1. Roles of circRNAs in prostate cancer: Expression, mechanism, application and potential
- Author
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Zhou Fenghai, Yindong Kang, Weiping Li, Yang Qi, Chang Dehui, and Chunlei Zhang
- Subjects
Male ,0301 basic medicine ,Mechanism (biology) ,Prostatic Neoplasms ,RNA ,RNA, Circular ,Cell Biology ,Biology ,Prognosis ,Bioinformatics ,medicine.disease ,Biochemistry ,MicroRNAs ,03 medical and health sciences ,Prostate cancer ,030104 developmental biology ,0302 clinical medicine ,Receptors, Androgen ,Circular RNA ,030220 oncology & carcinogenesis ,medicine ,Humans ,Clinicopathological features ,Treatment resistance ,Biomarkers - Abstract
Circular RNA (circRNA) is a member of the non-coding RNA family that is formed by trans-splicing. Because of its unique structure and characteristics, it has extraordinary value for the diagnosis, treatment, and prognosis of diseases, particularly for tumors. Study of the role of circRNAs in the occurrence and development of prostate cancer has made considerable progress, but many areas remain that require further exploration and improvement. This article describes research into sequencing expression profiles, expression regulation, potential value as biomarkers, mechanism in the occurrence and development, therapy resistance, relationship with clinicopathological features, and prognostic value of circRNAs in prostate cancer from the past few years.
- Published
- 2021