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Background: Kawasaki disease (KD) is a form of systemic vasculitis that occurs primarily in children under the age of 5 years old. No single laboratory data can currently distinguish KD from other febrile infection diseases. The purpose of this study was to establish a laboratory data model that can differentiate between KD and other febrile diseases caused by an infection in order to prevent coronary artery complications in KD.Methods: This study consisted of a total of 800 children (249 KD and 551 age- and gender-matched non-KD febrile infection illness) as a case-control study. Laboratory findings were analyzed using univariable, multivariable logistic regression, and nomogram models.Results: We selected 562 children at random as the model group and 238 as the validation group. The predictive nomogram included high eosinophil percentage (100 points), high C-reactive protein (93 points), high alanine transaminase (84 points), low albumin (79 points), and high white blood cell (64 points), which generated an area under the curve of 0.873 for the model group and 0.905 for the validation group. Eosinophilia showed the highest OR: 5.015 (95% CI:−3.068–8.197) during multiple logistic regression. The sensitivity and specificity in the validation group were 84.1 and 86%, respectively. The calibration curves of the validation group for the probability of KD showed near an agreement to the actual probability.Conclusion: Eosinophilia is a major factor in this nomogram model and had high precision for predicting KD. This report is the first among the existing literature to demonstrate the important role of eosinophil in KD by nomogram.

Fluoride, as the super reactive element fluorine, is found naturally throughout earth's crust. It has been identified as a strong, persistent powerful cumulative toxic agent, commonly distributed in the rivers, lakes, seas of earth. It is highly mobile and biologically active element in aquatic systems. Fish are considered as the excellent and valuable bioindicator of ecosystem pollution. The present study was designed to estimate acute fluoride toxicity on enzyme activity of liver of freshwater fish Tilapia mossambica. The major enzymes of Carbohydrate - Protein Metabolic pathways are Alkaline phosphatase (ALP), Alanine transaminase (ALT), Aspartate transaminase (AST) in association with carbohydrate, protein, lipid in the liver of Tilapia mossambica, from Kalri Lake (Keenjhar Lake), Sindh, Pakistan at low amount of fluoride (sub-lethal) was estimated by using UV- Visible Spectrophotometer. Results showed ALP, AST and ALT enzymes present in the liver tissue were significantly changed (p < 0.001). Finally, it is concluded that fluoride produces the adverse poisonous effect on liver functioning which may be associated with altered or elevated enzyme activity of protein-carbohydrate metabolism.

Typhoid infection and its effect on liver function assessment among pregnant women were evaluated. Serum and blood samples were collected and processed for liver function assessment, widal test and microbiological identification ofSalmonella typhiusing standard methods. A total of ninety (90) patients were studied. Serum alanine transaminase (ALT) and Serum aspartate transaminase (AST) values for healthy pregnant women and pregnant women with typhoid infection had progressive value increase with increase in pregnancy time, except for the slight reduction in the third trimester with ALT. Mean values of healthy pregnant women and pregnant women with typhoid infection(iu/L) for ALT and AST were (8.93 ±1.07/ 9.95 ±0.19; 7.52 ±0.45/ 8.50 ±0.14) at first trimester, (10.62 ±1.19/11.64 ±0.05; 9.34 ±1.03/ 10.32 ±0.86) at second trimester and (9.81 ±0.16/ 10.83 ±0.76; 10.40 ±0.49/ 11.38 ±0.08) at third trimester, Conversely, total and conjugated bilirubin followed a different trend of retrogressive decrease with increase in pregnancy time. Total and conjugated bilirubin (mg/dL) mean values for healthy pregnant women and pregnant women with typhoid infection at first trimester were (0.56 ±0.87/ 0.69 ±0.09; 0.57 ±0.66/ 0.70 ±0.26), followed by second trimester (0.43 ±1.06/ 0.56 ±0.05; 0.48 ±0.77/ 0.61 ±0.03) and third trimester (0.32 ±0.57/ 0.45 ±0.11; 0.39 ±0.54/ 0.52 ±0.41). Values of LFT results among pregnant women with typhoid infection were higher than that of healthy pregnant women (p

Vitamin D deficiency is common among patients with liver diseases. Both cholestatic and non-cholestatic liver diseases can cause vitamin D deficiency. Whether vitamin D status can also affect liver function is poorly understood. To investigate the association between vitamin D status, liver enzymes, and incident liver disease, we included a total of 2,649 individuals from the Monica10 study conducted in 1993-1994. Vitamin D status as assessed by serum 25-hydroxyvitamin, serum alanine transaminase (ALT), aspartate transaminase (AST), and gamma glutamyl transferase (GGT) were measured at baseline. Information on fatal and non-fatal liver disease was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death, respectively. Median follow-up time was 16.5 years, and there were 62 incident cases of fatal and non-fatal liver disease. Multivariable Cox regression analyses with age as underlying time axis and delayed entry showed a statistically significant inverse association between vitamin D status and incident liver disease with a hazard ratio = 0.88 (95 % confidence interval 0.79-0.99) per 10 nmol/l higher vitamin D status at baseline (adjusted for gender, season, alcohol consumption, smoking, physical activity, dietary habits, education, body mass index, and ALT). The risk of having a high level of ALT, AST, or GGT tended to be higher for lower vitamin D levels, although not statistically significant. In this general population study, vitamin D status was inversely associated with incident liver disease. Further studies are needed to determine whether patients in risk of developing impaired liver function should be screened for vitamin D deficiency for preventive purposes.

La pancreatitis aguda (PA) es una enfermedad de alta prevalencia e impacto socioeconómico. En nuestro medio la causa principal es la patología biliar. La ultrasonografía endoscópica no siempre está disponible dado su alto costo. Los niveles de alaninoaminotransferasa (ALT) mayores de 150 UI/1 se han relacionado con patología obstructiva de la vía biliar. Objetivo: determinar las características de la ALT en nuestra población para diagnosticar el origen biliar de la PA. Materialesy métodos: estudio de corte transversal en el Hospital de San José de Bogotá DC. Se revisaron historias clínicas con diagnóstico de PA de agosto 2010 a marzo 2012. Se analizaron datos sociodemográficos, clínicos, de laboratorio, imagenológicos, hallazgos intraoperatorios y diagnóstico etiológico. Resultados: se reclutaron 106 pacientes, 67% mujeres. Se estableció por análisis ROC que los niveles de ALT mayores de 74 UI/1 fueron más sensibles y específicos que los de 150 UI/1. Se encontró la relación de ALT mayor de 74 UI/1 con hiperbilirrubinemia, ictericia y hallazgos ecográficos compatibles con etiología biliar. Conclusión: existe significancia estadística para ALT mayor a 74 UI/1 con etiología biliar (sensibilidad 89%, especificidad 71%) con p