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2. Conceptual alignment in a joint picture-naming task performed with a social robot

Author

Elin Runnqvist, Nguyen N, Kristof Strijkers, Cristina Baus, Cirillo G, Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institute of Language, Communication and the Brain (ILCB), Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Universitat Pompeu Fabra [Barcelona] (UPF), University of Barcelona, ANR-16-CE28-0007,TIBLT,Vers une théorie intégrée de langage et cerveau(2016), and ANR-18-CE28-0013,SLIP,Auto-surveillance du langage en production(2018)

Subjects
picture naming, Linguistics and Language, Social robot, Computer science, Cognitive Neuroscience, joint action, lexical alignment, artificial partner, Social Interaction, Experimental and Cognitive Psychology, Robotics, co- representation, spoken word production, Language and Linguistics, Semantics, Task (project management), [SHS]Humanities and Social Sciences, Pattern Recognition, Visual, conceptual alignment, Human–computer interaction, Reaction Time, Developmental and Educational Psychology, Humans, Joint (building), Picture naming
Abstract

International audience; In this study we investigated whether people conceptually align when performing a language task together with a robot. In a joint picture-naming task, 24 French native speakers took turns with a robot in naming images of objects belonging to fifteen different semantic categories. For a subset of those semantic categories, the robot was programmed to produce the superordinate, semantic category name (e.g., fruit) instead of the more typical basic-level name associated with an object (e.g., pear). Importantly, while semantic categories were shared between the participant and the robot (e.g., fruits), different objects were assigned to each of them (e.g., the object of ‘a pear’ for the robot and of ‘an apple’ for the participant). Logistic regression models on participants' responses revealed that they aligned with the conceptual choices of the robot, producing over the course of the experiment more superordinate names (e.g., saying ‘fruit’ to the picture of an ‘apple’) for those objects belonging to the same semantic category as where the robot produced a superordinate name (e.g., saying ‘fruit’ to the picture of a ‘pear’). These results provide evidence for conceptual alignment affecting speakers' word choices as a result of adaptation to the partner, even when the partner is a robot.

Published
2022
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3. Pediatric non-alcoholic fatty liver disease: current perspectives on diagnosis and management

Author

Di Sessa A, Cirillo G, Guarino S, Marzuillo P, and Miraglia del Giudice E

Subjects
lcsh:RJ1-570, lcsh:Pediatrics, fatty, liver, pediatric, diagnosis, management
Abstract

Anna Di Sessa, Grazia Cirillo, Stefano Guarino, Pierluigi Marzuillo, Emanuele Miraglia del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Studies of Campania “Luigi Vanvitelli”, Napoli 80138, ItalyCorrespondence: Pierluigi MarzuilloDepartment of Woman, Child and General and Specialized Surgery, University of Studies of Campania “Luigi Vanvitelli”, 80138 Napoli, ItalyTel +39 081 566 5465Email pierluigi.marzuillo@gmail.comAbstract: Non-alcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disease in childhood. To date, the “multiple-hit” hypothesis is largely recognized as an explanation of NAFLD pathogenesis and progression. Obesity and features of the metabolic syndrome have been closely linked to NAFLD development. Due to the increased prevalence of obesity worldwide, NAFLD has reached epidemic proportions over time. Given its unfavorable cardiometabolic burden (such as cardiovascular and metabolic consequences), it represents a worrying phenomenon needing a more comprehensive and successful management. Laboratory tests and classical imaging techniques play a pivotal role in NAFLD diagnosis, but novel noninvasive alternative methods to diagnose and monitor NAFLD have been investigated. Currently, lifestyle modifications remain the mainstay treatment, although its efficacy is poor because of the lack of compliance. Pediatric research is focusing on multiple alternative treatments targeting the main pathogenic factors such as insulin-resistance, dyslipidemia, gut-liver axis and microbiota, oxidative stress, and proinflammatory pathways. Results from these studies are promising but larger validation is needed. Innovative therapeutic approaches might add an important piece in the complex knowledge of pediatric NAFLD. We aimed to summarize recent insights into NAFLD diagnosis and treatment in children, with a focus on possible future perspectives in pediatric research.Keywords: fatty, liver, pediatric, diagnosis, management &nbsp

Published
2019

4. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study

Author

James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionut Negoi, Milagros Niquen, Faustin Ntirenganya, Maricarmen Olivos, Kacimi Oussama, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Francesco Pata, Carlos Jose Perez Rivera, Thomas D Pinkney, Willemijn van der Plas, Peter Pockney, Ahmad Qureshi, Dejan Radenkovic, Antonio Ramos-De la Medina, Keith Roberts, April C Roslani, Martin Rutegård, Juan José Segura-Sampedro, Irène Santos, Sohei Satoi, Raza Sayyed, Andrew Schache, Andreas A Schnitzbauer, Justina O Seyi-Olajide, Neil Sharma, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Grant D Stewart, Malin Sund, Sudha Sundar, Stephen Tabiri, Philip Townend, Georgios Tsoulfas, Gabrielle H van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver J Warren, Duane Wedderburn, Naomi Wright, C Allemand, L Boccalatte, M Figari, M Lamm, J Larrañaga, C Marchitelli, F Noll, D Odetto, M Perrotta, J Saadi, L Zamora, C Alurralde, E L Caram, D Eskinazi, J P Mendoza, M Usandivaras, R Badra, A Esteban, J S García, P M García, J I Gerchunoff, S M Lucchini, M A NIgra, L Vargas, T Hovhannisyan, A Stepanyan, T Gould, R Gourlay, B Griffiths, S Gananadha, M McLaren, J Cecire, N Joshi, S Salindera, A Sutherland, J H Ahn, G Charlton, S Chen, N Gauri, R Hayhurst, S Jang, F Jia, C Mulligan, W Yang, G Ye, H Zhang, M Ballal, D Gibson, D Hayne, J Moss, T Richards, P Viswambaram, U G Vo, J Bennetts, T Bright, M Brooke-Smith, R Fong, B Gricks, Y H Lam, B S Ong, M Szpytma, D Watson, K Bagraith, S Caird, E Chan, C Dawson, D Ho, E Jeyarajan, S Jordan, A Lim, G J Nolan, A Oar, D Parker, H Puhalla, A Quennell, L Rutherford, P Townend, M Von Papen, M Wullschleger, A Blatt, D Cope, N Egoroff, M Fenton, J Gani, N Lott, P Pockney, N Shugg, M Elliott, D Phung, D Phan, D Townend, C Bong, J Gundara, A Frankel, S Bowman, G R Guerra, J Bolt, K Buddingh, N N Dudi-Venkata, S Jog, H M Kroon, T Sammour, R Smith, C Stranz, M Batstone, K Lah, W McGahan, D Mitchell, A Morton, A Pearce, M Roberts, G Sheahan, B Swinson, N Alam, S Banting, L Chong, P Choong, S Clatworthy, D Foley, A Fox, M W Hii, B Knowles, J Mack, M Read, A Rowcroft, S Ward, G Wright, M Lanner, I Königsrainer, M Bauer, C Freyschlag, M Kafka, F Messner, D Öfner, I Tsibulak, K Emmanuel, M Grechenig, R Gruber, M Harald, L Öhlberger, J Presl, A Wimmer, I Namazov, E Samadov, D Barker, R Boyce, S Corbin, A Doyle, A Eastmond, R Gill, A Haynes, S Millar, M O'Shea, G Padmore, N Paquette, E Phillips, S St John, K Walkes, N Flamey, P Pattyn, W Oosterlinck, J Van den Eynde, R Van den Eynde, A Gatti, C Nardi, R Oliva, R De Cicco, I Cecconello, P Gregorio, L Pontual Lima, U Ribeiro Junior, F Takeda, R M Terra, M Sokolov, B Kidane, S Srinathan, M Boutros, N Caminsky, G Ghitulescu, G Jamjoum, J Moon, J Pelletier, T Vanounou, S Wong, M Boutros, S Dumitra, A Kouyoumdjian, B Johnston, C Russell, M Boutros, S Demyttenaere, R Garfinkle, J Abou-Khalil, C Nessim, J Stevenson, F Heredia, A Almeciga, A Fletcher, A Merchan, L O Puentes, J Mendoza Quevedo, G Bacic, D Karlovic, D Krsul, M Zelic, I Luksic, M Mamic, B Bakmaz, I Coza, E Dijan, Z Katusic, J Mihanovic, I Rakvin, K Frantzeskou, N Gouvas, G Kokkinos, P Papatheodorou, I Pozotou, O Stavrinidou, A Yiallourou, L Martinek, M Skrovina, I Szubota, J Žatecký, V Javurkova, J Klat, T Avlund, P Christensen, J L Harbjerg, L H Iversen, D W Kjaer, Hø Kristensen, M Mekhael, A L Ebbehøj, P Krarup, N Schlesinger, H Smith, A Abdelsamed, A Y Azzam, H Salem, A Seleim, A Abdelmajeed, M Abdou, N E Abosamak, M Al Sayed, F Ashoush, R Atta, E Elazzazy, M Elhoseiny, M Elnemr, M S Elqasabi, M E Elsayed Hewalla, I Elsherbini, E Essam, M Eweda, I Ghallab, E Hassan, M Ibrahim, M Metwalli, M Mourad, M S Qatora, M Ragab, A Sabry, H Saifeldin, M Saleh Mesbah Mohamed Elkaffas, A Samih, A Samir Abdelaal, S Shehata, K Shenit, D Attia, N Kamal, N Osman, A M Abbas, Has Abd Elazeem, M M Abdelkarem, S Alaa, A K Ali, A Ayman, M G Azizeldine, H Elkhayat, S M Elghazaly, F A Monib, M A Nageh, M M Saad, M Salah, M Shahine, E A Yousof, A Youssef, A Eldaly, M ElFiky, A Nabil, G Amira, I Sallam, M Sherief, A Sherif, A Abdelrahman, H Aboulkassem, G Ghaly, R Hamdy, A Morsi, H Salem, G Sherif, H Abdeldayem, I Abdelkader Salama, M Balabel, Y Fayed, A E Sherif, D Bekele, J Kauppila, E Sarjanoja, O Helminen, H Huhta, J H Kauppila, C Beyrne, L Jouffret, L Lugans, L Marie-Macron, E Chouillard, B De Simone, J Bettoni, S Dakpé, B Devauchelle, N Lavagen, S Testelin, S Boucher, R Breheret, A Gueutier, A Kahn, J KÜn-Darbois, A Barrabe, Z Lakkis, A Louvrier, S Manfredelli, P Mathieu, A Chebaro, V Drubay, M El Amrani, C Eveno, K Lecolle, G Legault, L Martin, G Piessen, F R Pruvot, S Truant, P Zerbib, Q Ballouhey, B Barrat, J Laloze, H Salle, A Taibi, J Usseglio, D Bergeat, A Merdrignac, Roy B Le, L O Perotto, A Scalabre, A Aimé, A Ezanno, B Malgras, P Bouche, S Tzedakis, E Cotte, O Glehen, V Kepenekian, J Lifante, G Passot, A D'Urso, E Felli, D Mutter, P Pessaux, B Seeliger, J Bardet, R Berry, G Boddaert, S Bonnet, E Brian, C Denet, D Fuks, D Gossot, M Grigoroiu, A Laforest, Y Levy-Zauberman, C Louis-Sylvestre, A Moumen, G Pourcher, A Seguin-Givelet, E Tribillon, E Duchalais, F Espitalier, C Ferron, O Malard, U Bork, M Distler, J Fritzmann, J Kirchberg, C Praetorius, C Riediger, J Weitz, T Welsch, P Wimberger, K Beyer, C Kamphues, J Lauscher, F N Loch, C Schineis, M Albertsmeier, M Angele, A Kappenberger, H Niess, T Schiergens, J Werner, R Becker, J Jonescheit, I Pergolini, D Reim, C Boeker, I Hakami, J Mall, P Liokatis, W Smolka, K Nowak, T Reinhard, F Hölzle, A Modabber, P Winnand, M Knitschke, P Kauffmann, S Wolfer, J Kleeff, K Lorenz, C Michalski, U Ronellenfitsch, R Schneider, E Bertolani, A Königsrainer, M W Löffler, M Quante, C Steidle, L ÜberrÜck, C Yurttas, C S Betz, J Bewarder, A Böttcher, S Burg, C Busch, M Gosau, A Heuer, J Izbicki, T O Klatte, D Koenig, N Moeckelmann, C Nitschke, M Priemel, R Smeets, U Speth, S Thole, F G Uzunoglu, T Vollkommer, N Zeller, M J Battista, K Gillen, A Hasenburg, S Krajnak, V Linz, R Schwab, K Angelou, D Haidopoulos, A Rodolakis, P Antonakis, K Bramis, L Chardalias, I Contis, N Dafnios, D Dellaportas, G Fragulidis, A Gklavas, M Konstadoulakis, N Memos, I Papaconstantinou, A Polydorou, T Theodosopoulos, A Vezakis, M I Antonopoulou, D K Manatakis, N Tasis, N Arkadopoulos, N Danias, P Economopoulou, P Kokoropoulos, A Larentzakis, N Michalopoulos, J Selmani, T Sidiropoulos, V Tsaousis, P Vassiliu, K Bouchagier, S Klimopoulos, D Paspaliari, G Stylianidis, K Baxevanidou, K Bouliaris, P Chatzikomnitsa, M Efthimiou, A Giaglaras, C Kalfountzos, G Koukoulis, A M Ntziovara, K Petropoulos, K Soulikia, I Tsiamalou, K Zervas, S Zourntou, I Baloyiannis, A Diamantis, E Gkrinia, J Hajiioannou, C Korais, O Koukoura, K Perivoliotis, A Saratziotis, C Skoulakis, D Symeonidis, K Tepetes, G Tzovaras, D Zacharoulis, V Alexoudi, K Antoniades, I Astreidis, P Christidis, D Deligiannidis, T Grivas, O Ioannidis, I Kalaitsidou, L Loutzidou, A Mantevas, D Michailidou, K Paraskevopoulos, S Politis, A Stavroglou, D Tatsis, I Tilaveridis, K Vahtsevanos, G Venetis, I Karaitianos, T Tsirlis, A Charalabopoulos, T Liakakos, E Mpaili, D Schizas, E Spartalis, A Syllaios, C Zografos, C Anthoulakis, C Christou, V Papadopoulos, A Tooulias, D Tsolakidis, G Tsoulfas, D Zouzoulas, E Athanasakis, E Chrysos, J Tsiaoussis, S Xenaki, E Xynos, K Futaba, M F Ho, S F Hon, Twc Mak, Ssm Ng, C C Foo, B Banky, N Suszták, M Aremu, A Canas-Martinez, O Cullivan, C Murphy, P Owens, L Pickett, L Akmenkalne, J Byrne, M Corrigan, C Cullinane, A Daly, C Fleming, P Jordan, S Killeen, N Lynch, A McCarthy, H Mustafa, S O'Brien, P O'Leary, Was Syed, L Vernon, D Callanan, L Huang, A Ionescu, P Sheahan, I Balasubramanian, M Boland, K Conlon, D Evoy, N Fearon, T Gallagher, J Geraghty, H Heneghan, N Kennedy, D Maguire, D McCartan, E W McDermott, R S Prichard, D Winter, D Alazawi, C Barry, T Boyle, W Butt, E M Connolly, N Donlon, C Donohue, B A Fahey, R Farrell, C Fitzgerald, J Kinsella, J O Larkin, P Lennon, P J Maguire, P Mccormick, B J Mehigan, H Mohan, T Nugent, H O'Sullivan, N Ravi, J V Reynolds, A Rogers, P Shokuhi, J Smith, L A Smith, C Timon, Y Bashir, G Bass, T Connelly, B Creavin, H Earley, J A Elliott, A Gillis, D Kavanagh, P Neary, J O'riordan, I S Reynolds, D Rice, P Ridgway, M Umair, M Whelan, P Carroll, C Collins, K Corless, L Finnegan, A Fowler, A Hogan, M Kerin, A Lowery, P McAnena, K McKevitt, K Nizami, É Ryan, A Samy, J C Coffey, R Cunningham, M Devine, D Nally, C Peirce, S Tormey, N Hardy, P Neary, S O'Malley, M Ryan, S Macina, N M Mariani, E Opocher, A Pisani Ceretti, F Ferrari, F Odicino, E Sartori, C Cotsoglou, S Granieri, F Bianco, A Camillo, M Colledan, S Tornese, M F Zambelli, G Bissolotti, S Fusetti, F Lemma, M V Marino, A Mirabella, G Vaccarella, C Agostini, G Alemanno, I Bartolini, C Bergamini, A Bruscino, C Checcucci, R De Vincenti, A Di Bella, M Fambrini, L Fortuna, G Maltinti, P Muiesan, F Petraglia, P Prosperi, M N Ringressi, M Risaliti, F Sorbi, A Taddei, R Tucci, C Bassi, L Bortolasi, T Campagnaro, L Casetti, M De Pastena, A Esposito, M Fontana, A Guglielmi, L Landoni, G Malleo, G Marchegiani, S Nobile, S Paiella, C Pedrazzani, S Rattizzato, A Ruzzenente, R Salvia, G Turri, M Tuveri, P Bellora, G D'Aloisio, M Ferrari, E Francone, S Gentilli, H Nikaj, M Bianchini, M Chiarugi, F Coccolini, G Di Franco, N Furbetta, D Gianardi, S Guadagni, L Morelli, M Palmeri, D Tartaglia, G Anania, P Carcoforo, M Chiozza, A De Troia, M Koleva Radica, M Portinari, M G Sibilla, A Urbani, N Fabbri, C V Feo, S Gennari, S Parini, E Righini, L Ampollini, L Bellanti, M Bergonzani, G Bertoli, G Bocchialini, G D'Angelo, D Lanfranco, L Musini, T Poli, G P Santoro, A Varazzani, L Aguzzoli, G Borgonovo, C Castro Ruiz, S Coiro, G Falco, V D Mandato, V Mastrofilippo, M T Montella, V Annessi, M Zizzo, U Grossi, S Novello, M Romano, S Rossi, G Zanus, G Esposito, F Frongia, A Pisanu, M Podda, C Belluco, A Lauretta, G Montori, L Moras, M Olivieri, F Bussu, A G Carta, M L Cossu, P Cottu, A Fancellu, C F Feo, G C Ginesu, G Giuliani, M Madonia, T Perra, A Piras, A Porcu, D Rizzo, A M Scanu, A Tedde, M Tedde, P Delrio, D Rega, G Badalamenti, G Campisi, A Cordova, M Franza, G Maniaci, G Rinaldi, F Toia, M Calabrò, F Farnesi, E G Lunghi, A Muratore, N S Pipitone Federico, F Bàmbina, G D'Andrea, P Familiari, V Picotti, G De Palma, G Luglio, G Pagano, F P Tropeano, L Baldari, G A Beltramini, L Boni, E Cassinotti, A Gianni, L Pignataro, S Torretta, C Abatini, M Baia, D Biasoni, G Bogani, P Cadenelli, V Capizzi, Spb Cioffi, D Citterio, L V Comini, M Cosimelli, M Fiore, S Folli, M Gennaro, L Giannini, A Gronchi, M Guaglio, A Macchi, F Martinelli, V Mazzaferro, A Mosca, S Pasquali, C Piazza, F Raspagliesi, L Rolli, R Salvioni, G Sarpietro, C Sarre, L Sorrentino, A Agnes, S Alfieri, F Belia, A Biondi, V Cozza, A D'Amore, D D'Ugo, V De Simone, A Fagotti, G Gasparini, L Gordini, F Litta, C P Lombardi, L Lorenzon, A A Marra, F Marzi, A Moro, A Parello, E Perrone, R Persiani, C Ratto, F Rosa, G Saponaro, G Scambia, O Scrima, G Sganga, R Tudisco, A Belli, V Granata, F Izzo, R Palaia, R Patrone, F M Carrano, M M Carvello, A De Virgilio, F Di Candido, F Ferreli, F Gaino, G Mercante, V Rossi, A Spinelli, G Spriano, D M Donati, T Frisoni, E Palmerini, A Aprile, F Barra, P Batistotti, S Ferrero, P Fregatti, S Scabini, M Sparavigna, E Asti, D Bernardi, L Bonavina, A Lovece, L Adamoli, M Ansarin, S Cenciarelli, F Chu, R De Berardinis, U Fumagalli Romario, F Mastrilli, G Pietrobon, M Tagliabue, E Badellino, A Ferrero, R Massobrio, A De Manzoni Garberini, P Federico, P Maida, E Marra, G Marte, A Petrillo, T Tammaro, A Tufo, M Berselli, G Borroni, E Cocozza, L Conti, M Desio, L Livraghi, V Quintodei, A Rizzi, A Zullo, C Baldi, C Corbellini, G M Sampietro, P Cellerino, E Baldini, P Capelli, L Conti, S M Isolani, M Ribolla, A Bondurri, F Colombo, L Ferrario, C Guerci, A Maffioli, T Armao, M Ballabio, P Bisagni, A Gagliano, M Longhi, M Madonini, P PizziCni, A M Baietti, M Biasini, P Maremonti, F Neri, G M Prucher, S Ricci, F Ruggiero, A G Zarabini, R Barmasse, S Mochet, L Morelli, A Usai, F Bianco, P Incollingo, S Mancini, L Marino Cosentino, A Sagnotta, R Fruscio, T Grassi, L C Nespoli, N Tamini, A Anastasi, B Bartalucci, A Bellacci, G Canonico, L Capezzuoli, C Di Martino, P Ipponi, C Linari, M Montelatici, T Nelli, G Spagni, L Tirloni, A Vitali, E Abate, M Casati, T Casiraghi, L Laface, M Schiavo, A Arminio, A Cotoia, V Lizzi, F Vovola, R Vergari, S D'Ugo, N Depalma, M G Spampinato, P Bartolucci, G Brachini, P Bruzzaniti, A Chiappini, V Chiarella, F Ciccarone, P M Cicerchia, B Cirillo, G De Toma, A Di Bartolomeo, E Fiori, G B Fonsi, G Franco, A Frati, M Giugliano, I Iannone, F La Torre, P Lapolla, C Leonardo, G Marruzzo, S Meneghini, A Mingoli, D Ribuffo, M Salvati, A Santoro, P Sapienza, A K Scafa, L Simonelli, M Zambon, G T Capolupo, F Carannante, M Caricato, G Mascianà, E Mazzotta, A Gattolin, M Migliore, R Rimonda, D Sasia, E Travaglio, M Cervellera, A Gori, L Sartarelli, V Tonini, M Giacometti, S Zonta, A Chessa, A Fiorini, C Norcini, G Colletti, M Confalonieri, A Costanzi, C Frattaruolo, G Mari, M Monteleone, A Bandiera, L Bocciolone, G Bonavina, M Candiani, G Candotti, P De Nardi, F Gagliardi, M Medone, P Mortini, G Negri, P Parise, M Piloni, P Sileri, A Vignali, A Belvedere, P Bernante, P Bertoglio, S Boussedra, E Brunocilla, R Cipriani, G Cisternino, E De Crescenzo, P De Iaco, G Dondi, F Frio, E Jovine, F Mineo Bianchi, J Neri, D Parlanti, A M Perrone, A P Pezzuto, M Pignatti, V Pinto, G Poggioli, M Ravaioli, M Rottoli, R Schiavina, M Serenari, M Serra, P Solli, M Taffurelli, M Tanzanu, M Tesei, T Violante, S Zanotti, F Borghi, D Cianflocca, S Di Maria Grimaldi, D Donati, E Gelarda, P Geretto, G Giraudo, M C Giuffrida, A Marano, S Palagi, L Pellegrino, C Peluso, V Testa, F Agresta, D Prando, M Zese, F Aquila, C Gambacciani, L Lippa, F Pieri, O S Santonocito, G Armatura, G Bertelli, A Frena, P Marinello, F Notte, S Patauner, G Scotton, S F Fulginiti, G Gallo, G Sammarco, G Vescio, P Balercia, L Catarzi, G Consorti, F Di Marzo, T Fontana, H Daiko, M Ishikawa, K Ishiyama, S Iwata, K Kanematsu, Y Kanemitsu, T Kato, A Kawai, E Kobayashi, M Kobayashi Kato, K Moritani, F Nakatani, J Oguma, Y Tanase, M Uno, M Al Abdallah, F Ayasra, Y Ayasra, A Qasem, F J Abu Za'nouneh, T Fahmawee, A Hmedat, A Ibrahim, K Obeidat, S Abdel Al, R Abdel Jalil, M K Abou Chaar, M Al-Masri, H Al-Najjar, F Alawneh, O Alsaraireh, M Elayyan, R Ghanem, I Lataifeh, G Z Alkadeeki, F S Al Maadany, N Aldokali, O Senossi, M T Subhi, D Burgan, E Kamoka, A I Kilani, A Salamah, M Salem, A Shuwayyah, E Abdulwahed, E Alshareea, N Aribi, S Aribi, M Biala, R Ghamgh, M Morgom, Z Aldayri, I Ellojli, A Kredan, S Bradulskis, E Dainius, E Kubiliute, J Kutkevicius, A Parseliunas, A Subocius, D Venskutonis, F Rasoaherinomenjanahary, J B Razafindrahita, L H Samison, E C Ong, K H Hamdan, M R Ibrahim, J A Tan, M R Thanapal, N Amin Sahid, F Hayati, J Jayasilan, R K Sriram, S Subramaniam, A Che Jusoh, A H Hussain, A S Mohamed Sidek, M F Mohd Yunus, J Y Soh, Mpk Wong, A D Zakaria, Z Zakaria, A Fadzli, N Q Fathi, P S Koh, Y T Liew, A C Roslani, C Y Tang, L Y Teoh, W J Wong, A S Yahaya, M R Alvarez, R Arrangoiz, F Cordera, M A De la Rosa Abaroa, A Gómez-Pedraza, R Hernandez, A Maffuz-Aziz, J A Posada, F C Becerra García, A Alfaro-Goldaracena, G A Buerba, R A Castillejos-Molina, C Chan, I Dominguez-Rosado, H Medina-Franco, Má Mercado, M Oropeza-Aguilar, E Peña Gómez Portugal, O E Posadas-Trujillo, F Rodriguez-Covarrubias, N Salgado-Nesme, C Sarre, M Vilatoba, Y Arkha, H Bechri, A El Ouahabi, M Y Oudrhiri, F Derkaoui Hassani, N El Abbadi, L Amrani, Z H Belkhadir, A Benkabbou, O Chakib, B El Ahmadi, Y El Bouazizi, H Essangri, A Ghannam, A M Majbar, R Mohsine, A Souadka, R Hompes, E M Meima-van Praag, Ajm Pronk, S Sharabiany, B Grotenhuis, L Hartveld, S Reijers, W Van Houdt, J Baaij, M Bolster-van Eenennaam, M De Graaff, D Sloothaak, P Van Duijvendijk, L Posma-Bouman, T Derksen, J Franken, S Oosterling, R De Bree, J Konsten, M Van Heinsbergen, L Fidelis, T T Sholadoye, M A Tolani, J Olaogun, I K Egbuchulem, T A Lawal, O Ogundoyin, D I Olulana, L Abdur-Rahman, A Adeyeye, I Aremu, J Bello, O Olasehinde, A Popoola, J Massoud, R Massoud, T M Sorour, A Jamal, A A Kerawala, A S Memon, R Nafees Ahmed, L Rai, B Ayub, N Hassan, R S Martins, P Ramesh, R Sayyed, U Butt, M Kashif, M Kashif, W H Khan, A Qureshi, M Umar, M Waris Farooka, T Wasim, A Ayubi, I Rashid, S H Waqar, G M Falcon, R Robles, R Jocson, C Teh, P Major, M Bobinski, J Kotarski, K Rasoul-Pelinska, C Azevedo, D Machado, F Mendes, X De Sousa, U Fernandes, C Ferreira, G Guidi, C Leal, A Marçal, R Marques, D Martins, A Melo, N Tenreiro, R Vaz Pereira, B Vieira, J I Almeida, T Correia de Sá, Mjma Costa, V Fernandes, I Ferraz, C G Gil, C Lima da Silva, L Lopes, N Machado, J Marialva, M Nunes Coelho, J Pedro, C Pereira, R Reis, A Ribeiro, R Santos, P Saraiva, R Silva, F Tavares, M Teixeira, A C Almeida, M J Amaral, R Andrade, R Athayde Nemésio, D Breda, C Camacho, C Canhoto, M Colino, S Correia, M Costa, J De Barros, A L De Oliveira López, M Duque, S Garrido, P Guerreiro, A Guimarães, A Lázaro, C Lopes, R Martins, O Nogueira, A Oliveira, J M Oliveira, M Rodrigues, A Ruivo, E Santos, M Silva, J Simões, A Valente da Costa, A Almeida, S Cavaleiro, V Devezas, C S Faria, F Jácome, M Magalhães Maia, J Nogueiro, A Pereira, A Pereira-Neves, T Pina-Vaz, H Santos-Sousa, H Silveira, S Vaz, P Vieira, A Gomes da Costa, I Lobo Antunes, J Pinto, A Tojal, N Cardoso, P Cardoso, J C Domingues, P Henriques, M I Manso, G Martins Dos Santos, R Martins, H Morais, R Pereira, T Revez, R Ribeiro, V I Ribeiro, A Soares, S Sousa, J Teixeira, E Amorim, V H Baptista, B Cunha MFDias, A Fazenda, J P Melo Neves, F Policarpo, I I Sampaio da Nóvoa Gomes Miguel, D Veiga, A K Andrade, J P Bandovas, N Borges, A Branquinho, B Chumbinho, J Correia, H Fidalgo, I Figueiredo de Barros, S Frade, J Gomes, J Maciel, S Pina, A Rodrigues, N Silva, I Silveira Nunes, R Sousa, J Ascensão, P Azevedo, B Costeira, C Cunha, R Garrido, H Gomes, I Lourenço, G Mendinhos, P Miranda, A Nobre Pinto, M Peralta Ferreira, J Ribeiro, L Rio Rodrigues, M Sousa Fernandes, J Azevedo, D Galvão, A C Soares, A Vieira, B Vieira, B Patrício, Pmdd Santos, A C Vieira Paiva Lopes, R Cunha, A Faustino, A Freitas, J R Martins ABMendes, R Parreira, J Rosa, M Teves, A Abreu da Silva, M Claro, D Costa Santos, A C Deus, J V Grilo, F Borges, J Corte Real, S Henriques, M J Lima, P Matos Costa, F Brito da Silva, A Caiado, F Fonseca, M Ângelo, J M Baiao, D Martins Jordão, T Vieira Caroço, J Messias, A Millan, I Salgado, P Santos, C Baía, R Canotilho, A M Correia, A P Ferreira Pinto, M Peyroteo, J F Videira, P Escobar, M Maldonado Santiago, R Kassir, F Sauvat, C Bezede, A Chitul, E Ciofic, D Cristian, F Grama, L Pirtea, C Secosan, E Bonci, V Gata, S Titu, O Ginghina, N Iordache, R V Iosifescu, T Garmanova, E Kazachenko, D Markaryan, S Rodimov, P Tsarkov, I Tulina, Y Litvina, A Provozina, M Agapov, E Galliamov, V Kakotkin, V Kubyshkin, А Kamalov, M Alshahrani, F Alsharif, M Eskander, R Al Raddadi, S Majrashi, A Mashat, N Akeel, M Alharthi, M Aljiffry, M Basendowah, A Farsi, M Ghunaim, A Khoja, A Maghrabi, N Malibary, M Nassif, A Nawawi, A Saleem, A Samkari, N Trabulsi, S Al Awwad, M Alghamdi, T Alnumani, M Nasser, A Said Bayazeed, A Alhefdhi, O Almalik, A Alomair, N Alotaibi, F Alresaini, R Alsalamah, S Alsobhi, Z Mahasin, E Othman, S Velagapudi, S Ghedan, R Alharthi, S Awad, M I Sharara, S Abdelrahman, W Althobaiti, H Al Habes, A Alamri, S Alkarak, M Alqannas, M Alyami, M Alzamanan, D Cortés Guiral, A Elawad, O AlAamer, L Alriyees, N Alselaim, A Abdulkareem, A Ajlan, K Akkour, A Al-Habib, K Al-Khayal, A Alatar, A Alburakan, H Alhalal, B Alhassan, N Alhassan, O Alobeed, A Alsaif, F Alsaif, S Alshammari, I Alshaygy, M Barry, A Bin Nasser, T Bin Traiki, A Bokhari, S Elwatidy, H Helmi, A Madkhali, T Nouh, P D Rabah, A Zubaidi, I Paunovic, N Slijepcevic, L Aleksic, A Antic, G Barisic, M Ceranic, D Galun, Ž Grubac, J Jelenkovic, D Kecmanovic, S Kmezic, D Knezevic, Z Krivokapic, S Latincic, V Markovic, S Matic, M Miladinov, M Pavlov, I Pejovic, D Radenkovic, B Tadic, J Vasljevic, D Velickovic, M Zivanovic, M Perovic, L Srbinovic, S Andrijasevic, T Bozanovic, R Cerovic Popovic, M Dokic, T Janjic, K Jeremic, S Kadija, I Ladjevic Likic, L Mirkovic, S Pantovic, I Pilic, M Radojevic, A Stefanovic, S Vidakovic, Z Vilendecic, S Antic, D Dunderovic, D Jelovac, Z Jezdic, V Konstantinovic, B Kotlar, C Kuzmanovic, M Lazic, M Petrovic, F Popovic, A Pucar, M Romic, S Sumrak, V Vujanac, V Bascarevic, I Bogdanovic, D Grujicic, R Ilic, M Milicevic, F Milisavljevic, A Miljkovic, A Paunovic, V Scepanovic, A Stanimirovic, M Todorovic, A Jotic, J Milovanovic, A Trivic, U Bumbasirevic, Z Dzamic, B Kajmakovic, N Prijovic, M Zivkovic, M Buta, A Cvetkovic, I Djurisic, S Gacic, M Goran, Z Inic, N Jeftic, M Jevric, V Jokic, I Markovic, M Milanovic, S Nikolic, L Pejnovic, N Savkovic, I Spurnic, D Stevic, D Stojiljkovic, N Vucic, M Zegarac, A Karamarkovic, M Kenic, B Kovacevic, I Krdzic, V Milutinovic, C W Chan, B Lieske, B Gális, K Šimko, N Almgla, M Bernon, A Boutall, L Cairncross, A Herman, T Hilton, E Jonas, C Kloppers, F Malherbe, W Mugla, D Nel, S Rayamajhi, T Van Wyngaard, J Vogel, A M Castaño-Leon, J Delgado Fernandez, C Eiriz Fernandez, M Espino Segura-Illa, O Esteban Sinovas, D Garcia Perez, P Gomez, L Jimenez-Roldan, A Lagares, L Moreno-Gomez, I Paredes, A Pérez Núñez, G Sánchez Aniceto, M Santas, P Fernández Rodríguez, M Paniagua García Señorans, R Sanchez-Santos, V Vigorita, E Acrich, E Baena Sanfeliu, O Barrios, T Golda, C Santanach, M Serrano-Navidad, M Sorribas Grifell, R V Vives, D Escolà, A Jiménez, L Cayetano Paniagua, L Gómez Fernández, E Artigues, J C Bernal-Sprekelsen, J C Catalá Bauset, P Collera, L Diaz De, R Gobbo, R Farre Font, R Flores Clotet, C J Gómez Díaz, N Guàrdia, C A Guariglia, A Osorio, R Sanchez Jimenez, L Sanchon, C Soto Montesinos, B Albi Martin, J E García Villayzán, L Alonso-Lamberti, M Assaf, N Baeza Pintado, A Carabias, J García-Quijada, M A Huertas Fernandez, J Jimenez Miramón, V Jimenez, J M Jover, S A Landeo AgÜero, R Leon, M B Martín Salamanca, V Pérez Simón, S Ponce, J L Rodriguez, A Salazar, A Valle Rubio, H Aguado, I Aldecoa Ansorregui, R Bravo Infante, F B De Lacy, A Di Somma, B Díaz-Feijoo, J Enseñat Nora, N Fabregas, A Ferrés, B Gil Ibañez, J J Gonzalez Sanchez, I Gracia, J A Hoyos Castro, A M Lacy, C Langdon, D Momblán, X Morales, L Oleaga, A Otero, L Pedrosa, J Poblete Carrizo, L A Reyes Figueroa, P Roldan Ramos, J Rumia-Arboix, A I Tercero-Uribe, T E Topczewski, J Torales, A Torne, R Torné, V Turrado-Rodriguez, R Valero, S Valverde, R Anula, O Cano-Valderrama, M Del Campo Martín, L Díez-Valladares, I Domínguez, J Dziakova, M García Alonso, E García Romero, L Gómez Latorre, J M Muguerza, M J Pizarro, P Saez Carlin, C Sánchez Del Pueblo, A Sánchez-Pernaute, G Sanz Ortega, R Sanz-Lopez, A Torres, M Garcés-Albir, F Lopez, J Martín-Arévalo, D Moro-Valdezate, V Pla-Marti, J Beltrán de Heredia, B De Andrés Asenjo, T Gómez Sanz, C Jezieniecki, H Nuñez Del Barrio, F J Ortiz de Solórzano Aurusa, A Romero de Diego, M Ruiz Soriano, J Trujillo Díaz, A Vazquez Fernandez, P Lora-Cumplido, M V Sosa, E Gonzalez-Gonzalez, A M Minaya Bravo, N Alonso de la Fuente, M Cazador Labat, L Cecchini, C A Espinosa, M Jimenez Toscano, A López Campillo, G Mancebo, P Martorell, M Munarriz, E J Grau-Talens, B Martin-Perez, J A Benavides Buleje, M Carrasco Prats, P V Fernández, A Fernández-López, D García Escudero, V J García Porcel, V Garcia Soria, C Giménez Francés, F M González Valverde, E Gurrea, P López-Morales, A Marco Garrido, J A Martínez Alonso, E Medina, J M Muñoz Camarena, P A Parra Baños, E Peña Ros, M Ramirez Faraco, M Ruiz-Marín, C Sanchez Rodriguez, M Valero Soriano, M Estaire Gómez, Á Fernández Camuñas, E P Garcia Santos, E Jimenez Higuera, C Martínez-Pinedo, V Muñoz-Atienza, D Padilla-Valverde, R Picón Rodríguez, F J Redondo Calvo, S Sánchez-García, D Sanchez-Pelaez, R C Colombari, E Del Valle, M Fernández, P Lozano Lominchar, L Martín, C Rey Valcarcel, M A Steiner, M Tudela, J Zorrilla Ortúzar, F Alcaide Matas, J M García Pérez, P Troncoso Pereira, I Mora-Guzmán, M Abellán, M Achalandabaso Boira, R Jorba, R Memba Ikuga, C Olona, R Sales Mallafré, P Cavallé Busquets, Mgp Gavalda Pellice, J Salinas Peña, E J Aragon Achig, L Barbier, P Caja Vivancos, A Gainza, J J García Gutierrez, G Mallabiabarrena Ormaechea, H Marín, P Martin Playa, I Melchor Corcóstegui, M Prieto Calvo, A Rodriguez Fraga, I Villalabeitia Ateca, U De Andres Olabarria, M Durán Ballesteros, F J Fernández Pablos, F J Ibáãez-Aguirre, A Sanz Larrainzar, B Ugarte-Sierra, Á De la Hoz Rodríguez, M Di Martino, J García Septiem, E Martin-Perez, J L Muñoz de Nova, P Calvo Espino, P Guillamot Ruano, L Colao García, D Díaz Pérez, E Esteban Agustí, P Galindo Jara, M Gutierrez Samaniego, M A Hernandez Bartolome, J Serrano González, A Alonso Poza, B Diéguez, M García-Conde, M Hernández-García, M Losada, C M Chiesa-Estomba, Já González García, E Larruscain, J A Sistiaga-Suárez, E Alvarez, N Chavarrias, L Frías, V García Pineda, A Gegúndez Simón, S Gortázar, M Gracia, J Guevara, A Hernández Gutierrez, A Loayza, D T María Dolores, C Martí, M Melendez, E Moreno-Palacios, Y Perez, M I Prieto Nieto, P Ramos-Martín, I Rubio-Perez, J Saavedra, J I Sanchez-Mendez, J Siegrist Ridruejo, A Urbieta, I Zapardiel, M Cantalejo Diaz, Mdc De Miguel Ardevines, V Duque-Mallén, I Gascon Ferrer, M T González-Nicolás Trébol, C Gracia-Roche, M Herrero Lopez, U M Jariod Ferrer, A Lanzon, A Martinez German, M Matute, C Redondo, N Sánchez Fuentes, M Sánchez-Rubio, M S Santero-Ramirez, S Saudí, M V Simón Sanz, T Uson-Bouthelier, A Blazquez Martin, M Diez Alonso, E García Rico, E Garcia-Loarte Gomez, F Garcia-Moreno Nisa, A Gutierrez Calvo, P Hernandez, I Lasa, F Mendoza-Moreno, N Morales Palacios, E Ovejero Merino, C Vera Mansilla, F Acebes García, M Bailón, A D Bueno Cañones, E Choolani Bhojwani, P Marcos-Santos, T Miguel, D Pacheco Sánchez, B Pérez-Saborido, J Sanchez Gonzalez, F J Tejero-Pintor, F Alconchel, A Conesa, J Gil Martínez, A I Gutiérrez Fernández, A Lopez Abad, T Nicolás-López, P Ramirez Romero, M J Roca Calvo, K Rodrigues, J J Ruiz Manzanera, A I Soriano, A Cano, L Capitan-Morales, J Cintas Catena, J Gomez-Rosado, F Oliva Mompean, M A Pérez Sánchez, F D Río Lafuente, C Torres Arcos, J Valdes-Hernandez, H Cholewa, S Domingo, M Frasson, V Lago, T Marina Martin, C Martínez Chicote, J Sancho-Muriel, A Landaluce-Olavarria, D Lecumberri, A Abad Gurumeta, A Abad-Motos, E Martínez-Hurtado, J Ripollés-Melchor, A Ruiz Escobar, A Cuadrado-García, L Garcia-Sancho Tellez, J Heras Aznar, P Maté, I Ortega Vázquez, A L Picardo, J A Rojo López, F Sanchez Cabezudo Noguera, D Serralta de Colsa, J Anchuelo Latorre, C Cagigas Fernandez, R Caiña Ruiz, M Gomez Ruiz, F Hernanz, J Jimeno Fraile, P Martínez-Pérez, C Poch, S Santarrufina Martinez, V Valbuena Jabares, C Moliner-Sánchez, L Pingarron-Martin, J Rey-Biel, I Ruiz Martin, J L Blas Laina, B Cros, J Escartin, J Garcia Egea, A Nogués, I Talal El-Abur, C Yánez, E P Cagigal Ortega, I Cervera, P Díaz Peña, Gdcr Elena, D Enjuto, P Fernández Bernabé, R Garcés García, J Gonzalez, I Hernández, N Herrera-Merino, M Marqueta De Salas, P Martinez Pascual, M Perez Gonzalez, A Ramos Bonilla, L Rodríguez Gómez, C Bescós, R Blanco-Colino, I Brana, B Caimari, A De Pablo García-Cuenca, F Duran-Valles, E Espin-Basany, J Giralt Lóez de Sagredo, J Pamias, G Pellino, N Prat, R Pujol Pina, M Saez Barba, A Arulanantham, Gbk Bandara, U Jayarajah, S Ravindrakumar, V S Rodrigo, S Srishankar, A A Ali Karar, P Elbe, E K Lindqvist, H Taflin, A Älgå, G Heinius, M Nordberg, E Pieniowski, I Gkekas, N Löfgren, M Rutegård, M Sund, M Arigoni, M Bernasconi, D Christoforidis, M Di Giuseppe, D La Regina, F Mongelli, M Chevallay, O Dwidar, E Gialamas, M Sauvain, F Klenke, A Kollàr, C Kurze, M Adamina, T Bächler, A S Crugnale, M Giardini, L Guglielmetti, G Peros, F Solimene, A Aghayeva, I Hamzaoglu, I Sahin, E Akaydin, Z Aliyeva, E Aytac, B Baca, O DÜlgeroğlu, V Ozben, B B Ozmen, C Uras, A E Arikan, I A Bilgin, B Bozkirli, G O Ceyhan, H Kara, T Karahasanoglu, C Uras, H Celik, M M Meydanli, H Akilli, A Ayhan, E Kuscu, M A Onan, U Akgor, H A Dincer, T Erol, M Gultekin, N Orhan, N Ozgul, M C Salman, B Soyak, A Alhamed, S ErgÜn, M F OZcelik, A N Sanli, S S Uludag, M Velidedeoglu, A K Zengin, M A Bozkurt, Y Kara, A Kocatas, B Cimenoglu, R Demirhan, K Saracoglu, I F Azamat, E Balik, D Bugra, B Giray, C B Kulle, C Taskiran, D Vatansever, K Gözal, S A GÜler, H Köken, O C Tatar, N Z Utkan, A Yildirim, E YÜksel, E Akin, F Altintoprak, Z Bayhan, G Cakmak, R Çapoglu, F Çelebi, H Demir, E Dikicier, N Firat, E GönÜllÜ, M B Kamburoglu, B Kocer, I F KÜçÜk, B Mantoglu, E Çolak, G O Kucuk, M S Uyanik, B Göksoy, E Bozkurt, B Citgez, M Mihmanli, M Tanal, G Yetkin, M Akalin, C Arican, E K Avci, C Aydin, S Demirli Atici, M Emiroglu, T Kaya, E Kebabçi, G Kilinc, Y Kirmizi, H Ogucu, S Salimoglu, I Sert, C Tugmen, K Tuncer, G Uslu, D Yesilyurt, E Karaman, A Kolusari, A Yildiz, O Benson, H Lule, J Agilinko, A Ahmeidat, M Barabasz, M Bekheit, L K Cheung, T Colloc, W Cymes, M Elhusseini, G Gradinariu, A Hannah, B S Kamera, G Mignot, S Shaikh, P Sharma, I Abu-Nayla, A Agrawal, A Al-Mohammad, S Ali, J Ashcroft, A Azizi, O Baker, A Balakrishnan, M Byrne, A Colquhoun, A Cotter, P Coughlin, R J Davies, A Durrani, M Elshaer, S Fordington, P Forouhi, F Georgiades, H Grimes, A Habeeb, V Hudson, P Hutchinson, E Irune, A Jah, D Z Khan, A Kolias, H Kyriacou, B Lamb, S Liau, L Luke, R Mahmoud, R Mannion, L Masterson, C G Mitrofan, M Mohan, A Morris, S Murphy, R O'Neill, S Price, J Pushpa-Rajah, W Raby-Smith, J Ramzi, S Rooney, T Santarius, A Singh, G D Stewart, X S Tan, A Townson, E Tweedle, C Walker, S Waseem, S Yordanov, T Jones, A Kattakayam, C Loh, R Lunevicius, S Pringle, A Schache, R Shaw, A Sheel, C Rossborough, D Angelou, M Choynowski, B McAree, A McCanny, D Neely, G Tutoveanu, S Ahad, Mfi De La Cruz Monroy, F Mosley, V Oktseloglou, A Alanbuki, M Patel, A Shabana, E Perera, D Raveendran, K Ravi-Shankar, J Thiruchelvam, L Arrowsmith, W Campbell, T Grove, C Kontovounisios, O Warren, P Rolland, A Aggarwal, S Brown, C Jelley, N Neal, R Clifford, N Eardley, E Krishnan, N Manu, E Martin, S Roy Mahapatra, O L Serevina, C Smith, D Vimalachandran, M Bordenave, R Houston, G Putnam, A Robson, H Tustin, K Emslie, P L Labib, A Marchbank, D Miller, G Minto, J Natale, H Nwinee, P Panahi, L Rogers, A Abubakar, M M Akhter Rahman, E Chan, Kyk Ko, H O'Brien, K Sasapu, H Woodun, R Inglis, H J Ng, A De Gea Rico, N Ghazali, J Lambert, G Markose, S Math, I Sarantitis, D Shrestha, A Sultana, M Taggarsi, S Timbrell, O P Vaz, L Vitone, A Day, H Dent, M Fahim, S Waheed, A Hunt, N Laskar, A Gupta, J Steinke, S Thrumurthy, E Massie, K McGivern, D Rutherford, M Wilson, J Hardie, S Kazzaz, S Handa, M Kaushal, A Kler, P Patel, J Redfern, S Tezas, Y Aawsaj, S Amonkar, C Barry, L Blackwell, D Blake, J Carter, H Emerson, A Fisher, M Katory, P Korompelis, W McCormick, A Mustafa, L Pearce, N Ratnavelu, R Reehal, L Kretzmer, L Lalou, B Manku, I Parwaiz, J Stafford, M Abdelkarim, A Asqalan, T Gala, S Ibrahim, A Maw, R Mithany, R Morgan, G Sundaram Venkatesan, K Ang, E J Caruana, M F Chowdhry, A Mohammad, A Nakas, S Rathinam, M Boal, O Brown, S Dwerryhouse, S Higgs, A Vallance, E Boyd, V Irvine, A Kirk, G Bakolas, A Boulton, A Chandock, T Khan, M Kumar, P Agoston, A Bille, B Challacombe, S Fraser, K Harrison-Phipps, J King, G Mehra, L Mills, M Najdy, R Nath, L Okiror, J Pilling, V Rizzo, T Routledge, A Sayasneh, L Stroman, A Wali, M Fehervari, C Fotopoulou, N Habib, S Hamrang-Yousefi, Z Jawad, L Jiao, M Pai, J Ploski, P Rajagopal, S Saso, M Sodergren, D Spalding, S Laws, C Hardie, C McNaught, R Alam, A Budacan, J Cahill, M Kalkat, S Karandikar, L Kenyon, D Naumann, A Patel, J Ayorinde, T Chase, T Cuming, A Ghanbari, L Humphreys, S Tayeh, A Aboelkassem Ibrahim, R Bichoo, H Cao, Akw Chai, J Choudhury, C Evans, H Fitzjohn, H Ikram, M Langstroth, M Loubani, A McMillan, S Nazir, Ssa Qadri, A Robinson, E Ross, T Sehgal, A Wilkins, J Dixon, J Dunning, K Freystaetter, M Jha, S Lester, A Madhavan, S V Thulasiraman, Y Viswanath, T Curl-Roper, C Delimpalta, Ccl Liao, V Velchuru, E Westwood, E Belcher, G Bond-Smith, S Chidambaram, F Di Chiara, K Fasanmade, L Fraser, H Fu, M Ganau, S Gore, J Graystone, D Jeyaretna, H Khatkar, M Lami, M Maher, S Mastoridis, R Mihai, R Piper, S Prabhu, Obf Risk, U Selbong, K Shah, R Smillie, H Soleymani Majd, S Sravanam, D Stavroulias, G D Tebala, M Vatish, C Verberne, K Wallwork, S Winter, M I Bhatti, H Boyd-Carson, E Elsey, E Gemmill, P Herrod, M Jibreel, E Lenzi, T Saafan, D Sapre, T Sian, N Watson, A Athanasiou, G Bourke, L Bradshaw, A Brunelli, J Burke, P Coe, F Costigan, H Elkadi, M Ho, J Johnstone, A Kanatas, V Kantola, A Kaufmann, A Laios, S Lam, E MacInnes, S Munot, C Nahm, M Otify, C Pompili, I Smith, G Theophilou, G Toogood, R Wade, D Ward, C West, S Annamalai, C Ashmore, A Boddy, T Hossain, A Kourdouli, A Gvaramadze, A Jibril, L Prusty, D Thekkinkattil, A Harky, M Shackcloth, A Askari, C Chan, N Cirocchi, S Kudchadkar, K Patel, J Sagar, S Shaw, R Talwar, M Abdalla, R Edmondson, O Ismail, D Jones, K Newton, N Stylianides, A Aderombi, U Andaleeb, O Bajomo, K Beatson, W Garrett, M Mehmood, V Ng, R Al-Habsi, G S Divya, B Keeler, B Al-Sarireh, R Egan, R Harries, A Henry, M Kittur, Z Li, K Parkins, F Soliman, N Spencer, D Thompson, C Burgess, C Gemmell, C Grieco, M Hollyman, L Hunt, J Morrison, S Ojha, N Ryan, F Abbadessa, S Barnard, C Chan, N Dawe, J Hammond, Ali F Mahmoud, I McPherson, C Mellor, J Moir, S Pandanaboyana, J Powell, B Rai, A Rogers, C Roy, A Sachdeva, C Saleh, S Tingle, T Williams, J Manickavasagam, C McDonald, N McGrath, N McSorley, K Ragupathy, L Ramsay, A Solth, O Kakisi, K Seebah, I Shaikh, L Sreedharan, M Youssef, J Shah, P Ameerally, N McLarty, S Mills, A Shenfine, K Sahnan, J Abu, E Addae-Boateng, D Bratt, L Brock, N Burnside, S Cadwell-Sneath, K Gajjar, C Gan, C Grundy, K Hallam, K Hassell, M Hawari, A Joshi, H Khout, K Konstantinidi, Rxn Lee, D Nunns, R Schiemer, T Walton, H Weaver, L Whisker, K Williamson, J McVeigh, R Myatt, M A Williams, R Kaur, E Leung, S Sundar, M Michel, S Patil, S Ravindran, J Sarveswaran, L Scott, M Edmond, E King, M Almond, A Bhangu, O Breik, L D Cato, A Desai, S Ford, E Griffiths, M Idle, M Kamal, A Kisiel, R Kulkarni, Jkc Mak, T Martin, P Nankivell, A Parente, S Parmar, A M Pathanki, L Phelan, P Praveen, S Saeed, N Sharma, J Singh, F Tirotta, D Vijayan, A Geddes, J McCaul, J McMahon, A H Khan, F Khan, A Mansuri, S Mukherjee, M Patel, M Sarigul, S Singh, K L Tan, A Woodham, A Adiamah, H Brewer, A Chowdhury, J Evans, D Humes, J Jackman, A Koh, C Lewis-Lloyd, O Oyende, J Reilly, D Worku, P Cool, G Cribb, K Shepherd, C Bisset, S Moug, N Elson, G Faulkner, P Saleh, C Underwood, G Brixton, L Findlay, T Klatte, A Majkowska, J Manson, R Potter, A Bhalla, Z Chia, P Daliya, A Goyal, E Grimley, A Hamad, A Kumar, F L Malcolm, E Theophilidou, J Bowden, N Campain, I Daniels, C Evans, G Fowler, J John, L Massey, F McDermott, J McGrath, A McLennan, M Ng, J Pascoe, N Rajaretnam, S Bulathsinhala, B Davidson, G Fusai, C Hidalgo Salinas, N Machairas, T Pissanou, J M Pollok, D A Raptis, F Soggiu, H Tzerbinis, S E Xyda, A Beamish, E Davies, R Foulkes, D Magowan, H Nassa, R Ooi, C Price, L Smith, F Solari, A Tang, G Williams, Y Al-Tamimi, A Bacon, N Beasley, D Chew, M Crank, N Ilenkovan, M Macdonald, B Narice, O Rominiyi, A Thompson, I Varley, T Drake, E Harrison, G Linder, J Mayes, R McGregor, R Skipworth, V Zamvar, E Davies, P Hawkin, T Raymond, O Ryska, R Baron, D Dunne, S Gahunia, C Halloran, N Howes, R McKinney, F McNicol, J Russ, P Szatmary, J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso

Subjects
Aged, 80 and over, Male, Critical Care, SARS-CoV-2, International Cooperation, COVID-19, Middle Aged, Cohort Studies, Logistic Models, Postoperative Complications, Elective Surgical Procedures, Neoplasms, Outcome Assessment, Health Care, Humans, Female, Epidemics, Aged
Abstract

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.

Published
2021

5. PROKR 2 in in girls with idiopathic central precocious puberty

Author

Grandone A, Luongo C, Cassio A, Salerno M, Tornese G, Festa A, Miraglia del Giudice E, Cirillo G., Grandone, A, Luongo, C, Cassio, A, Salerno, M, Tornese, G, Festa, A, Miraglia del Giudice, E, and Cirillo, G.

Subjects
PROKR2, precocious puberty
Published
2019

7. When polymers meet carbon nanostructures: expanding horizons in cancer therapy

Author

Cirillo, G., Peitzsch, C., Vittorio, O., Curcio, M., Farfalla, A., Voli, F., Dubrovska, A., Iemma, F., Kavallaris, M., and Hampel, S.

Subjects
Functional Polymers, Nanohybrids, Cancer Therapy, Carbon Nanotubes, Graphene Oxide, Chemosensitization, Radiosensitization
Abstract

The development of hybrid materials, which combines inorganic with organic materials, is receiving increasing attention by researchers. As a consequence of carbon nanostructures high chemical versatility, they exhibit enormous potential for new highly engineered multifunctional nanotherapeutic agents for cancer therapy. Whereas many groups are working on drug delivery systems for chemotherapy, the use of carbon nanohybrids for radiotherapy is rarely applied. Thus, nanotechnology offers a wide range of solutions to overcome the current obstacles of conventional chemo- and/or radiotherapies. Within this review, the structure and properties of carbon nanostructures (carbon nanotubes, nanographene oxide) functionalized preferentially with different types of polymers (synthetic, natural) are discussed. In short, synthesis approaches, toxicity investigations and anticancer efficacy of different carbon nanohybrids are described.

Published
2019

8. Relationships between Sr isotopic composition of mineral waters and deciduous human teeth: a contribution to human mobility and food traceability studies in Italy

Author

Arienzo I., Cirillo G., D’Antonio M., Di Vito M. A., Società Geologica Italiana, Arienzo, I., Cirillo, G., D’Antonio, M., and Di Vito, M. A.

Subjects
Sr isotopic composition, Human mobility, Food traceability
Abstract

In recent years, isotopic studies have provided a huge contribution to archaeology. Several studies, carried out in variable localities of the world, have focused their attention on human mobility, to identify non local individuals from ancient burials and reconstruct their migrations, by measuring the strontium isotope ratios (87Sr/86Sr) of their teeth enamel. This method is based on the premise that rocks display variable 87Sr/86Sr ratios depending on several factors associated with the geological characteristics of the site, i.e., age and type of the parent rocks (e.g., Price & Gestsdóttir, 2006; Kenoyer et al., 2013), and original rubidium (Rb) content. The bioavailable Sr present in soil and groundwater is incorporated into local plants and, through the food chain, enters the human body. On this basis, 87Sr/86Sr signatures in human tissue mirror the 87Sr/86Sr values of water, plants and consumed food, which in turn reflect that of bedrock of a given region (Ericson, 1985). In this study, Sr isotope ratios were measured on commercial mineral waters from variable Italian water springs, on soils and plants from the Neapolitan area, and on teeth enamel of children. The latter were born and still live in the Neapolitan area (south Italy), so that constraints on their childhood diet are available. The aim was to discriminate among the contributions of soil, water, food etc., and identify the main one affecting the isotopic signature of teeth enamel. The results of this investigation will be important for human mobility studies because they will allow understanding to which extent Sr isotopes can be effectively used for i) discriminating non-local from local individuals, and ii) assessing the effects on the modern society of a diet based on food from different geographic areas. Ericson, J.E. (1985): Strontium isotope characterization in the study of prehistoric human ecology. J. Hum. Evol., 14, 503-514. Kenoyer, J.M, Price, T.D., Burton, J.H. (2013): A new approach to tracking connections between the Indus Valley and Mesopotamia: initial results of Strontium isotope analyses from Harappa and Ur. J. Archaeol. Sci., 40, 2286-2297. Price, T.D. & Gestsdóttir, H. (2006): The first settlers of Iceland: an isotopic approach to colonisation. Antiquity, 80, 130-144.

Published
2017

9. Magmatic processes inferred from geochemical and Sr-Nd-isotopic data on the < 5 ka Zaro lava complex, Ischia Island (southern Italy)

Author

Pelullo C., Arienzo I., Cirillo G., Mazzeo F. C., Aulinas M., Turiel J. L. F., D’Antonio M., Società Geologica Italiana, Pelullo, C., Arienzo, I., Cirillo, G., Mazzeo, F. C., Aulinas, M., Turiel, J. L. F., and D’Antonio, M.

Subjects
Ischia Island, Zaro lava complex, magmatic evolution, mineral chemistry, isotope geochemistry, mingling
Abstract

The Zaro lava complex, located on the western sector of the Ischia volcanic island (Gulf of Naples, southern Italy), is the product of one of the few effusive eruptions occurred in the last period of activity (< 5 ka). The complex is made up of a white trachytic main lava flow (Zaro lava s.s.), hosting rounded-shaped enclaves of both mafic (shoshonite) and felsic (trachyte) composition. Major and trace elements and isotopic (87Sr/86Sr and 143Nd/144Nd) data have been acquired on whole rocks and separated minerals. Mafic enclaves (Mg# = 60-62, CaO = 7.71-8.31 wt%, Cr =117-143 ppm, Ni = 52-61 ppm, Zr =150-164 ppm, Sr = 503-526 ppm, LREE enriched compared to HREE) have low 87Sr/86Sr (0.70495- 0.70501) and high 143Nd/144Nd (0.51268-0.51269). Trachytic lavas and felsic enclaves (SiO2 = 60.61-61.71 wt%, K2O = 6.51-7.43 wt%, Na2O = 5.00-6.83 wt%, Rb = 243-428 ppm, Sr = 90-158 ppm, Zr = 385-773 ppm) exhibit higher 87Sr/86Sr (0.70608-0.70615) and lower 143Nd/144Nd (0.51255-0.51256). The strong isotopic difference between mafic enclaves and trachytes rules out a simple crystallization process for the variable facies of the Zaro lava complex. Moreover, in mafic enclaves petrochemical and possibly isotopic disequilibria between phenocrysts and their host rocks suggest occurrence of mingling processes or crystals entrapment from a distinct magmatic phase: indeed, many clinopyroxene and feldspar crystals are in chemical equilibrium with more evolved compositions (trachytic to trachyphonolitic). Trachytic lavas and felsic enclaves are chemically similar and do not display isotopic disequilibria between phenocrysts and host rocks. The last 5 ka of volcanic activity at Ischia were characterized by emplacement of products resulting from interaction between chemically and isotopically distinct batches of magma (Cava Nocelle, Vateliero and Molara; D’Antonio et al., 2013). Although these products show features comparable to those of the Zaro mafic enclaves, the last have significantly lower Sr and higher Nd isotopic ratios. Therefore, enrichment processes, such as assimilation of continental crust or mantle contamination in different conditions, should be invoked to justify the difference in isotopic features. Additionally, although the two evolved facies of the Zaro lavas have comparable chemical compositions and “uniform” isotopic signature, field analysis shows evidence of mingling between similar magmas with different viscosities. This process could have played a significant role in triggering the eruption. D’Antonio, M., Tonarini, S., Arienzo, I., Civetta, L., Dallai, L., Moretti, R., Orsi, G., Andria, M., Trecalli, A. (2013): Mantle and crustal processes in the magmatism of the Campania region: inferences from mineralogy, geochemistry, and Sr–Nd–O isotopes of young hybrid volcanics of the Ischia island (South Italy). Contrib. Mineral. Petrol., 165,1173-1194.

Published
2017

10. Sr-He-O isotopes in mafic phenocrysts from products of the Neapolitan volcanoes (southern Italy): constraints on the geochemical features of the mantle sources

Author

Cirillo G., Arienzo I., Mazzeo F. C., Paonita A., Rizzo A., Petrosino P., PELULLO, CARLO, Iovine R. S., D’Antonio M., Società Geologica Italiana, Cirillo, G., Arienzo, I., Mazzeo, F. C., Paonita, A., Rizzo, A., Petrosino, P., Pelullo, Carlo, Iovine, R. S., and D’Antonio, M.

Subjects
Helium isotopes, Neapolitan volcanoes, Mantle sources
Abstract

An investigation through Sr-He-O isotopes and major oxides was carried out on Mg-rich olivine and clinopyroxene phenocrysts from a selection of volcanic rocks of the Neapolitan Volcanoes (southern Italy), which include Somma- Vesuvius, Phlegraean Fields, and the islands of Ischia and Procida. The data produced in the present work extend the Sr-He-O dataset available for the Neapolitan volcanic districts (e.g., Graham et al., 1993; Martelli et al., 2004; Di Renzo et al., 2011; D’Antonio et al., 2013; Iovine et al., 2017), improving the knowledge especially on helium isotopic compositions of the Mt. Somma rocks, never analysed before. 3He/4He ratios (2.60-5.12 R/RA) of the investigated Mgrich phenocrysts are markedly lower than those measured at most volcanic arcs worldwide, and are among the lowest measured in subduction zones. This range of 3He/4He is coupled with quite large ranges of 87Sr/86Sr (0.704882 – 0.708480) and δ18O (4.85 – 6.70‰) measured in the same mafic minerals. The 3He/4He values, and the lowest measured Sr- and O-isotope ratios, do not suggest significant crustal or fluid contamination occurred during magmatic evolution, and they should reflect the composition of the metasomatized mantle beneath the Neapolitan region. Moreover, these values display a clear geographic trend, with radiogenic 4He-87Sr, and 18O generally increasing in on-lands districts. The results of these investigations are expected to allow us to better understand the original characteristics of the mantle source(s), and to define those of other components, likely originated in the continental crust, that were involved in the genesis of the primitive magmas feeding the Neapolitan volcanoes. D’Antonio, M., Tonarini, S., Arienzo, I., Civetta, L., Dallai, L., Moretti, R., Trecalli, A. (2013): Mantle and crustal processes in the magmatism of the Campania region: inferences from mineralogy, geochemistry, and Sr–Nd–O isotopes of young hybrid volcanics of the Ischia island (South Italy). Contrib. Mineral. Petrol., 165, 1173-1194. Di Renzo, V., Arienzo, I., Civetta, L., D'Antonio, M., Tonarini, S., Di Vito, M.A., Orsi, G. (2011): The magmatic feeding system of the Campi Flegrei caldera: architecture and temporal evolution. Chem. Geol., 281, 227-241. Graham, D.W., Allard, P., Kilburn, C.R.J., Spera, F.J., Lupton, J.E. (1993): Helium isotopes in some historical lavas from Mount Vesuvius. J. Volcanol. Geotherm. Res., 58, 359-366. Iovine, R.S., Mazzeo, F.C., Arienzo, I., D’Antonio, M., Wörner, G., Civetta, L., Orsi, G. (2017): Source and magmatic evolution inferred from geochemical and Sr-O-isotope data on hybrid lavas of Arso, the last eruption at Ischia island (Italy; 1302AD). J. Volcanol. Geotherm. Res., 331, 1-15. Martelli, M., Nuccio, P.M., Stuart, F.M., Burgess, R., Ellam, R.M., Italiano, F. (2004): Helium-strontium isotope constraints on mantle evolution beneath the Roman Comagmatic Province, Italy. Earth Planet. Sci. Letters, 224, 295-308.

Published
2017

11. PNPLA3 I148M variant is associated with liver steatosis and fat distribution in chronic hepatitis B

Author

Zampino R, Coppola N, Cirillo G, Boemio A, Grandone A, Stanzione M, Capoluongo N, Marrone A, Macera M, Sagnelli E, Adinolfi LE, Miraglia Del Giudice E., Zampino R, Coppola N, Cirillo G, Boemio A, Grandone A, Stanzione M, Capoluongo N, Marrone A, Macera M , Sagnelli E, Adinolfi LE, Miraglia Del Giudice E, Zampino, R, Coppola, N, Cirillo, G, Boemio, A, Grandone, A, Stanzione, M, Capoluongo, N, Marrone, A, Macera, M, Sagnelli, E, Adinolfi, Le, and Miraglia Del Giudice, E.

Published
2015

12. The TM6SFZ 8167K variant is an independent predictor of severe liver steatosis in chronic hepatitis C

Author

Coppola N, Zampino R, Cirillo G, Stanzione M, Macera M, Boemio A, Grandone A, Pisaturo M, Marrone A, Adinolfi LE, Miraglia Del Giudice E, Sagnelli E., Coppola N, Zampino R, Cirillo G, Stanzione M, Macera M, Boemio A, Grandone A, Pisaturo M, Marrone A, Adinolfi LE, Miraglia Del Giudice E, Sagnelli E, Coppola, N, Zampino, R, Cirillo, G, Stanzione, M, Macera, M, Boemio, A, Grandone, A, Pisaturo, M, Marrone, A, Adinolfi, Le, Miraglia Del Giudice, E, and Sagnelli, E.

Published
2015

13. No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis

Author

Zampino, R., Macera, M., Cirillo, G., PIA CLARA PAFUNDI, Rinaldi, L., Coppola, N., Pisaturo, M., Adinolfi, L. E., Del Giudice, E. M., Ingrosso, D., Capasso, R., Zampino, Rosa, Macera, Margherita, Cirillo, Grazia, Pafundi, Pia Clara, Rinaldi, Luca, Coppola, Nicola, Pisaturo, Mariantonietta, Adinolfi, Luigi Elio, Miraglia Del Giudice, Emanuele, Ingrosso, Diego, and Capasso, Rosanna

Subjects
Adult, Male, Anthropometry, Biopsy, Membrane Proteins, Lipase, Hepatitis C, Chronic, Middle Aged, Polymorphism, Single Nucleotide, Fatty Liver, Italy, Liver, Humans, Female, Genetic Predisposition to Disease, Insulin Resistance, Carrier Proteins
Abstract

PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required.

Published
2018

14. New constraints on the origin of the ophiolitic rocks within sinorogenic turbiditic sequences at Cilento region (southern Italy)

Author

Mazzeo, F.C., De Vita, P., Aulinas Juncà, Meritxell, Arienzo, I., Cirillo, G., Iovine, R.S., Sparice, D., Mazzeo, FABIO CARMINE, DE VITA, Pantaleone, Aulinas, M., Arienzo, I., Cirillo, G., Iovine, R. S., and Sparice, Domenico

Subjects
Southern Apennine, Mount Centaurino, Geology, Southern apennine, Cilento region, Ophiolitic olistoliths, MORB-type rocks, Mount centaurino, Ophiolitic olistolith, MOR B-type rock, Morb-type rocks
Abstract

Mafic igneous rocks (pillow lavas and gabbros) embedded as olistoliths within Miocene turbiditic sequences crop out in the Cilento area at the Mount Centaurino (Campania region, Southern Italy). The concentration of major oxides, as well as trace element ratios (Nb/Yb, Nb/Ta, Th/Nb) and the chondrite-normalized Rare Earth Elements (REE) patterns suggest a tholeiitic character with Mid Oceanic Ridge Basalts (MORB) affinity. The chemical composition of pillow lavas is consistent with magmas generated by 10% degrees of non-modal fractional partial melting, of a spinel-bearing MORB-type asthenospheric mantle. Regarding gabbros, the calculated composition of parental melts in equilibrium with the clinopyroxenes show a wide compositional range, and there are very different from the pillow basalts of the Mount Centaurino, suggesting that the clinopyroxenes might have derived from more evolved melts compared to those that produced the basalts. The origin of these olistoliths is not yet understood. Here we suggest that these rocks represent fragment of a dismantled accretionary wedge embedded during the deposition of the Cilento group sedimentary successions in a thrust top basin.

Published
2016

15. Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children

Author

Menale C., Grandone A., Nicolucci C., Cirillo G., Crispi S., Di Sessa A., Marzuillo P., Rossi S., Mita D. G., Perrone L., Diano N., Miraglia Del Giudice E., Menale, C., Grandone, A., Nicolucci, C., Cirillo, G., Crispi, S., Di Sessa, A., Marzuillo, P., Rossi, S., Mita, D. G., Perrone, L., Diano, N., and Miraglia Del Giudice, E.

Subjects
endocrine system, Bisphenol A, Adipokines, urogenital system, Adipokine, nutritional and metabolic diseases, Insulin resistance, Childhood obesity, bisphenol A, childhood obesity, insulin resistance, hormones, hormone substitutes, and hormone antagonists
Abstract

Background: Bisphenol A (BPA) exposure has been associated with increased incidence of diabetes and obesity in adults. Objectives: To evaluate whether an association between BPA urinary levels and insulin resistance as well as adiponectin and resistin production and serum concentrations may occur in obese children. Methods: Clinical and biochemical features of 141 obese children were collected. Serum resistin and adiponectin were evaluated. Insulin resistance and urinary BPA levels were assessed. Moreover, the effect of BPA on adiponectin and resistin gene expression in adipocytes from eight normal weight prepubertal children was investigated by quantitative real-time RT-PCR (qPCR). Results: Direct association between BPA and homeostasis model assessment (r = 0.23; p: 0.0069) and a strong inverse association between BPA and adiponectin have been found (r = −0.48; p < 0.0001). In adipocytes, resistin expression was detected only after BPA treatment, while adiponectin expression resulted down-regulated after BPA exposure (p < 0.05 at both 10 and 100 nM BPA concentrations). Conclusions: We suggest the involvement of BPA in the development of insulin resistance in childhood obesity highlighting that urinary BPA levels are directly associated with insulin resistance regardless of BMI. This association may be explained, at least partly, by the findings that BPA affects resistin and adiponectin production in adipose tissue cultures.

Published
2016
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16. TM6SF2 Glu167Lys polymorphism is associated with low levels of LDL-cholesterol and increased liver injury in obese children

Author

GRANDONE, Anna, COZZOLINO, Domenico, Marzuillo, P, Cirillo, G., Di Sessa, A., Ruggiero, L., Di Palma, M. R., PERRONE, Laura, MIRAGLIA DEL GIUDICE, Emanuele, Grandone, Anna, Cozzolino, Domenico, Marzuillo, P, Cirillo, G., Di Sessa, A., Ruggiero, L., Di Palma, M. R., Perrone, Laura, and MIRAGLIA DEL GIUDICE, Emanuele

Subjects
Male, Pediatric Obesity, Adolescent, Genotype, Triglyceride, Polymorphism, Single Nucleotide, Non-alcoholic Fatty Liver Disease, NAFLD, non-HDL-C, Nutrition and Dietetic, Genetic Predisposition to Disease, Child, Lipoprotein, Membrane Protein, PNPLA3, Allele, Risk Factor, Health Policy, Medicine (all), Cholesterol, HDL, Public Health, Environmental and Occupational Health, Alanine Transaminase, Cholesterol, LDL, Lipase, Italy, Liver, TMS6SF2, Pediatrics, Perinatology and Child Health, Female, Human
Abstract

Background The Glu167Lys (E167K) transmembrane 6 superfamily member 2 (TM6SF2) variant has been associated with liver steatosis, high alanine transaminase (ALT) levels and reduced plasma levels of liver-derived triglyceride-rich lipoproteins. Objectives The objectives of this study were to investigate in a group of obese children the association among the 167K allele of TM6SF2 gene and ALT, cholesterol and triglycerides levels, and hepatic steatosis, and to evaluate the potential interaction between this variant and the I148M patatin like phospholipase 3 gene (PNPLA3) polymorphism on liver enzymes. Methods We genotyped 1010 obese children for TM6SF2 E167K and PNPLA3 I148M polymorphisms. Anthropometrical and biochemical data were collected. Ultrasound imaging of the liver was performed. Results The 167K allele showed an association with steatosis (P < 0.0001), higher ALT levels (P < 0.001) and lower total cholesterol (P < 0.00001), low-density lipoprotein cholesterol (P < 0.0001), triglycerides (P = 0.02) and non-high-density lipoprotein cholesterol levels (P < 0.000001). The subjects homozygous for the PNPLA3 148M allele carrying the rare variant of TM6SF2 showed an odds ratio of 12.2 (confidence interval 3.8-39.6, P = 0.000001) to present hypertransaminasaemia compared with the remaining patients. Conclusion Although the TMS6SF2 E167K variant predisposes the obese children to non-alcoholic fatty liver disease, there is an association between this variant and lower levels of cardiovascular risk factors. Overall, the data suggest differential effects of TMS6SF2 E167K variant on liver and heart health.

Published
2016

20. Astrocyte-neuron interplay in maladaptive plasticity

Author

PAPA, Michele, De Luca C, Petta F, Alberghina L, Cirillo G., Papa, Michele, De Luca, C, Petta, F, Alberghina, L, and Cirillo, G.

Subjects
nervous system
Abstract

The complexity of neuronal networks cannot only be explained by neuronal activity so neurobiological research in the last decade has focused on different components of the central nervous system: the glia. Glial cells are fundamental elements for development and maintenance of physiological brain work. New data confirm that glia significantly influences neuronal communication through specific molecules, named "gliotransmitters", and their related receptors. This new approach to the traditional model of the way synapses work is also supported by changes occurring in pathological conditions, such as neurodegenerative diseases or toxic/traumatic injury to nervous system. Experimental models have revealed that glial cells are the starting point of damage progression that subsequently involves neurons. The "bedside to bench" approach has demonstrated that clinical phenotypes are strictly related to neuronal death, however it is conceivable that the disease begins earlier, years before clinical onset. This temporal gap is necessary to determine complex changes in the neuro-glial network organization and produce a "maladaptive plasticity". We review the function of glial cells in health and disease, pointing the putative mechanisms of maladaptive plasticity, suggesting that glial cells may represent a fascinating therapeutic target to prevent irreversible neuronal cell death.

Published
2014

24. Clinical features of a new acid-labile subunit (IGFALS) heterozygous mutation: anthropometric and biochemical characterization and response to growth hormone administration

Author

GRANDONE, Anna, MIRAGLIA DEL GIUDICE, Emanuele, Cirillo G, ABBONDANZA, Ciro, CIOFFI, Michele, Romano T, Micillo F, Marzuillo P, PERRONE, Laura, Grandone, Anna, MIRAGLIA DEL GIUDICE, Emanuele, Cirillo, G, Abbondanza, Ciro, Cioffi, Michele, Romano, T, Micillo, F, Marzuillo, P, and Perrone, Laura

Subjects
Heterozygote, Endocrinology, Diabetes and Metabolism, Dwarfism, Endocrinology, Child Development, Growth hormone treatment, Humans, Body Weights and Measures, Child, Children, GH and growth factor, Glycoproteins, Human Growth Hormone, Medicine (all), Body Weights and Measure, Pedigree, Short stature, Treatment Outcome, Pediatrics, Perinatology and Child Health, Mutation, Female, Acid-labile subunit, Glycoprotein, Carrier Protein, Carrier Proteins, Human
Abstract

Background: Homozygous mutations in acid-labile subunit (IGFALS) gene result in short stature, very low circulating levels of acid-labile subunit (ALS), insulin growth factor 1 (IGF1) and insulin growth factor binding protein 3 (IGFBP3) and a poor response to growth hormone (GH). The impact of IGFALS mutations heterozygosity on growth is unknown. Patient and Methods: We describe a 10-year-old girl with severe short stature (height -3.2 SDS), heterozygous for a new IGFALS mutation. Results: The girl showed low circulating IGF1, IGFBP3 and ALS levels and normal GH secretion. We found a novel heterozygous frameshift IGFALS mutation (c.1283delA, p.Gln428Argfs*14). Size-exclusion chromatography showed a reduction of the IGF1, IGFBP3 and ALS 150-kDa ternary complex (by about 55%) compared to a control. An IGF-1 generation test, with two different GH dosages, showed a good response in term of increase in IGF1 and in formation of the ternary complex at size-exclusion chromatography. Clinical response after 6 months of therapy with GH was satisfactory (height velocity increased from 3 to 8 cm/year). Conclusion: We suggest that (1) heterozygous IGFALS mutations can be responsible for a subset of patients with severe short stature (below -2.5 SDS), low IGF1 (below -2 SDS) and normal GH secretion, and (2) the identification by IGFALS molecular screening of this subset of patients could help in the administration of the appropriate therapy. Background: Homozygous mutations in acid-labile subunit (IGFALS) gene result in short stature, very low circulating levels of acid-labile subunit (ALS), insulin growth factor 1 (IGF1) and insulin growth factor binding protein 3 (IGFBP3) and a poor response to growth hormone (GH). The impact of IGFALS mutations heterozygosity on growth is unknown. Patient and Methods: We describe a 10-year-old girl with severe short stature (height -3.2 SDS), heterozygous for a new IGFALS mutation. Results: The girl showed low circulating IGF1, IGFBP3 and ALS levels and normal GH secretion. We found a novel heterozygous frameshift IGFALS mutation (c.1283delA, p.Gln428Argfs*14). Size-exclusion chromatography showed a reduction of the IGF1, IGFBP3 and ALS 150-kDa ternary complex (by about 55%) compared to a control. An IGF-1 generation test, with two different GH dosages, showed a good response in term of increase in IGF1 and in formation of the ternary complex at size-exclusion chromatography. Clinical response after 6 months of therapy with GH was satisfactory (height velocity increased from 3 to 8 cm/year). Conclusion: We suggest that (1) heterozygous IGFALS mutations can be responsible for a subset of patients with severe short stature (below -2.5 SDS), low IGF1 (below -2 SDS) and normal GH secretion, and (2) the identification by IGFALS molecular screening of this subset of patients could help in the administration of the appropriate therapy. © 2013 S. Karger AG, Basel.

Published
2013

25. Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C

Author

ZAMPINO, Rosa, COPPOLA, Nicola, Cirillo G, Boemio A, Pisaturo M, MARRONE, Aldo, Macera M, Sagnelli E, PERRONE, Laura, ADINOLFI, Luigi Elio, MIRAGLIA DEL GIUDICE, Emanuele, Zampino, Rosa, Coppola, Nicola, Cirillo, G, Boemio, A, Pisaturo, M, Marrone, Aldo, Macera, M, Sagnelli, E, Perrone, Laura, Adinolfi, Luigi Elio, and MIRAGLIA DEL GIUDICE, Emanuele

Published
2013

26. Advanced Systems for Harsh Environment Off-Grid Renewable Generation using Battery Energy Storage

Author

Lanuzza, L., Bizzarri, F., Cirillo, G., Del Gaizo, C., Justiniano, J., Bonemazzi, F., Santilli, A., and Pellegrini, A.

Subjects
PV APPLICATIONS, PV Applications Without a Centralised Grid
Abstract

31st European Photovoltaic Solar Energy Conference and Exhibition; 2709-2712, In this paper a project is presented which was thought with the double aim of satisfying the energy demand of a rural village in desert region in Chile and to become a experimentation test site for advanced technical solutions and operation models for renewable off-grid systems. Design solutions will be reported, together with feedback from the experimentation activities during the first months of operation.

Published
2015
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27. Lack of red hair phenotype in a North-African obese child homozygous for a novel POMC-null mutation: nonsense-mediated decay RNA evaluation and hair pigment chemical analysis

Author

Cirillo G, Marini R, Ito S, Wakamatsu K, Scianguetta S, Bizzarri C, Romano A, GRANDONE, Anna, PERRONE, Laura, Cappa M, MIRAGLIA DEL GIUDICE, Emanuele, Cirillo, G, Marini, R, Ito, S, Wakamatsu, K, Scianguetta, S, Bizzarri, C, Romano, A, Grandone, Anna, Perrone, Laura, Cappa, M, and MIRAGLIA DEL GIUDICE, Emanuele

Published
2012

28. Integrazione dei saperi per la salute

Author

GIANI, UMBERTO, TRIASSI, MARIA, SANTOIANNI, FLAVIA, GARZILLO, CARMINE, Pacifico A., Citro V., Ventre V., Cillo B., Sandri S., Montella E., Giani E., Noschese S., Sibilia L., RANISIO, GIANFRANCA ANGELA RITA, Pavic B., Griffo G., Sorrentino M., Lamberti E., Citarella A., Cirillo G., Saporito M., Arsieri R., Trevisan M., Cito F., Giordano V., Giani, Umberto, Triassi, Maria, Santoianni, Flavia, Pacifico, A., Citro, V., Ventre, V., Cillo, B., Sandri, S., Montella, E., Giani, E., Noschese, S., Sibilia, L., Ranisio, GIANFRANCA ANGELA RITA, Pavic, B., Griffo, G., Sorrentino, M., Lamberti, E., Citarella, A., Cirillo, G., Saporito, M., Arsieri, R., Trevisan, M., Cito, F., Garzillo, Carmine, and Giordano, V.

Subjects
multiprofessionalità e multidisciplinarità, medicina e complessità, integrazione dei saperi
Abstract

Il volume nasce dall’iniziativa di un gruppo di persone confluite in un’associazione culturale Knowledge Integration for Health il cui obiettivo è superare la parcellizzazione del sapere medico in una pluralità di iperspecializzazioni formate da professionisti che spesso non comunicano tra loro. Tutto ciò si riflette non solo sulla cura dei pazienti, costretti a peregrinare tra diversi specialisti, non di rado in disaccordo tra loro, ma anche sulla ricerca scientifica, sulla formazione, sull'organizzazione dei servizi sanitari e sulla spesa pubblica. Sebbene tale esigenza sia avvertita dai cittadini, dai profes-sionisti della salute e dai ricercatori, tuttora non è emerso un modello e/o una teoria coerente dell'integrazione dei saperi per la salute a causa di barriere culturali, economiche ed organizzative. Il volume, espressione del progetto ambizioso di abbattere tali barriere, raccoglie le riflessioni scaturite da una serie di inziative (convegni, workshop, corsi di perfezionamento, sperimentazioni didattiche, ricerche sul campo, conversazioni telematiche e in-formali, e così via) realizzatesi a partire dall'anno 2010. Esso è concepito come uno strumento di lavoro e aperto alla discussione volto a creare una rete comunicativa ed informativa tra esperti di "discipline" diverse, e tra questi e gli stessi pazienti che sono portatori di conoscenze e saperi poco rappresentati nell’attuale scenario scientifico e organizzativo. Su questa falsariga è stata data voce anche a saperi "minoritari" che si configurano a volte come ipotesi di lavoro, più o meno eterodosse, ancora da provare scientificamente ma che sono un sintomo dell’esigenza sempre più sentita di una visione unitaria della salute, della malattia e della terapia. I contributi sono stati scritti da professionisti diversi appartenenti non solo al mondo accademico, ma anche istanze extrauniver-sitarie, istituzionali e non: medici di medicina generale,, ostetriche, fisioterapisti riabilitatori, pediatri, infermieri, logopedisti, tecnici di radiolo-gia, tecnici di laboratorio, epidemiologi, pedagogisti, antropo-logi, psichiatri, chimici, veterinari, statistici, urbanisti, igienisti, informatici. E'stato altresì dato spazio anche ai lavori condotti da studenti e discussi sotto forma di tesi di laurea. La struttura del volume si articola su tre livelli interconnessi: clinico, sociale ed ecologico. Il livello clinico, centrato sull'individuo e la sua malattia, ha co-me paradigma di riferimento il cosiddetto modello bio-medico, noto anche come modello dell'acuzie, fondato sul processo diagnostico-terapeutico e sulla diade terapeuta-paziente. Al secondo livello, quello sociale, il malessere del paziente è iscritto in una serie di dinamiche interpersonali, espressione di comportamenti individuali e collettivi, fattori economici, cultu-rali, e così via. Mentre il modello dell'acuzie concettualizza la malattia come un evento che ha un inizio ed una fine (almeno momentanea), il modello sociale si incentra su cronicità e disabilità che richiedono la partecipazione di familiari, badanti, servizi di riabilitazione e di supporto sociale per un tempo indefinito. I due modelli non sono mutuamente incompatibili perché spesso le condizioni di cronicità e disabilità sono costel-late da esacerbazioni o nuovi eventi che richiedono il ricorso ad interventi clinici. Il livello ecologico riguarda il modo in cui le popolazioni umane si modificano a seguito dell'interazione con altre popolazioni umane, con il mondo animale e vegetale e con l'ambiente chimi-co-fisico, formando ecosistemi la cui dinamica si dipana su scale temporali e geografiche differenti e si riflette sui profili delle malattie di ciascuna popolazione. Così, ad esempio, le grandi trasformazioni demografiche dovute ai processi migratori e alla creazione di barriere efficienti contro alcuni micro-organismi (attraverso il miglioramento delle condizioni igieniche e della conservazione degli alimenti) determinano modificazioni della composizione per età delle popolazioni che a loro volta com-portano transizioni epidemiologiche caratterizzate da cambia-menti più o meno profondi della prevalenza e l'incidenza dei diversi tipi di patologia.

Published
2012

30. Methylphenidate administration determines enduring changes in neuroglial network in rats

Author

CAVALIERE C, CIRILLO G, BIANCO MR, ADRIANI W, DE SIMONE A, LEO D, PERRONE CAPANO, C, PAPA, Michele, Cavaliere, C, Cirillo, G, Bianco, Mr, Adriani, W, DE SIMONE, A, Leo, D, Perrone, Capano, and Papa, Michele

Subjects
nervous system, ttention deficit and hyperactivity disorder, prefrontal cortex, limbic areas, plastic synaptic changes
Abstract

Repeated exposure to psychostimulant drugs induces complex molecular and structural modifications in discrete brain regions of the meso-cortico-limbic system. This structural remodeling is thought to underlie neurobehavioral adaptive responses. Administration to adolescent rats of methylphenidate (MPH), commonly used in attention deficit and hyperactivity disorder (ADHD), triggers alterations of reward-based behavior paralleled by persistent and plastic synaptic changes of neuronal and glial markers within key areas of the reward circuits. By immunohistochemistry, we observe a marked increase of glial fibrillary acidic protein (GFAP) and neuronal nitric oxide synthase (nNOS) expression and a down-regulation of glial glutamate transporter GLAST in dorso-lateral and ventro-medial striatum. Using electron microscopy, we find in the prefrontal cortex a significant reduction of the synaptic active zone length, paralleled by an increase of dendritic spines. We demonstrate that in limbic areas the MPH-induced reactive astrocytosis affects the glial glutamatergic uptake system that in turn could determine glutamate receptor sensitization. These processes could be sustained by NO production and synaptic rearrangement and contribute to MPH neuroglial induced rewiring.

Published
2012

33. Long-term outcome of HBV-HCV co-infection and HBV mono-infection acquired in youth

Author

ZAMPINO, Rosa, MARRONE, Aldo, MEROLA A., TRANI B., CIRILLO G., KARAYIANNIS P., COPPOLA, Nicola, ZAPPALÀ R., UTILI, Riccardo, RUGGIERO G., ADINOLFI, Luigi Elio, Zampino, Rosa, Marrone, Aldo, Merola, A., Trani, B., Cirillo, G., Karayiannis, P., Coppola, Nicola, Zappalà, R., Utili, Riccardo, Ruggiero, G., and Adinolfi, Luigi Elio

Subjects
HBV HCV coinfection outcome young patients, virus diseases, digestive system diseases
Abstract

Co-infection with HBV and HCV seems to be associated with more severe liver disease in retrospective and cross-sectional studies in adults, but no data are available when co-infection is acquired in youth. The long-term outcome of infection acquired in youth was assessed in patients co-infected with HBV and HCV and in patients with HBV infection only. Twenty-seven patients with HBV and HCV co-infection and 27 patients infected with HBV only were enrolled. Seventy-six per cent of the patients were treated with alpha-interferon for 1 year. After a median follow-up of 23 years, the annual progression rate of fibrosis was 0.07 in patients co-infected with HBV and HCV, and in those infected with HBV it was 0.07 and 0.11 (P < 0.004) for HBe and anti-HBe-positive patients, respectively. In co-infected patients, the development of cirrhosis was observed in 2 (7.4%) and of hepatocellular carcinoma (HCC) in 1 (3.7%), while in those with HBV, cirrhosis appeared in one patient (3.7%). Alcohol intake (OR = 9.5 +/- 1.2; 95% CI = 6.6-13.9; P < 0.0001) was independently associated with cirrhosis and HCC. alpha-interferon showed no efficacy during treatment, but the treated group showed higher HCV RNA clearance during post-treatment follow-up. Co-infection with HBV and HCV and single HBV infection acquired in youth showed a low rate of progression to liver fibrosis, no liver failure, and low development of HCC during a median follow-up of 23 years (range 17-40).

Published
2009

34. Different serological, molecular and cytokine profiles characterize active and inactive disease in patients with chronic hepatitis B virus (HBV) infection

Author

MARRONE, Aldo, ZAMPINO, Rosa, Trani B, Marino R, Guerrera B, Cirillo G, Cafaro M, COPPOLA, Nicola, Pisapia R, Rinaldi L, Merola A, Tufano MA, UTILI, Riccardo, ADINOLFI, Luigi Elio, Ruggiero R., Marrone, Aldo, Zampino, Rosa, Trani, B, Marino, R, Guerrera, B, Cirillo, G, Cafaro, M, Coppola, Nicola, Pisapia, R, Rinaldi, L, Merola, A, Tufano, Ma, Utili, Riccardo, Adinolfi, Luigi Elio, and Ruggiero, R.

Published
2009

35. Effect of the rs997509 Polymorphism on the Association Between ENPP1, Metabolic Syndrome, and Impaired Glucose Tolerance in Childhood Obesity

Author

SANTORO N., CIRILLO G., LEPORE M., PALMA A., AMATO A., SAVARESE P., MARZUILLO P., GRANDONE, Anna, PERRONE, Laura, MIRAGLIA DEL GIUDICE, Emanuele, Santoro, N., Cirillo, G., Lepore, M., Palma, A., Amato, A., Savarese, P., Marzuillo, P., Grandone, Anna, Perrone, Laura, and MIRAGLIA DEL GIUDICE, Emanuele

Subjects
K121Q and rs997509 ENPP-1 variant, obesity, metabolic syndrome
Abstract

Context: Variants on the nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP-1) gene have been associated with obesity and insulin resistance. Because insulin resistance is a pivotal factor in the development of metabolic syndrome (MS) and impaired glucose tolerance (IGT), we aimed to test the association between the K121Q and rs997509 ENPP-1 variants with obesity, MS and IGT in obese children and adolescents. Methods: We screened 809 children, 409 obese and 400 lean controls. Obese subjects underwent a standard oral glucose tolerance test, whole body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) were calculated. Results: No difference in prevalence for K121Q and rs997509 polymorphisms between obese and controls (P > 0.05) were observed. Obese children carrying the rs997509 rare allele showed higher insulin (P = 0.001), HOMA (P < .001) and lower WBISI values (P = 0.04) compared with common allele homozygous. A similar observation was done for K121Q variant, with 121Q allele carriers showing higher insulin (P = 0.03) and HOMA(P = 0.04) values than 121K homozygotes. Moreover, subjects carrying the rs997509 rare allele had higher risk of MS (odds ratio 2.4, 95% confidence interval: 1.3– 4.3) and IGT (odds ratio 4.7, 95% confidence interval: 1.9 –11.4) than common allele homozygotes. Evaluating combined effects of both polymorphisms, which are in strong linkage disequilibrium, we showed that the effect on insulin sensitivity was due to the rs997509 T variant. Conclusion:We conclude that the ENPP1 rs997509T allele can predispose obese children to MS and IGT and that this variant might drive the association between the ENPP1 121Q allele and insulin resistance.

Published
2009

37. Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy

Author

Barban, F, Annicchiarico, R, Pantelopoulos, S, Federici, A, Perri, R, Fadda, Lm, Carlesimo, G, Ricci, C, Giuli, S, Scalici, F, Turchetta, C, Adriano, F, Lombardi, M, Zaccarelli, C, Cirillo, G, Passuti, S, Mattarelli, P, Lymperopoulou, O, Sakka, P, Ntanasi, E, Moliner, R, Garcia Palacios, A, and Caltagirone, C

Subjects
Male, Alzheimer's disease, aging, cognitive training, computerized training, mild cognitive impairment, reminiscence therapy, Neuropsychological Tests, Executive Function, Cognition, Alzheimer Disease, Memory, Activities of Daily Living, Humans, Cognitive Dysfunction, Aged, Aged, 80 and over, Cross-Over Studies, Cognitive Behavioral Therapy, Middle Aged, Psychotherapy, Mental Recall, Settore MED/26 - Neurologia, Female, Alzheimer’s disease
Abstract

Objective The aim of this paper was to assess the efficacy of process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and in healthy elderly (HE) subjects. Methods This multicenter, randomized, controlled trial involved 348 participants with mAD, MCI, and HE from four European countries. Participants were randomly assigned to two arms of a crossover design: those in arm A underwent 3 months of computerized pb-CT for memory and executive functions combined with RT and 3 months of rest; those in arm B underwent the reverse. The primary outcome was the effect of the training on memory and executive functions performance. The secondary outcome was the effect of the training on functional abilities in mAD assessed with the instrumental activities of daily living. Results We found a significant effect of the training for memory in all three groups on delayed recall of the Rey Auditory Verbal Learning Test and for executive functions in HE on the phonological fluency test. MCI and HE participants maintained these effects at follow-up. MCI and mAD participants also showed a significant effect of the training on the Mini-mental state examination scale. Participants with mAD showed more stable instrumental activities of daily living during the training versus the rest period. Conclusions Our results corroborate the positive effect of pb-CT and its maintenance primarily on memory in HE and MCI participants that did not seem to be potentiated by RT. Moreover, our results are very promising for the mAD participants. Copyright © 2015 John Wiley & Sons, Ltd.

Published
2014

39. Hepatitis B virus (HBV) core promoter (CP), precore (PC) and surface mutations in hepatitis D virus infection: a molecular epidemiology study

Author

MARRONE, Aldo, Niro GA, ZAMPINO, Rosa, Costagliola L, Cirillo G, COPPOLA, Nicola, Cafaro M, Merola A, Guerrera B, Ciotti M, Fontana R, ADINOLFI, Luigi Elio, Andriulli A, Ruggiero G., Marrone, Aldo, Niro, Ga, Zampino, Rosa, Costagliola, L, Cirillo, G, Coppola, Nicola, Cafaro, M, Merola, A, Guerrera, B, Ciotti, M, Fontana, R, Adinolfi, Luigi Elio, Andriulli, A, and Ruggiero, G.

Published
2008

42. Le imprese conserviere campane produttrici di pomodorino

Author

CIRILLO G., GORGITANO, MARIA TERESA, GORGITANO M.T., Cirillo, G., and Gorgitano, MARIA TERESA

Subjects
"Economia agroalimentare", "Organizzazione industrie agroalimentari", "Pomodoro trasformato"
Abstract

L’efficacia degli interventi operativi a favore della competitività delle imprese dipende in primo luogo dalla precisa conoscenza delle imprese destinatarie. Con riferimento alle imprese conserviere campane, quelle impegnate nella trasformazione del pomodoro sono state attentamente analizzate considerando le caratteristiche della struttura di produzione e le loro scelte relative alla qualità, agli indirizzi di marketing strategico ed operativo adottati per tutti i prodotti trasformati in particolare per il pomodorino. I risultati sono sintetizzati nella proposta di una loro tipologia ottenuta con l’ausilio di tecniche d’analisi multidimensionale combinate con procedure di classificazione automatica.

Published
2007

46. La programmazione distrettuale: uno studio pilota per la realizzazione di un sistema di base di indicatori integrati di salute

Author

CIRILLO G, Arillo N., Arsieri R., de Gaetano M., Dello Iacono P., Di Maio P., FASANELLI, ROBERTO, Iapicca G., Papa R., Piscitelli A., Rettura R., Russo R., Sagitto R., Tessitore C., Cirillo, G, Arillo, N., Arsieri, R., de Gaetano, M., Dello Iacono, P., Di Maio, P., Fasanelli, Roberto, Iapicca, G., Papa, R., Piscitelli, A., Rettura, R., Russo, R., Sagitto, R., and Tessitore, C.

Published
2002

48. Molecular screening of the proopiomelanocortin (POMC ) gene in Italian obese children: report of three new mutations

Author

MIRAGLIA DEL GIUDICE, Emanuele, CIRILLO G, SANTORO N, D'URSO L, CARBONE MT, DI TORO, R, PERRONE, Laura, MIRAGLIA DEL GIUDICE, Emanuele, Cirillo, G, Santoro, N, D'Urso, L, Carbone, Mt, Di, Toro, R, and Perrone, Laura

Subjects
Adult, Leptin, Male, endocrine system, medicine.medical_specialty, Heterozygote, Pro-Opiomelanocortin, Adolescent, Endocrinology, Diabetes and Metabolism, Prohormone, Mutation, Missense, Medicine (miscellaneous), Protein Sorting Signals, medicine.disease_cause, Polymerase Chain Reaction, Genetic determinism, Translocation, Genetic, law.invention, Body Mass Index, Proopiomelanocortin, law, Internal medicine, medicine, Humans, Obesity, Child, Codon, Gene, Molecular Biology, Polymerase chain reaction, Polymorphism, Single-Stranded Conformational, Genetics, Mutation, Nutrition and Dietetics, biology, business.industry, digestive, oral, and skin physiology, Heterozygote advantage, Endocrinology, nervous system, Italy, Child, Preschool, biology.protein, Female, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Although linkage studies strongly suggest that proopiomelanocortin (POMC) alterations could play a role in the genetic predisposition to obesity, systematic POMC mutational analysis did not completely confirm this hypothesis.To verify the presence of mutations of the POMC coding region in Italian children with very early onset obesity.Eighty seven unrelated Italian obese children and adolescents were studied. Mean age at obesity onset was 4.7+/-2.5 y. The POMC gene coding region was screened using single-strand conformation polymorphism (SSCP) analysis. Bi-directional automatic sequencing of PCR products was performed for all individuals who showed an aberrant SSCP pattern.Three new mutations have been identified in the heterozygous state in three patients: (a) G3834C, resulting in the substitution of Ser with Thr at codon 7 within the POMC signal peptide; (b) C3840T, resulting in the substitution of Ser with Leu at codon 9 of the pre-proopiomelanocortin signal peptide; and (c) C7406G, producing the substitution of Arg with Gly at codon 236 within the beta-endorphin peptide. A polymorphism consisting of a 9 bp insertion, AGC AGC CGC, between position 6997 and 6998 has been found at the heterozygous state in nine patients. They showed leptin levels adjusted for BMI, gender and pubertal stage significantly higher than obese subjects homozyous for the POMC wild-type allele.Mutations in codons 7 and 9 of the signal peptide may alter the translocation of the pre-proopiomelanocortin into the endoplasmic reticulum and, therefore, can be implicated in obesity. Although further studies are required, the polymorphism between position 6997 and 6998 may represent one of the genetic variations that explain the linkage between obesity and POMC. International Journal of Obesity (2001) 25, 61-67

Published
2001

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