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1. High-Resolution Wavefront-Guided Photorefractive Keratectomy and Accelerated Corneal Crosslinking for Stabilization and Visual Rehabilitation of Keratoconus Eyes

Author

Tamayo GE, Castell C, Vargas P, Polania E, and Tamayo J

Subjects
Ophthalmology, genetic structures, visual rehabilitation of keratoconus, high resolution wavefront-guided surface ablation with corneal crosslinking, sense organs, keratoconus management, RE1-994, wavefront-guided prk with cxl, eye diseases
Abstract

Gustavo E Tamayo, Claudia Castell, Pilar Vargas, Eduardo Polania, Juliana Tamayo Bogota Laser Ocular Surgery Center, Bogota, ColombiaCorrespondence: Gustavo E Tamayo Tel +1 305 987 0527Email centrogustavotamayo@gmail.comPurpose: To evaluate the visual and refractive outcomes after high-resolution wavefront-guided (HRWG) surface ablation with corneal crosslinking (CXL) in keratoconus eyes.Patients and Methods: In this prospective, interventional case series, 47 eyes of 28 progressive keratoconus patients older than age 18 were enrolled. All patients underwent HRWG photorefractive keratectomy (PRK) with simultaneous accelerated CXL. The study parameters were manifest refraction spherical equivalent (MRSE), keratometric outcomes, uncorrected (UDVA) and corrected distance visual acuity (CDVA) at postoperative 6 and 12 months.Results: There was improvement in mean MRSE from − 2.39± 1.89 D preoperatively to − 0.13 ± 0.68 D at 12 months, with corresponding improvement in UDVA from 0.77 ± 0.35 logMAR to 0.08 ± 0.12 logMAR and CDVA from 0.10 ± 0.11 logMAR to 0.02 ± 0.04 logMAR. Preoperative flat and steep keratometry (K) were 4wct 32.49 ± 1.67 D and 45.94 ± 2.10 D, respectively, and at postoperative 12 months were 41.36 ± 2.08 D and 42.65 ± 2.78 D, respectively. At postoperative 12 months, visual and refractive outcomes were maintained. Comparisons between preoperative and postoperative 12 month timepoints were statistically significant for all parameters.Conclusion: Simultaneous wavefront-guided PRK followed by CXL is a promising treatment for the visual rehabilitation of keratoconus patients.Keywords: keratoconus management, high-resolution wavefront-guided surface ablation with corneal crosslinking, wavefront-guided PRK with CXL

Published
2020

2. Guías de práctica clínica basadas en la evidencia para el manejo de la sedoanalgesia y delirium en el paciente adulto críticamente enfermo

Author

Celis Rodríguez, E., Díaz Cortés, J. C., Cárdenas Bolívar, Y. R., Carrizosa González, J. A., Pinilla, D. I., Ferrer Záccaro, L. E., Birchenall, C., Caballero López, J., Argüello, B. M., Castillo Abrego, G., Castorena Arellano, G., Dueñas Castell, C., Jáuregui Solórzano, J.M., Leal, R., Pardo Oviedo, J. M., Arroyo, M., Raffán Sanabria, F., Raimondi, N., Reina, R., Rodríguez Lima, D. R., Silesky Jiménez, J. I., Ugarte Ubiergo, S., Gómez Escobar, L.G., Gómez Escobar, L. G., Díaz Aya, D.P., Díaz Aya, D. P., Fowler, C., and Nates, J. L.

Subjects
Guía de práctica clínica, Agitation, Critical care, Delirio, Sedación consciente, Delirium, Pain, Cuidado intensivo, Agitación, Analgesia, Dolor, Critical Care and Intensive Care Medicine
Abstract

Dada la importancia del manejo de la sedación, analgesia y delirium en las unidades de cuidados intensivos, y con el fin de actualizar las guías publicadas anteriormente, se decidió elaborar una nueva guía de práctica clínica con los soportes, manejos e intervenciones más relevantes acordes con las publicaciones recientes. Para elaborar esta guía, se reunió un grupo de 24 intensivistas procedentes de 9 países de la Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva. Se acogió la propuesta del Grading of Recommendations Assessment, Development and Evaluation Working Group para emitir el grado de recomendación y evaluar la calidad de la evidencia. Se realizó una búsqueda sistemática de la literatura utilizándose: MEDLINE, las siguientes bases de datos de la biblioteca Cochrane: Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects (DARE), National Health Service Economic Evaluation Database (NHS EED), y la base de datos de Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS). Finalmente, se seleccionaron 438 referencias, permitiendo realizar 47 recomendaciones fuertes con evidencia alta y moderada, 14 recomendaciones condicionales con evidencia moderada y 65 recomendaciones condicionales con evidencia baja. Se confirma la importancia del manejo inicial y multimodal del dolor, se hace énfasis en la disminución de los niveles de sedación y la utilización de sedación profunda solo en casos específicos. Aumenta la evidencia y recomendaciones para el uso de medicamentos como dexmedetomidina, remifentanil, ketamina, entre otros. Abstract Given the importance of the management of sedation, analgesia and delirium in Intensive Care Units, and in order to update the previously published guidelines, a new clinical practice guide is presented, addressing the most relevant management and intervention aspects based on the recent literature. A group of 24 intensivists from 9 countries of the Pan-American and Iberian Federation of Societies of Critical Medicine and Intensive Therapy met to develop the guidelines. Assessment of evidence quality and recommendations was made according to the Grading of Recommendations Assessment, Development and Evaluation Working Group. A systematic search of the literature was carried out using MEDLINE, Cochrane Library databases such as the Cochrane Database of Systematic Reviews (CDSR) and the Cochrane Central Register of Controlled Trials (CENTRAL), the Database of Abstracts of Reviews of Effects (DARE), the National Health Service Economic Evaluation Database (NHS EED) and the database of Latin American and Caribbean Literature in Health Sciences (LILACS). A total of 438 references were selected. After consensus, 47 strong recommendations with high and moderate quality evidence, 14 conditional recommendations with moderate quality evidence, and 65 conditional recommendations with low quality evidence were established. Finally, the importance of initial and multimodal pain management was underscored. Emphasis was placed on decreasing sedation levels and the use of deep sedation only in specific cases. The evidence and recommendations for the use of drugs such as dexmedetomidine, remifentanil, ketamine and others were incremented

Published
2021

3. Iodine Deficiency and Mortality in Spanish Adults: Di@bet.es Study

Author

Maldonado-Araque C, Valdes S, Badia-Guillen R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, Gutierrez-Repiso C, Goday-Arno A, Calle-Pascual A, Castano L, Castell C, Delgado Alvarez E, Menendez Torre E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Soriguer F, and Rojo-Martinez G

Subjects
iodine, Spain, epidemiology, mortality
Abstract

BACKGROUND: Longitudinal data assessing the impact of Iodine deficiency on mortality are scarce. We aimed to study the association between the state of iodine nutrition and the risk of total and cause-specific mortality in a representative sample of the Spanish adult population.; METHODS: We performed a longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the nation-wide study Di@bet.es (2008-2010). We used Cox regression to assess the association between UI at the start of the study (

Published
2021

4. Validity of a method for the self-screening of cardiovascular risk

Author

Barroso M, Pérez- Fernández S, Vila MM, Zomeño MD, Martí-Lluch R, Cordon F, Ramos R, Elosua R, Degano IR, Fitó M, Cabezas C, Salvador G, Castell C, and Grau M

Subjects
Preventive medicine, Cardiovascular diseases, Epidemiology, lcsh:RC109-216, Public Health, Risk assessment, lcsh:Infectious and parasitic diseases
Abstract

María Barroso,1–3 Silvia Pérez-Fernández,1,4 M Mar Vila,1,4,5 M Dolors Zomeño,6,7 Ruth Martí-Lluch,8 Ferran Cordon,9 Rafel Ramos,8,10,11 Roberto Elosua,1,4 Irene R Degano,1,4 Montse Fitó,5,12 Carmen Cabezas,13 Gemma Salvador,13 Conxa Castell,13 María Grau1,4,14 1Cardiovascular Epidemiology and Genetics Research Group, IMIM-Hospital del Mar Research Institute, 2Centre d’Atenció Primària La Marina, Direcció d’Atenció Primària Barcelona, Institut Català de la Salut, 3Department of Pediatrics, Obstetrics, Gynecology and Preventive Medicine, School of Medicine, Autonomous University of Barcelona, 4Consortium for Biomedical Research in Cardiovascular Disease (CIBERCV), 5Department of Mathematics and Computer Science, University of Barcelona, 6Cardiovascular Risk and Nutrition, IMIM-Hospital del Mar Research Institute, 7School of Health Sciences, Blanquerna-Ramon Llull University, Barcelona, Spain; 8Unitat de Suport a la Recerca de Girona, Institut Universitari d’Investigació en Atenció Primària Jordi Gol, 9Centre d’Atenció Primària Montilivi, Direcció d’Atenció Primària Girona, Institut Català de la Salut, 10Department of Medical Sciences, School of Medicine, University of Girona, 11Girona Biomedical Research Institute, Girona, Spain; 12Consortium for Biomedical Research in Obesity and Nutrition (CIBEROBN), 13Catalan Agency of Public Health, 14Department of Medicine, University of Barcelona, Barcelona, Spain Background: The validity of a cardiovascular risk self-screening method was assessed. The results obtained for self-measurement of blood pressure, a point-of-care system’s assessment of lipid profile and glycated hemoglobin, and a self-administered questionnaire (sex, age, diabetes, tobacco consumption) were compared with the standard screening (gold standard) conducted by a health professional. Methods: Crossover clinical trial on a population-based sample from Girona (north-eastern Spain), aged 35–74, with no cardiovascular disease at recruitment. Participants were randomized to one of the two risk assessment sequences (standard screening followed by self-screening or vice versa). Cardiovascular risk was estimated with the Framingham-REGICOR function. Concordance between methods was estimated with the intraclass correlation coefficient (ICC). Sensitivity, specificity, and positive and negative predictive values were estimated, considering 5% cardiovascular risk as the cutoff point. ClinicalTrials.gov Registration #NCT02373319. Clinical Research Ethic Committee of the Parc de Salut Mar Registration #2014/5815/I. Results: The median cardiovascular risk in men was 2.56 (interquartile range: 1.42–4.35) estimated by standard methods and 2.25 (1.28–4.07) by self-screening with ICC=0.92 (95% CI: 0.90–0.93). In women, the cardiovascular risk was 1.14 (0.61–2.10) by standard methods and 1.10 (0.56–2.00) by self-screening, with ICC=0.89 (0.87–0.90). The sensitivity, specificity, and positive and negative predictive values for the self-screening method were 0.74 (0.63–0.82), 0.97 (0.95–0.99), 0.86 (0.77–0.93), and 0.94 (0.91–0.96), respectively, in men. In women, these values were 0.50 (0.30–0.70), 0.99 (0.98–1), 0.81 (0.54–0.96), and 0.97 (0.95–0.99), respectively. Conclusion: The self-screening method for assessing cardiovascular risk provided similar results to the standard method. Self-screening had high clinical performance to rule out intermediate or high cardiovascular risk. Keywords: risk assessment, cardiovascular diseases, preventive medicine, public health, epidemiology, empowerment

Published
2018

5. High-resolution wavefront-guided surface ablation with corneal cross-linking in ectatic corneas: a pilot study

Author

Tamayo GE, Castell C, Vargas P, Polania E, and Tamayo J

Subjects
ectasia, Ophthalmology, genetic structures, High resolution wavefront-guided ablation, wavefront-guided PRK with CXL, high resolution wavefront aberrometry, sense organs, keratoconus treatment, RE1-994, eye diseases
Abstract

Gustavo E Tamayo, Claudia Castell, Pilar Vargas, Eduardo Polania, Juliana Tamayo Bogota Laser Ocular Surgery Center, Bogota, Colombia Purpose: A preliminary study to evaluate the outcomes of high-resolution wavefront-guided (HRWG) photorefractive keratectomy (PRK) with simultaneous corneal cross-linking (CXL) in ectasia eyes.Methods: Sixteen eyes of 11 patients (mean age 31.9±9.8 years; range: 15–48 years) with keratoconus or post-laser-assisted in situ keratomileusis ectasia underwent HRWG PRK with simultaneous CXL. Manifest refraction, uncorrected (UDVA) and corrected distance visual acuity (CDVA), and keratometric and aberrometric outcomes are reported at 12 months.Results: Significant improvement was observed postoperatively in visual acuity, refraction, and keratectomy in all eyes. At postoperative 12 months, 87.5% eyes were within ±1.0 D of attempted correction and 81.25% of eyes had a postoperative UDVA of 20/32 or better. A gain of 2 or more lines of CDVA was observed in 12.5% (2/16) of eyes and there was no change in CDVA lines in 25% (4/16) eyes. A substantial reduction in higher-order aberrations was observed in all eyes postoperatively; however, the improvement was not statistically significant.Conclusion: The outcomes of HRWG PRK in ectasia eyes with estimated residual stromal bed thickness of at least 350 µm (without epithelium) are promising at postoperative 1year and provide surgeons with a valuable tool to improve vision with a high degree of refractive predictability. Keywords: wavefront ablation, corneal cross linking, irregular astigmatism, keratoconus, ectasia

Published
2017

6. The Incidence of Obesity, Assessed as Adiposity, Is Reduced After 1 Year in Primary Schoolchildren by the POIBA Intervention

Author

Ariza, C, Sanchez-Martinez, F, Serral, G, Valmayor, S, Juarez, O, Pasarin, MI, Castell, C, Rajmil, L, Lopez, MJ, Cortina, C, Diez, E, Lorenzo, C, Roca, D, Sagarra, N, Suades, E, Roure, E, Lozano, N, Llinas, M, Moncada, A, Montero, Y, Ortega, E, and Guerra, M

Subjects
adiposity, effectiveness evaluation, physical activity, childhood prevention, school-based program, healthy eating
Abstract

Background: Childhood obesity is becoming a serious problem, and prevention programs are needed. Objective: The purpose of this study was to evaluate, after 1 y, the effectiveness of a multicomponent, school-based obesity intervention program. Methods: This intervention, conducted in Barcelona, Spain, was a quasi-experimental obesity primary prevention intervention targeting schoolchildren aged 9-10 y. Participants were assigned to an intervention group (IG) (1464 students) or to a comparison group (CG) (1609 students). The intervention consisted of a 9-session classroom program, 6 weekly sessions of physical education and out-of-school physical activity, and a workshop for families. It lasted from October 2011 to May 2012. Data obtained at baseline (spring 2011) and follow-up (spring 2012) included information on nutrition and physical activity, through 2 self-reported questionnaires, and measurement of weight, height, triceps skinfold thickness, and waist circumference. The cumulative incidence rate (CIR) of obesity was calculated from triceps skinfold measures. A multilevel logistic regression model was fitted to determine the association between the intervention and the CIR of obesity. The effect size of the program was estimated with Cohen's criteria. Results: The overall prevalence of obesity at baseline was 12.7%. At the 12-mo follow-up, the incidence of obesity was 7.8% in the IG compared with 11.4% in the CG (P < 0.005), representing 31% fewer new cases of obesity in the IG. The Cohen's d effect size of the program was 0.33. In the multilevel analysis, there was a protective effect of the intervention on the CIR of obesity at 12 mo (OR: 0.7; 95% CI: 0.5, 0.9) (P = 0.009). Conclusions: The first Prevencion de la Obesidad Infantil en Barcelona (Childhood Obesity Prevention in Barcelona) (POIBA) intervention, targeting children aged 9-10 y, reduced the incidence of obesity as measured by adiposity. The intervention could prevent 1 in 3 new cases of childhood obesity in this age range.

Published
2019

7. Dairy Product Consumption and Metabolic Diseases in the Di@bet.es Study

Author

Lago-Sampedro A, García-Escobar E, Rubio-Martín E, Pascual-Aguirre N, Valdés S, Soriguer F, Goday A, Calle-Pascual A, Castell C, Menéndez E, Delgado E, Bordiú E, Castaño L, Franch-Nadal J, Girbés J, Chaves FJ, Gaztambide S, Rojo-Martínez G, and Olveira G

Published
2019

8. Overweight and childhood obesity according to socioeconomic variables in third grade school-age children in the city of Barcelona

Author

Cano, GS, Ciges, RB, Sanchez-Martinez, F, Cardenal, CA, Cortina, C, Diez, E, Juarez, O, Lorenzo, C, Pasarin, M, Roca, D, Sagarra, N, Castell, C, Roure, E, Lozano, N, Llinas, M, Moncada, A, Rajmil, L, Montero, Y, and Ortega, E

Subjects
Obesity, Overweight, Socioeconomic factors, Childhood
Abstract

Introduction: childhood overweight and obesity have increased progressively in the last decades, especially in countries of Southern Europe. Objective: to analyze the association of overweight and obesity childhood in the city of Barcelona according to socioeconomic variables in schoolchildren in third grade primary school. Methods: transversal study. Study population: third grade primary school students in the city of Barcelona in year 2011 (n = 3,624). Body mass index was studied as the dependent variable, and sex, age, social class, parental status, origin, ownership school, neighborhood socioeconomic status of the school and district were studied as independent. Logistic regression models were analyzed, obtaining odds ratio (OR) with 95% confidence intervals (95% CI). Results: the prevalence of overweight and obesity in childhood were 24.5% and 13.8%, respectively. The variables associated with obesity were: boy (OR = 1.26; 95% CI = 1.02-1.57), low socioeconomic status (OR = 1.60; 95% CI = 1.16-2.20), single-parent family (OR = 1.35; 95% CI = 1.03-1.77), immigrant (OR = 1.68; 95% CI = 1.33-2.13) and living in one of the less favored districts of Barcelona. Conclusions: it is evident that social class, origin, family status and the district of residence play an important role in childhood obesity.

Published
2019

9. The photosynthetic cytochrome c550 from the diatom Phaeodactylum tricornutum

Author

Bernal-Bayard, P., Puerto-Galán, L., Yruela, I., García-Rubio, I., Castell, C., Ortega, J. M., Alonso, P. J., Roncel, M., Martínez, J. I., Hervás, M., and Navarro, J. A.

Abstract

The photosynthetic cytochrome c550 from the marine diatom Phaeodactylum tricornutum has been purified and characterized. Cytochrome c550 is mostly obtained from the soluble cell extract in relatively large amounts. In addition, the protein appeared to be truncated in the last hydrophobic residues of the C-terminus, both in the soluble cytochrome c550 and in the protein extracted from the membrane fraction, as deduced by mass spectrometry analysis and the comparison with the gene sequence. Interestingly, it has been described that the C-terminus of cytochrome c550 forms a hydrophobic finger involved in the interaction with photosystem II in cyanobacteria. Cytochrome c550 was almost absent in solubilized photosystem II complex samples, in contrast with the PsbO and Psb31 extrinsic subunits, thus suggesting a lower affinity of cytochrome c550 for the photosystem II complex. Under iron-limiting conditions the amount of cytochrome c550 decreases up to about 45% as compared to iron-replete cells, pointing to an iron-regulated synthesis. Oxidized cytochrome c550 has been characterized using continuous wave EPR and pulse techniques, including HYSCORE, and the obtained results have been interpreted in terms of the electrostatic charge distribution in the surroundings of the heme centre.

Published
2017

10. Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease

Author

Dégano, I.R. Subirana, I. Fusco, D. Tavazzi, L. Kirchberger, I. Farmakis, D. Ferrières, J. Azevedo, A. Torre, M. Garel, P. Brosa, M. Davoli, M. Meisinger, C. Bongard, V. Araújo, C. Lekakis, J. Francès, A. Castell, C. Elosua, R. Marrugat, J. on behalf of the EUROTRACS investigators

Abstract

Background Percutaneous coronary intervention (PCI) reduces mortality in most myocardial infarction (MI) patients but the effect on elderly patients with comorbidities is unclear. Our aim was to analyse the effect of PCI on in-hospital mortality of MI patients, by age, sex, ST elevation on presentation, diabetes mellitus (DM) and chronic kidney disease (CKD). Methods Cohort study of 79,791 MI patients admitted at European hospitals during 2000–2014. The effect of PCI on in-hospital mortality was analysed by age group (18–74, ≥ 75 years), sex, presence of ST elevation, DM and CKD, using propensity score matching. The number needed to treat (NNT) to prevent a fatal event was calculated. Sensitivity analyses were conducted. Results PCI was associated with lower in-hospital mortality in ST and non-ST elevation MI (STEMI and NSTEMI) patients. The effect was stronger in men [Odds ratio (95% confidence interval) 0.30 (0.25–0.35)] than in women [0.46 (0.39–0.54)] aged ≥ 75 years, and in NSTEMI [0.22 (0.17–0.28)] than in STEMI patients [0.40 (0.31–0.5)] aged < 75 years. PCI reduced in-hospital mortality risk in patients with and without DM or CKD (54–72% and 52–73% reduction in DM and CKD patients, respectively). NNT was lower in patients with than without CKD [≥ 75 years: STEMI = 6(5–8) vs 9(8–10); NSTEMI = 10(8–13) vs 16(14–20)]. Sensitivity analyses such as exclusion of hospital stays < 2 days yielded similar results. Conclusions PCI decreased in-hospital mortality in MI patients regardless of age, sex, and presence of ST elevation, DM and CKD. This supports the recommendation for PCI in elderly patients with DM or CKD. © 2017 The Authors

Published
2017

11. Reference Values for TSH may be Inadequate to Define Hypothyroidism in Persons with Morbid Obesity: Di@bet.es Study

Author

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, Gutiérrez-Repiso C, Garcia-Escobar E, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Bordiú E, Castaño L, Castell C, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Ortega E, Vendrell J, Chacón MR, Javier Chaves F, Soriguer F, and Rojo-Martínez G

Subjects
Adult, Aged, 80 and over, Male, Observer Variation, Adolescent, Thyrotropin, Middle Aged, Overweight, Thyroid Function Tests, Obesity, Morbid, Thyroxine, Young Adult, Cross-Sectional Studies, Hypothyroidism, Thinness, Reference Values, Spain, Prevalence, Humans, Triiodothyronine, Female, Aged, Autoantibodies
Abstract

Objective: To analyze the reference range of thyroid-stimulating hormone (TSH) in different BMI categories and its impact on the classification of hypothyroidism. Methods: The study included 3,928 individuals free of thyroid disease (without previous thyroid disease, no interfering medications, TSH < 10 mu UI/mL and thyroid peroxidase antibodies [TPO Abs] < 50 IU/mL) who participated in a national, cross-sectional, population-based study and were representative of the adult population of Spain. Data gathered included clinical and demographic characteristics, physical examination, and blood and urine sampling. TSH, free thyroxine, free triiodothyronine, and TPO Ab were analyzed by electrochemiluminescence (E170, Roche Diagnostics, Basel, Switzerland). Results: The reference range (p2.5-97.5) for TSH was estimated as 0.6 to 4.8 mu UI/mL in the underweight category (BMI= 40). By using the reference criteria for the normal-weight population, the prevalence of high TSH levels increased threefold in the morbid obesity category (P < 0.01). Conclusions: Persons with morbid obesity might be inappropriately classified if the standard ranges of normality of TSH for the normal-weight population are applied to them.

Published
2017

12. Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999

Author

THE DIAMOND PROJECT GROUP, BESSAOUD K, BOUDRAA G, DE ROPOLO MM, DE SEREDAY M, MARTI ML, MOSER M, LAPERTOSA S, DAMIANO M, VERGE C, HOWARD N, SCHOBER E, JORDAN O, WEETS I, GORUS F, COECKELBERGHS M, ROOMAN R, VAN GAAL L, FRANCO LJ, FERREIRA SRG, LISBOA HPK, KURTZ LA, GRAEBIN R, KUTZKE L, RODRIGES C, SAVOVA R, CHRISTOV V, IOTOVA V, TZANEVA V, PACAUD D, TOTH E, TAN MH, CARRASCO E, PEREZ F, ZE Y, BO Y, CHEN S, FU L, DENG L, SHEN S, TENG K, WANG C, JIAN H, JU J, YAN C, DENG Y, LI C, ZHANG Y, LIU Y, LONG X, ZHEN Z, SUN Z, WANG B, WONG G, ORREGO OV, ASCHNER P, DIAZ DIAZ O, DE ACOSTA OM, CINEK O, VAVRINEC J, OLSEN BS, SVENDSEN AJ, KREUTZFELDT J, LUND E, TULL ES, SELMAN GEARA A, ALMONTE AS, PODAR T, TUOMILEHTO J, KARVONEN M, NOTKOLA IL, MOLTCHANOVA E, TASKINEN O, LEVY MARCHAL C, CZERNICHOW P, KOCAVA M, NEU A, EHEHALT S, ROSENBAUER J, GIANI G, ICKS A, BARTSOCAS C, VAZEOU A, SOLTESZ G, LARON Z, GORDON O, ALBAG Y, SHAMIS I, PURRELLO F, ARPI M, FICHERA G, MANCUSO M, LUCENTI C, CHIUMELLO G, BRUNO G, PAGANO G, SONGINI M, CASU A, MARINARO A, FRONGIA P, ZEDDA MA, MILIA A, TENCONI MT, POZZILLI P, VISALLI N, SEBASTIANI L, MARIETTI G, BUZZETTI R, CHERUBINI V, OKUNO A, HARADA S, MATSUURA N, MIKI E, MIYAMOTO S, SASAKI N, MIMURA G, SHALTOUT A, QABAZRD M, AL KHAWARI M, BRIGIS G, DZIVITE I, KADIKI O, URBONAITE B, DE BEAUFORT C, GAREEBOO H, RUEDA OA, REESER M, ELLIOTT R, SCOTT R, WILLIS J, DARLOW B, JONER G, RAFIQUE G, JAWAD F, JIMENEZ J, PALACIOS CM, CANETE F, VERA J, ALMIRON R, BENITEZ GE, ESPINOLA CS, SECLEN S, WOZNICKA D, SZYBINSKI Z, PLACZKIEWICZ E, JAROSZ CHOBOT P, MENEZES C, PINA EA, RUAS MMA, RODRIGUES FJC, ABREU S, IONESCU TIRGOVISTE C, SHUBNIKOV E, MICHALKOVA D, BARK L, HLAVA P, MIKULECKY M, KRZISNIK C, BATTELINO T, URSIC NB, KOTNIK P, KO KW, CASTELL C, GODAY A, MAGZOUB M, DAHLQUIST G, SCHOENLE E, NAGATI K, KHALIFA FB, BURDEN A, RAYMOND N, MILLWARD BA, ZHAO H, PATTERSON CC, CARSON D, HADDEN D, SMAIL P, MCSPORRAN B, WAUGH N, BINGLEY P, MCKINNEY PA, FELTBOWER RG, BODANSKY HJ, CAMPBELL F, LAPORTE RE, LIBMAN I, ROSEMAN J, RAHMAN SMA, DE LLADO TF, LIPTON R, JORGE AM, GUNCZLER P, LANES R., DEVOTI, Gabriele, THE DIAMOND PROJECT, Group, Bessaoud, K, Boudraa, G, DE ROPOLO, Mm, DE SEREDAY, M, Marti, Ml, Moser, M, Lapertosa, S, Damiano, M, Verge, C, Howard, N, Schober, E, Jordan, O, Weets, I, Gorus, F, Coeckelberghs, M, Rooman, R, VAN GAAL, L, Franco, Lj, Ferreira, Srg, Lisboa, Hpk, Kurtz, La, Graebin, R, Kutzke, L, Rodriges, C, Savova, R, Christov, V, Iotova, V, Tzaneva, V, Pacaud, D, Toth, E, Tan, Mh, Carrasco, E, Perez, F, Ze, Y, Bo, Y, Chen, S, Fu, L, Deng, L, Shen, S, Teng, K, Wang, C, Jian, H, Ju, J, Yan, C, Deng, Y, Li, C, Zhang, Y, Liu, Y, Long, X, Zhen, Z, Sun, Z, Wang, B, Wong, G, Orrego, Ov, Aschner, P, DIAZ DIAZ, O, DE ACOSTA, Om, Cinek, O, Vavrinec, J, Olsen, B, Svendsen, Aj, Kreutzfeldt, J, Lund, E, Tull, E, SELMAN GEARA, A, Almonte, A, Podar, T, Tuomilehto, J, Karvonen, M, Notkola, Il, Moltchanova, E, Taskinen, O, LEVY MARCHAL, C, Czernichow, P, Kocava, M, Neu, A, Ehehalt, S, Rosenbauer, J, Giani, G, Icks, A, Bartsocas, C, Vazeou, A, Soltesz, G, Laron, Z, Gordon, O, Albag, Y, Shamis, I, Purrello, F, Arpi, M, Fichera, G, Mancuso, M, Lucenti, C, Chiumello, G, Bruno, G, Pagano, G, Songini, M, Casu, A, Marinaro, A, Frongia, P, Zedda, Ma, Milia, A, Tenconi, Mt, Devoti, Gabriele, Pozzilli, P, Visalli, N, Sebastiani, L, Marietti, G, Buzzetti, R, Cherubini, V, Okuno, A, Harada, S, Matsuura, N, Miki, E, Miyamoto, S, Sasaki, N, Mimura, G, Shaltout, A, Qabazrd, M, AL KHAWARI, M, Brigis, G, Dzivite, I, Kadiki, O, Urbonaite, B, DE BEAUFORT, C, Gareeboo, H, Rueda, Oa, Reeser, M, Elliott, R, Scott, R, Willis, J, Darlow, B, Joner, G, Rafique, G, Jawad, F, Jimenez, J, Palacios, Cm, Canete, F, Vera, J, Almiron, R, Benitez, Ge, Espinola, C, Seclen, S, Woznicka, D, Szybinski, Z, Placzkiewicz, E, JAROSZ CHOBOT, P, Menezes, C, Pina, Ea, Ruas, Mma, Rodrigues, Fjc, Abreu, S, IONESCU TIRGOVISTE, C, Shubnikov, E, Michalkova, D, Bark, L, Hlava, P, Mikulecky, M, Krzisnik, C, Battelino, T, Ursic, Nb, Kotnik, P, Ko, Kw, Castell, C, Goday, A, Magzoub, M, Dahlquist, G, Schoenle, E, Nagati, K, Khalifa, Fb, Burden, A, Raymond, N, Millward, Ba, Zhao, H, Patterson, Cc, Carson, D, Hadden, D, Smail, P, Mcsporran, B, Waugh, N, Bingley, P, Mckinney, Pa, Feltbower, Rg, Bodansky, Hj, Campbell, F, Laporte, Re, Libman, I, Roseman, J, Rahman, Sma, DE LLADO, Tf, Lipton, R, Jorge, Am, Gunczler, P, and Lanes, R.

Subjects
Male, Adolescent, type 1 diabetes, Incidence, Endocrinology, Diabetes and Metabolism, Infant, Newborn, Infant, Global Health, World Health Organization, trend, Diabetes Mellitus, Type 1, Endocrinology, Child, Preschool, geographical distribution, incidence, Internal Medicine, Humans, epidemiology, Female, Child
Abstract

Aims. To examine incidence and trends of Type 1 diabetes worldwide for the period 1990–1999. Methods. The incidence of Type 1 diabetes (per 100000/year) was analysed in children aged ≤ 14 years from 114 populations in 112 centres in 57 countries. Trends in the incidence of Type 1 diabetes were analysed by fitting Poisson regression models to the dataset. Results. A total of 43013 cases were diagnosed in the study populations of 84 million children. The age-adjusted incidence of Type 1 diabetes among 112 centres (114 populations) varied from 0.1 per 100000/year in China and Venezuela to 40.9 per 100000/year in Finland. The average annual increase in incidence calculated from 103 centres was 2.8% (95% CI 2.4–3.2%). During the years 1990–1994, this increase was 2.4% (95% CI 1.3–3.4%) and during the second study period of 1995–1999 it was slightly higher at 3.4% (95% CI 2.7– 4.3%). The trends estimated for continents showed statistically significant increases all over the world (4.0% in Asia, 3.2% in Europe and 5.3% in North America), except in Central America and the West Indies where the trend was a decrease of 3.6%. Only among the European populations did the trend in incidence diminish with age. Conclusions. The rising incidence of Type 1 diabetes globally suggests the need for continuous monitoring of incidence by using standardized methods in order to plan or assess prevention strategies.

Published
2006

13. Increase in direct diabetes-related costs and resource use in the 6 months following initiation of insulin in patients with type 2 diabetes in five European countries: data from the INSTIGATE study

Author

Jones S, Castell C, Goday A, Smith HT, Nicolay C, Simpson A, and Salaun-Martin C

Subjects
lcsh:R5-920, lcsh:Therapeutics. Pharmacology, lcsh:RM1-950, lcsh:Medicine (General), health care economics and organizations
Abstract

Stephen Jones,1 Conxa Castell,2 Albert Goday,3 Helen T Smith,4 Claudia Nicolay,5 Alexander Simpson,4 Carole Salaun-Martin61James Cook University Hospital, Middlesborough, UK; 2Department of Health, Barcelona, Spain; 3Hospital Del Mar, Barcelona, Spain; 4Eli Lilly and Company, Erl Wood, UK; 5Lilly Deutschland GmbH, Bad Homburg, Germany; 6Lilly France, Suresnes, FranceBackground: The purpose of this study was to describe the resource use and associated direct costs of diabetes care for patients with type 2 diabetes mellitus in the 6 months before and after initiation of insulin therapy.Methods: INSTIGATE is a prospective, noninterventional, multicenter study of patients with type 2 diabetes who were initiating insulin for the first time as part of their usual care in 2006. The study was conducted in France, Germany, Greece, Spain, and the UK, and observed the course of diabetes therapy for up to 6 months. Direct medical costs were evaluated from the national health care system (third-party payer) perspective at 2006 prices.Results: Of the 1153 patients with type 2 diabetes, 1051 (91.2%) had follow-up visits in the 6 months after insulin initiation and were included in the cost analysis. In all countries in our study, mean total direct costs per patient increased in the 6-month follow-up period, compared with the 6-month period prior to insulin initiation, and ranged from €577 in Greece to €1402 in France. The incremental cost of adding insulin treatment ranged from €81 in France to €471 in Spain.Conclusion: In all countries, the mean total direct cost of care for diabetes increased after starting insulin. The breakdown of total direct costs by expenditure category varied considerably across countries, reflecting differences in resource use patterns, prices of medical resources, and different health care systems.Keywords: type 2 diabetes mellitus, costs, resource use, insulin

Published
2012

14. Mapping and assessment of ecosystems and their services. Urban ecosystems

Author

Maes, J, Zulian, G, Thijssen, M, Castell, C, Baró, F, Ferreira, Am, Melo, J, Garrett, Cp, David, N, Alzetta, C, Geneletti, D, Cortinovis, C, Zwierzchowska, I, Louro Alves, F, Souto Cruz, C, Blasi, Carlo, ALOS ORTI, MARTA MARIA, Attorre, Fabio, Azzella, MATTIA MARTIN, Capotorti, Giulia, Copiz, Riccardo, Fusaro, Lina, Manes, Fausto, Marando, Federica, Marchetti, Marco, Mollo, Barbara, Salvatori, Elisabetta, Zavattero, Laura, Zingari, Pc, Giarratano, Mc, Bianchi, E, Duprè, E, Barton, D, Stange, E, Perez Soba, M, van Eupen, M, Verweij, P, de Vries, A, Kruse, H, Polce, C, Cugny Seguin, M, Erhard, M, Nicolau, R, Fonseca, A, Fritz, M, and Teller, A

Subjects
ecosystem, environmental policy, common strategy, environmental economics, environmental indicator, research report, ecology, environmental protection, biodiversity, environmental monitoring, urban area
Published
2016

15. Seasonal variation in month of diagnosis in children with type 1 diabetes registered in 23 European centers during 1989-2008: little short-term influence of sunshine hours or average temperature

Author

Patterson, Cc, Gyürüs, E, Rosenbauer, J, Cinek, O, Neu, A, Schober, E, Parslow, Rc, Joner, G, Svensson, J, Castell, C, Bingley, Pj, Schoenle, E, Jarosz-Chobot, P, Urbonaité, B, Rothe, U, Kržišnik, C, Ionescu-Tirgoviste, C, Weets, I, Kocova, M, Stipancic, G, Samardzic, M, de Beaufort, Ce, Green, Anders, Soltész, G, Dahlquist, Gg, Pathology/molecular and cellular medicine, Clinical sciences, and Diabetes Pathology & Therapy

Subjects
Europe, Male, Diabetes Mellitus, Type 1, Adolescent, Child, Preschool, Photoperiod, Temperature, Humans, Infant, Female, Registries, Seasons, Child
Abstract

BACKGROUND: The month of diagnosis in childhood type 1 diabetes shows seasonal variation.OBJECTIVE: We describe the pattern and investigate if year-to-year irregularities are associated with meteorological factors using data from 50 000 children diagnosed under the age of 15 yr in 23 population-based European registries during 1989-2008.METHODS: Tests for seasonal variation in monthly counts aggregated over the 20 yr period were performed. Time series regression was used to investigate if sunshine hour and average temperature data were predictive of the 240 monthly diagnosis counts after taking account of seasonality and long term trends.RESULTS: Significant sinusoidal pattern was evident in all but two small centers with peaks in November to February and relative amplitudes ranging from ±11 to ±38% (median ±17%). However, most centers showed significant departures from a sinusoidal pattern. Pooling results over centers, there was significant seasonal variation in each age-group at diagnosis, with least seasonal variation in those under 5 yr. Boys showed greater seasonal variation than girls, particularly those aged 10-14 yr. There were no differences in seasonal pattern between four 5-yr sub-periods. Departures from the sinusoidal trend in monthly diagnoses in the period were significantly associated with deviations from the norm in average temperature (0.8% reduction in diagnoses per 1 °C excess) but not with sunshine hours.CONCLUSIONS: Seasonality was consistently apparent throughout the period in all age-groups and both sexes, but girls and the under 5 s showed less marked variation. Neither sunshine hour nor average temperature data contributed in any substantial way to explaining departures from the sinusoidal pattern.

Published
2014

16. The association between waist circumference and risk of mortality considering body mass index in 65-to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons

Author

de Hollander, Ellen L, Bemelmans, Wanda JE, Boshuizen, Hendriek C, Friedrich, Nele, Wallaschofski, Henri, Guallar-Castillón, Pilar, Walter, Stefan, Zillikens, M Carola, Rosengren, Annika, Lissner, Lauren, Bassett, Julie K, Giles, Graham G, Orsini, Nicola, Heim, Noor, Visser, Marjolein, de Groot, Lisette CPGM, Rosengren, A., Sundh, V., Blair, S., Lee, D.C., Sui, X., Woodward, M., Welborn, T., Dhaliwal, S., Wannamethee, G., Roure, E., Castell, C., Biggs, M.L., Wolk, A., Orsini, N., Ducimetiere, P., Verschuren, M., Kaprio, J., Menotti, A., Lee, I.M., Sesso, H., Knekt, P., Sääksjärvi, K., Dekker, J., Nijpels, G., Stehouwer, C., Bandinelli, S., Corsi, A.M., Lauretani, F., Visser, M., Heim, N., Seeman, T., Ishii, S., Giles, G., Bassett, J., Spiro, A., Phillips, C., Blazer, D., Lind, L., Zillikens, M.C., Uitterlinden, A., Hofman, A., Walter, S., Tiemeier, H., de Groot, L., Wallaschofski, H., Friedrich, N., Baumeister, S., Guallar-Castillón, P., Rodríguez-Artalejo, F., Lissner, L., Skoog, I., Tunstall-Pedoe, H., Shipley, M., Kivimäki, M., Interne Geneeskunde, RS: CARIM School for Cardiovascular Diseases, Nutrition and Health, EMGO+ - Lifestyle, Overweight and Diabetes, Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Epidemiology, Internal Medicine, and Child and Adolescent Psychiatry / Psychology

Subjects
Gerontology, Male, Nutrition and Disease, Epidemiology, Respiratory Tract Diseases, cardiovascular-disease, middle-aged men, Overweight, adipose-tissue, Wiskundige en Statistische Methoden - Biometris, Body Mass Index, older-people, Microbiologie, Voeding en Ziekte, Neoplasms, Risk of mortality, follow-up, health outcomes, Non-U.S. Gov't, Abdominal obesity, Human Nutrition & Health, cardiorespiratory fitness, Research Support, Non-U.S. Gov't, Humane Voeding & Gezondheid, General Medicine, PE&RC, Cardiovascular Diseases, all-cause mortality, Waist circumference, Female, medicine.symptom, Waist Circumference, Waist, body mass index, Research Support, Microbiology, Risk Assessment, elderly, abdominal obesity, SDG 3 - Good Health and Well-being, medicine, Journal Article, Humans, Obesity, Mortality, Mathematical and Statistical Methods - Biometris, VLAG, Aged, Global Nutrition, Wereldvoeding, business.industry, Body Weight, Anthropometry, mortality, Confidence interval, Relative risk, business, coronary-heart-disease, Body mass index, Demography, Meta-Analysis
Abstract

BACKGROUND: For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined.METHODS: Age- and smoking-adjusted relative risks (RRs) of mortality associated with WC-BMI categories and continuous WC (including WC and WC(2)) were calculated by the investigators and pooled by means of random-effects models.RESULTS: During a 5-year-follow-up of 32 678 men and 25 931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: ≥102 cm, women: ≥88 cm) was associated with increased all-cause mortality RRs for those in the 'healthy' weight {1.7 [95% confidence interval (CI): 1.2-2.2], 1.7 (95% CI: 1.3-2.3)}, overweight [1.1(95% CI: 1.0-1.3), 1.4 (95%: 1.1-1.7)] and obese [1.1 (95% CI: 1.0-1.3), 1.6 (95% CI: 1.3-1.9)] BMI category compared with the 'healthy' weight (20-24.9 kg/m(2)) and a small WC (CONCLUSIONS: Our results showed increased mortality risks for elderly people with an increased WC-even across BMI categories- and for those who were classified as 'underweight' using BMI. The results provide a solid basis for re-evaluation of WC cut-points in ageing populations.

Published
2012

17. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study

Author

Vendrell, J., Vázquez, J.A., Valdés, S., Serrano-Rios, M., Rojo-Martínez, G., Pascual-Manich, G., Ortega, E., Mora-Peces, I., Menéndez, E., Martínez-Larrad, M.T., López-Alba, A., Gutiérrez, G., Gomis, R., Girbés, J., Gaztambide, S., Franch, J., Delgado, E., Catalá, M., Castell, C., Castaño, L., Casamitjana, R., Carmena, R., Bordiú, E., Bosch-Comas, A., Goday, A., Soriguer, F., Runkle, I., Fuentes, M., Calle-Pascual, A.L., Marcuello, C., Medicina i Cirurgia, and Universitat Rovira i Virgili.

Subjects
1687-8337, humanities
Abstract

10.1155/2012/872305 Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population. Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted. Results. Mean PCS-12/MCS-12 values were /, respectively. Men had higher scores than women in both PCS-12 ( versus ; ) and MCS-12 ( versus ; ). Increasing age and obesity were associated with a poorer PCS-12 score. In women lower PCS-12 and MCS-12 scores were associated with a higher level of glucose metabolism abnormality (prediabetes and diabetes), ( for trend), but only the PCS-12 score was associated with altered glucose levels in men ( for trend). The Odds Ratio adjusted for age, body mass index (BMI) and educational level, for a PCS-12 score below the median was 1.62 (CI 95%: 1.2–2.19; ) for men with KDM and 1.75 for women with KDM (CI 95%: 1.26–2.43; ), respectively. Conclusion. Current study indicates that increasing levels of altered carbohydrate metabolism are accompanied by a trend towards decreasing quality of life, mainly in women, in a representative sample of Spanish population.

Published
2012
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18. Incidence of Childhood Type 1 Diabetes Worlwide

Author

KARVONEN M, VIIK KAJANDER M, MOLTCHANOVA E, LIBMAN I, LAPORTE R, TUOMILEHTO J, THE DIABETES MONDIALE DIAMOND PROJECT GROUP, BESSAOUD K, BOUDRAA G, DE ROPOLO MM, DE SEREDAY M, MARTI ML, MOSER M, LAPERTOSA S, DAMIANO M, VERGE C, HOWARD N, SCHOBER E, JORDAN O, WEETS I, GORUS F, COECKELBERGHS M, ROOMAN R, VAN GAAL L, FRANCO LJ, FERREIRA SRG, LISBOA HPK, KURTZ LA, GRAEBIN R, KUTZKE L, RODRIGES C, SAVOVA R, CHRISTOV V, IOTOVA V, TZANEVA V, PACAUD D, TOTH E, TAN MH, CARRASCO E, PEREZ F, ZE Y, BO Y, CHEN S, FU L, DENG L, SHEN S, TENG K, WANG C, JIAN H, JU J, YAN C, DENG Y, LI C, ZHANG Y, LIU Y, LONG X, ZHEN Z, SUN Z, WANG B, WONG G, ORREGO OV, ASCHNER P, DIAZ DIAZ O, DE ACOSTA OM, CINEK O, VAVRINEC J, OLSEN BS, SVENDSEN AJ, KREUTZFELDT J, LUND E, TULL ES, SELMAN GEARA A, ALMONTE AS, PODAR T, NOTKOLA IL, TASKINEN O, LEVY MARCHAL C, CZERNICHOW P, KOCAVA M, NEU A, EHEHALT S, ROSENBAUER J, GIANI G, ICKS A, BARTSOCAS C, VAZEOU A, SOLTESZ G, LARON Z, GORDON O, ALBAG Y, SHAMIS I, PURRELLO F, ARPI M, FICHERA G, MANCUSO M, LUCENTI C, CHIUMELLO G, BRUNO G, PAGANO G, SONGINI M, CASU A, MARINARO A, FRONGIA P, ZEDDA MA, MILIA A, TENCONI MT, POZZILLI P, VISALLI N, SEBASTIANI L, MARIETTI G, BUZZETTI R, CHERUBINI V, OKUNO A, HARADA S, MATSUURA N, MIKI E, MIYAMOTO S, SASAKI N, MIMURA G, SHALTOUT A, AL KHAWARI M, BRIGIS G, DZIVITE I, KADIKI O, URBONAITE B, DE BEAUFORT C, GAREEBOO H, RUEDA OA, REESER M, ELLIOTT R, SCOTT R, WILLIS J, DARLOW B, JONER G, RAFIQUE G, JIMENEZ J, PALACIOS CM, CANETE F, VERA J, ALMIRON R, BENITEZ GE, ESPINOLA CS, SECLEN S, WOZNICKA D, SZYBINSKI Z, PLACZKIEWICZ E, RUAS MMA, RODRIGUES FJC, ABREU S, IONESCU TIRGOVISTE C, SHUBNIKOV E, MICHALKOVA D, BARK L, HLAVA P, MIKULECKY M, KRZISNIK C, BATTELINO T, URSIC NB, KOTNIK P, KO KW, CASTELL C, DAHLQUIST G, SCHOENLE E, NAGATI K, KHALIFA FB, BURDEN A, RAYMOND N, MILLWARD BA, ZHAO H, PATTERSON CC, CARSON D, HADDEN D, SMAIL P, MCSPORRAN B, WAUGH N, BINGLEY P, MCKINNEY PA, FELTBOWER RG, BODANSKY HJ, CAMPBELL F, ROSEMAN J., DEVOTI, Gabriele, Karvonen, M, VIIK KAJANDER, M, Moltchanova, E, Libman, I, Laporte, R, Tuomilehto, J, THE DIABETES MONDIALE DIAMOND PROJECT, Group, Bessaoud, K, Boudraa, G, DE ROPOLO, Mm, DE SEREDAY, M, Marti, Ml, Moser, M, Lapertosa, S, Damiano, M, Verge, C, Howard, N, Schober, E, Jordan, O, Weets, I, Gorus, F, Coeckelberghs, M, Rooman, R, VAN GAAL, L, Franco, Lj, Ferreira, Srg, Lisboa, Hpk, Kurtz, La, Graebin, R, Kutzke, L, Rodriges, C, Savova, R, Christov, V, Iotova, V, Tzaneva, V, Pacaud, D, Toth, E, Tan, Mh, Carrasco, E, Perez, F, Ze, Y, Bo, Y, Chen, S, Fu, L, Deng, L, Shen, S, Teng, K, Wang, C, Jian, H, Ju, J, Yan, C, Deng, Y, Li, C, Zhang, Y, Liu, Y, Long, X, Zhen, Z, Sun, Z, Wang, B, Wong, G, Orrego, Ov, Aschner, P, DIAZ DIAZ, O, DE ACOSTA, Om, Cinek, O, Vavrinec, J, Olsen, B, Svendsen, Aj, Kreutzfeldt, J, Lund, E, Tull, E, SELMAN GEARA, A, Almonte, A, Podar, T, Notkola, Il, Taskinen, O, LEVY MARCHAL, C, Czernichow, P, Kocava, M, Neu, A, Ehehalt, S, Rosenbauer, J, Giani, G, Icks, A, Bartsocas, C, Vazeou, A, Soltesz, G, Laron, Z, Gordon, O, Albag, Y, Shamis, I, Purrello, F, Arpi, M, Fichera, G, Mancuso, M, Lucenti, C, Chiumello, G, Bruno, G, Pagano, G, Songini, M, Casu, A, Marinaro, A, Frongia, P, Zedda, Ma, Milia, A, Tenconi, Mt, Devoti, Gabriele, Pozzilli, P, Visalli, N, Sebastiani, L, Marietti, G, Buzzetti, R, Cherubini, V, Okuno, A, Harada, S, Matsuura, N, Miki, E, Miyamoto, S, Sasaki, N, Mimura, G, Shaltout, A, AL KHAWARI, M, Brigis, G, Dzivite, I, Kadiki, O, Urbonaite, B, DE BEAUFORT, C, Gareeboo, H, Rueda, Oa, Reeser, M, Elliott, R, Scott, R, Willis, J, Darlow, B, Joner, G, Rafique, G, Jimenez, J, Palacios, Cm, Canete, F, Vera, J, Almiron, R, Benitez, Ge, Espinola, C, Seclen, S, Woznicka, D, Szybinski, Z, Placzkiewicz, E, Ruas, Mma, Rodrigues, Fjc, Abreu, S, IONESCU TIRGOVISTE, C, Shubnikov, E, Michalkova, D, Bark, L, Hlava, P, Mikulecky, M, Krzisnik, C, Battelino, T, Ursic, Nb, Kotnik, P, Ko, Kw, Castell, C, Dahlquist, G, Schoenle, E, Nagati, K, Khalifa, Fb, Burden, A, Raymond, N, Millward, Ba, Zhao, H, Patterson, Cc, Carson, D, Hadden, D, Smail, P, Mcsporran, B, Waugh, N, Bingley, P, Mckinney, Pa, Feltbower, Rg, Bodansky, Hj, Campbell, F, and Roseman, J.

Published
2000

21. Familial insulin-dependent diabetes mellitus (IDDM) epidemiology: standardization of data for the DIAMOND Project

Author

WHO MULTINATIONAL PROJECT FOR CHILDHOOD DIABETES GROUP, DORMAN JS, BESSAOUD K, DE SEREDAY M, MARTI ML, SCHOBER E, FRANCO LJ, NEGRATO C, RUSSO E, SCHMIDT M, VIVOLO M, COLLE E, SCHIFFRIN A, SIEMIATYCKI J, TAN MH, WORNELL C, CARRASCO E, LOPEZ G, GARCIAS DE LOS RIOS M, MATEO DE ACOSTA O, DIAZ DIAZ O, VERA M, NOROT T, URIATE A, SELMAN GEARA A, HASHEM N, SHAWKI R, EID S, TAHA S, REUNANEN A, TUOMILEHTO J, TUOMILEHTO WOLF E, BOEHM B, ROSAK C, SCHMIDT K, SOLTESZ G, HUNGARIAN CHILDHOOD DIABETES EPIDEMIOLOGY STUDY GROUP, RAMACHANDRAN A, MOHAN V, SNEHALATHA C, VISWANATHAN M, VERMA NPS, GOEL A, MUNTONI S, MASILE P, SILVETTI M, SONGINI M, TRONCI P, CHIARELLI F, CHIUMELLO G, MESCHI F, BOGNETTI E, TENCONI M, MARTINETTI M, LORINI R, SEVERI F, POZZILLI P, BOCCUNI M, BUZZETTI R, SEBASTIANI L, VISALLI N, PAGANO G, BRUNO G, MERLETTI F, PISU E, MATSUURA N, FUJIEDA K, OKUNO A, OOYANAGI K, YANO K, MIMURA G, FUTENMA H, HIGA S, MURAKAMI K, NAGAYOSHI M, KHOGALI M, ABDELLA N, GUMAA K, SHALTOUT A, ELLIOTT R, SCOTT R, JONER G, SOVIK O, JIMENEZ J, PALACIOS C, CANETE F, VERA J, ALMIRON R, REWERS M, FICHNA P, WALCZAK M, JOZWIAK M, WOZNICKA D, IONESCU TIRGOVISTE C, CHETA D, GODAY A, CASTELL C, GOMIS R, LLOVERAS G, SERRANO RIOS M, ELAMIN A, ELTAYEB K, OMER M, ZEIN K, DAHLQVIST G, BURDEN A, BODDIGTON M, BURDEN M, SHEERA S, PATTERSON C, HADDEN D, ROSEMAN J, ACTON R, GO R, WAGENKNECHT L, HAMMAN R, KOSTRABA J, MALONE J, LEAVERTON P, SCHOCKEN D, HODGE T, LIPTON R, BALLARD D, PALUMBO P, BROSSEAU J, SUMBURERU D, LAPORTE R, MOY C, TRUCCO M, FRAZER DE LLADO T, PODAR T, ADOJAAN B, KALITS I, GRABAUSKAS V, NORKUS A, PADAIGA Z, PREIKSA R, URBONAITE B, SHUBNIKOV E, KALASHNIKOVA L, KRZISNIK C, KING H., DEVOTI, Gabriele, WHO MULTINATIONAL PROJECT FOR CHILDHOOD DIABETES, Group, Dorman, J, Bessaoud, K, DE SEREDAY, M, Marti, Ml, Schober, E, Franco, Lj, Negrato, C, Russo, E, Schmidt, M, Vivolo, M, Colle, E, Schiffrin, A, Siemiatycki, J, Tan, Mh, Wornell, C, Carrasco, E, Lopez, G, GARCIAS DE LOS RIOS, M, MATEO DE ACOSTA, O, DIAZ DIAZ, O, Vera, M, Norot, T, Uriate, A, SELMAN GEARA, A, Hashem, N, Shawki, R, Eid, S, Taha, S, Reunanen, A, Tuomilehto, J, TUOMILEHTO WOLF, E, Boehm, B, Rosak, C, Schmidt, K, Soltesz, G, HUNGARIAN CHILDHOOD DIABETES EPIDEMIOLOGY STUDY, Group, Ramachandran, A, Mohan, V, Snehalatha, C, Viswanathan, M, Verma, Np, Goel, A, Muntoni, S, Masile, P, Silvetti, M, Songini, M, Tronci, P, Chiarelli, F, Chiumello, G, Meschi, F, Bognetti, E, Tenconi, M, Devoti, Gabriele, Martinetti, M, Lorini, R, Severi, F, Pozzilli, P, Boccuni, M, Buzzetti, R, Sebastiani, L, Visalli, N, Pagano, G, Bruno, G, Merletti, F, Pisu, E, Matsuura, N, Fujieda, K, Okuno, A, Ooyanagi, K, Yano, K, Mimura, G, Futenma, H, Higa, S, Murakami, K, Nagayoshi, M, Khogali, M, Abdella, N, Gumaa, K, Shaltout, A, Elliott, R, Scott, R, Joner, G, Sovik, O, Jimenez, J, Palacios, C, Canete, F, Vera, J, Almiron, R, Rewers, M, Fichna, P, Walczak, M, Jozwiak, M, Woznicka, D, IONESCU TIRGOVISTE, C, Cheta, D, Goday, A, Castell, C, Gomis, R, Lloveras, G, SERRANO RIOS, M, Elamin, A, Eltayeb, K, Omer, M, Zein, K, Dahlqvist, G, Burden, A, Boddigton, M, Burden, M, Sheera, S, Patterson, C, Hadden, D, Roseman, J, Acton, R, Go, R, Wagenknecht, L, Hamman, R, Kostraba, J, Malone, J, Leaverton, P, Schocken, D, Hodge, T, Lipton, R, Ballard, D, Palumbo, P, Brosseau, J, Sumbureru, D, Laporte, R, Moy, C, Trucco, M, FRAZER DE LLADO, T, Podar, T, Adojaan, B, Kalits, I, Grabauskas, V, Norkus, A, Padaiga, Z, Preiksa, R, Urbonaite, B, Shubnikov, E, Kalashnikova, L, Krzisnik, C, and King, H.

Published
1991

23. WHO Multinational Project for Childhood Diabetes

Author

WHO DIAMOND PROJECT GROUP, LAPORTE R. E, TUOMILEHTO J, KING H, BESSAOUD K, BOUDRAA G, ZIMMET P, DE SEREDAY M, MARTI ML, MOSER M, LAPERTOSA S, DAMIANO M, VERGE C, HOWARD N, SCHOBER E, JORDAN O, WEETS I, GORUS F, COECKELBERGHS M, ROOMAN R, VAN GAAL L, FRANCO LJ, FERREIRA SRG, LISBOA HPK, KURTZ LA, GRAEBIN R, KUTZKE L, RODRIGES C, SAVOVA R, CHRISTOV V, IOTOVA V, TZANEVA V, PACAUD D, TOTH E, TAN MH, CARRASCO E, PEREZ F, ZE Y, BO Y, CHEN S, FU L, DENG L, SHEN S, TENG K, WANG C, JIAN H, JU J, YAN C, DENG Y, LI C, ZHANG Y, LIU Y, LONG X, ZHEN Z, SUN Z, WANG B, WONG G, ORREGO OV, ASCHNER P, DIAZ DIAZ O, DE ACOSTA OM, CINEK O, VAVRINEC J, OLSEN BS, SVENDSEN AJ, KREUTZFELDT J, LUND E, TULL ES, SELMAN GEARA A, ALMONTE AS, PODAR T, KARVONEN M, NOTKOLA IL, MOLTCHANOVA E, TASKINEN O, LEVY MARCHAL C, CZERNICHOW P, KOCAVA M, NEU A, EHEHALT S, ROSENBAUER J, GIANI G, ICKS A, BARTSOCAS C, VAZEOU A, SOLTESZ G, LARON Z, GORDON O, ALBAG Y, SHAMIS I, PURRELLO F, ARPI M, FICHERA G, MANCUSO M, LUCENTI C, CHIUMELLO G, BRUNO G, PAGANO G, SONGINI M, CASU A, MARINARO A, FRONGIA P, ZEDDA MA, MILIA A, TENCONI MT, POZZILLI P, VISALLI N, SEBASTIANI L, MARIETTI G, BUZZETTI R, CHERUBINI V, OKUNO A, HARADA S, MATSUURA N, MIKI E, MIYAMOTO S, SASAKI N, MIMURA G, SHALTOUT A, QABAZRD M, AL KHAWARI M, BRIGIS G, DZIVITE I, KADIKI O, URBONAITE B, DE BEAUFORT C, GAREEBOO H, RUEDA OA, REESER M, ELLIOTT R, SCOTT R, WILLIS J, DARLOW B, JONER G, RAFIQUE G, JAWAD F, JIMENEZ J, PALACIOS CM, CANETE F, VERA J, ALMIRON R, BENITEZ GE, ESPINOLA CS, SECLEN S, WOZNICKA D, SZYBINSKI Z, PLACZKIEWICZ E, JAROSZ CHOBOT P, MENEZES C, PINA EA, RUAS MMA, RODRIGUES FJC, ABREU S, IONESCU TIRGOVISTE C, SHUBNIKOV E, MICHALKOVA D, BARK L, HLAVA P, MIKULECKY M, KRZISNIK C, BATTELINO T, URSIC NB, KOTNIK P, KO KW, CASTELL C, GODAY A, MAGZOUB M, DAHLQUIST G, SCHOENLE E, NAGATI K, KHALIFA FB, BURDEN A, RAYMOND N, MILLWARD BA, ZHAO H, PATTERSON CC, CARSON D, HADDEN D, SMAIL P, MCSPORRAN B, WAUGH N, BINGLEY P, MCKINNEY PA, FELTBOWER RG, BODANSKY HJ, CAMPBELL F, LAPORTE RE, LIBMAN I, ROSEMAN J, RAHMAN SMA, DE LLADO TF, LIPTON R, JORGE AM, GUNCZLER P, LANES R., DEVOTI, Gabriele, WHO DIAMOND PROJECT, Group, LAPORTE R., E, Tuomilehto, J, King, H, Bessaoud, K, Boudraa, G, Zimmet, P, DE SEREDAY, M, Marti, Ml, Moser, M, Lapertosa, S, Damiano, M, Verge, C, Howard, N, Schober, E, Jordan, O, Weets, I, Gorus, F, Coeckelberghs, M, Rooman, R, VAN GAAL, L, Franco, Lj, Ferreira, Srg, Lisboa, Hpk, Kurtz, La, Graebin, R, Kutzke, L, Rodriges, C, Savova, R, Christov, V, Iotova, V, Tzaneva, V, Pacaud, D, Toth, E, Tan, Mh, Carrasco, E, Perez, F, Ze, Y, Bo, Y, Chen, S, Fu, L, Deng, L, Shen, S, Teng, K, Wang, C, Jian, H, Ju, J, Yan, C, Deng, Y, Li, C, Zhang, Y, Liu, Y, Long, X, Zhen, Z, Sun, Z, Wang, B, Wong, G, Orrego, Ov, Aschner, P, DIAZ DIAZ, O, DE ACOSTA, Om, Cinek, O, Vavrinec, J, Olsen, B, Svendsen, Aj, Kreutzfeldt, J, Lund, E, Tull, E, SELMAN GEARA, A, Almonte, A, Podar, T, Karvonen, M, Notkola, Il, Moltchanova, E, Taskinen, O, LEVY MARCHAL, C, Czernichow, P, Kocava, M, Neu, A, Ehehalt, S, Rosenbauer, J, Giani, G, Icks, A, Bartsocas, C, Vazeou, A, Soltesz, G, Laron, Z, Gordon, O, Albag, Y, Shamis, I, Purrello, F, Arpi, M, Fichera, G, Mancuso, M, Lucenti, C, Chiumello, G, Bruno, G, Pagano, G, Songini, M, Casu, A, Marinaro, A, Frongia, P, Zedda, Ma, Milia, A, Tenconi, Mt, Devoti, Gabriele, Pozzilli, P, Visalli, N, Sebastiani, L, Marietti, G, Buzzetti, R, Cherubini, V, Okuno, A, Harada, S, Matsuura, N, Miki, E, Miyamoto, S, Sasaki, N, Mimura, G, Shaltout, A, Qabazrd, M, AL KHAWARI, M, Brigis, G, Dzivite, I, Kadiki, O, Urbonaite, B, DE BEAUFORT, C, Gareeboo, H, Rueda, Oa, Reeser, M, Elliott, R, Scott, R, Willis, J, Darlow, B, Joner, G, Rafique, G, Jawad, F, Jimenez, J, Palacios, Cm, Canete, F, Vera, J, Almiron, R, Benitez, Ge, Espinola, C, Seclen, S, Woznicka, D, Szybinski, Z, Placzkiewicz, E, JAROSZ CHOBOT, P, Menezes, C, Pina, Ea, Ruas, Mma, Rodrigues, Fjc, Abreu, S, IONESCU TIRGOVISTE, C, Shubnikov, E, Michalkova, D, Bark, L, Hlava, P, Mikulecky, M, Krzisnik, C, Battelino, T, Ursic, Nb, Kotnik, P, Ko, Kw, Castell, C, Goday, A, Magzoub, M, Dahlquist, G, Schoenle, E, Nagati, K, Khalifa, Fb, Burden, A, Raymond, N, Millward, Ba, Zhao, H, Patterson, Cc, Carson, D, Hadden, D, Smail, P, Mcsporran, B, Waugh, N, Bingley, P, Mckinney, Pa, Feltbower, Rg, Bodansky, Hj, Campbell, F, Laporte, Re, Libman, I, Roseman, J, Rahman, Sma, DE LLADO, Tf, Lipton, R, Jorge, Am, Gunczler, P, and Lanes, R.

Published
1990

24. [Analysis of the geographic distribution of the incidence of diabetes mellitus type I in Catalonia]

Author

Goday A, Castell C, Tresserras R, and Lloveras G

Subjects
Adult, Male, Diabetes Mellitus, Type 1, Adolescent, Spain, Child, Preschool, Incidence, Humans, Infant, Female, Poisson Distribution, Child, Demography
Abstract

The aim of the present study was to evaluate the geographic distribution of the incidence of diabetes mellitus type I (DMI) in Catalonia from 1987-1990.The base of the study is the Catalonian registry of incidence of DMI in the period from 1987-1990. The definition criteria were: diagnostic criteria of diabetes (WHO norms 1985), age of diagnosis under 30 years, residence in Catalonia in the period of diagnosis and exclusion of other types of diabetes. The population at risk was estimated according to the general census of the population of 1986. The total incidence of Catalonia was calculated by provinces and counties according to the Poisson distribution.The incidence of DMI observed in Catalonia was of 11.5/100,000 inhabitants per year (CI 95%, 10.6-12.4) in the age group from 0-14 years and 10.7/100,000 inhabitants per year (CI 95% 10.1-11.3) in the age group from 0-29 years. The exhaustivity in the detection of the cases was of 90.3%. No differences were found in interprovincial incidence in the 0-14 age group: Barcelona 11.6 (10.6-12.7), Girona 10.2 (7.2-13.4), Lleida 11.7 (7.7-15.8), Tarragona 10.5 (7.6-13.5). In the 15-29 age group a lower incidence was observed in Tarragona. The incidence by counties varied between 2.9 and 15.0/100,000 inhabitants per year with those of greatest incidence being observed in the Vallés Oriental (15.0/100,000 inhabitants/years), Alt Penedés (14.5/100,000 inhabitants/year), Segrià (15.0/100,000 inhabitants/year) and the Priorat (13.7/100,000 inhabitants/year).No differences were found in the incidence of diabetes mellitus type I in the four Catalonian provinces. Distribution by counties was more heterogeneous without defining zones with a much higher incidence to that observed in the whole of Catalonia.

Published
1993

26. Estudio microcalorimétrico del metabolismo de bacterias marinas: Detección de procesos rítmicos

Author

Wagensberg, J., Castell, C., Torra, V., Rodellar, J., and Vallespinós, Ferrán

Abstract

Trabajo presentado en la III Reunión de calorimetría celebrada en Barcelona.-- 10 pages, 5 figures, [EN ] In order to record the heat dissipation of marine strains metabolism a specially sensitive and stable flow microcalorimeter has been need. The dissipation for viable bacteria is obtained by means of parallel experiments prepared identically. [...] Vibrio sp`., Flavobacterium sp., Escherichia coli, Dictyostelium discoideum, [ES] La microcalorimetría de flujo se ha revelado últimamente como una poderosa técnica para la detección de componentes biológicos. En este trabajo se aplica al estudio del aspecto energético del metabolismo de bacterias marinas.. [...]

Published
1978

27. Identificación de las fases metabólicas en termogramas de cultivos bacterianos

Author

Castell, C., Wagensberg, J., Tejero, Alberto, and Vallespinós, Ferrán

Subjects
Microcalorimetry, Pxygen, Microcalorimetría, Metabolic phases, Fases metabólicas, Bacteriology, Oxígeno, Bacteriología
Abstract

6 pages, 3 figures, 1 table, [EN] We present an experimental device specially conceived in order to measure two relevant parameters of the growing of a bacterial culture: the microcalorimetric thermogram and the evolution of the oxygen resources in the medium. The results obtained with several strains suggest a general metabolic interpretation of the microbiological thermograms. [...] Enterobacter, Pseudomonas, Flavobacterium, [ES] En el trabajo se comenta un dispositivo experimental destinado a la medición simultánea de dos parámetros relacionados con la cinética del crecimiento de un cultivo bacteriano: termograma microcalorimétrico y evolución de la concentración de oxígeno en el medio. Los resultados obtenidos con diversas cepas bacterianas aisladas en el medio marino sugieren una interpretación metabólica general de los termogramas de cultivos bacterianos

Published
1981

28. FAMILIAL INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM) EPIDEMIOLOGY - STANDARDIZATION OF DATA FOR THE DIAMOND PROJECT

Author

Dorman, Js, Bessaoud, K., Desereday, M., Marti, M., Schober, E., Franco, L., Carlos Antonio Negrato, Russo, E., Schmidt, M., Vivolo, M., Colle, E., Schiffrin, A., Siemiatycki, J., Tan, Mh, Wornell, C., Carrasco, E., Lopez, G., Delosrios, Mg, Deacosta, Om, Diazdiaz, O., Vera, M., Norot, T., Uriate, A., Selmangeara, A., Hashem, N., Shawki, R., Eid, S., Taha, S., Reunanen, A., Tuomilehto, J., Tuomilehtowolf, E., Boehm, B., Rosak, C., Schmidt, K., Soltesz, G., Ramachandran, A., Mohan, V., Snehalatha, C., Viswanathan, M., Verma, Nps, Goel, A., Muntoni, S., Masile, P., Silvetti, M., Songini, M., Tronci, P., Chiarelli, F., Chiumello, G., Meschi, F., Bognetti, E., Tenconi, M., Devoti, G., Martinetti, M., Lorini, R., Severi, F., Pozzilli, P., Boccuni, M., Buzzetti, R., Sebastiani, L., Visalli, N., Pagano, G., Bruno, G., Merletti, F., Pisu, E., Matsuura, N., Fujieda, K., Okuno, A., Ooyanagi, K., Yano, K., Mimura, G., Futenma, H., Higa, S., Murakami, K., Nagayoshi, M., Khogali, M., Abdella, N., Gumaa, K., Shaltout, A., Elliott, R., Scott, R., Joner, G., Sovik, O., Jimenez, J., Palacios, C., Canete, F., Vera, J., Almiron, R., Rewers, M., Fichna, P., Walczak, M., Jozwiak, M., Woznicka, D., Ionescutirgoviste, C., Cheta, D., Goday, A., Castell, C., Gomis, R., Lloveras, G., Serranorios, M., Elamin, A., Eltayeb, K., Omer, M., Zein, K., Dahlqvist, G., Burden, A., Boddington, M., Burden, M., Sheera, S., Patterson, C., Hadden, D., Roseman, J., Acton, R., Go, R., Wagenknecht, L., Hamman, R., Kostraba, J., Malone, J., Leaverton, P., Schocken, D., Hodge, T., Lipton, R., Ballard, D., Palumbo, P., Brosseau, J., Sumbureru, D., Dorman, J., Laporte, R., Moy, C., Trucco, M., Dellado, Tf, Podar, T., Adojaan, B., Kalits, I., Grabauskas, V., Norkus, A., Padaiga, Z., Preiksa, R., Urbonaite, B., Shubnikov, E., Kalashnikova, L., Krzisnik, C., and King, H.

29. Significant incidence of type 2 diabetes on high-risk Spanish population. The IGT study (2)

Author

Costa, B., Piñol, J. L., Martín, F., Donado, Á, Castell, C., Acera, T., Álvarez, M., Aragonés, E., Badía, M. W., Basora, J., Basora, T., Bel, M., Calviño, O., Camacho, M., Carmós, P., Campani, M., Canalejo, J., Carrascosa, R., Castelar, M. J., Castro, M. P., Cervera, F., Colomés, L. I., Daniel, J., Donado-Mazarron, A., Estopa, M. A., Feliu, R., Fernandez, A., Ferre, J., Ferrer, M. P., Folch, M. M., Josep Franch-Nadal, Frigola, J. L., García, A., García, C., García, J., Garreta, I., Giné, C., Glaría, I., Grivé, M., Guinea, I., Henrich, M., Hernandez, S., Hernandez, M., Hernandez, N., Hospital, I., Isach, A., Llobet, P., Lhor, C., Lucena, C., Vercet, M., Marimon, J., Marti, F., Masdeu, R. M., Melich, N., Mendoza, J., Molto, E., Montañes, M. D., Morato, J., Oliver, M. A., Otero, X., Palacio, F., Palacios, L., Parera, F., Paris, F., Pedret, R., Pino, M., Policarpo, M., Real, J., Ricart, C., Riera, M. A., Rios, L., Roca, T., Roig, R., Romero, M., Rovira, M., Rubiales, R. M., Sartz, J., Sola, A., Solé, E., Taverna, L., Timón, M., Verge, F., Vidal, E., Vila, A., and Vinuesa, A.

31. [Prevalence of nephropathy in type I diabetes]

Author

Esmatjes E, Castell C, Goday A, Eduard Montanya, Jm, Pou, Salinas I, Simó R, Mt, González, Tresserras R, and Lloveras G

Subjects
Adult, Male, Diabetes Mellitus, Type 1, Logistic Models, Risk Factors, Spain, Prevalence, Humans, Diabetic Nephropathies, Female
Abstract

Diabetic nephropathy is a serious complication of diabetes, of which there are few epidemiological data in Spain. The aim of this study is to determine diabetic nephropathy prevalence in a group of patients with type I diabetes mellitus, representative of the population of Barcelona, Spain, evaluating several risk factors related with its development.639 patients (296 males and 343 women), from 6 hospitals, selected according with the diabetes duration (194 between 5 and 9 years [group I], 227 between 10 and 19 years [group II] and 218 with 20 years or more [group III]) were studied. In all patients urinary albumin excretion and plasma levels of creatinine, HbA1c, cholesterol and triglycerides were determined. The presence of retinopathy, neuropathy, vasculopathy and tobacco consumption were also evaluated.The prevalence of diabetic nephropathy increased with longer diabetes duration (8.1% [CI: 4.3-11.9] in group I, 24.7% [CI: 19.1-30.3] in group II and 44.7% [CI: 38.1-51.3] in group III), as well as that of hypertension, diabetes complications, cholesterol and triglycerides plasma levels. Related to people with normal renal function, after logistic regression, microalbuminuria was associated with hypertension and longer diabetes duration. Clinical nephropathy (macroalbuminuria + renal failure) to hypertension, longer duration, hypertriglyceridemia, male sex and tobacco consumption.The prevalence of diabetic nephropathy in Barcelona area is high and similar to that observed in other european regions. Its existence is associated with other diabetic complications. In addition to the classic risk factors, tobacco consumption must also be considered as a factor for diabetic nephropathy.

32. DIRECT MEDICAL COSTS RELATED TO COVID-19 IN COLOMBIA

Author

ALVIS ZAKZUK, NELSON RAFAEL, Florez Tanus, A, Diaz Jimenez, Diana F, Chaparro Narvaez, Pablo Enrique, Castaneda Orjuela, Carlos Andres, De La Hoz, Fernando Pio, Castell C, Duenas, and Alvis Guzman, N

Subjects
COVID - 19, Medical Costs, Colombia
Abstract

We studied 113 patients hospitalized by COVID-19, 51.3% men. On average, the hospital length of stay for COVID-19 hospitalized patient was 7,3 (± 6,2) days with a median cost of $1,688 (IQR 788-2,523). In women, the median direct medical cost of hospitalization was $1,328 (IQR $463-$2,098), while in men was 1.4 times greater. Being 60 years of age or older triggers hospitalization costs almost twice as high as those under this age ($1,813 vs. $2,994), and when the cost is compared by type of hospitalization, this difference is more than three times (ICU: 4,118; general ward: $1,312).

36. [Nutritional and food counseling]

Author

Lluis Serra-Majem, Ribas L, Castell C, Arija V, Lloveras G, and Salleras L

Subjects
Counseling, Primary Health Care, Nutritional Sciences, Risk Factors, Preventive Health Services, Humans, Feeding Behavior, Dietary Services, Diet

37. [Physical exercise and disease (and II)]

Author

Roure E, Esteve Saltó, Serra L, Vallbona C, Castell C, Guayta R, Treserras R, Jl, Taberner, and Salleras L

Subjects
Humans, Preventive Medicine, Exercise

40. New insights Into the evolution of the electron transfer from cytochrome f to photosystem I in the green and red branches of photosynthetic eukaryotes

Author

José A. Navarro, Luis A. Rodríguez-Lumbreras, Manuel Hervás, Juan Fernández-Recio, Carmen Castell, Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular, Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, European Commission, Ministerio de Educación, Cultura y Deporte (España), Castell, C. [0000-0002-0920-4718], Rodríguez-Lumbreras, Luis A. [0000-0002-7502-3157], Hervás, Manuel [0000-0003-4523-8891], Fernández-Recio, Juan [0000-0002-3986-7686], Navarro, J. A. [0000-0002-0536-6074], Ministerio de Economía y Competitividad (España), and CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)

Subjects
0301 basic medicine, Cyanobacteria, Photosystem I, Lineage (genetic), Cytochrome, Physiology, Photosynthetic green and red lineages, Plant Science, Special Issue - Review, Cytochrome f, Photosynthesis, AcademicSubjects/SCI01180, Electron Transport, Evolution, Molecular, Electron transfer, 03 medical and health sciences, Chlorophyta, Plastocyanin, 030102 biochemistry & molecular biology, biology, Photosystem I Protein Complex, Chemistry, AcademicSubjects/SCI01210, Cell Biology, General Medicine, biology.organism_classification, Cytochromes f, Protein Structure, Tertiary, Molecular Docking Simulation, Kinetics, 030104 developmental biology, Cytochrome c6, Biophysics, biology.protein, Green algae
Abstract

In cyanobacteria and most green algae of the eukaryotic green lineage, the copper-protein plastocyanin (Pc) alternatively replaces the heme-protein cytochrome c6 (Cc6) as the soluble electron carrier from cytochrome f (Cf) to photosystem I (PSI). The functional and structural equivalence of ‘green’ Pc and Cc6 has been well established, representing an example of convergent evolution of two unrelated proteins. However, plants only produce Pc, despite having evolved from green algae. On the other hand, Cc6 is the only soluble donor available in most species of the red lineage of photosynthetic organisms, which includes, among others, red algae and diatoms. Interestingly, Pc genes have been identified in oceanic diatoms, probably acquired by horizontal gene transfer from green algae. However, the mechanisms that regulate the expression of a functional Pc in diatoms are still unclear. In the green eukaryotic lineage, the transfer of electrons from Cf to PSI has been characterized in depth. The conclusion is that in the green lineage, this process involves strong electrostatic interactions between partners, which ensure a high affinity and an efficient electron transfer (ET) at the cost of limiting the turnover of the process. In the red lineage, recent kinetic and structural modeling data suggest a different strategy, based on weaker electrostatic interactions between partners, with lower affinity and less efficient ET, but favoring instead the protein exchange and the turnover of the process. Finally, in diatoms the interaction of the acquired green-type Pc with both Cf and PSI may not yet be optimized., The Spanish Ministry of Economy, Industry and Competitiveness (BIO2015-64169-P and BIO2016-79930-R) and the Andalusian Government (PAIDI BIO-022). These grants were partially financed by the EU FEDER Program. C.C. is the recipient of a FPU Program fellowship (FPU16/04040; Spanish Ministry of Education, Culture and Sports). We acknowledge the support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI).

Published
2021

41. Low physical activity and its association with diabetes and other cardiovascular risk factors: a nationwide, population-based study

Author

Sonia Gaztambide, Edelmiro Menéndez, Gemma Pascual-Manich, Federico Soriguer, Anna Bosch-Comas, Rafael Carmena, Ramon Gomis, Inmaculada Mora-Peces, Albert Goday, Miguel Catalá, Laura Brugnara, María Teresa Martínez-Larrad, Anna Novials, Joan Vendrell, Emilio Ortega, Josep Franch, Alfonso L. Calle-Pascual, Serafín Murillo, Juan Girbés, Roser Casamitjana, Alfonso López-Alba, Manuel Serrano-Ríos, Elena Bordiú, Gemma Rojo-Martínez, Luis Castaño, Sergio Valdés, Elías Delgado, Conxa Castell, Universitat de Barcelona, [Brugnara,L, Murillo,S, Novials,A, Rojo-Martínez,G, Soriguer,F, Castaño,L, Gaztambide,S, Valdés,S, Vendrell,J, Casamitjana,R, Boch-Comas,A, Carmena,R, Catalá,M, Martínez-Larrad,MT, Pascual-Manich,G, Serrano-Rios,M, Gomis,R] CIBERDEM—Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain. [Brugnara,L, Bosch-Comas,A, Gomis,R] IDIBAPS—August Pi i Sunyer Biomedical Research Institute / Hospital Clínic de Barcelona, Barcelona, Spain. [Rojo-Martínez,G, Valdés,S] Hospital Universitario Carlos Haya, Department of Endocrinology and Nutrition, Málaga, Spain. [Goday,A] Hospital del Mar, Department of Endocrinology and Nutrition, Barcelona, Spain. [Calle-Pascual,A, Bordiú,E] Hospital Universitario San Carlos, Madrid, Spain. [Gaztambide,S] Hospital Universitario de Cruces, UPV-EHU, Diabetes Research Group, Baracaldo, Spain. [Franch,J] EAP Raval Sud, Institut Català de la Salut, Red GEDAPS, IDIAP, Barcelona, Spain. [Castell,C] Public Health Division, Autonomous Government of Catalonia, Barcelona, Spain. [Vendrell,J] Department of Endocrinology and Nutrition, Hospital Universitario Joan XXIII, Tarragona, Spain. [Carmena,R, Catalá,M] Department of Medicine and Endocrinology, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Delgado,E, Menéndez,E] Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Oviedo, Spain. [Gilbés,J] Hospital Arnau de Vilanova, Valencia, Spain. [López-Alba,A] Fundación Hospital de Jove, Gijón, Spain. [Serrano-Ríos,M] Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Mora-Peces,I] Canarian Health Service, San Cristóbal de la Laguna, Tenerife, Spain. [Martínez-Larraz,MT, Ortega,E] CIBEROBN - Spanish Biomedical Research Centre in Physiopathology of Obesity. [Ortega,E] Department of Endocrinology and Nutrition, ICMDM, Hospital Clinic Barcelona., This work was supported by the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM, ISCIII Ministerio de Ciencia e Innovación), Ministerio de Sanidad y Consumo and the Spanish Diabetes Society (SED)., [Brugnara, Laura] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Murillo, Serafin] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Novials, Anna] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Rojo-Martinez, Gemma] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Soriguer, Federico] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Castano, Luis] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Gaztambide, Sonia] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Valdes, Sergio] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Vendrell, Joan] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Casamitjana, Roser] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Bosch-Comas, Anna] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Carmena, Rafael] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Catala, Miguel] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Teresa Martinez-Larrad, Maria] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Pascual-Manich, Gemma] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Serrano-Rios, Manuel] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Gomis, Ramon] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Brugnara, Laura] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Murillo, Serafin] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Novials, Anna] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Casamitjana, Roser] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Bosch-Comas, Anna] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Pascual-Manich, Gemma] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Gomis, Ramon] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Rojo-Martinez, Gemma] Hosp Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain, [Soriguer, Federico] Hosp Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain, [Valdes, Sergio] Hosp Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain, [Goday, Albert] Hosp Mar, Dept Endocrinol & Nutr, Barcelona, Spain, [Calle-Pascual, Alfonso] Hosp Univ San Carlos, Madrid, Spain, [Bordiu, Elena] Hosp Univ San Carlos, Madrid, Spain, [Castano, Luis] Univ Basque Country, Hosp Univ Cruces, Diabet Res Grp, Baracaldo, Spain, [Gaztambide, Sonia] Univ Basque Country, Hosp Univ Cruces, Diabet Res Grp, Baracaldo, Spain, [Franch, Josep] IDIAP, Red GEDAPS, Inst Catala Salut, EAP Raval Sud, Barcelona, Spain, [Castell, Conxa] Autonomous Govt Catalonia, Publ Hlth Div, Barcelona, Spain, [Vendrell, Joan] Hosp Univ Joan XXIII, Dept Endocrinol & Nutr, Tarragona, Spain, [Carmena, Rafael] Hosp Clin Univ Valencia, Dept Med & Endocrinol, Valencia, Spain, [Catala, Miguel] Hosp Clin Univ Valencia, Dept Med & Endocrinol, Valencia, Spain, [Delgado, Elias] Univ Oviedo, Hosp Univ Cent Asturias, Fac Med & Ciencias Salud, Dept Endocrinol & Nutr, Oviedo, Spain, [Menendez, Edelmiro] Univ Oviedo, Hosp Univ Cent Asturias, Fac Med & Ciencias Salud, Dept Endocrinol & Nutr, Oviedo, Spain, [Girbes, Juan] Hosp Arnau Vilanova, Valencia, Spain, [Lopez-Alba, Alfonso] Fdn Hosp Jove, Gijon, Spain, [Serrano-Rios, Manuel] Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain, [Mora-Peces, Inmaculada] Canarian Hlth Serv, Tenerife, Spain, [Teresa Martinez-Larrad, Maria] CIBEROBN Spanish Biomed Res Ctr Physiopathol Obes, Pamplona, Spain, [Ortega, Emilio] CIBEROBN Spanish Biomed Res Ctr Physiopathol Obes, Pamplona, Spain, [Ortega, Emilio] Hosp Clin Barcelona, ICMDM, Dept Endocrinol & Nutr, Barcelona, Spain, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM, ISCIII Ministerio de Ciencia e Innovacion), Ministerio de Sanidad y Consumo, and Spanish Diabetes Society (SED)

Subjects
Questionnaires, Male, Dislipidemias, Cross-sectional study, Estudios transversales, España, Obesidad, Índice de masa corporal, Biochemistry, Body Mass Index, 0302 clinical medicine, Endocrinology, Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings], Public and Occupational Health, lcsh:Science, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, Mediterranean [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings], Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Aged, 80 and over, Diabetis, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity, Abdominal [Medical Subject Headings], Cardiovascular Diseases, Obesitat, Enfermedades cardiovasculares, Factores de riesgo, medicine.medical_specialty, Endocrine Disorders, Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Smoking [Medical Subject Headings], Qüestionaris, Triglicéridos, Exercici -- Aspectes sanitaris, 03 medical and health sciences, Diabetes Mellitus, Humans, Diseases::Cardiovascular Diseases [Medical Subject Headings], Exercise, Aged, Survey Research, Malalties cardiovasculars, Prevention, lcsh:R, Enfermedad crónica, Biology and Life Sciences, Physical Activity, Insulin-resistance, medicine.disease, Actividad motora, Obesity, Lipid metabolism, Cross-Sectional Studies, Dyslipidemia, Adherence, Glucosa, lcsh:Q, Body mass index, Demography, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style::Sedentary Lifestyle [Medical Subject Headings], Physiology, Physical fitness, Sistema cardiovascular -- Malalties, Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings], lcsh:Medicine, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Obesidad abdominal, Geographical Locations, Glucose Metabolism, Risk Factors, Hábito de fumar, Medicine and Health Sciences, Prevalence, 030212 general & internal medicine, Prediabetes, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [Medical Subject Headings], Multidisciplinary, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings], Diabetes, Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Europe, Encuestas y cuestionarios, Physiological Parameters, Research Design, Carbohydrate Metabolism, Female, Research Article, Adult, Adolescent, 030209 endocrinology & metabolism, Vida sedentaria, Research and Analysis Methods, HDL-colesterol, Young Adult, Sex Factors, Diabetes mellitus, medicine, Adults, Espanya, Diseases::Endocrine System Diseases::Diabetes Mellitus::Prediabetic State [Medical Subject Headings], Sedentary lifestyle, business.industry, Estado prediabético, Body Weight, Dieta mediterránea, Metabolisme dels lípids, Diet, Metabolism, Spain, Metabolic Disorders, People and Places, Physical therapy, Sedentary Behavior, business, Prevalencia, Condició física
Abstract

Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM; ISCIII Ministerio de Ciencia e Innovacion); Ministerio de Sanidad y Consumo; Spanish Diabetes Society (SED), Brugnara, L., Murillo, S., Novials, A., Rojo-Martínez, G., Soriguer, F., Goday, A., Calle-Pascual, A., Castaño, L., Gaztambide, S., Valdés, S., Franch, J., Castell, C., Vendrell, J., Casamitjana, R., Bosch-Comas, A., Bordiú, E., Carmena, R., Catalá, M., Delgado, E., Girbés, J., López-Alba, A., Martínez-Larrad, M.T., Menéndez, E., Mora-Peces, I., Pascual-Manich, G., Serrano-Ríos, M., Gomis, R., Ortega, E.

Published
2016

42. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study)

Author

Rafael Carmena, Inmaculada Mora-Peces, Galder Gutierrez, Juan Girbés, Gemma Pascual-Manich, Federico Soriguer, E. Menéndez, Emilio Ortega, Roger R. Gomis, Elena Bordiú, Sonia Gaztambide, Miguel Catalá, Luis Castaño, Josep Franch, Sergio Valdés, Manuel Fuentes, Gemma Rojo-Martínez, Manuel Serrano-Ríos, Joan Vendrell, Albert Goday, Elías Delgado, Clara Marcuello, Anna Bosch-Comas, Alfonso Calle-Pascual, Roser Casamitjana, María Teresa Martínez-Larrad, J.A. Vázquez, Conxa Castell, Isabelle Runkle, Alfonso López-Alba, [Marcuello,C, Calle-Pascual,AL, Runkle,I] Department of Endocrinology and Nutrition, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Fuentes,M] Preventive Medicine Service, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Soriguer,F, Bosch-Comas,A, Carmena,R, Casamitjana,R, Castaño,L, Catalá,M, Gaztambide,S, Gomis,R, Gutiérrez,G, Martínez-Larrad,MT, Ortega,E, Pascual-Manich,G, Rojo-Martínez,G, Serrano-Rios,M, Valdés,S, Vendrell,J] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain. [Soriguer,F, Valdés,S] Department of Endocrinology and Nutrition, Hospital Regional Universitario Carlos Haya Málaga, Málaga, Spain. [Goday,A] Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain. [Bosch-Comas,A, Ortega,E] Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Bordiú,E] Laboratorio de Endocrinología, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Carmena,R, Catalá,M] Department of Medicine and Endocrinology, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Casamitjana,R] Biomedic Diagnostic Centre, Hospital Clínic de Barcelona, Barcelona, Spain. [Castaño,L, Gutiérrez,G] Diabetes Research Group, Hospital Universitario de Cruces, UPV-EHU, Barakaldo, Spain. [Castell,C] Public Health Division, Department of Health, Autonomous Government of Catalonia, Barcelona, Spain. [Delgado,E, Menéndez,E] Department of Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain. [Franch,J] EAP Raval Sud, Institut Català de la Salut, Red GEDAPS, Primary Care, Unitat de Suport a la Recerca (IDIAP—Fundació Jordi Gol), Barcelona, Spain. [Girbés,J] Diabetes Unit, Hospital Arnau de Vilanova, Valencia, Spain. [Gomis,R, Ortega,E] Endocrinology and Diabetes Unit, Hospital Clínic de Barcelona, Universitat de Barcelona (UB), Barcelona, Spain. [López-Alba,A] Spanish Diabetes Society, Madrid, Spain. [Martínez-Larrad,MT, and Serrano-Rios,M] Lipids and Diabetes Laboratory, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Mora-Peces,I] Canarian Health Service, Tenerife, Spain. [Vázquez,JA] Diabetes National Plan, Ministry of Health, Madrid, Spain. [Vendrell,J] Department of Endocrinology and Nutrition, Hospital Universitario Joan XXIII, Institut d’Investigacions Sanitaries Pere Virgili, Tarragona, Spain.

Subjects
Gerontology, Article Subject, Endocrinology, Diabetes and Metabolism, España, Estudios Transversales, Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Logistic regression, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis::Logistic Models [Medical Subject Headings], lcsh:Diseases of the endocrine glands. Clinical endocrinology, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [Medical Subject Headings], Named Groups::Persons::Men [Medical Subject Headings], Endocrinology, Quality of life, Disciplines and Occupations::Social Sciences::Quality of Life [Medical Subject Headings], Diabetes mellitus, Metabolismo de los Hidratos de Carbono, medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Modelos Logísticos, Prediabetes, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Sampling Studies [Medical Subject Headings], Análisis de Regresión, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], lcsh:RC648-665, Endocrine and Autonomic Systems, business.industry, Odds ratio, Anthropometry, medicine.disease, Obesity, Muestreo, humanities, Named Groups::Persons::Women [Medical Subject Headings], Glucosa, Calidad de Vida, business, Body mass index, Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate Metabolism [Medical Subject Headings], Demography, Research Article
Abstract

Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population.Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted.Results. Mean PCS-12/MCS-12 values were50.9±8.5/47.6±10.2, respectively. Men had higher scores than women in both PCS-12 (51.8±7.2versus50.3±9.2;P<0.001) and MCS-12 (50.2±8.5versus45.5±10.8;P<0.001). Increasing age and obesity were associated with a poorer PCS-12 score. In women lower PCS-12 and MCS-12 scores were associated with a higher level of glucose metabolism abnormality (prediabetes and diabetes), (P<0.0001for trend), but only the PCS-12 score was associated with altered glucose levels in men (P<0.001for trend). The Odds Ratio adjusted for age, body mass index (BMI) and educational level, for a PCS-12 score below the median was 1.62 (CI 95%: 1.2–2.19;P<0.002) for men with KDM and 1.75 for women with KDM (CI 95%: 1.26–2.43;P<0.001), respectively.Conclusion. Current study indicates that increasing levels of altered carbohydrate metabolism are accompanied by a trend towards decreasing quality of life, mainly in women, in a representative sample of Spanish population.

Published
2012

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