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Oral cancer imposes a great threat to an individual’s life, which can be mitigated effectively if detection, confirmation takes place earlier during the disease. Transforming growth factor-𝛽 (TGF-𝛽) plays an integral role as a regulator in governing many biological processes. TGF-𝛽 level rises in saliva of oral cancer patients, thus it could be used as a biomarker for detection. The aim of this study was to construct a recombinant expression system containing transforming growth beta receptor II (TGF𝛽RII) and Collagen type II alpha I chain (Col2a1) (intronic region) along with green fluorescent proteins signals.