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Introducción: La caracterización anatómica de la cadera ha demostrado ser significativamente variable entre grupos poblacionales (1,2,3); estas diferencias morfológicas están asociadas a factores intrínsecos como la edad, el sexo y la etnia, o factores extrínsecos como el medio ambiente y el estilo de vida (4,5). Existen múltiples estudios descriptivos de la geometría del fémur proximal y el acetábulo en diferentes países y grupos de individuos pertenecientes a una etnia, sin embargo, el conocimiento de la morfología y morfometría ósea de la cadera en la ciudad de Bogotá procede principalmente de estos estudios centrados en población extranjera ya que no existe ninguna descripción anatómica de la cadera en la actualidad basada en nuestra población. Teniendo en cuentas estas diferencias y variabilidad, este estudio tiene como objetivo describir la morfología y morfometría ósea de la cadera en adultos sin patología articular que permita ser aplicada para detectar tempranamente anomalías estructurales y mejorar los enfoques de tratamiento. Métodos: Se realizó un estudio descriptivo por medio de radiografías simples AP de cadera, obtenidas en los últimos 2 años de la base de datos de dos instituciones privadas de la ciudad de Bogotá. Se incluyó un total de 61 pacientes, para un total de 121 caderas (89 de mujeres y 32 de hombres). Los parámetros morfológicos y morfométricos de la cadera evaluados fueron: orientación acetabular (profundidad, ancho, y relación de profundidad/ancho acetabular), morfología femoral (longitud del cuello y diámetro de la cabeza del fémur), alineación femoral (ángulo de la diáfisis del cuello femoral), cobertura acetabular (ángulo centro borde lateral) y asfericidad de la cabeza femoral (ángulo alfa) Resultados: Todas las variables analizadas obtuvieron diferencias relacionadas con el sexo. Los hombres mostraron valores medios superiores excepto para el ángulo alfa (mujeres: 53,2°; hombres: 49,2°). Con relación a las medidas de orientación acetabular: ancho y profundidad acetabular, estos resultados son similares con respecto a la población estudiada en china (profundidad acetabular: mujeres: 27,6 mm; hombres: 31,9 mm en Bogotá y mujeres: 29.65 mm; hombres: 32.76 mm en China) (ancho acetabular: mujeres: 57,2 mm; hombres: 63,4 mm en Bogotá y mujeres: 57.86 mm; hombres: 64.27 mm en China). El fémur resultó ser más corto (30. 47 mm), la cabeza femoral más pequeña (50.71 mm) y el desplazamiento femoral (41.84 mm) fue menor en esta muestra en comparación con las poblaciones revisadas en la literatura. Por otra parte, el ángulo de la diáfisis del cuello femoral de la muestra obtenida en Bogotá fue mayor en ambos sexos (mujeres: 131°; hombres 132°). Conclusión: Es realizada la primera descripción de las características morfológicas y morfométricas de la cadera en una muestra de población de la ciudad de Bogotá-Colombia. Los resultados coinciden con otros estudios en dónde existe una gran diversidad en la morfología y morfometría de la cadera relacionadas con diferencias geográficas y del sexo. (Texto tomado de la fuente) Introduction: The anatomical characterization of the hip has been shown to be significantly variable between population groups (1,2,3); These morphological differences are associated with intrinsic factors such as age, sex and ethnicity, or extrinsic factors such as environment and lifestyle (4,5). There are multiple descriptive studies of the geometry of the proximal femur and acetabulum in different countries and groups of individuals belonging to an ethnic group, however, knowledge of the morphology and bone morphometry of the hip in the city of Bogotá comes mainly from these focused studies in foreign population since there is currently no anatomical description of the hip based on our population. Considering these differences and variability, this study aims to describe the bone morphology and morphometry of the hip in adults without joint pathology that allows it to be applied to detect structural abnormalities early and improve treatment approaches. Methods: A descriptive study was carried out by means of plain AP radiographs of the hip, obtained in the last 2 years from the database of the Colsubsidio Calle 100 Clinic and 94 Clinic. The number of patients studied was 61 for a total of 121 hips (89 for women and 32 for men). The morphological and morphometric parameters of the hip evaluated were the following: acetabular orientation (depth, width, and ratio of acetabular depth / width), femoral morphology (length of neck, lateral femoral offset and diameter of femoral head), femoral alignment (femoral neck-shaft angle), acetabular coverage (center lateral border angle) and asphericity of femoral head (alpha angle) Results: All the variables analyzed obtained differences related to sex. Men showed higher mean values except for the alpha angle (women: 53.2 °; men: 49.2 °). Regarding the acetabular orientation measurements: acetabular width and depth, these results are similar with respect to the population studied in China (acetabular depth: women: 27.6 mm; men: 31.9 mm in Bogotá and women: 29.65 mm; men: 32.76 mm in China) (acetabular width: women: 57.2 mm; men: 63.4 mm in Bogotá and women: 57.86 mm; men: 64.27 mm in China). The femur was found to be shorter (30. 47 mm), the femoral head smaller (50.71 mm), and the femoral displacement (41.84 mm) was less in this sample compared to the populations reviewed in the literature. On the other hand, the angle of the diaphysis of the femoral neck of the sample obtained in Bogotá was greater in both sexes (women: 131 °; men: 132 °). Conclusion. The first description of morphological and morphometric characteristics of the hip is made in a population sample from the city of Bogotá-Colombia. Results coincide with other studies where there is great diversity in morphology and morphometry of the hip related to geographic and sex differences. Ninguno Maestría Magíster en Morfología Humana

The burrower bugScaptocoris castaneaPerty, 1830 (Hemiptera: Cydnidae) is an agricultural pest feeding on roots of several crops. The histology and ultrastructure of the salivary glands ofS. castaneawere described. The salivary system has a pair of principal salivary glands and a pair of accessory salivary glands. The principal salivary gland is bilobed with anterior and posterior lobes joined by a hilus where an excretory duct occurs. The accessory salivary gland is tubular with a narrow lumen that opens into the hilus near the excretory duct, suggesting that its secretion is stored in the lumen of the principal gland. The cytoplasm of the secretory cells is rich in the rough endoplasmic reticulum, secretory vesicles with different electron densities and mitochondria. At the base of the accessory gland epithelium, there were scattered cells that do not reach the gland lumen, with the cytoplasm rich in the rough endoplasmic reticulum, indicating a role in protein production. Data show that principal and accessory salivary glands ofS. castaneaproduce proteinaceous saliva. This is the first morphological description of theS. castaneasalivary system that is similar to other Hemiptera Pentatomomorpha, but with occurrence of basal cells in the accessory salivary gland.

The Korean shuttles mudskipper Periophthalmus modestus has paired olfactory organs on its snout, consisting of anterior and posterior nostrils, a single olfactory canal with sensory and nonsensory epithelia, and a single accessory nasal sac. Its sensory epithelium consists of numerous islets forming a pseudostratified layer and contains various cells: olfactory receptor neurons, supporting cells, basal cells, lymphatic cells (LCs), and axon bundles. The sensory epithelium is a stratified squamous layer comprising stratified epithelial cells, mucous cells (MCs) with glycogen, flattened cells (FCs), LCs, and unidentified cells. Specific structures are as follows: (a) a tubular anterior nostril projecting outward, (b) a slit posterior nostril, (c) an elongated olfactory canal, (d) an ethmoidal accessory nasal sac, (e) axon bundles found only in the basal layer of the sensory epithelium, (f) FCs only at the top of the nonsensory epithelium, and (g) glycogen-containing MCs. Such structures seem to be unique in that they have not been observed in most teleost fishes spending their whole life in water.

A fundamental aspect that is commonly overlook when assessing thymic tumors is the normal histology and immunohistochemical features of the normal thymus. Given the fact that most epithelial tumors occur in the adult population, it is only rarely that we are confronted with assessing normal immunohistochemistry of the thymus. However, we consider that such knowledge is of utmost importance is assessing pathological conditions including epithelial tumors or tumors of other lineages. Therefore, in this writing we have concentrated our efforts in providing an overview of the embryology and anatomy of the thymus as well as putting the normal histology and immunohistochemistry in perspective when assessing pathological conditions.

Introduction. Currently surgical findings dictate the post-operative treatment of patients with acute appendicitis; however, this relies only on the judgement of the surgeon during the appendectomy. This study aimed to determine the inter-rater reliability between surgeons and pathologists at a tertiary hospital. Methods. This was a cross-sectional retrospective study conducted between October 2015 and October 2016 at the Central Military Hospital in Bogotá. Patients who underwent appendectomy due to suspected acute appendicitis and had histopathological with their respective surgical findings were included. Our aim was to determine the agreement between surgical and pathology reports. Results. During the study period, we identified 418 patients who underwent appendectomy. Surgeons assessed 32 (7.77%) appendix as negative, 78 (18.93%) as inflamed, 110 (26.7%) as suppurative, 137 (33.25%) gangrenous and 55 (13.35%) as perforated. Highest agreement was observed in patients with suppurative appendicitis (82/110; 74.5%). Overall Kappa indicated a poor-fair agreement between the pathologist and surgeons (Kappa = 0.2950, 95% CI 0.2384-035.17, p < 0.0001). Conclusion. There is a poor concordance between surgical and pathologic findings in our study, which is similar to previous articles. As a take home message, surgeons and pathologist should revise the definition of the clinical and the histopathological criteria to better describe the findings and reach a better agreement. Resumen Introducción. Los hallazgos quirúrgicos actuales dictan el tratamiento postoperatorio de los pacientes con apendicitis aguda; sin embargo, esto se basa únicamente en el juicio del cirujano durante la apendicectomía. Este estudio tuvo como objetivo determinar la correlación de la evaluación entre cirujanos y patólogos en un hospital de tercer nivel. Métodos. Estudio transversal retrospectivo realizado entre octubre de 2015 y octubre de 2016 en el Hospital Militar Central de Bogotá. Se incluyeron pacientes que se sometieron a apendicectomía debido a sospecha de apendicitis aguda y tenían histopatología con sus respectivos hallazgos quirúrgicos. Nuestro objetivo fue determinar la concordancia entre el informe quirúrgico y el de patología. Resultados. Durante el período de estudio, identificamos a 418 pacientes que se sometieron a apendicectomía. Los cirujanos evaluaron 32 (7,77%) apéndices como negativos, 78 (18,93%) como inflamados, 110 (26,7%) como supurativos, 137 (33,25%) gangrenosos y 55 (13,35%) como perforados. La mayor concordancia se observó en pacientes con apendicitis supurativa (82/110; 74.5%). En general, Kappa indicó un acuerdo poco equitativo entre el patólogo y los cirujanos (Kappa = 0.2950, IC 95% 0.2384-035.17, p

The cervix represents the lower portion of the uterus and plays an important anatomical role in supporting the internal genital organs during pregnancy and at birth. It also has importance as a cervical mucin-producing organ. The cervical stroma comprises a mixture of fibrous, muscular, and elastic tissue. It is lined by a columnar epithelium in the endocervical canal and by a mature, nonkeratinizing squamous epithelium in the ectocervix. The location of endocervical epithelium varies throughout life and is influenced by the hormonal milieu, such that endocervical epithelium can be visualized by colposcopy in women of reproductive age. The “transformation zone” encompasses a junctional area, containing combinations of glandular and metaplastic squamous epithelium, bounded proximally by endocervix and, distally, by ectocervix. This is considered to be the area where most neoplastic processes occur.

Introducción. Los hallazgos quirúrgicos actuales dictan el tratamiento postoperatorio de los pacientes con apendicitis aguda; sin embargo, esto se basa únicamente en el juicio del cirujano durante la apendicectomía. Este estudio tuvo como objetivo determinar la confiabilidad entre evaluadores entre cirujanos y patólogos en un hospital de tercer nivel. Métodos. Estudio transversal retrospectivo realizado entre octubre de 2015 y octubre de 2016 en el Hospital Central Militar de Bogotá. Se incluyeron pacientes que se sometieron a apendicectomía debido a sospecha de apendicitis aguda y tenían histopatología con sus respectivos hallazgos quirúrgicos. Nuestro objetivo fue determinar el acuerdo entre el informe quirúrgico y el de patología. Resultados. Durante el período de estudio, identificamos a 418 pacientes que se sometieron a apendicectomía. Los cirujanos evaluaron 32 (7,77%) apéndices como negativos, 78 (18,93%) como inflamados, 110 (26,7%) como supurativos, 137 (33,25%) gangrenosos y 55 (13,35%) como perforados. La mayor concordancia se observó en pacientes con apendicitis supurativa (82/110; 74.5%). En general, Kappa indicó un acuerdo poco equitativo entre el patólogo y los cirujanos (Kappa = 0.2950, ​​IC 95% 0.2384-035.17, p

Chronic kidney disease is a condition in which parathyroid are affected by a combination of elevated extracellular phosphate concentration, decreased extracellular ionized calcium concentration, and markedly reduced serum calcitriol, leading to increased PTH synthesis and release. At early stages in the development of hyperparathyroidism, these changes are compounded of variable down-regulation of the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), making the parathyroid cells unable to respond appropriately to calcium and/or calcitriol. The resulting increase in proliferative activity in the parathyroid glands leads to parathyroid hyperplasia.

In this chapter, the fundamental aspects related to the anatomical and physiological characteristics of the bone are described, essential for the development of nanomaterials suitable for the treatment of the various pathologies that affect the bone system.

Objective: The foramen of Luschka is a natural hole between the fourth ventricle and the subarachnoid space of the cerebellopontine angle (CPA). The obstruction of the foramen is a rare entity with primary and secondary forms. The secondary form is a result of various pathologies, while the primary [for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Emil Theodor Kocher and Theodor Billroth pioneered the surgical management of thyroid disease. Their surgical techniques, knowledge of thyroid anatomy, embryology, histology, physiology, and antisepsis practices transitioned a life-threatening operation to one with acceptable morbidity. The modern head and neck surgeon should have a meticulous surgical technique, combined with a thorough understanding of thyroid embryology and anatomy that is central to the understanding and treatment of the different disease processes of the thyroid gland and the consequences of thyroid gland surgery. In this manuscript we will be examining thyroid gland embryology, anatomy, histology, and physiology that is essential to the practicing thyroid surgeon.

Goals Periarticular fat pads of the human knee are relatively well studied structures, but the majority of the reviewed articles focus on fat pads of the anterior part of the knee. Therefore, the goal of this scoping systematic review is to summarize and disseminate current knowledge about the only fat pad in the posterior part of the knee – the pericruciate fat pad (PCFP). Methods In November 2020 two independent researchers, in order to gather the maximally broad set of articles pertaining to the studied topic, searched the following databases: PubMed, Embase, Karger, Scopus, using terms: pericruciate fat pad, PCL fat pad, posterior cruciate ligament fat pad. The article inclusion criteria was that it contained any scientific or clinical data about the PCFP, regardless of the type of article (original study, case report, review), and the year of its publication. Article exclusion criteria were that the study was not related to the PCFP and the article was written in any other language than English. In order to write each section of this review the included studies were then sorted into subtopics related to the PCFP. Main findings During the initial search of medical databases only eight articles mentioning the PCFP were identified, and only four directly focused on the PCFP. PCFP is located in the intercondylar fossa, filling the space between cruciates near their femoral attachment sites, surrounding the posterior cruciate ligament (PCL) and directly contacting the posterior capsule of the knee joint. The PCFP is composed of fatty tissue, covered by a thin synovial layer. It can be visualized on a magnetic resonance imaging (MRI) and during arthroscopy. Injuries of the PCFP may occur, resulting in nonspecific posterior knee pain. It has been proposed that alterations of the PCFP signal in MRI were a secondary sign of acute anterior cruciate ligament (ACL) injury, and an early indicator of osteoarthritis of the knee joint. While functions of the PCFP are not yet well studied, the PCFP is hypothesized to be a container of reparative stem cells. In agreement with this hypothesis, „the PCL fat pad transfer technique” was described as a promising treatment to enhance synovialization and revascularization of the ACL, after its repair or reconstruction. Conclusions Anatomy and imaging of PCFP is relatively well studied, however, we still need additional studies concerning its histology, functions, injuries, and a role in osteoarthritis. While there are theoretical promising benefits of using PCFP in ACL repair or reconstruction, high level-of-evidence research is needed to formulate any stronger opinions on the topic.

The study of the International Morphological Terminology, the creation of a dictionary or guide and its implementation is complex. The creation of SILATs meant an advance in the studying, spreading and acceptance of the international morphology in Ibero-America. However, there are some problems that have not been completely solved. This paper tries to explain some aspects that will get us closer to the understanding of those challenges, together with a possible way of solving them.

Background The medical care currently to brown lemurs (Eulemur fulvus) is limited by a lack of knowledge of their anatomy. The aim of this study was to describe the anatomy and histology and obtain ultrasonographic measurements of normal adrenal glands in these animals. Methods The adrenal glands of four lemurs cadavers were used for the anatomical and histological studies, and those of 15 anesthetized lemurs were examined by ultrasonography. Results Anatomically, the adrenal glands of brown lemurs are comparable to those of other species. The histological findings showed that the cortex is organized into three distinct layers, whereas most domestic mammals have an additional zone. The surface area of the adrenal glands increased with body weight, and the area of the right adrenal was slightly larger than the left. Conclusions We suggest using ultrasonography to aid the etiological diagnosis of behavioral abnormalities that might be due to dysfunctions of the adrenal gland.

The Gymnotus inaequilabiatus is a Neotropical fish widely distributed in marginal areas of bays. The aim of this study was to describe the main histological and histopathological traits in the head and exocrine kidney. Here, histometric and structural density techniques were associated with renosomatic index (RSI). The kidney was processed for light microscopy. Lipofuscin and hemosiderin content were visually estimated in the melonomacrophages centers (MMCs). All the biometric body variables were correlated with RSI, especially the kidney weight and gross lesions count. The general architecture of head and exocrine kidney was similar to that described for other teleost species. MMCs were prevalent in both portions and correlated with RSI in the head and exocrine kidney. Granulomatous structures were often observed in both portions; however, they were associated only in the exocrine kidney with RSI. Of all the structures hystometrically estimated, only proximal tubular diameter and thickness, and distal tubular thickness were correlated to renosomatic index. The RSI is an useful biometric variable that represent some physiological and morphological characteristics of kidney in G. inaequilabiatus. These findings may be used in future studies to evaluate the effects of environmental stressors on the renal adaptative physiological process. RESUMO Gymnotus inaequilabiatus é um peixe neotropical amplamente distribuído em áreas marginais de baías. O objetivo deste estudo foi descrever características anatômicas, histológicas e histopatológicas no rim cefálico e exócrino. Análises histométricas e a densidade volumétrica estrutural foram associadas ao índice renossomático (IRS). Fragmentos de ambos tecidos foram processados para análise e microscopia de campo claro. O conteúdo de lipofuscina e hemossiderina foi estimado visualmente nos centros de melanomacrófagos (CMMs). Todas as variáveis corporais biométricas foram correlacionadas com o IRS, principalmente o peso renal e a contagem de lesões superficiais. A arquitetura geral do rim cefálico e exócrino foi semelhante à descrita para outras espécies de teleósteos. Os CMMs foram frequentes em ambas as porções e correlacionaram-se com o IRS. Estruturas granulomatosas foram frequentemente observadas em ambas porções; no entanto, foram associadas ao IRS apenas no rim exócrino. De todas as estruturas estimadas histometricamente, apenas o diâmetro e espessura dos túbulos proximais e distais correlacionaram-se ao IRS. Este índice mostrou-se uma variável útil associada a características fisiológicas e morfológicas do rim de G. inaequilabiatus. Esses achados podem ser empregados em futuros estudos a fim de avaliar efeitos ambientais bem como processos adaptativos fisiológicos.

Untersuchung von Einflussfaktoren auf die Milzgröße anhand einer Bevölkerungsstichprobe in Süddeutschland im Rahmen eines Follow-Ups über 11 Jahre.

To cover the broad topic of juvenile pathology, an overview of the regulatory landscape and explanation regarding when and why pathologists examine juvenile tissues in preclinical safety studies are provided. There are unique challenges and opportunities associated with examining juvenile tissues, and these collectively help determine the safety of test articles and shed light on mechanism of action. Delving into selected organ systems, salient or unique features of normal development are discussed, with emphasis on those features that provide opportunity to help design targeted studies as well as those morphologic features that can complicate evaluation. In addition, for each organ, special pathology procedures utilized on juvenile tissues, toxic lesions that have been published in the relevant literature, and spontaneous diseases that may be encountered are highlighted.

The aim of the current study was to use gene therapy to attenuate or reverse the degenerative process within the intervertabral disc. The effect of survivin gene therapy via lentiviral vector transfection on the course of intervertebral disc degeneration was investigated in the current study in an in vivo rabbit model. A total of 15 skeletally mature female New Zealand White rabbits were randomly divided into three groups: Punctured blank control group (group A, n=5), punctured empty vector control group (group B, n=5) and the treatment group (group C, n=5). Computed tomography-guided puncture was performed at the L3-L4 and L4-L5 discs, in accordance with a previously validated rabbit annulotomy model for intervertebral disc degeneration. After 3 weeks, a lentiviral vector (LV) carrying survivin was injected into the nucleus pulposus. The results demonstrated that through magnetic resonance imaging, histology, gene expression, protein content and apoptosis analyses, group A and B were observed to exhibit disc degeneration, which increased over time, and no significant difference was observed between the two groups (P>0.05). However, there was reduced disc degeneration in group C compared with the punctured control groups, and the difference was statistically significant (P

To observe the influence of electroacupuncture (EA) on histomorphologies of lacrimal glands, cornea and conjunctiva in experimental dry eye syndrome, and to explore the repair effects of EA on lacrimal glands and ocular surface damage. Twenty-four healthy male New Zealand rabbits were randomly divided into a normal group, a model group, an EA group and a medication group, 6 rabbits in each group. Experimental dry eye syndrome models were prepared in rabbits by using 0.1% benzalkonium chloride for eye drops. Tear secretion volume, break-up time of tear film (BUT) and corneal fluorescein staining score were observed before and after the treatment. Periodic acid Schiff (PAS) staining method was used to observe the changes of conjunctival goblet cells in rabbits. After hematoxylin eosin (HE) staining, morphological changes of rabbit cornea, conjunctiva and lacrimal gland tissues were observed under light microscope. Compared with the normal group, tear secretion volume and BUT were significantly reduced (both P

This study evaluated the morphology and elemental composition of Asian elephant (Elephas maximus) bones (humerus, radius, ulna, femur, tibia, fibula and rib). Computerized tomography was used to image the intraosseous structure, compact bones were processed using histological techniques, and elemental profiling of compact bone was conducted using X-ray fluorescence. There was no clear evidence of an open marrow cavity in any of the bones; rather, dense trabecular bone was found in the bone interior. Compact bone contained double osteons in the radius, tibia and fibula. The osteon structure was comparatively large and similar in all bones, although the lacuna area was greater (P < 0.05) in the femur and ulna. Another finding was that nutrient foramina were clearly present in the humerus, ulna, femur, tibia and rib. Twenty elements were identified in elephant compact bone. Of these, ten differed significantly across the seven bones: Ca, Ti, V, Mn, Fe, Zr, Ag, Cd, Sn and Sb. Of particular interest was the finding of a significantly larger proportion of Fe in the humerus, radius, fibula and ribs, all bones without an open medullary cavity, which is traditionally associated with bone marrow for blood cell production. In conclusion, elephant bones present special characteristics, some of which may be important to hematopoiesis and bone strength for supporting a heavy body weight.

The research was aimed at examining 230 skulls and mandibles (113 males and 117 females) of the red fox (Vulpes vulpes) in the territory of the Republic of Lithuania. The object of the study was macroscopic evaluation of dental and periodontal pathologies, including changes in the structure of the skull and mandible. The most common teeth pathology was indicated to be hypodontia 13.27% in males and 5.98% in females (excluding M3 molar tooth). The hypodontia of the M3 was found to be common in males 6.19% and 7.69% in females. The findings of the research reveal that pathologies such as hyperdontia, dental fractures, enamel hypoplasia, abrasion, periodontitis stage 3 and stage 4 were less common: 1-4% in both males and females. In four skulls and mandibles of females a complex of severe pathologies of teeth and periodontium were found. There were no similar cases observed in males. This was the only significant difference between males and females. Other pathologies, including fractures of the skull or mandible, atypical form of foramen magnum, and changes in bone structure were rare overall, though slightly more common in males but not significantly.

Ascending aorta is the part which is prone to intervention. With the increasing number of such cases the only unchangeable thing is the basic understanding of aorta’s morphology which is critical for successful diagnostics and treatment. The purpose for writing this article is to systemize the data of anatomy, histology, topographic anatomy of aortic root and present them in the Ukrainian language based on the latest information from English sources. It is anatomically known that the initial part of the ascending part of aorta is the bulbus aortae. The clinic is increasingly using the direct analogue of the English version “aortic root”. It is still controversially referred to as either a component of the ascending aorta or as a separate unit. Thus, the bulbus aortae or aortic root is a segment of the aorta from the aortic valve to the sinotubular junction. It consists of three semilunar leaflets, interleaflet triangles, aortic sinuses (Valsalva sinuses) and sinotubular junction. The names of the Valsalva sinuses correspond to the three semilunar leaflets of the aortic valve: right, left, and posterior. The height of the valves is less than the height of the corresponding sinuses of Valsalva. This makes it impossible to cover the coronary orifice with valves in left ventricular systole. The prevention mechanism of regurgitation from aorta to a left ventricle is also provided by the anatomic features of the semilunar leaflets: nodules of Arantius and lunules. The semilunar leaflets are formed by the folds of the endocardium and consist of four layers: the endothelium, the subendothelial layer, the muscularelastic and connective tissue layers. Based on the diameter and the particularities of its structure the aortic wall belongs to the arteries of elastic type. The wall is made of three shells: tunica intima, media and adventitia. Tunica intima consists of endothelium and sub-endothelium layers. Media: as an elastic type vessel, the number of elastic fibers is dominant. Adventitia: consists of collagen, the unformed loose fibrous connective tissue.

There are no generally accepted histopathological reference values in paraspinal skeletal muscle biopsies. Methods: We examined multifidii muscle biopsies from 20 neuromuscularly healthy subjects using routine histological stains and biochemical analyses of respiratory chain enzymes. Results: Staining showed incomplete myopathic features, such as increased variability in fiber size, type 1 hypertrophy, rounded fiber shape, endomysial fibrosis, and replacement by adipose tissue. Acid phosphatase reaction was positive in up to 35% of the selected muscle fibers. Mitochondrial changes were obvious but revealed no selective age dependence. Reduced complex I, cytochrome c oxidase (COX), and citrate synthase (CS) could be observed.Conclusions: Because the increased variability in morphological details can easily be misinterpreted as myopathic changes, analysis of paraspinal muscles should take into consideration that incomplete myopathic features and reduced oxidative enzyme activities for complex I, COX, and CS are normal variations at this location.

The reproductive tracts of three captive male aardvark ( Orycteropus afer) were evaluated to characterize the gross and histological anatomy, with correlations to ultrasonographic and computed tomographic imaging. Observations were made from a reproductive tract examined at necropsy, with subsequent evaluation of tissues histologically. Two living specimens were evaluated via ultrasonography with a 10-MHz linear transducer. One living animal was also evaluated via computed tomography. Prominent external scent glands were present at the base of the prepuce. Testicles were present internally at the level of the inguinal canal and capable of sliding into a subcutaneous position. Accessory sex glands consisted of seminal vesicles, prostate gland, and bulbourethral glands, with histological characteristics similar to other species. Ultrasonography was an effective tool for evaluation of internal and external reproductive structures, while the usefulness of computed tomography was limited in the evaluation of pelvic organs due to artifact from nearby bony structures. While a larger study population is desirable, this report provides an important comparative anatomical reference and will help improve the clinical management and care of this species.

The range of benign and malignant entities encountered in the oropharynx is much smaller, relative to the oral cavity and there are no “precursor” lesions in the oropharynx. The biology, morphology, treatment, and staging of oropharyngeal squamous carcinomas are vastly different than squamous carcinomas just centimeters anterior, in the oral cavity. High-risk Human Papillomavirus (HR-HPV) -mediated oropharyngeal cancers can be recognized by the following possible features: nonkeratinizing, “inside-out” maturation, and multinucleated and/pr pleomorphic tumor cells. Metastatic HR-HPV mediated oropharyngeal cancers are frequently cystic. Immunohistochemistry for p16 is now standard of care for staging oropharyngeal carcinomas according to new 8th American Joint Cancer Committee standards.

Background The bicipital tunnel is the extra-articular, fibro-osseous structure that encloses the long head of the biceps tendon. Methods Twelve cadaveric shoulder specimens underwent in situ casting of the bicipital tunnel with methyl methacrylate cement to demonstrate structural competence (n = 6) and en bloc harvest with gross and histologic evaluation (n = 6). The percentage of empty tunnel was calculated histologically by subtracting the proportion of cross-sectional area of the long head of the biceps tendon from that of the bicipital tunnel for each zone. Results Cement casting demonstrated that the bicipital tunnel was a closed space. Zone 1 extended from the articular margin to the distal margin of the subscapularis tendon. Zone 2 extended from the distal margin of the subscapularis tendon to the proximal margin of the pectoralis major tendon. Zone 3 was the subpectoral region. Zones 1 and 2 were both enclosed by a dense connective tissue sheath and demonstrated the presence of synovium. Zone 3 had significantly greater percentage of empty tunnel than zones 1 and 2 did ( P Conclusion The bicipital tunnel is a closed space with 3 distinct zones. Zones 1 and 2 have similar features, including the presence of synovium, but differ from zone 3. A significant bottleneck occurs between zone 2 and zone 3, most likely at the proximal margin of the pectoralis major tendon. The bicipital tunnel is a closed space where space-occupying lesions may produce a bicipital tunnel syndrome. Careful consideration should be given to surgical techniques that decompress both zones 1 and 2 of the bicipital tunnel.

Online version: ; Seagal, Z. M. (Zoltan Moishevich), 1944- author. ; Topographical and pathotopographical medical atlas of the head and neck ; Hoboken, New Jersey : Wiley, [2018] ; 9781119459767 ; (DLC) 2017053720.

To assess retrospectively whether diffusion-weighted magnetic resonance imaging (DW-MRI) allows physicians to determine the severity of histopathologic findings in biopsies of renal allograft patients with deteriorating renal function. Forty consecutive kidney transplant patients underwent DW-MRI and biopsy. Patients were assigned to one group with severe and to another group with normal or mild histopathologic findings. These two groups were compared based on a qualitative DW-MRI assessment (homo-/heterogeneity) and the combination of qualitative and quantitative DW-MRI parameters (ADC, and intravoxel incoherent motion, IVIM, parameters: D, f, D*). Sensitivity, specificity, and accuracy were determined for each parameter. Biopsy findings were severe in 25 patients and normal or mild in 15 patients. Qualitative DW-MRI led to a sensitivity of 44.0% and a specificity of 93.3%. Combined qualitative and quantitative DW-MRI led to an accuracy of 80% for both the minimal ADC (ADCmin) and the minimal perfusion fraction (fmin) with a sensitivity of 84.0% and 92.0% and a specificity of 73.3% and 60.0%, respectively. Combined qualitative and quantitative DW-MRI might allow physicians to determine the severity of histopathologic findings in biopsies of a high number of kidney transplant patients. • Qualitative DW-MRI is highly specific when predicting the severity of kidney transplant biopsy. • Allografts appearing heterogeneous on ADC are associated with severe histopathologic findings. • Combining qualitative and quantitative DW-MRI parameters improves the classification’s sensitivity and accuracy. • Kidney transplant biopsies might be spared by combining qualitative and quantitative DW-MRI.

Background: This study aimed to develop a classification that precisely describes the extensor carpi ulnaris (ECU) groove morphology. Methods: Reconstructed axial plane computed tomography scans of the wrists of 200 patients were reviewed. Three groups of groove shape were created based on the position of the deepest point: deviated to the ulnar side (Type U), in the middle of the groove (Type M), and deviated to the radial side (Type R). Groove depth, width, carrying angle, and radius of the curvature were measured using the Picture Archiving and Communication System in a slice in which the ulnar head was the largest. Results: Type U was present in 88 patients (44%), Type M in 74 patients (37%), and Type R in 38 patients (19%). The average depth, width, carrying angle, and radius of curvature were 2.2 mm, 9.2 mm, 135.8° and 7.0 mm, respectively. Depth, width, and carrying angle were normally distributed. Both depth and width were statistically correlated with the carrying angle; groove depth and width were not correlated. ECU groove shape and depth showed excellent intra- and inter-observer reliabilities; the reliabilities for the width were poor. Therefore, depth subgroups were defined using cutoffs of ±2 standard deviations (SD): d1 (≤-2 SD), ≤1.0 mm; d2 (±SD), 1.1–3.3 mm; and d3 (≥+2 SD), ≥3.4 mm. The 200 wrists were classified as follows: 0.5% Ud1, 40.2% Ud2, 1.3% Ud3, 0.8% Md1, 38.3% Md2, 0.8% Md3, 1.5% Rd1, 16.4% Rd2, and 0.2% Rd3. Conclusions: The detailed morphology of the ECU groove was classified using three major types and depth subgroups. The Type R ECU groove, which lacks a medial bony buttress, might be more prone to ECU-related injuries. This classification helps to understand the ECU tendon-related injury pathologies and may provide valuable information for treatment decisions; however, further research is necessary.

The plantar calcaneal spur (PCS) is a bony outgrowth from the calcaneal tuberosity and has been studied using various methods including cadavers, radiography, histology and surgery. However, there are currently a number of discrepancies in the literature regarding the anatomical relations, histological descriptions and clinical associations of PCS. Historically, authors have described the intrinsic muscles of the foot and/or the plantar fascia as attaching to the PCS. In this article we review the relationship between the PCS and surrounding soft tissues as well as examining the histology of the PCS. We identify a number of key associations with PCS, including age, weight, gender, arthritides, plantar fasciitis and foot position; these factors may function as risk factors in PCS formation. The etiology of these spurs is a contentious issue and it has been explained through a number of theories including the degenerative, inflammatory, traction, repetitive trauma, bone-formers and vertical compression theories. We review these and finish by looking clinically at the evidence that PCS causes heel pain.

Sebaceous glands are composed of sebaceous lobules and sebaceous ducts. Each sebaceous lobule consists of a group of sebocytes, which produce a holocrine secretion.

The males of four species of the Asian frog genus Limnonectes [Limnonectes dabanus (Smith, 1922a), Limnonectes gyldenstolpei (Andersson, 1916), Limnonectes macrognathus (Boulenger, 1917), and Limnonectes plicatellus (Stoliczka, 1873)] exhibit remarkable ornamentation in the form of a swollen, or cap-like, structure (caruncle) on the top of their heads. These caruncles vary in their appearance among species, and neither their function nor their actual systematic value is known. We compared their anatomy via dissections, morphometrics, radiography, and histology, and analysed the available mitochondrial DNA sequences as well as new data to place these species within the context of a larger phylogenetic hypothesis for Limnonectes. Despite the externally different morphology, the underlying histological structure is virtually identical. Beneath skin that is densely packed with mucous glands lies a pad of connective tissue overlaying the parietal bone. The actual function of the caruncle, however, remains enigmatic. In addition to the presence of the caruncle, independent evidence from osteological characters and molecular data support the monophyly of a clade comprising of L. dabanus, L. gyldenstolpei, L. macrognathus, and L. plicatellus. The caruncles are therefore interpreted as a robust autapomorphy for this clade, and suggest that the subgenus Elachyglossa should be restricted to the four species in question. © 2014 The Linnean Society of London

A heightened sense of self-esteem is associated with a reduced risk for several types of affective and psychiatric disorders, including depression, anxiety and eating disorders. However, little is known about how brain systems integrate self-referential processing and positive evaluation to give rise to these feelings. To address this, we combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) to test how frontostriatal connectivity reflects long-term trait and short-term state aspects of self-esteem. Using DTI, we found individual variability in white matter structural integrity between the medial prefrontal cortex and the ventral striatum was related to trait measures of self-esteem, reflecting long-term stability of self-esteem maintenance. Using fMRI, we found that functional connectivity of these regions during positive self-evaluation was related to current feelings of self-esteem, reflecting short-term state self-esteem. These results provide convergent anatomical and functional evidence that self-esteem is related to the connectivity of frontostriatal circuits and suggest that feelings of self-worth may emerge from neural systems integrating information about the self with positive affect and reward. This information could potentially inform the etiology of diminished self-esteem underlying multiple psychiatric conditions and inform future studies of evaluative self-referential processing.

This study provides a detailed description of the major morphoanatomic and ultrastructural features of the nasal gland in turkeys. In this avian species, nasal or salt glands are bilateral, pale pink, elongated to spindle-shaped, serous, tubuloalveolar structures, with a mean length ranging from 0.64 ± 0.15 cm in poults of 4 days of age to 2.15 ± 0.17 cm at 22 weeks. Instead of having a supraorbital location as commonly seen in waterfowl and other avian species, these glands run underneath the lacrimal, frontal, and nasal bones in turkeys. The reference point for sample collection for histologic examination is just before the rostral edge of the eyelid. Each gland adheres to the surrounding bone through a thick capsule of dense connective tissue merging with the skull periosteum. Histologically, the salt gland consists of secretory tubuloalveolar structures, lined by cuboidal epithelial cells with a central canaliculus and ducts. There are small and large ducts lined by a bilayered epithelium consisting of large apical columnar secretory cells occasionally admixed with rare cuboidal cells. These cells are periodic acid Schiff negative and slightly Alcian blue positive. Both alveolar and secretory ductal cells contain slightly electrondense granular vesicles, highly folded lateral surfaces, and large numbers of mitochondria, characteristic of ion-transporting epithelia. This study provides valuable information for the accurate identification and localization of the nasal gland during necropsy, as well as its correct histologic interpretation, ultimately improving our understanding of the role of this gland in the pathophysiology of specific diseases in turkeys.

The cerebral ventricles have been recognized since ancient medical history. Their true function started to be realized more than a thousand years later. Their anatomy and function are extremely important in the neurosurgical panorama. The literature was searched for articles and textbooks of different topics related to the history, anatomy, physiology, histology, embryology and surgical considerations of the brain ventricles. Herein, we summarize the literature about the cerebral ventricular system.

The intracranial bridging veins are pathways crucial for venous drainage of the brain. They are not only involved in pathological conditions but also serve as important landmarks within neurological surgery. The medical literature on bridging veins was reviewed in regard to their historical aspects, embryology, histology, anatomy, and surgery. Knowledge on the intracranial bridging veins and their dynamics has evolved over time and is of great significance to the neurosurgeon.

Background:The major lymphatic vessels may be damaged during neck dissection or other cervical surgery, resulting in chyloma or chyle fistula. While commonly considered to be predominantly a complication of left-sided surgery, the thoracic duct may be damaged on either side of the neck due to the extreme variability in the anatomy of the central lymphatic system.Method and results:This paper reviews the variable anatomy and embryology of the thoracic and right lymphatic ducts, particularly aspects relevant to head and neck surgery.

Understanding the structure and function of the oropharynx is paramount for providing excellent patient care. In clinical oncology, the oropharynx is generally divided into four distinct components: (i) the base of the tongue; (ii) the soft palate; (iii) the palatine tonsillar fossa; and (iv) the pharyngeal wall. The oropharyngeal mucosa is distinct from other mucosal surfaces in the body, as it is composed of a reticulated epithelium with a discontinuous basement membrane, also known as lymphoepithelium. This review describes the anatomy, histology, immunology and surgical resection of the oropharynx as they relate to oncological care.

PURPOSE: To describe the anatomical course of the intralaryngeal portion of the inferior laryngeal nerve (ILN) and to standardize the surgical access to its thyroarytenoid branch (TAb) through the thyroid cartilage. METHODS: Under surgical microscopy, 33 adult human excised larynges were dissected, to expose the intralaryngeal portion of ILN. The point of entry of TAb, ILN's terminal branch, in the thyroarytenoid (TA) muscle was determined and correlated with thyroid cartilage dimensions. RESULTS: After entering the larynx, the ILN consistently traveled between the thyroid cartilage and the lateral cricoarytenoid muscle in an anterior and slightly cranial course. The distance from the point of entry of the TAb in the TA muscle to the midline (TAb-H) and to the inferior border (TAb-V) of the thyroid cartilage differed according to gender. In females, mean distances of TAb-H and TAb-V were 20.5mm and 5.2mm and in males, 22.3mm and 5.9mm, respectively. CONCLUSION: The intralaryngeal course of the inferior laryngeal nerve presents low variability and measures from landmarks in the thyroid cartilage help to estimate the point of entry of thyroarytenoid branch in thyroarytenoid muscle.

Introduction The aim of the present study was to demonstrate that lung elastance and transpulmonary pressure can be determined without using oesophageal pressure measurements. Methods Studies were performed on 13 anesthetized and sacrificed ex vivo pigs. Tracheal and oesophageal pressures were measured and changes in end-expiratory lung volume (ΔEELV) determined by spirometry as the cumulative inspiratory-expiratory tidal volume difference. Studies were performed with different end-expiratory pressure steps [change in end-expiratory airway pressure (ΔPEEP)], body positions and with abdominal load. Results A PEEP increase results in a multi-breath build-up of end-expiratory lung volume. End-expiratory oesophageal pressure did not increase further after the first expiration, constituting half of the change in ΔEELV following a PEEP increase, even though end-expiratory volume continued to increase. This resulted in a successive left shift of the chest wall pressure–volume curve. Even at a PEEP of 12 cmH2O did the end-expiratory oesophageal (pleural) pressure remain negative. Conclusions A PEEP increase resulted in a less than expected increase in end-expiratory oesophageal pressure, indicating that the chest wall and abdomen gradually can accommodate changes in lung volume. The rib cage end-expiratory spring-out force stretches the diaphragm and prevents the lung from being compressed by abdominal pressure. The increase in transpulmonary pressure following a PEEP increase was closely related to the increase in PEEP, indicating that lung compliance can be calculated from the ratio of the change in end-expiratory lung volume and the change in PEEP, ΔEELV/ΔPEEP.