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18 páginas.- 5 figuras.- referencias.- Additional supporting information can be found online in the Supporting Information section at the end of this article https://doi.org/10.1111/gcb.16765, Microbial communities in soils are generally considered to be limited by carbon (C), which could be a crucial control for basic soil functions and responses of microbial heterotrophic metabolism to climate change. However, global soil microbial C limitation (MCL) has rarely been estimated and is poorly understood. Here, we predicted MCL, defined as limited availability of substrate C relative to nitrogen and/or phosphorus to meet microbial metabolic requirements, based on the thresholds of extracellular enzyme activity across 847 sites (2476 observations) representing global natural ecosystems. Results showed that only about 22% of global sites in terrestrial surface soils show relative C limitation in microbial community. This finding challenges the conventional hypothesis of ubiquitous C limitation for soil microbial metabolism. The limited geographic extent of C limitation in our study was mainly attributed to plant litter, rather than soil organic matter that has been processed by microbes, serving as the dominant C source for microbial acquisition. We also identified a significant latitudinal pattern of predicted MCL with larger C limitation at mid- to high latitudes, whereas this limitation was generally absent in the tropics. Moreover, MCL significantly constrained the rates of soil heterotrophic respiration, suggesting a potentially larger relative increase in respiration at mid- to high latitudes than low latitudes, if climate change increases primary productivity that alleviates MCL at higher latitudes. Our study provides the first global estimates of MCL, advancing our understanding of terrestrial C cycling and microbial metabolic feedback under global climate change., This study was financially supported by the National Natural Science Foundation of China (32101378) and Project funded by the China Postdoctoral Science Foundation (2022M710004)

Whether and how to synchronously regulate stream water nitrogen (N) and phosphorus (P) concentrations and ratios is a major challenge for sustainable aquatic functions. Soil carbon (C):N:P ratios influence soil N and P stocks and biogeochemical processes that elicit subsequent substantial impacts on stream water N and P concentrations and ratios. Therefore, bridging soil and stream water with ecological stoichiometry is one of the most promising technologies for improving stream water quality. Here, we quantified the ecological stoichiometry of soil and stream water relationships across nine catchments. Soil C:P ratio was the main driver of water quality, showing negative correlations with stream water N and P concentrations, and positive correlations with the N:P ratio in P-limited catchments. We revealed that soil C:P ratios higher than 97.8 mol mol−1 are required to achieve the simultaneous regulation of stream water N and P concentrations below the eutrophication threshold and make algal growth P-limited. Furthermore, we found that the relationships between catchment landscape and soil ecological stoichiometry likely provided practical options for regulating soil ecological stoichiometry. Our work highlights that soil ecological stoichiometry can effectively indicate the amount and proportion of soil N and P losses, and can be intervened through rational landscape planning to achieve sustainable aquatic ecosystems in catchments.

Tidal wetland plants can maintain high primary productivity under salinization, even with low phosphorus (P) availability. However, little is known about how they adapt to salinization-induced ecosystem P limitation over time. We established mesocosms using tidal freshwater wetland soils and the salt-tolerant plant Cyperus malaccensis and subjected them to short-term (6 months) and long-term (3.5 years) salinization. Overall, short-term salinization did not change plant or microbial biomass nitrogen/P ratios, whereas long-term salinization increased both, indicating that short-term salinization did not alter ecosystem P limitation, but long-term salinization exacerbated it. Concurrently, short-term salinization reduced the moderately labile inorganic P (Pi) pool, whereas long-term salinization also reduced the hydrolyzable organic P (Po) and primary mineral P pools. During both short- and long-term salinization, moderately labile Pi mobilization exhibited a negative correlation with Fe sulfide concentration and a positive correlation with Fe(III) concentrations. These results suggested that both short- and long-term salinization obtained P through abiotic P-acquisition strategies. Mobilization of the primary mineral P pool and hydrolyzable Po pools was negatively linked to root arbuscular mycorrhizal fungi (AMF) biomass and soil alkaline phosphomonoesterase (ALP) activity, respectively. This indicated that long-term salinization acquired P via biotic P-acquisition strategies. Specifically, soil microorganisms increased fungi predominance and thereby increased ALP activity to convert hydrolyzable Po, while tidal wetland plants enhanced root AMF associations to release carboxylate to transform primary mineral P. Overall, our results highlight that abiotic P-acquisition strategies could offset the ecosystem P limitation during short-term salinization, whereas biotic P-acquisition strategies play a more important role in soil P transformation under long-term salinization. Through biotic P-acquisition, tidal wetland ecosystems can maintain high plant primary productivity through biotic P-acquisition even under P-limited conditions, exhibiting increased resilience to sea-level rise.

Copper (Cu) is a kind of micronutrient element that is essential for human metabolism. However, it is also considered as an environmental pollutant which is toxic to organisms at a high concentration level. Probiotics, regarded as beneficial microorganisms for promoting human health, have functions of antioxidant capacity, immune-enhancing properties, intestinal barrier protection and regulation. Several studies have reported that probiotics show positive effects on alleviating and intervening heavy metals toxicity. However, evidence for relieving copper-induced toxicity by probiotics is still limited. In this study, we firstly conducted a zebrafish larvae model to screen out microorganisms which are helpful for CuSO

Increases in urban population and inadequate rainfall result in imbalanced water budgets in urban and sub-urban regions. Water conservation becomes important in urban landscapes because of increased water demands. Modern landscape designs require drought-resistant plants to maintain urban landscape greenness during water scarcity. Irrigating plants at their irrigation requirements, which is the minimum irrigation rate that can achieve acceptable aesthetic quality, can also conserve water. However, the drought tolerance and irrigation requrements of most landscape plants have not been widely evaluated. Shepherdia ×utahensis ‘Torrey’ (‘Torrey’ buffaloberry) and Penstemon species (beardtongues) are low-water-use landscape plants, but their drought resistance mechanisms are largely unknown. Despite garden roses (Rosa ×hybrida L.) being widely used in residential landscapes, their responses to reduced irrigation frequency and irrigation requirements are unclear. The objectives of this research were to determine the plant growth, morphology, and physiology of ‘Torrey’ buffaloberry, four penstemon species, and five garden rose cultivars under drought stress resulting from reduced substrate water content or irrigation frequency. Shepherdia ×utahensis ‘Torrey’ and the four penstemons were grown using an automated irrigation system to preciously control their substrate volumetric water contents at their setpoints between 0.40 to 0.05 m3·m-3 in a greenhouse for 50 days, whereas the five rose cultivars were irrigated at three irrigation frequencies (high, medium, and low) in an open field, where the irrigation frequency at the high, medium, and low levels was controlled using 80%, 50%, and 20% reference evapotranspiration (ETO), respectively. Under reduced substrate moisture levels, S. ×utahensis promoted root growth, closed stomata, and increased leaf trichomes density to regulate canopy temperature. Penstemon species native to arid regions, such as P. barbatus (Cav.) Roth ‘Novapenblu’ (Rock Candy Blue® penstemon) and P. strictus Benth. (Rocky Mountain penstemon), showed greater leaf reflectance, a higher volume of root system, and cooler canopy temperatures than the mesic penstemon species, including P. digitalis Nutt. ex Sims ‘TNPENDB’ (Dakota™ Burgundy beardtongue) and P. ×mexicali Mitch. ‘P007S’ (Pikes Peak Purple® penstemon). Rose cultivars were able to partially close their stomata to reduce water loss when irrigation frequency dereased or air temperatures increased. ‘MEIRIFTDAY’ and ‘Meibenbino’ roses, which showed reductions in the dry weights of leaves and stems and exhibited unacceptable overall appearance, were less tolerant to reduced irrigation compared with ‘ChewPatout’, ‘Overedclimb’, and ‘Radbeauty’ roses when irrigation events decreased from eight to one time during the growing season. Our research showed that landscape plants might change their morphology and physiology to allow them to tolerate water deficit and leaf overheating under drought conditions. Using plants with drought resilience could maintain acceptable visual quality with reduced irrigation water.

Mao-Min Jiang,1,* Ji-Neng Chen,2,* Xin-Cheng Huang,3,* Yi-Lin Zhang,4 Jia-Bo Zhang,5 Jia-Wen Zhang6 1School of Public Affairs, Xiamen University, Xiamen, People’s Republic of China; 2Graduate School, St.Paul University Philippines, Tuguegarao, Philippines; 3School of Economics and Management, Beijing Institute of Graphic Communication, Beijing, People’s Republic of China; 4School of Humanities, Yangzhou University, Yangzhou, People’s Republic of China; 5School of Literature and Media, Lingnan Normal University, Zhanjiang, People’s Republic of China; 6School of Education, Silliman University, Dumaguete, 6200, Philippines*These authors contributed equally to this workCorrespondence: Jia-Bo Zhang; Jia-wen Zhang, Email zhjiabo22@gmail.com; jiawenzhang@su.edu.phIntroduction:  Suicidal ideation and suicidal behavior, as the most severe psychological and behavioral problems among adolescents, bring not only significant damage to individual social functioning but also cause enormous economic and social pressure, which will ultimately be detrimental to social development and social stability. This paper aimed to explore the potential relationship between teacher discrimination behavior, peer bullying victimization, anxiety disorders, and adolescent suicidal ideation based on the Vulnerability-Stress Model.Methods:  From September to November 2022, our research team surveyed 21,017 junior high school students from 12 secondary schools in ten cities in China. Mplus 8.3 software was used to analyze the pathways of teacher discrimination behavior on adolescent suicidal ideation.Results:  The results showed that teacher preference had a significant negative effect on suicidal ideation, and teacher prejudice significantly positively affected suicidal ideation. Mediation test results indicated that there were significant independent mediating effects of peer bullying victimization and anxiety disorders between teacher discrimination behavior and adolescents’ suicidal ideation, as well as significant chain mediating effects.&#x00A0Conclusion:  Secondary school teachers should improve their self-quality and pay more attention to adolescents’ suicidal ideation. Teachers are expected to put love into their education, respect and trust each student, and attend to their emotional needs unbiasedly. Educators should develop targeted prevention and intervention measures according to the actual situation of school bullying and also strengthen adolescents’ life-value education to improve the psychological quality of adolescents and create a healthy campus atmosphere.Keywords: teacher discrimination behavior, peer bullying victimization, anxiety disorders, suicidal ideation, adolescents

Diagrammatic summation is a common bottleneck in modern applications of projected entangled-pair states (PEPS), especially in computing low-energy excitations of a two dimensional quantum many-body system. To solve this problem, here we extend the generating function approach for tensor network diagrammatic summation, previously proposed in the context of matrix product states. With the excited state expressed as a one-particle excitation, we show that relevant objects in determining the variational parameters, i.e. effective hamiltonian and norm matrices in the variational parameter space can be easily computed in the generating function formalism, which can further be used in evaluating the dynamical structure factor. Our benchmark results for the spin-$1/2$ transverse field Ising model and Heisenberg model on the square lattice provide a desirable accuracy, showing good agreement with known results. Then we study the spin-$1/2$ $J_1-J_2$ model on the same lattice and investigate the dynamical properties of the putative gapless spin liquid phase. We conclude with a discussion on generalizations to multi-particle excitations., 12 pages, 6 figures

Neural network-based variational Monte Carlo (NN-VMC) has emerged as a promising cutting-edge technique of ab initio quantum chemistry. However, the high computational cost of existing approaches hinders their applications in realistic chemistry problems. Here, we report the development of a new NN-VMC method that achieves a remarkable speed-up by more than one order of magnitude, thereby greatly extending the applicability of NN-VMC to larger systems. Our key design is a novel computational framework named Forward Laplacian, which computes the Laplacian associated with neural networks, the bottleneck of NN-VMC, through an efficient forward propagation process. We then demonstrate that Forward Laplacian is not only versatile but also facilitates more developments of acceleration methods across various aspects, including optimization for sparse derivative matrix and efficient neural network design. Empirically, our approach enables NN-VMC to investigate a broader range of atoms, molecules and chemical reactions for the first time, providing valuable references to other ab initio methods. The results demonstrate a great potential in applying deep learning methods to solve general quantum mechanical problems.

International audience; We study the parton construction of chiral spin liquids (CSLs) using projected Gaussian fermionic entangled pair states (GfPEPSs). First, we show that GfPEPSs can represent generic spinless Chern insulators faithfully with finite bond dimensions. Then, by applying the Gutzwiller projection to a bi-layer GfPEPSs, spin-1/2 Abelian and non-Abelian CSLs are obtained for Chern number $C=1$ and $C=2$, respectively. As a consequence of the topological obstruction for GfPEPSs, very weak Gossamer tails are observed in the correlation functions of the fermionic projected entangled pair state (PEPS) ansatze, suggesting that the no-go theorem for chiral PEPS is universal but does not bring any practical limitation. Remarkably, without fine tuning, all topological sectors can be constructed showing the expected number of chiral branches in the respective entanglement spectra, providing a sharp improvement with respect to the known bosonic PEPS approach.

Water and its dissociated species at the solid‒liquid interface play critical roles in catalytic science; e.g., functions of oxygen species from water dissociation are gradually being recognized. Herein, the relationship between oxide identity (PtOHads, PtOads, and PtO2) and electrocatalytic activity of platinum for ethanol electrooxidation was obtained in perchlorate acidic solution over a wide potential range with an upper potential of 1.5 V (reversible hydrogen electrode, RHE). PtOHads and α-PtO2, rather than PtOads, act as catalytic centers promoting ethanol electrooxidation. This relationship was corroborated on Pt(111), Pt(110), and Pt(100) electrodes, respectively. A reaction mechanism of ethanol electrooxidation was developed with DFT calculations, in which platinum oxides-mediated dehydrogenation and hydrated reaction intermediate, geminal diol, can perfectly explain experimental results, including pH dependence of product selectivity and more active α-PtO2 than PtOHads. This work can be generalized to the oxidation of other substances on other metal/alloy electrodes in energy conversion and electrochemical syntheses.

Using S-wave records at epicentral distances less than 60 km we determine the apparent stress for 62 Mw≥4.5 earthquakes in southern California since 2000. All earthquakes have reliable network moment tensor solutions. We compute seismic radiated energy with two methods: a time domain method by Kanamori et al. (2020) and a frequency domain method by Boatwright et al. (2002). The Kanamori approach (GR) is a modified Gutenberg-Richter in which attenuation and near surface effects are not considered. The Boatwright method uses path attenuation, near surface kappa0, and a station specific radiation pattern. With Boatwright we compute seismic energy 1) with an average radiation pattern (F0) and 2) with station specific radiation pattern (F1). The geometric means of apparent stress are 0.48, 0.40 and 0.57 MPa for GR, F0 and F1, respectively. Apparent stress is independent of seismic moment for these earthquakes. Converting apparent stress to Brune’s stress drop (Andrews, 1986), we find stress drops of 2.1, 1.7 and 2.5 MPa for GR, F0 and F1, respectively. From the perspective of seismic radiated energy, a Brune stress drop is nearly the same as that when using Madariaga (1976) and Kaneko and Shearer (2014) models (Ji, Archuleta and Wang, 2022). The standard deviation of stress drop (log10) is 0.35—almost the same for GR, F0 and F1. Cotton et al. (2013) show the standard deviation from stochastic vibration theory used in ground motion prediction equations is 0.15 for Mw>5.5 earthquakes. Seismic moment/corner frequency methods produce a standard deviation of 0.61, though the magnitude range is larger in some studies. Apparent stress (and consequently stress drop) shows a statistically significant depth dependence (~0.05 MPa/km).

An Mw 7.8 earthquake occurred on the East Anatolian Fault (EAF) and the secondary Narlı Fault (NF) on Feb 6, 2023, closely followed by an Mw 7.5 event on the Sürgü Fault 9 hours later. We analyze the distant and local seismic data, high-rate GPS recordings, and radar satellite images by Slowness Enhanced Back-Projection and joint Finite Fault Inversion for the Mw 7.8 event to resolve its rupture process. The rupture first initiates and propagates on the NF. After reaching the junction with the EAF, it propagates bilaterally on the EAF, extending 120 km to the northeast at 3.05 km/s and 200 km to the southwest at 3.11 km/s. The southwest speed is further verified by local seismic recordings and the absence of Mach surface wave characteristics. Compared with the EAF, the NF features denser seismic activity in recent decades, suggesting that it was more favorable for rupture nucleation. The EAF segments where the largest coseismic slip occurred have been relatively quiescent since the late 1800s. But the coseismic slip is much larger than the slip deficit accumulated during this period, which could be attributed to an ~900-year supercycle. The EAF geometry is similar to other active fault systems, such as the San Andreas Fault (SAF) and San Jacinto Fault (SJF). Considering high slip rates, resemblant supercycle mode, and the lack of large earthquakes on the southern SAF and SJF since 1857, an M8 earthquake could potentially occur there if most moment accumulation is released at once.

Pulmonary arterial hypertension (PAH) is a rare but severe complication of connective tissue disease (CTD). CTD-associated PAH (CTD-PAH) is the most common subgroup of PAH in East Asia. We prospectively collected 41 patients with CTD-PAH and followed them for a mean period of 43 ± 36 months. The long-term survival rates of the CTD-PAH patients at 1, 2, 3 and 5 years were 90%, 80%, 77%, and 60%, respectively. The non-survivors had more dilated main pulmonary arteries, higher pulmonary artery pressure and pulmonary vascular resistance (PVR). PAH-specific therapy resulted in improvements in functional class, 6-minute walk distance, serum uric acid, right ventricular function and PVR. Increased C-reactive protein during follow-up, indicating inflammatory processes, was also crucial for the management of CTD-PAH. Therefore targeting both PAH and inflammation is important in this specific subgroup of PAH. The results of this study may help develop treatment strategies for CTD-PAH patients.

We examine the source parameters of four Mw≥7.0 intraslab earthquakes that occurred near the Tohoku coast over the past two decades: 2003, 2011, 2021, and 2022. By analyzing the finite fault slip histories constrained by inland strong motion observations, we found that these earthquakes occurred within the upper plane of the subducted Pacific Plate due to downdip compression caused by plate unbending. These earthquakes have a more compact fault area and higher stress drop compared to shallow crustal earthquakes. Additionally, intraslab earthquakes have much slower relative rupture velocity than shallow crustal earthquakes. Good spatial correlations between the static stress drop and slip rate are found, which may suggest the compatibility between dynamic stress drop and static stress drop. The rupture area, average slip, asperity area, average static stress drop over the entire fault, and asperities are consistent with the reported scaling relationship for global intraslab earthquakes within a similar depth range. Using plate unbending, we found the recurrence intervals of these intraslab earthquakes are around 600 years, which is comparable with that of the 2011 Tohoku earthquake. A visual spatial-correlation between the locations of these earthquakes and seismicity in the lower plane is reported. These findings provide insights into the tectonic background and source parameters of intraslab earthquakes in the Tohoku region and contribute to better seismic hazard assessment.

We theoretically analyzed the detailed carrier transport process based on the drift-diffusion model in the InGaAs/InP modified Uni-Traveling-Carrier Photodiode (MUTC-PD) under high optical input power conditions. A high-speed MUTC-PD design was simulated in depth using the commercial simulation software APSYS. The complex interplay between photo-electron and hole transport processes was quantitatively analyzed. The slowdown of hole transit time due to E field reduction in the undoped InGaAs absorber layer dominated the response speed of MUTC-PDs at a high optical power level. The optimized MUTC-PD design has a relatively strong dependence on optical power level. Based on an optimized design, an O–E conversion responsivity around 0.15 A/W and the intrinsic 3 dB bandwidth of 172 GHz were demonstrated when the input optical power density reached 20 mW/μm2. Our simulation analysis results presented here can be utilized for designing broadband MUTC-PDs in future sub-Terahertz free-space data link applications.

A review of a collection of theoretical source spectral models revealed: (1) Despite the well-known variation in predicting static stress drop Δσs from the seismic moment and corner frequency, all models, especially the three conventional models, suggest that earthquakes radiate about half of the available strain energy into the surrounding medium. This similarity justifies a less model-dependent approach to estimate Δσs, though estimates for natural earthquakes rely on apparent seismic radiation efficiency (=2σa/Δσs; σa is apparent stress of an earthquake). (2) When one attempts to use Δσs and spectral models to make predictions, such as apparent stress σa, there is a model-dependent discrepancy between the σa inferred from theoretical energy partitioning and the σa predicted using spherical mean corner frequency. Their ratio cp varies significantly from 1.0 for the Brune (1970, 1971) model to 6.38 for the Madariaga (1976) model. If one uses spectral models to predict the ground motion, cp must be considered. (3) We infer that the constancy of the “stress parameter” (Δσ˜) found in engineering seismology (e.g., Boore, 1983; Atkinson and Beresnev, 1998) is similar to having constant apparent stress, σa (e.g., Ide and Beroza, 2001). The observation that Δσ˜ is generally larger than the average static stress drop Δσs for global M >5.5 shallow crustal earthquakes in active tectonic regions implies that these earthquakes radiate, on average, more seismic energy than predicted from the conventional dynamic crack models.

Purpose The purpose of this paper is to introduce a novel method to study the flutter coupling mechanism of the twin-fuselage aircraft, which is becoming a popular transportation vehicle recently. Design/methodology/approach A new method of flutter mode indicator is proposed based on the principle of work and power, which is realized through energy accumulation of generalized force work on generalized coordinates, based on which flutter coupling mechanism of the twin-fuselage aircraft is studied using ground vibration test and computational fluid dynamics/computational solid dynamics method. Findings Verification of the proposed flutter mode indicator is provided, by which the flutter mechanism of the twin fuselage is found as the horizontal tail’s torsion coupled with its bending effect and the “frequency drifting” phenomenon of twin-fuselage aircraft is explained logically, highlighting the proposed method in this paper. Originality/value This paper proposed a new method of flutter mode indicator, which has advantages in flutter modes indexes reliability, clear physical meaning and results normalization. This study found the flutter coupling mechanism of twin-fuselage aircraft, which has important guiding significance to the development of twin-fuselage aircraft.

SUMMARY Precisely constraining the source parameters of large earthquakes is one of the primary objectives of seismology. However, the quality of the results relies on the quality of synthetic earth response. Although earth structure is laterally heterogeneous, particularly at shallow depth, most earthquake source studies at the global scale rely on the Green's functions calculated with radially symmetric (1-D) earth structure. To avoid the impact of inaccurate Green's functions, these conventional source studies use a limited set of seismic phases, such as long-period seismic waves, broad-band P and S waves in teleseismic distances (30° < ∆ 40 mHz) S wave and (>20 mHz) Rayleigh wave yet. Though the mean time-shifts are close to zero, the standard deviations are notable. Careful calibration using the records of nearby better located earthquakes is still recommended to take full advantage of better waveform similarity due to the use of 3-D models. Our results indicate that it is now feasible to systematically study global large earthquakes using full 3-D earth response in a global scale.

BACKGROUND: To investigate the value of intraoperative frozen section examination (IFSE) in multiparametric magnetic resonance imaging/transrectal ultrasound (mpMRI/TRUS) fusion prostate biopsy in a major pandemic. METHODS: A total of 35 patients were prospectively enrolled in our hospital from March 2020 to January 2021. The mpMRI/TRUS fusion system was used to perform a targeted biopsy, and the collected specimens were examined by IFSE (Observation Group 1). Then, a targeted biopsy was performed again for routine pathological examination (Observation Group 2). Finally, a systemic biopsy was performed, and the obtained specimens were routinely examined (Control Group). The positive rate, single core positive rate, Gleason score, and time to obtain pathological reports were compared between the groups. RESULTS: The positive rate was 48.6% (17/35) in the control group, 48.6% (17/35) in Observation Group 1, and 51.4% (18/35) in Observation Group 2, showing no significant difference (P>0.05). The single core positive rates were 17.8%, 44.6%, and 47.1% in the Control Group, Observation Group 1, and Observation Group 2, respectively. Observation Group 1 and Observation Group 2 were significantly different from the Control Group (P

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent association signals at genome-wide significance (P

Water absorption and dissociation processes on pristine low-index TiO$_2$ interfaces are important but poorly understood outside the well-studied anatase (101) and rutile (110). To understand these, we construct three sets of machine learning potentials that are simultaneously applicable to various TiO$_2$ surfaces, based on three density-functional-theory approximations. We compute the water dissociation free energies on seven pristine TiO$_2$ surfaces, and predict that anatase (100), anatase (110), rutile (001), and rutile (011) surfaces favor water dissociation, anatase (101) and rutile (100) surfaces have mostly molecular absorption, while the calculated dissociation fraction on rutile (110) surface may depend on the density functional assumed. Moreover, using an automated algorithm, we reveal that these surfaces follow different types of atomistic mechanisms for proton transfer and water dissociation: one-step, two-step, or both. Our finding thus demonstrates that the different pristine TiO$_2$ surfaces react with water in distinct ways, and cannot be represented using just the low-energy anatase (101) and rutile (110) surfaces.

Stem cells play a crucial role in re-establishing homeostasis in the body, and the search for mechanisms by which they interact with the host to exert their therapeutic effects remains a key question currently being addressed. Considering their significant regenerative/therapeutic potential, research on mesenchymal stem cells (MSCs) has experienced an unprecedented advance in recent years, becoming the focus of extensive works worldwide to develop cell-based approaches for a variety of diseases. Initial evidence for the effectiveness of MSCs therapy comes from the restoration of dynamic microenvironmental homeostasis and endogenous stem cell function in recipient tissues by systemically delivered MSCs. The specific mechanisms by which the effects are exerted remain to be investigated in depth. Importantly, the profound cell-host interplay leaves persistent therapeutic benefits that remain detectable long after the disappearance of transplanted MSCs. In this review, we summarize recent advances on the role of MSCs in multiple disease models, provide insights into the mechanisms by which MSCs interact with endogenous stem cells to exert therapeutic effects, and refine the interconnections between MSCs and cells fused to damaged sites or differentiated into functional cells early in therapy.

Localization due to disorder has been one of the most intriguing theoretical concepts evolved in condensed matter. Here, we expand the theory of localization by considering two types of disorder at the same time, namely the original Anderson's disorder and the structural defect disorder, which has been suggested to be a key component in recently discovered two-dimensional amorphous materials. While increasing the degree of both disorders could induce localization of wavefunction in real space, we find that a small degree of structural defect disorder can significantly enhance the localization. As the degree of structural defect disorder increases, localized states quickly appear within the extended phase to enter a broad crossover region with mixed phases. Full localization occurs when structural defect disorder reaches about 10 percent, even without considering the Anderson type disorder. Our theoretical model provides a comprehensive understanding of localization in two-dimensional amorphous materials and highlights the promising tunability of their transport properties.

Diamond is a solid-state platform to develop quantum technologies, but it has been a long-standing problem that the current understanding of quantum states in diamond is mostly limited to single-electron pictures. Here, we combine the full configuration interaction quantum Monte Carlo method and the density-matrix functional embedding theory, to achieve unprecedented accuracy in describing the many-body quantum states of nitrogen vacancy (NV) centers in diamond. More than 30 electrons and 130 molecular orbitals are correlated, which reveals the multi-configurational wavefunction of the many-body quantum states in diamond. The multi-configurational description explains puzzling experimental measurements in intersystem crossing and charge state transition in NV centers in diamond. The calculations not only reproduce the available experimental measurements of the energy gaps between quantum states but also provide new benchmarks for states that are still subject to considerable uncertainty. This study highlights the importance of multi-configurational wavefunction in the many-body quantum states in solids.

We study a $\mathbb{Z}_3$ Kitaev model on the honeycomb lattice with nearest neighbor interactions. Based on matrix product state simulations and symmetry considerations, we find evidence that, with ferromagnetic isotropic couplings, the model realizes a chiral Fibonacci spin liquid, characterized by the $\mathbb{Z}_3$ parafermion topological order. This is supported by simulations on both cylinder and strip geometries. On infinitely long cylinders with various widths, scaling analysis of entanglement entropy and maximal correlation length suggests that the model has a gapped 2D bulk. The topological entanglement entropy is extracted and found to be in agreement with the $\mathbb{Z}_3$ parafermion topological order. On infinitely long strips with moderate widths, we find the model is critical with a central charge consistent with the chiral edge theory of the $\mathbb{Z}_3$ parafermion topological phase. We conclude by commenting on an experimental realization of this model in Rydberg atom arrays., 4.5+2 pages, 4+4 figures

Background Postal screening has not previously been validated as a method for identifying fall and fracture risk in community-dwelling populations. We examined prognostic performance of a postal risk screener used in the UK Prevention of Falls Injury Trial (PreFIT; ISRCTN71002650), to predict any fall, recurrent falls, and fractures over 12 months. We tested whether adding variables would improve screener performance. Methods Nine thousand eight hundred and eight community-dwelling participants, aged 70 years and older, and 63 general practices in the UK National Health Service (NHS) were included in a large, pragmatic cluster randomised trial comparing screen and treat fall prevention interventions. The short postal screener was sent to all participants in the trial intervention arms as an A4 sheet to be completed and returned to the GP (n = 6,580). The postal screener items were embedded in the baseline pre-randomisation postal questionnaire for all arms of the trial (n = 9,808). We assessed discrimination and calibration using area under the curve (AUC). We identified additional predictors using data from the control arm and applied these coefficients to internal validation models in the intervention arm participants. We used logistic regression to identify additional predictor variables. Findings A total of 10,743 falls and 307 fractures were reported over 12 months. Over one third of participants 3,349/8,136 (41%) fell at least once over 12 month follow up. Response to the postal screener was high (5,779/6,580; 88%). Prediction models showed similar discriminatory ability in both control and intervention arms, with discrimination values for any fall AUC 0.67 (95% CI 0.65 to 0.68), and recurrent falls (AUC 0.71; 95% CI 0.69, 0.72) but poorer discrimination for fractures (AUC 0.60; 95% CI 0.56, 0.64). Additional predictor variables improved prediction of falls but had modest effect on fracture, where AUC rose to 0.71 (95% CI 0.67 to 0.74). Calibration slopes were very close to 1. Conclusion A short fall risk postal screener was acceptable for use in primary care but fall prediction was limited, although consistent with other tools. Fracture and fall prediction were only partially reliant on fall risk although were improved with the additional variables.

IntroductionIt is essential to understand plant adaptive strategies on plant stoichiometric traits at the species level rather than at the community level under various environmental conditions across the Tibetan Plateau (TP).MethodsHere, plant community function and edaphic and meteorological factors were collected at 111 sites along an extensive water–heat gradient during the peak growing season in 2015. Community-weighted mean trait (CWM) was introduced to illuminating dynamics of the functional trait at the community level.ResultsOur results indicated that plant functional traits, including CWM-leaf total carbon (CWM_LTC), CWM-leaf total nitrogen (CWM_LTN), and CWM-leaf total phosphorus (CWM_LTP), showed similar and comparatively marked increases from alpine meadow (AM) to alpine steppe (AS). Moreover, since the tightly coordinated variation among each plant functional trait of AM was higher than that of AS, a more stable coupling mechanism of these plant functional traits could be observed in AM under a long-term evolutionary habit. Specifically, there was higher annual mean precipitation (AMP) in AM than that in AS significantly (P < 0.01), and AMP was significantly correlated with soil moisture and soil total phosphorus in AM. Generally, our findings suggest that precipitation determines divergent coupling plant community function in both AS and AM.

PURPOSE: To preliminarily clarify the mechanism of paclitaxel (PTX) resistance in cervical squamous cell carcinoma with the involvement of ZBTB5. RESULTS: 1) Overexpression of ZBTB5 was cultured in PTX, and immunofluorescence showed that overexpression of ZBTB5 enhanced cervical squamous cell carcinoma resistance to PTX by functioning in the cell nucleus. 2) ZBTB5knockdown inhibited cell cloningand proliferation and enhanced apoptosis of cervical squamous carcinoma cells in PTX and reduced resistance to PTX in SiHa cells compared with the non-knockdown group (p < 0.05). 3) A ChIP assay was performed after overexpression of ZBTB5, which suggested that the BCL6 gene is located 395 kb from the TSS region and may be regulated by ZBTB5, which may be the promoter of BCL6. This result was consistent with that of the IPA bioinformatics analysis. 4) Further in-gel enzymatic digestion and shotgun-mass spectrometry protein identification were performed after Co-IP, and 322 differential proteins were identified in the overexpression group. Bioinformatics analysis of different proteins was conducted and 13 proteins were selected for validation: U2AF2, RBM5, ILK, ENAH, JUP, RELA/P65, SQSTM1, YY1, STIM1, Integrin alpha V, EED, SUGT1, and NFKB1. Among them, U2AF2 was successfully detected in the input, suggesting a possible interaction of ZBTB5 with U2AF2. CONCLUSION: There is a protein–protein interaction between ZBTB5 and U2AF2, and ZBTB5 is involved in PTX resistance in cervical squamous cell carcinoma by regulating BCL6. It was hypothesized that ZBTB5 may form a transcriptional complex with U2AF2 to regulate BCL6 to affect tumor cell proliferation and participate in PTX resistance in cervical squamous cell carcinoma.

Hepatocellular carcinoma (HCC) is characterized by high rates of recurrence and metastasis and poor prognosis. A recently discovered concept of T cell tolerance (TCT) has become an entirely new target of cancer immunotherapy. Unfortunately, the effect of TCT on the outcomes of HCC has not been explored. In this study, 7 public datasets and one external clinical cohort, including 1716 HCC patients were explored. Through WGCNA analysis and differential analysis, we explored the key TCT-related modulates. A total of 95 machine learning integrations across all validation cohorts were compared and the optimal method with the highest average C-index value was selected to construct the TCT derived signature (TCTS). In all independent clinical cohorts, TCTS showed accurate prediction of the prognosis, and was significantly correlated with clinical indicators and molecular features. Compared with 77 published gene signatures, the TCTS exhibited superior predictive performance. In the external clinical cohort, a novel nomogram (comprising TNM stage, Hepatitis B, Vascular invasion, Perineural invasion, AFP and TCTS) was constructed to test the clinical performance of TCTS. The results showed that the high TCTS scoring group showed dismal prognosis, improved sensitivity to oxaliplatin and good response to anti-PD-1/PD-L1 immunotherapy. Moreover, the low TCTS score group had few genomic alterations, low immune activation and low PD-1/PD-L1 expression levels. In conclusion, TCTS is an ideal biomarker for predicting the clinical outcomes and improving precision treatment of HCC.

(2+1)-D chiral topological phases are often identified by studying low-lying entanglement spectra (ES) of their wavefunctions on long cylinders of finite circumference. For chiral topological states that possess global $\mathrm{SU}(3)$ symmetry, we can now understand, as shown in this work, the nature of the topological phase from the study of the splittings of degeneracies in the finite-size ES, at a given momentum, solely from the perspective of conformal field theory (CFT). This is a finer diagnostic than Li-Haldane "state-counting", extending the approach of PRB 106, 035138 (2022) by two of the authors. We contrast ES of such chiral topological states with those of a non-chiral PEPS (Kure\v{c}i\'c, Sterdyniak, and Schuch [PRB 99, 045116 (2019)]) also possessing $\mathrm{SU}(3)$ symmetry. That latter PEPS has the same discrete symmetry as the chiral PEPS: strong breaking of separate time-reversal and reflection symmetries, with invariance under the product of these two operations. However, the full analysis of the topological sectors of the ES of the latter PEPS in prior work [arXiv:2207.03246] shows lack of chirality, as would be manifested, e.g., by a vanishing chiral central charge. In the present work, we identify a distinct indicator and hallmark of chirality in the ES: the splittings of conjugate irreps. We prove that in the ES of the chiral states conjugate irreps are exactly degenerate, because the operators [related to the cubic Casimir invariant of $\mathrm{SU}(3)$] that would split them are forbidden. By contrast, in the ES of non-chiral states, conjugate splittings are demonstrably non-vanishing. Such a diagnostic significantly simplifies identification of non-chirality in low-energy finite-size ES for $\mathrm{SU}(3)$-symmetric topological states., Comment: 49 pages, 14 figures, 8 tables

Motivated by the search for chiral spin liquids (CSL), we consider a simple model defined on the kagome lattice of interacting SU(3) spins (in the fundamental representation) including two-site and three-site permutations between nearest neighbor sites and on triangles, respectively. By combining analytical developments and various numerical techniques, namely exact Lanczos diagonalizations and tensor network variational approaches, we find a rich phase diagram with non-topological (``trivial") and topological (possibly chiral) gapped spin liquids (SLs). Trivial spin liquids include an Affleck-Kennedy-Lieb-Tasaki (AKLT)-like phase and a trimerized phase, the latter breaking the inversion center between the up and down triangles of the kagome lattice. A topological SL is stabilized in a restricted part of the phase diagram by the time-reversal symmetry breaking (complex) 3-site permutation term. Analyzing the chiral edge modes of this topological SL on long cylinders or on finite disks, we have come up with two competing scenarios, either a CSL or a double Chern-Simon SL characterized by a single or by two counter-propagating Wess-Zumino-Witten SU(3)$_1$ chiral mode(s), respectively. In the vicinity of the extended ferromagnetic region we have found a magnetic phase corresponding either to a modulated canted ferromagnet or to a uniform partially magnetized ferromagnet., Comment: 24 pages, 25 figures, 4 tables

Supplemental material, sj-docx-1-dhj-10.1177_20552076231184048 for Global research landscape on artificial intelligence in arthroplasty: A bibliometric analysis by Zhuo Li, Zulipikaer Maimaiti, Jun Fu, Ji-Ying Chen and Chi Xu in DIGITAL HEALTH