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1. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Author

Butte, Atul, Mazur, PK, Reynoird, N, Khatri, P, Jansen, PWTC, Wilkinson, AW, Liu, S, Barbash, O, Van, GS, Huddleston, M, and Dhanak, D

Subjects
bacteria, complex mixtures
Abstract

Deregulation of lysine methylation signalling has emerged as a common aetiological factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics. The largely cytoplasmic KMT SMYD3 (S

Published
2014

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