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245 results on '"Buschmann J"'

1. RIFM fragrance ingredient safety assessment, isoeugenyl acetate, CAS Registry Number 93-29-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

2. RIFM fragrance ingredient safety assessment, cis-3-hexenyl propionate, CAS Registry Number 33467-74-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

3. RIFM fragrance ingredient safety assessment, p-mentha-1,3-diene, CAS Registry Number 99-86-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

4. Corrigendum to 'RIFM fragrance ingredient safety assessment, 2,2,6-trimethylcyclohexanone, CAS Registry Number 2408-37-9' [Food and Chemical Toxicology 134, Supplement 1, 2019, 110723, ISSN 0278-6915]

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Francis, M., Fryer, A.D., Jones, L., Joshi, K., La Cava, S., Lapczynski, A., Liebler, D.C., O'Brien, D., Patel, A., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Salvito, D., Schultz, T.W., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., Tsang, S., and Publica

Abstract

The authors regret that the following paragraph (the first paragraph under ""9.1.2. Risk assessment"") was included in error and should be disregarded: ""2,2,6-Trimethylcyclohexanone was assessed in the BlueScreen assay and found negative for both cytotoxicity (positive: < 80% relative cell density) and genotoxicity, with and without metabolic activation (RIFM, 2013). BlueScreen is a screening assay that assesses genotoxic stress through alterations in gene expressions in a human cell line. Additional assays were considered to fully assess the potential mutagenic or clastogenic effects of the target material."" The authors would like to apologise for any inconvenience caused.

Published
2022

5. RIFM fragrance ingredient safety assessment, citronellyl butyrate, CAS Registry number 141-16-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

6. RIFM fragrance ingredient safety assessment, hex-3-enyl acetate, CAS Registry Number 1708-82-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

7. RIFM fragrance ingredient safety assessment, cadinene, CAS Registry Number 29350-73-0

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

8. RIFM fragrance ingredient safety assessment, p-tert-butylcyclohexanone, CAS Registry Number 98-53-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

9. RIFM fragrance ingredient safety assessment, 3,5,5-trimethyl-1-hexanol, CAS Registry Number 3452-97-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

10. RIFM fragrance ingredient safety assessment, cyclooct-4-en-1-yl methyl carbonate, CAS registry number 87731-18-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

11. RIFM fragrance ingredient safety assessment, 6-methoxy-2,6-dimethylheptan-1-al, CAS Registry Number 62439-41-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

12. RIFM fragrance ingredient safety assessment, ethyl isovalerate, CAS Registry Number 108-64-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

13. RIFM fragrance ingredient safety assessment, tetrahydro-6-(3-pentenyl)-2H-pyran-2-one, CAS Registry Number 32764-98-0

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Abstract

The existing information supports the use of this material as described in this safety assessment. Tetrahydro-6-(3-pentenyl)-2H-pyran-2-one was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that tetrahydro-6-(3-pentenyl)-2H-pyran-2-one is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class II material, and the exposure to tetrahydro-6-(3-pentenyl)-2H-pyran-2-one is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). Data and read-across to 5-hydroxy-7-decenoic acid δ-lactone (CAS # 25,524-95-2) show that there are no safety concerns for tetrahydro-6-(3-pentenyl)-2H-pyran-2-one for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on data and ultraviolet/visible (UV/Vis) spectra; tetrahydro-6-(3-pentenyl)-2H-pyran-2-one is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; tetrahydro-6-(3-pentenyl)-2H-pyran-2-one was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are

Published
2022

14. RIFM fragrance ingredient safety assessment, 3-thujopsanone, CAS Registry Number 25966-79-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

15. RIFM fragrance ingredient safety assessment, myraldyl acetate, CAS Registry Number 72403-67-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

16. RIFM fragrance ingredient safety assessment, cis-3-hexenyl formate, CAS registry number 33467-73-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

17. RIFM fragrance ingredient safety assessment, 5-heptenenitrile, 2,6-dimethyl-, CAS Registry Number 54088-65-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

18. RIFM fragrance ingredient safety assessment, oxacyclopentadec-10-en-2-one, 13-methyl-, CAS Registry Number 329925-33-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

19. RIFM fragrance ingredient safety assessment, trans-methylgeranate, CAS Registry Number 1189-09-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

20. RIFM fragrance ingredient safety assessment, dl-limonene (racemic), CAS Registry Number 138-86-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

21. RIFM fragrance ingredient safety assessment, citronellyl acetate, CAS Registry Number 150-84-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

22. RIFM fragrance ingredient safety assessment, 4-ethylguaiacol, CAS Registry Number 2785-89-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

23. RIFM fragrance ingredient safety assessment, l-carvone, CAS Registry Number 6485-40-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Abstract

l-Carvone was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that l-carvone is not genotoxic and provided a No Expected Sensitization Induction Level (NESIL) of 2600 μg/cm2 for the skin sensitization endpoint. Data on l-carvone provided a calculated Margin of Exposure (MOE) >100 for the repeated dose toxicity and reproductive toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on data and ultraviolet/visible (UV/Vis) spectra; l-carvone is not phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class II material (0.47 mg/day); the exposure to l-carvone is below the TTC. The environmental endpoints were evaluated; l-carvone was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are

Published
2022

24. RIFM fragrance ingredient safety assessment, phenethyl phenylacetate, CAS Registry Number 102-20-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Abstract

The existing information supports the use of this material as described in this safety assessment. Phenethyl phenylacetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that phenethyl phenylacetate is not genotoxic. Data provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data on read-across analog benzyl benzoate (CAS # 120-51-4) provide an MOE >100 for the developmental toxicity endpoint. The fertility and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to phenethyl phenylacetate is below the TTC (0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from analog benzyl phenylacetate (CAS # 102-16-9) show that there are no safety concerns for phenethyl phenylacetate for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra; phenethyl phenylacetate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; phenethyl phenylacetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are

Published
2022

25. RIFM fragrance ingredient safety assessment, o-tolylethanol, CAS Registry Number 19819-98-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

26. RIFM fragrance ingredient safety assessment, α-methylcinnamic alcohol, CAS Registry Number 1504-55-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

27. RIFM fragrance ingredient safety assessment, cis-3-hexenyl methyl carbonate, CAS Registry Number 67633-96-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Abstract

The following paper presents the method of determination of the percolation threshold in cement composites with expanded graphite by impedance spectroscopy. Most of the applications of cement composites with conductive additives require exceeding the percolation threshold. The ionic conductivity of cement matrix below the percolation threshold has a major impact on the conductivity of the composite, as a result, it significantly hinders the exploitation of these composites. The electric properties of cement composites with expanded graphite were evaluated by DC measurements and impedance spectroscopy (IS). Based on Nyquist plots, two equivalent circuits were adopted for the composites. Next, the values of capacitance and inductance of cement composites with expanded graphite were calculated from the fitted equivalent circuits. The analysis of the results shows that the percolation threshold occurs when the reactance of the composite changes from captative to in ductive. Comparison between the values of percolation threshold obtained from DC measurements and IS shows that the method is effective for cement composites with conductive additives.

Published
2022

28. RIFM fragrance ingredient safety assessment, cis-3-hexenyl butyrate, CAS Registry Number 16491-36-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

29. RIFM fragrance ingredient safety assessment, hydroxycitronellal, CAS Registry Number 107-75-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

30. RIFM fragrance ingredient safety assessment, trans-2-nonenal, CAS Registry Number 18829-56-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

31. RIFM fragrance ingredient safety assessment, α-pinene, CAS Registry Number 80-56-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

32. RIFM fragrance ingredient safety assessment, tetrahydrolinalyl acetate, CAS Registry Number 20780-48-7

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

33. RIFM fragrance ingredient safety assessment, myrcenyl acetate, CAS Registry Number 1118-39-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura Y., and Publica

Published
2022

34. RIFM fragrance ingredient safety assessment, methyl N-methylanthranilate, CAS Registry Number 85-91-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

35. RIFM fragrance ingredient safety assessment, 4,8-undecadienal, (4Z,8E)-, CAS Registry Number 1958027-16-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

36. RIFM fragrance ingredient safety assessment, bisabolene, CAS registry number 495-62-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

37. RIFM fragrance ingredient safety assessment, anisole, CAS Registry Number 100-66-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

38. RIFM fragrance ingredient safety assessment, sodium benzoate, CAS Registry Number 532-32-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

39. RIFM fragrance ingredient safety assessment, cis-jasmone, CAS registry number 488-10-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A. Jr., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2022

40. RIFM fragrance ingredient safety assessment, 2-decenal, CAS registry number 3913-71-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Subjects
Aldehydes, Odorants, TOXICOLOGIA AMBIENTAL, General Medicine, Registries, Alkenes, Toxicology, Food Science, Perfume
Published
2021

41. RIFM fragrance ingredient safety assessment, cinnamyl isobutyrate, CAS Registry Number 103-59-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

42. RIFM fragrance ingredient safety assessment, 4,9-dodecadienal, (4Z,9Z)-, CAS Registry Number 1801275-28-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

43. RIFM fragrance ingredient safety assessment, trans-3-heptenyl 2-methylpropanoate, CAS Registry Number 67801-45-0

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

44. RIFM fragrance ingredient safety assessment, dihydrocoumarin, CAS Registry Number 119-84-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

45. RIFM fragrance ingredient safety assessment, p-tolualdehyde, CAS Registry Number 104-87-0

Author

Api, A.M., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Lavelle, M., Liebler, D.C., Na, M., O'Brien, D., Patel, A., Penning, T.M., Ritacco, G., Rodriguez-Ropero, F., Romine, J., Sadekar, N., Salvito, D., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., Tsang, S., and Publica

Abstract

The existing information supports the use of this material as described in this safety assessment. p-Tolualdehyde was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, and environmental safety. Data from read-across analog benzaldehyde (CAS # 100-52-7) show that p-tolualdehyde is not expected to be genotoxic. Data from read-across analog cuminaldehyde (CAS # 122-03-2) provided p-tolualdehyde a No Expected Sensitization Induction Level (NESIL) of 1100 mg/cm2 for the skin sensitization endpoint. The repeated dose toxicity, developmental and reproductive toxicity, and local respiratory toxicity endpoints were completed using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to p-tolualdehyde is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on data from read-across analog 4-ethylbenzaldehyde (CAS # 4748-78-1); p-tolualdehyde is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; p-tolualdehyde was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are

Published
2021

46. RIFM fragrance ingredient safety assessment, cis-3-Heptenyl acetate, CAS Registry Number 1576-78-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

47. RIFM fragrance ingredient safety assessment, ethyl heptanoate, CAS Registry Number 106-30-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

48. RIFM fragrance ingredient safety assessment, 3-methyl-1-cyclopentadecanone, CAS Registry Number 541-91-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

49. RIFM fragrance ingredient safety assessment, citronellyl formate, CAS Registry number 105-85-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Published
2021

50. RIFM fragrance ingredient safety assessment, 4,8-decadienal, (4Z,8Z)-, CAS Registry Number 1958027-35-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Buschmann, J., Cancellieri, M.A., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., Tokura, Y., and Publica

Abstract

4,8-Decadienal, (4Z,8Z)- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs 4,7-decadienal (CAS # 934534-30-2) and nona-2-trans-6-cis-dienal (CAS # 557-48-2) show that 4,8-decadienal, (4Z,8Z)- is not expected to be genotoxic. Data on analog 10-undecenal (CAS # 112-45-8) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and fertility endpoints and a No Expected Sensitization Induction Level (NESIL) of 1700 mg/cm2 for the skin sensitization endpoint. The developmental toxicity and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class I materials; exposure is below the TTC (0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 4,8-decadienal, (4Z,8Z)- is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 4,8-decadienal, (4Z,8Z)- was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. Its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are

Published
2021

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