1. Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients
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Forés Raurell, Rosa, Manresa, Josep M., López-Lifante, Victor M., Heras, Antonio, Delgado Martínez, María Pilar, Vázquez, Xose, Ruiz, Susana, Alzamora, M. Teresa, Torán Montserrat, Pere, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Forés R, Heras A] Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain. Riu Nord-Riu Sud Primary Healthcare Centre, Santa Coloma de Gramenet, Gerència d’Àmbit d’Atenció Primària Metropolitana Nord, Institut Català de la Salut, 08921 Barcelona, Spain. [Manresa JM] Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain. [López-Lifante VM] Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain. Palau Healthcare Centre, Palau-Solità Plegamans, Gerència d’Àmbit d’Atenció Primària Metropolitana Nord, Institut Català de la Salut, 08124 Barcelona, Spain. [Delgado P] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Demència, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Vázquez X] Hospital Municipal de Badalona, Badalona Serveis Assistencials, Secció d’Oftalmologia, Badalona, 08911 Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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cardiovascular risk ,medicine.medical_specialty ,Hipertensió - Complicacions ,Medicine (General) ,hypertension ,Clinical Biochemistry ,Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia::Brain Infarction [DISEASES] ,Primary care ,Cardiovascular Diseases::Vascular Diseases::Hypertension [DISEASES] ,enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::isquemia cerebral::infarto encefálico [ENFERMEDADES] ,retinal microvasculature ,030204 cardiovascular system & hematology ,Retinography ,Logistic regression ,Cardiovascular System::Blood Vessels::Retinal Vessels [ANATOMY] ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores] ,0302 clinical medicine ,R5-920 ,Internal medicine ,medicine ,sistema cardiovascular::vasos sanguíneos::vasos retinianos [ANATOMÍA] ,Retina - Vasos sanguinis ,Retinal microvasculature ,Silent brain infarction ,medicine.diagnostic_test ,business.industry ,Retinal ,Magnetic resonance imaging ,Odds ratio ,Cardiovascular risk ,Risk evaluation ,silent brain infarction ,chemistry ,Brain infarction ,Hypertension ,Cardiology ,business ,enfermedades cardiovasculares::enfermedades vasculares::hipertensión [ENFERMEDADES] ,030217 neurology & neurosurgery ,Malalties cerebrovasculars ,Other subheadings::Other subheadings::/complications [Other subheadings] - Abstract
Objective: The aims of this study are to analyze the role of artery-vein ratio AVR assessment using VesselMap 2 software (Imedos Systems) and cardiovascular risk evaluation by means of REGICOR in the prediction of silent brain infarction (SBI) in middle-age hypertensive patients from the ISSYS study. Material and Methods: A cross-sectional study with 695 patients with hypertension aged 50 to 70 years who participated in the project Investigating Silent Strokes in HYpertensives: a Magnetic Resonance Imaging Study (ISSYS), was conducted in two Primary Care Centres of Barcelona. Participants agreed to a retinography and an MRI to detect silent brain infarction (SBI). The IMEDOS software was used for the semiautomatic caliber measurement of retinal arteries and veins, and the AVR was considered abnormal when <, 0.66. The REGICOR score was calculated for all patients. Results: Multivariate logistic regression analysis was used to evaluate the impact of AVR and REGICOR scores on SBI. The OR (odds ratio) for a high REGICOR score and an abnormal AVR were 3.16 and 4.45, respectively. When analysing the interaction of both factors, the OR of an abnormal AVR and moderate REGICOR score was 3.27, whereas with a high REGICOR score it reached 13.07. Conclusions: The measurement of AVR in patients with hypertension and with a high REGICOR score can contribute to the detection of silent brain infarction.
- Published
- 2021
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