1. 18F-FDG PET/CT as Predictive of Response after Chemoradiation in Esophageal Cancer Patients
- Author
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Elimova, Elena, Wang, Xuemei, Etchebehere, Elba, Shiozaki, Hironori, Shimodaira, Yusuke, Wadhwa, Roopma, Planjery, Venkatram, Charalampakis, Nikolaos, Blum, Mariela A., Hofstetter, Wayne, Lee, Jeff H., Weston, Brian R., Bhutani, Manoop S., Rogers, Jane E., Maru, Dipen, Skinner, Heath D., Macapinlac, Homer A., and Ajani, Jaffer A.
- Subjects
Adult ,Bridged-Ring Compounds ,Male ,Esophageal Neoplasms ,Organoplatinum Compounds ,Kaplan-Meier Estimate ,Multimodal Imaging ,Article ,Fluorodeoxyglucose F18 ,Antineoplastic Combined Chemotherapy Protocols ,Outcome Assessment, Health Care ,Humans ,Prospective Studies ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Remission Induction ,Chemoradiotherapy ,Middle Aged ,Prognosis ,Oxaliplatin ,Positron-Emission Tomography ,Female ,Taxoids ,Fluorouracil ,Tomography, X-Ray Computed - Abstract
The purpose of this study was to evaluate if a baseline, an interim or a post-chemoradiation (CTRT) 18-fluorodeoxy-glucose positron emission computed tomography (18F-FDG PET/CT) studies could provide information on pathologic response to CTRT and overall survival (OS).Thirty-one patients with histologically proven adenocarcinoma or squamous cell carcinoma of the oesophagus, fit for trimodality therapy were prospectively enrolled. Most were men (93.5%), and had a stage III cancer (74.2%). Chemotherapy consisted of oxaliplatin/5-fluorouracil (45.2%) and taxane/5-fluorouracil (54.8%). All patients underwent a baseline, an interim (performed 12 ± 2 days after the onset of CTRT) and a post-CTRT 18F-FDG PET/CT study. The 18F-FDG PET/CT variables evaluated were at baseline, interim and post-CTRT studies maximum standardised uptake value (SUV max) and total lesion glycolysis (TLG). Clinical and 18F-FDG PET/CT parameters were correlated with pathologic complete response (pathCR) and OS.Among the 31 patients studied, 61.3% achieved a clinical complete response (cCR) and 87.1% had surgery. The median OS was 35.1 months (95% confidence interval (CI): 19.9-NA). PathCR rate was 22.2%. There was only a marginal association between cCR and pathCR (p = 0.06). None of the other variables was predictive of pathCR. There was association between OS and baseline TLG (p = 0.03) at the optimal cutoff TLG value of 75.15. Additionally, TLG and ΔTLG post-CTRT were also associated with OS (p = 0.01 and 0.03, respectively).None of the PET parameters is predictive of pathCR but TLG at baseline and post-CTRT are prognostic of OS.
- Published
- 2015