1. Gut microbiome associations with host genotype vary across ethnicities and potentially influence cardiometabolic traits
- Author
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Boulund, Ulrika, Bastos, Diogo M., Ferwerda, Bart, van den Born, Bert-Jan, Pinto-Sietsma, Sara-Joan, Galenkamp, Henrike, Levin, Evgeni, Groen, Albert K., Zwinderman, Aeilko H., Nieuwdorp, Max, Experimental Vascular Medicine, Graduate School, ACS - Diabetes & metabolism, ACS - Amsterdam Cardiovascular Sciences, Epidemiology and Data Science, ANS - Neuroinfection & -inflammation, Public and occupational health, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, APH - Global Health, APH - Personalized Medicine, ACS - Heart failure & arrhythmias, APH - Methodology, APH - Health Behaviors & Chronic Diseases, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Amsterdam Gastroenterology Endocrinology Metabolism
- Subjects
causality ,Genotype ,microbiome ,Microbiology ,Gastrointestinal Microbiome ,immune system ,Glutamates ,Cardiovascular Diseases ,Virology ,Mendelian randomization ,Ethnicity ,Humans ,Parasitology ,HELIUS cohort ,metabolism ,genome wide association study ,cardiometabolic health ,Genome-Wide Association Study - Abstract
Previous studies in mainly European populations have reported that the gut microbiome composition is associated with the human genome. However, the genotype-microbiome interaction in different ethnicities is largely unknown. We performed a large fecal microbiome genome-wide association study of a single multiethnic cohort, the Healthy Life in an Urban Setting (HELIUS) cohort (N = 4,117). Mendelian randomization was performed using the multiethnic Pan-UK Biobank (N = 460,000) to dissect potential causality. We identified ethnicity-specific associations between host genomes and gut microbiota. Certain microbes were associated with genotype in multiple ethnicities. Several of the microbe-associated loci were found to be related to immune functions, interact with glutamate and the mucus layer, or be expressed in the gut or brain. Additionally, we found that gut microbes potentially influence cardiometabolic health factors such as BMI, cholesterol, and blood pressure. This provides insight into the relationship of ethnicity and gut microbiota and into the possible causal effects of gut microbes on cardiometabolic traits.
- Published
- 2022