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2. Grade 4 Neutropenia Secondary to Immune Checkpoint Inhibition — A Descriptive Observational Retrospective Multicenter Analysis

Author

Zaremba, Anne, Kramer, Rafaela, De Temple, Viola, Bertram, Stefanie, Salzmann, Martin, Gesierich, Anja, Reinhardt, Lydia, Baroudjian, Barouyr, Sachse, Michael M., Mechtersheimer, Gunhild, Johnson, Douglas B., Weppler, Alison M., Spain, Lavinia, Loquai, Carmen, Dudda, Milena, Pföhler, Claudia, Hepner, Adriana, Long, Georgina V., Menzies, Alexander M., Carlino, Matteo S., Lebbé, Céleste, Enokida, Tomohiro, Tahara, Makoto, Bröckelmann, Paul J., Eigentler, Thomas, Kähler, Katharina C., Gutzmer, Ralf, Berking, Carola, Ugurel, Selma, Stadtler, Nadine, Sucker, Antje, Becker, Jürgen, Livingstone, Elisabeth, Meier, Friedegund, Hassel, Jessica C., Schadendorf, Dirk, Hanoun, Maher, Heinzerling, Lucie, and Zimmer, Lisa

Subjects
Medizinische Fakultät » Universitätsklinikum Essen » Westdeutsches Tumorzentrum Essen (WTZ) » Pädiatrische Hämatologie/Onkologie, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Pathologie und Neuropathologie, Oncology, Medizin, malignant melanoma, immune checkpoint inhibition, neutropenia, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Dermatologie, adverse events, Original Research, hematotoxicity
Abstract

Introduction: Immune checkpoint inhibitors (ICI) are increasingly being used to treat numerous cancer types. Together with improved recognition of toxicities, this has led to more frequent identification of rare immune-related adverse events (irAE), for which specific treatment strategies are needed. Neutropenia is a rare hematological irAE that has a potential for a high mortality rate because of its associated risk of sepsis. Prompt recognition and timely treatment of this life-threatening irAE are therefore critical to the outcome of patients with immune-related neutropenia. Methods: This multicenter international retrospective study was conducted at 17 melanoma centers to evaluate the clinical characteristics, diagnostics, treatment, and outcomes of melanoma patients with grade 4 neutropenia (

Published
2021

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