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5 results on '"Bagnarelli L."'

2. Synthesis, reactivity and cytotoxic properties of water soluble coinage metal N-Heterocyclic Carbene complexes

Author

Bagnarelli L., Santini C., Porchia M., Tisato F., Marzano C., Gandin V., and Pellei M.

Subjects
Reactivity properties, Cytotoxic properties, ynthesis, Ag(I), Cu(I), Au(I)
Abstract

Recently we have focused the research work on 11th group metal-NHCs complexes obtained from water soluble 1,3-symmetrically and 1,3-unsymmetrically substituted NHCs precursors based on imidazole and benzoimidazole scaffolds4-6...

Published
2019

4. Cu(I) and Cu(II) Complexes Based on Lonidamine-Conjugated Ligands Designed to Promote Synergistic Antitumor Effects

Author

Fabio Del Bello, Maura Pellei, Luca Bagnarelli, Carlo Santini, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Chiara Battocchio, Giovanna Iucci, Irene Schiesaro, Carlo Meneghini, Iole Venditti, Nitya Ramanan, Michele De Franco, Paolo Sgarbossa, Cristina Marzano, Valentina Gandin, Del Bello, F., Pellei, M., Bagnarelli, L., Santini, C., Giorgioni, G., Piergentili, A., Quaglia, W., Battocchio, C., Iucci, G., Schiesaro, I., Meneghini, C., Venditti, I., Ramanan, N., De Franco, M., Sgarbossa, P., Marzano, C., and Gandin, V.

Subjects
Tumor, Crystallography, Indazoles, Molecular Structure, Antineoplastic Agents, Crystallography, X-Ray, Ligands, Cell Line, Inorganic Chemistry, Cell Line, Tumor, Copper, Humans, Coordination Complexes, X-Ray, copper complexes, Physical and Theoretical Chemistry
Abstract

Bis(pyrazol-1-yl)- and bis(3,5-dimethylpyrazol-1-yl)-acetates were conjugated with the 2-hydroxyethylester and 2-aminoethylamide derivatives of the antineoplastic drug lonidamine to prepare Cu(I) and Cu(II) complexes that might act through synergistic mechanisms of action due to the presence of lonidamine and copper in the same chemical entity. Synchrotron radiation-based complementary techniques [X-ray photorlectron spectroscopy and near-edge X-ray absorption fine structure (NEXAFS)] were used to characterize the electronic and molecular structures of the complexes and the local structure around the copper ion (XAFS) in selected complexes. All complexes showed significant antitumor activity, proving to be more effective than the reference drug cisplatin in a panel of human tumor cell lines, and were able to overcome oxaliplatin and multidrug resistance. Noticeably, these Cu complexes appeared much more effective than cisplatin against 3D spheroids of pancreatic PSN-1 cancer cells; among these, PPh3-containing Cu(I) complex 15 appeared to be the most promising derivative. Mechanistic studies revealed that 15 induced cancer cell death by means of an apoptosis-alternative cell death.

Published
2022

5. Metal Coordination Core in Copper(II) Complexes Investigated by XAFS

Author

Luca Bagnarelli, Irene Schiesaro, Giovanna Iucci, Chiara Battocchio, Carlo Meneghini, Maura Pellei, Iole Venditti, Carlo Santini, Schiesaro, I., Venditti, I., Pellei, M., Santini, C., Bagnarelli, L., Iucci, G., Battocchio, C., and Meneghini, C.

Subjects
chemistry.chemical_classification, Valence (chemistry), Extended X-ray absorption fine structure, Synchrotron radiation, XAFS, Inorganic chemistry, Copper complexe, chemistry.chemical_element, Context (language use), Anticancer drug, Copper, XANES, Coordination complex, X-ray absorption fine structure, Metal, Nanoparticle, chemistry, visual_art, visual_art.visual_art_medium
Abstract

In recent years the biomedical research has focused on new metal-based anticancer drugs. Among them Cu-based antitumor agents are arising some attention based on the observation that endogenous metals appear to be less toxic toward normal cells with respect to cancer ones. Conjugating the Cu(II) complexes with hydrophilic gold nanoparticles (Au-NPs) appears a promising way, suitable to improve the complexes solubility and stability in water and to raise their bioavailability. In this context, we investigated the valence state and coordination chemistry of Cu for a selection of Cu-complexes suitable for grafting on Au-NPs. The Cu K-edge XAFS data were analysed in the near edge (XANES) and extended (EXAFS) regions to obtain preliminary characterization aimed at understanding local coordination chemistry and electronic structure of Cu.

Published
2021

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