi, F., Frigo, A., Campo, M. R., Sorrentino, M. R., Malandrino, D., Manfredini, R., Fabbian, F., Ragusa, L., Caliendo, L., Carbone, L., Frigiola, A., Generali, T., Giacomazzi, F., de Vincentiis, C., Garofalo, P., Malizia, G., Milano, S., Misiano, G., Israr, M. Z., Bernieh, D., Cassambai, S., Yazaki, Y., and Heaney, L. M.

Subjects
medicine.medical_specialty, Multiple hormonal and metabolic deficiency syndrome, Epidemiology, Prognosi, Anabolic deficiency, Socio-culturale, Heart failure, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Diabetes mellitus, Internal medicine, Multiple hormonal, medicine, Clinical endpoint, Humans, 030212 general & internal medicine, Prospective Studies, Registries, TOSCA, LS4_7, Ejection fraction, business.industry, Hazard ratio, Metabolic deficiency syndrome, Heart failure • Anabolic deficiency • Multiple hormonal and metabolic deficiency syndrome • Hormones • Prognosis • TOSCA, Stroke Volume, medicine.disease, Prognosis, Hormone, Confidence interval, Heart failure, Anabolic deficiency, Multiple hormonal and metabolic deficiency syndrome, Hormones, Prognosis, TOSCA, Hormones, Hospitalization, Observational study, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Recent evidence supports the occurrence of multiple hormonal and metabolic deficiency syndrome (MHDS) in chronic heart failure (CHF). However, no large observational study has unequivocally demonstrated its impact on CHF progression and outcome. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Treatment in Heart Failure) Registry has been specifically designed to test the hypothesis that MHDS affects morbidity and mortality in CHF patients. Methods and Results The T.O.S.CA. Registry is a prospective, multicentre, observational study involving 19 Italian centres. Thyroid hormones, insulin-like growth factor-1, total testosterone, dehydropianoandrosterone sulfate, insulin resistance, and the presence of diabetes were evaluated. A MHDS was defined as the presence of ≥2 hormone deficiencies (HDs). Primary endpoint was a composite of all-cause mortality and cardiovascular hospitalizations. Four hundred and eighty heart failure patients with ejection fraction ≤45% were enrolled. MHDS or diabetes was diagnosed in 372 patients (77.5%). A total of 271 events (97 deaths and 174 cardiovascular hospitalizations) were recorded, 41% in NO-MHDS and 62% in MHDS (P Conclusion MHDS is common in CHF and independently associated with increased all-cause mortality and cardiovascular hospitalization, representing a promising therapeutic target. Trial registration ClinicalTrials.gov identifier: NCT023358017

Published
2021

5. Therapy of esophageal motility disorders and manometric abnormalities in patients with scleroderma

Author

La Manna S., Spano A., Loi G., Pellegrino C., Abete R., La Manna V., ABATE, SERGIO, La Manna, S., Spano, A., Loi, G., Pellegrino, C., Abete, R., La Manna, V., and Abate, Sergio

Abstract

Symptoms of gastro-oesophageal reflux disease and dysphagia have a substantial impact on patients with scleroderma. Proton pump inhibitors can treat GERD, prokinetic agents are often used but are rarely effective. Patients with systemic sclerosis were studied to determine the esophageal motility disorders and if the treatment with proton pump inhibitors and prokinetics were safe and effective

Published
2008

6. Physical activity in the prevention of peripheral artery disease in the elderly

Author

Schiattarella, G.G., Perrino, C., Magliulo, F., Carbone, A., Bruno, A.G., De Paulis, M., Sorropago, A., Corrado, R.V., Bottino, R., Menafra, G., Abete, R., Toscano, E., Giugliano, G., Trimarco, B., and Esposito, G.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Aging is a well-known cardiovascular risk factor and cardiovascular diseases (CVD) are estimated to be the most common cause of death in the elderly. Peripheral arterial disease (PAD) represents an important clinical manifestation of CVD leading to increase morbidity and mortality, especially in elderly population. The correct management of PAD population includes the prevention of cardiovascular events and relief of symptoms, most commonly intermittent claudication. Progressive physical activity is an effective treatment to improve walking distance and to reduce mortality and cardiovascular events in patients with PAD, however the ability to effectively engage in physical activity often declines with increasing age. The maintenance and increase of reserve functional capacity are important concepts in the elderly population. Ultimately, the goal in participation of physical activity in the healthy elderly population is maintenance and development of physical functional reserve capacity. Therefore, for individuals suffering of PAD, appropriate physical activity in the form of supervised exercise may serve as a primary therapy. Although there are few direct comparisons of therapeutic exercise programs vs. pharmacological or surgical interventions, these increases in walking distance are greater than those reported for the most widely used agents for claudication, pentoxyphylline, and cilostazol. Despite a reduction in mortality and improvement of quality of life caused by physical activity in the PAD population, the molecular, cellular, and functional changes that occur during physical activity are not completely understood. Therefore, this review article aims at presenting an overview of recent established clinical and molecular findings addressing the role of physical activity on PAD in the older population.

Published
2014

8. THE TOSCA REGISTRY: AN ONGOING, OBSERVATIONAL, MULTICENTER REGISTRY FOR CHRONIC HEART FAILURE

Author

Arcopinto M, Salzano A, Ferrara F, Bobbio E, Alberto Maria Marra, Abete R, Stagnaro F, Polizzi R, Giallauria F, Illario M, Menditto E, Vigorito C, Bossone E, Cittadini A, Arcopinto, Michele, Salzano, ANNA MARIA, Ferrara, F, Bobbio, Emanuele, Marra, A. M, Abete, Roberta, Stagnaro, F, Polizzi, R, Giallauria, Francesco, Illario, Maddalena, Menditto, Enrica, Vigorito, Carlo, Bossone, E, and Cittadini, Antonio

Subjects
Registry, Ageing, hormones, ageing, heart failure, Heart failure, Articles, Hormones
Abstract

The ageing of the population in western countries, the continuous increase of the prevalence of chronic diseases, the frequent coexistence of several morbid conditions (comorbidity) requires health professionals and Institutions to face difficult challenges, including increasing costs, need for more effective and sustainable therapies, and organizational issues. The European Innovation Partnership on Active and Healthy Ageing aims at enabling European citizens to lead healthy, active and independent lives while ageing. We herein discuss some key concepts bearing a special significance in the light of the Partnership aims, and present research and educational projects active in our local environment. Among these, the multicentre project TOSCA (Trattamento Ormonale nello Scompenso CArdiaco) that, although primarily focused on the understanding of the interactions between hormones and chronic heart failure (CHF), is also aimed at developing more effective models of clinical care. We provide the scientific background and current stage of the project. In the context of a growing complexity of the patients’ clinical management, the polipharmacy is a new arising challenge for clinicians, bearing direct economic, organizational and clinical implications. A better understanding, characterization and management of this issue represent an additional target of the TOSCA network.

10. Ventricular arrhythmias and ARNI: is it time to reappraise their management in the light of new evidence?

Author

Attilio Iacovoni, Jacopo Marazzato, Andrea Lorenzo Vecchi, Michele Senni, Andrea Mortara, Roberto De Ponti, Raffaele Abete, Vecchi, A, Abete, R, Marazzato, J, Iacovoni, A, Mortara, A, De Ponti, R, and Senni, M

Subjects
medicine.medical_specialty, Angiotensin receptor, medicine.medical_treatment, Cardiomyopathy, Tetrazoles, 030204 cardiovascular system & hematology, Implantable cardioverter-defibrillator, Sudden cardiac death, Angiotensin Receptor Antagonists, 03 medical and health sciences, Ventricular arrhythmias, 0302 clinical medicine, Internal medicine, Heart failure reduced ejection fraction, medicine, Humans, Angiotensin receptor neprilysin inhibitor, Angiotensin receptor neprilysin inhibitors, Sacubitril/valsartan, 030212 general & internal medicine, Heart Failure, Receptors, Angiotensin, Ejection fraction, business.industry, Mechanism (biology), Aminobutyrates, Biphenyl Compounds, Arrhythmias, Cardiac, Stroke Volume, medicine.disease, Heart failure, Ventricular arrhythmia, Cardiology, Valsartan, Cardiology and Cardiovascular Medicine, business, Sacubitril, Valsartan
Abstract

The remarkable scientific progress in the treatment of patients with heart failure (HF) and reduced ejection fraction (HFrEF) has more than halved the risk of sudden cardiac death (SCD) in this setting. However, SCD remains one of the major causes of death in this patient population. Beyond the acknowledged role of beta blockers and inhibitors of the renin-angiotensin-aldosterone system (RAAS), a new class of drugs, the angiotensin receptor neprilysin inhibitors (ARNI), proved to reduce the overall cardiovascular mortality and, more specifically, the risk of SCD in HFrEF patients. The mechanism by which ARNI may reduce the mortality connected with harmful ventricular arrhythmias is not utterly clear. A variety of direct and indirect mechanisms have been suggested, but a favorable left ventricular reverse remodeling seems to play a key role in this setting. Furthermore, the well-known protective effect of implantable cardioverter-defibrillator (ICD) has been debated in HFrEF patients with non-ischemic cardiomyopathy (NICM) arguing against the role of primary prevention ICD in this setting, particularly when ARNI therapy is considered. The purpose of this review was to provide insights into the SCD mechanisms involved in HFrEF patients together with the current role of electrical therapies and new drug agents in this setting. [Figure not available: see fulltext.].

Published
2020
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11. Telemedicine and Teleconsulting in the Era of COVID-19 Pandemic: A Useful Tool from Screening to Intensive Care Monitoring

Author

Raffaele Abete, Andrea Lorenzo Vecchi, Attilio Iacovoni, Andrea Mortara, Michele Senni, Abete, R, Vecchi, A, Iacovoni, A, Mortara, A, and Senni, M

Subjects
Intensive care monitoring, Telehealth, Biomedical Engineering, Screening, Medicine (miscellaneous), COVID-19, Bioengineering, Telemedicine, Teleconsulting
Abstract

The COVID-19 global pandemic has had striking effects on clinical practice and medical assistance and the progressive evolution of telemedicine and telehealth systems has allowed healthcare professionals to connect with patients yet respecting the striking need for social distancing. This article aims to review the possible ways to use telehealth and teleconsulting systems to guarantee an adequate level of clinical assistance starting from screening procedures up to support the management of patients admitted to intensive care units area, thus balancing the need to ensure continuity of care and at the same time limiting the possible sources of contagion expansion. Telemedicine may be a useful tool to improve clinical assistance and reduce the financial burden on the health system in a long-term view. Although it cannot completely replace patient-physician interactions, it would be desirable to implement this field and made it accessible to the largest part of the population.

Published
2021

12. An unexpected recovery of patients with pulmonary arterial hypertension and SARS-CoV-2 pneumonia: a case series

Author

Attilio Iacovoni, Alberto Cereda, Aurelia Grosu, Michele Senni, Piermario Scuri, Raffaele Abete, Scuri, P, Iacovoni, A, Abete, R, Cereda, A, Grosu, A, and Senni, M

Subjects
Pulmonary and Respiratory Medicine, 2019-20 coronavirus outbreak, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, Disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, pulmonary hypertension, Research Letter, medicine, In patient, skin and connective tissue diseases, lcsh:RC705-779, business.industry, fungi, Outbreak, COVID-19, lcsh:Diseases of the respiratory system, medicine.disease, Pulmonary hypertension, respiratory tract diseases, body regions, Pneumonia, 030228 respiratory system, pulmonary circulation, lcsh:RC666-701, business
Abstract

Since the beginning of the SARS-CoV-2 outbreak, few cases of COVID-19 pneumonia in patients with pulmonary arterial hypertension have been reported. We present four patients with known history of PAH admitted to our hospital with SARS-CoV-2 pneumonia to analyze the impact of this disease on their clinical outcome.

Published
2020

13. Association between sleep disordered breathing, neurocognitive impairment and diastolic function in acute heart failure patients: an insight after the vulnerable phase of the hospitalization

Author

Michele Senni, Claudio Ferri, Pierangelo Baio, Raffaele Abete, Antonello Gavazzi, Mauro Gori, Vincenzo Duino, Emilia D'Elia, Andrea Lorenzo Vecchi, Aurelia Grosu, Cosimo Andrea Stamerra, D'Elia, E, Stamerra, C, Vecchi, A, Duino, V, Grosu, A, Abete, R, Baio, P, Gori, M, Gavazzi, A, Ferri, C, and Senni, M

Subjects
Male, medicine.medical_specialty, Diastolic function, Polysomnography, Population, Diastole, 030204 cardiovascular system & hematology, 03 medical and health sciences, Neurocognitive disorders, 0302 clinical medicine, Sleep Apnea Syndromes, Internal medicine, Internal Medicine, medicine, Neurocognitive disorder, Humans, 030212 general & internal medicine, education, Aged, Heart Failure, education.field_of_study, Ejection fraction, medicine.diagnostic_test, business.industry, Acute heart failure, Sleep apnea, Acute Disease, Case-Control Studies, Cognition Disorders, Echocardiography, Female, Hospitalization, Stroke Volume, Stroke volume, medicine.disease, Heart failure, Emergency Medicine, Cardiology, business, Neurocognitive
Abstract

Sleep disordered breathing (SDB) and neurocognitive impairment (NI) are a typical feature of HF (heart failure), especially with preserved ejection fraction (HFpEF). So far, very few data exist regarding changes in the severity of SDB, the degree of NI, and the diastolic function in acute HF (AHF) patients and during follow up. In a population of 24 AHF patients (12 with reduced ejection fraction-HFrEF- and 12 HFpEF) with SDB a complete echocardiogram, a set of NI tests, and a polysomnography were performed in the acute phase and after 90days. A control group of 12 non-HF patients hospitalized for other cardiovascular causes was considered. At baseline, SDB were present both in HFpEF and HFrEF, and a consistent reduction of apneic events was observed at follow up. Improvements in diastolic and right ventricular function were documented at three months compared to baseline, both in HFpEF and in HFrEF. Compared to HFrEF patients and controls, HFpEF patients showed lower NI scores at baseline tests, but a more significant improvement at three months follow-up. In AHF patients with SDB the achievement of a better compensation could lead to important beneficial effect not only on echocardiographic variables and nocturnal respiratory profile, but also on NI, especially in HFpEF.

Published
2020

14. Ultrasound diagnosis of typhlitis

Author

Stefania Tamburrini, Roberta Abete, Giuseppe Sarti, Maria Gabriella Della Casa, Francesca Rosa Setola, Ines Marano, Pietro Paolo Saturnino, Maria Paola Belfiore, Tamburrini, S., Setola, F. R., Belfiore, M. P., Saturnino, P. P., Della Casa, M. G., Sarti, G., Abete, R., and Marano, I.

Subjects
Emergency Medical Services, medicine.medical_specialty, Cyclophosphamide, Case Report, Churg-Strauss Syndrome, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Immunosuppressive Agent, 0302 clinical medicine, Bedside ultrasound, Submucosa, Early Diagnosi, Internal Medicine, medicine, Humans, Emergency ultrasound, Radiology, Nuclear Medicine and imaging, Cecum, Acute colitis, Ultrasonography, business.industry, Emergency Medical Service, Mortality rate, Ultrasound, Typhliti, General Medicine, Gold standard (test), Middle Aged, Acute coliti, Abdominal Pain, Typhlitis, Early Diagnosis, medicine.anatomical_structure, Bedside, Point-of-Care Testing, 030220 oncology & carcinogenesis, Female, Radiology, business, Immunosuppressive Agents, medicine.drug, Human
Abstract

PURPOSE: Typhlitis, also known as neutropenic colitis, is a rare inflammatory condition and a potentially life-threatening disease process that typically involves the cecum. Delay in diagnosis may lead to a fatal prognosis with a death rate of 21–48%. Ultrasound evaluation of right lower quadrant may lead to an accurate and rapid diagnosis. METHODS: We describe the case of a 59-year-old female with advanced Churg–Strauss syndrome treated with cyclophosphamide, with acute right lower quadrant pain. RESULTS: Ultrasound was the first diagnostic step in the diagnosis of typhlitis. Sonographic findings were comparable to CT imaging. CONCLUSIONS: Bowel bedside ultrasound evaluation in emergency settings may lead to a prompt and definitive diagnosis. Although CT is considered the gold standard in the diagnosis and staging of neutropenic colitis, ultrasound was able to identify the pathology accurately. Ultrasound findings of typhlitis are highly characteristic, showing circumferential wall thickening with predominant submucosa.

Published
2019

15. Physical activity in the prevention of peripheral artery disease in the elderly

Author

Evelina Toscano, Giovanni Esposito, Antonio Sorropago, Giovanni Menafra, Roberta Bottino, Michele De Paulis, Bruno Trimarco, Antonio Bruno, Gabriele G. Schiattarella, Fabio Magliulo, Andreina Carbone, Cinzia Perrino, Roberto Vincenzo Corrado, Raffaele Abete, Giuseppe Giugliano, Schiattarella G.G., Perrino C., Magliulo F., Carbone A., Bruno A.G., De Paulis M., Sorropago A., Corrado R.V., Bottino R., Menafra G., Abete R., Toscano E., Giugliano G., Trimarco B., Esposito G., Gabriele G., Schiattarella, Perrino, Cinzia, Fabio, Magliulo, Andreina, Carbone, Antonio G., Bruno, Michele De, Pauli, Antonio, Sorropago, Roberto V., Corrado, Roberta, Bottino, Giovanni, Menafra, Raffaele, Abete, Evelina, Toscano, Giugliano, Giuseppe, Trimarco, Bruno, and Esposito, Giovanni

Subjects
medicine.medical_specialty, Aging, Physiology, Fitne, Population, Disease, lcsh:Physiology, Mini Review Article, Quality of life, Physiology (medical), Medicine, Risk factor, Intensive care medicine, education, Exercise, education.field_of_study, lcsh:QP1-981, business.industry, Intermittent claudication, PAD, Review article, Cilostazol, fitness, Atherosclerosi, Physical therapy, Claudication, medicine.symptom, atherosclerosis, business, medicine.drug
Abstract

Aging is a well-known cardiovascular risk factor and cardiovascular diseases (CVD) are estimated to be the most common cause of death in the elderly. Peripheral arterial disease (PAD) represents an important clinical manifestation of CVD leading to increase morbidity and mortality, especially in elderly population. The correct management of PAD population includes the prevention of cardiovascular events and relief of symptoms, most commonly intermittent claudication. Progressive physical activity is an effective treatment to improve walking distance and to reduce mortality and cardiovascular events in patients with PAD, however the ability to effectively engage in physical activity often declines with increasing age. The maintenance and increase of reserve functional capacity are important concepts in the elderly population. Ultimately, the goal in participation of physical activity in the healthy elderly population is maintenance and development of physical functional reserve capacity. Therefore, for individuals suffering of PAD, appropriate physical activity in the form of supervised exercise may serve as a primary therapy. Although there are few direct comparisons of therapeutic exercise programs vs. pharmacological or surgical interventions, these increases in walking distance are greater than those reported for the most widely used agents for claudication, pentoxyphylline, and cilostazol. Despite a reduction in mortality and improvement of quality of life caused by physical activity in the PAD population, the molecular, cellular, and functional changes that occur during physical activity are not completely understood. Therefore, this review article aims at presenting an overview of recent established clinical and molecular findings addressing the role of physical activity on PAD in the older population. © 2014 Schiattarella, Perrino, Magliulo, Carbone, Bruno, De Paulis, Sorropago, Corrado, Bottino, Menafra, Abete, Toscano, Giugliano, Trimarco and Esposito.

Published
2014

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