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Additional file 1 Additional tables and R code to reproduce the analyses.

Genital warts are a common and highly contagious sexually transmitted disease. They have a large economic burden and affect several aspects of quality of life. Incidence data underestimate the real occurrence of genital warts because this infection is often under-reported, mostly due to their specific characteristics such as the asymptomatic course. Genital warts cases for the analysis were obtained from the catalan public health system database (SIDIAP) for the period 2009-2016, covering 74\% of the Catalan population. People under 15 and over 94 years old were excluded from the analysis as the incidence of genital warts in this population is negligible. This work introduces a time series model based on a mixture of two distributions, capable of detecting the presence of under-reporting in the data. In order to identify potential differences in the magnitude of the under-reporting issue depending on sex and age, these covariates were included in the model. This work shows that only about 80\% in average of genital warts incidence in Catalunya in the period 2009-2016 was registered, although the frequency of under-reporting has been decreasing over the study period. It can also be seen that the under-reported issue has a deeper impact on women over 30 years old. The registered incidence in the Catalan public health system is underestimating the real burden in almost 10,000 cases in Catalunya, around 23\% of the registered cases. The total annual cost in Catalunya is underestimated in at least about 10 million Euros respect the 54 million Euros annually devoted to genital warts in Catalunya, representing 0.4\% of the total budget of the public health system.

Fundamentos: La conducta sexual en jóvenes se ve influida por factores externos que pueden favorecer una disminución del control de la situación y mayor desprotección. Objetivo: describir y comparar según sexo la conducta sexual y otros indicadores de salud sexual y reproductiva en jóvenes (16-24 años) en Cataluña e identificar factores asociados a las conductas sexuales de riesgo. Métodos: Estudio transversal realizado en 2012 mediante encuesta en línea a partir de un panel de población (n=800). Se identificaron factores asociados al no uso del preservativo (no UP) en la última relación sexual con penetración (RS) mediante modelos de regresión logística multivariantes. Resultados: El 76,1% de los chicos y el 83,3% de las chicas declararon RS alguna vez (p=0,012). El 39,7% de los chicos y el 22,5% de las chicas tuvieron parejas ocasionales, siendo el uso de Internet para contactar parejas del 31,4% y 10,3%, respectivamente. Entre los factores asociados al no UP durante la última RS destacó no haber usado preservativo en la primera RS (OR=2,50 en chicos y OR=3,18 en chicas). Haber contactado parejas sexuales por Internet se mostró asociado en chicos (OR=2,29) y haber usado la anticoncepción de emergencia ≥3 veces en chicas (OR=3,38). Conclusiones: Se observan diferencias en la conducta sexual de los jóvenes según sexo, siendo el uso del preservativo en la primera relación sexual un buen predictor de su uso en la última. Los chicos presentan mayor número de parejas ocasionales que las chicas y utilizan más las nuevas tecnologías de la información para contactar estas parejas. Background: Sexual behavior in young people is influenced by external factors that may increase their vulnerability. Objective: to describe sexual behavior and other indicators of sexual and reproductive health among young people (16 to 24 years) in Catalonia and to identify factors associated with sexual risk behaviors. Methods: Cross-sectional study in 2012 carried out by an online survey from a panel of population (n=800). Factors associated with not using a condom at last sexual intercourse were evaluated using multivariate logistic regression models. Results: 76.1% of boys and 83.3% of girls reported having had complete sexual intercourse (p=0.012). The proportion of boys and girls who reported casual partners was 39.7% and 22.5%, respectively. 31.4% of boys and 10.3% of girls reported having contacted partners through Internet. Not using a condom at first sexual intercourse showed significant association with reporting not using a condom in the last sexual intercourse, for both, boys (OR= 2.50) and girls (OR= 3.18). Having contacted partners through the Internet (OR=2.29) was associated with this risky sexual behavior in boys, and having used the emergency contraception 3 or more times (OR=3.38) was associated in girls. Conclusions: There are differences in the sexual behavior of young people by sex, being condom use at first sexual relationship a good predictor of condom use at last sexual intercourse. Boys show a higher number of casual partners than girls, as well as a higher use of the Internet to contact sexual partners.