13 results on '"Clement, Franck"'
Search Results
2. Cold Atmospheric Plasmas in interactions with materials and liquids for biological applications
- Author
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Clement, Franck, Held, Bernard, Gazeli, Kristacq, Marlin, Laurent, Morel, Erwan, Girard-Sahun, Fanny, Blanc, Sylvie, Grassl, Bruno, Reynaud, Stephanie, Marcasuzaa, Pierre, Veclin, Cloé, Lebouachera, Seif El Islam, Léonardi, Frédéric, Hoqui, Quentin, Nardin, Corinne, Callies, Xavier, Arbault, Stéphane, Badets, Vasilica, Lefrançois, Pauline, Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Pau et des Pays de l'Adour (UPPA), and ANR-14-CE16-0007,PLASMAREGEN,Régénération cutanée induite par des plasmas froids atmosphériques au travers d'une production contrôlée d'espèces réactives(2014)
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[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,[CHIM.POLY]Chemical Sciences/Polymers ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,[CHIM.MATE]Chemical Sciences/Material chemistry - Abstract
International audience; Cold Atmospheric Plasmas (CAPs) are now currently used for numerous applications concerning the surface treatment of solid materials at the macro-, micro- and nano- scales. Surface modifications produced lead to new functionnalities induced by the interactions of the materials with the different energy components (electrons, ions, photons, reactive species) of these partially ionised gases, produced at atmospheric pressure and temperature closed to the room one. Another large area of applications is related to the treatment of liquids in which it is possible to increase the chemical reactivity, thus allowing nanoparticles synthetisis or bacterial decontamination. In this presentation we will first discuss on the physical and chemical properties of these specific plasmas. Their principles of manufacturing will be summarized and particular attentions will be indicated on the environment around the plasma-surface interaction zone. A non-exhaustive state of the art will provide a better understanding of the physical mechanisms associated with their propagation up to the material to be treated. A large biological applications field will be then shown, illustrated by the analyses of modifications produced on steels, polymers but also on physiological liquids and living cells. Methods of the interactions characterizations are numerous and we will present some known techniques but with an innovative approach as for instance the IR-ATR spectroscopy for tracking of modifications of polymers surface. The insitu electrochemistry1 has been also developed during the plasma exposure of liquids and results obtained will be given, showing that it is possible to measure very low current in the nA range and in the presence of high electric fields used for the plasma formation. Bio-chemically Reactive Oxygen and Nitrogen Species (RONS) production (H2O2, NO2-) can thus be followed and quantified, as well as the detection of short-living species.
- Published
- 2019
3. Formation of rons including ONOO- and O2 .- in physiological buffers exposed to cold atmospheric plasmas
- Author
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Girard-Sahun, Fanny, Badets, Vasilica, Lefrançois, Pauline, Blanc, Sylvie, Sojic, Neso, Arbault, Stéphane, Clement, Franck, Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and ANR-14-CE16-0007,PLASMAREGEN,Régénération cutanée induite par des plasmas froids atmosphériques au travers d'une production contrôlée d'espèces réactives(2014)
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[SDE]Environmental Sciences ,[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,[CHIM.MATE]Chemical Sciences/Material chemistry ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
4. Mechanistic insights into the impact of cold atmospheric pressure plasma on human epithelial cell lines
- Author
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Bulteau, Anne-Laure, Dezest, Marlène, Clement, Franck, Iséni, Sylvain, Douat, Claire, Pouvesle, Jean-Michel, Robert, Eric, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), ANR-14-CE16-0007,PLASMAREGEN,Régénération cutanée induite par des plasmas froids atmosphériques au travers d'une production contrôlée d'espèces réactives(2014), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
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[SDV]Life Sciences [q-bio] ,[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,cellules épitheliales ,Plasma Jet and DBD ,Plasma Medicine - Abstract
International audience; Compelling evidence suggests that Cold Atmospheric Pressure Plasma (CAPPs) has potential as a new cancer therapy. However, knowledge about cellular signaling events and toxicity subsequent to plasma treatment of is still poorly documented. The aim of this study was to focus on the interaction between 3 different types of plasma (He, He-O2, He-N2) and human epithelial cell lines to gain better insight into plasma-cell interaction. We choose epithelial cell lines (human keratinocytes, human fibroblasts, human colorectal carcinoma and skin melanoma) to gain insight into plasma-cell interaction and to determine which cellular pathways are induced by CAPP treatment in normal and malignant cells. We provide evidence that the proteasome, a major intracellular proteolytic system which is important for tumor cell growth and survival, is a target for (He or He-N2) CAPP. This is accompanied by apoptosis, DNA damage, mitochondrial dysfunction and mild oxidative protein damage. By differential label-free quantitative proteomic analysis we found that CAPP triggers antioxidant and cellular defense but also seen cancerous processes in keratinocytes. Moreover we found that malignant cells are more resistant to CAPP treatment than normal cells. However, reactiveoxygen and nitrogen species (RONS) are not the only actors involved in cell death; electric field and charged particles could play a significant role especially for He-O2 CAPP. Particular attention was paid to the contribution of the electric field (EF) and RONS in cellular response to plasma treatment. Taken together, our findings provide insight into potential mechanisms of CAPP-induced cell death.
- Published
- 2017
5. Formation of reactive oxygen and nitrogen species including peroxynitrite in physiological buffer exposed to cold atmospheric plasmas
- Author
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Girard, Fanny, Badets, Vasilica, Blanc, Sylvie, Sojic, Neso, Clement, Franck, Arbault, Stéphane, Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Pau et des Pays de l'Adour (UPPA), Institut des Sciences Moléculaires (ISM), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Université Sciences et Technologies - Bordeaux 1-Université Montesquieu - Bordeaux 4-Institut de Chimie du CNRS (INC), and ANR-14-CE16-0007,PLASMAREGEN,Régénération cutanée induite par des plasmas froids atmosphériques au travers d'une production contrôlée d'espèces réactives(2014)
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[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,[SPI]Engineering Sciences [physics] ,[CHIM.POLY]Chemical Sciences/Polymers ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,[CHIM.MATE]Chemical Sciences/Material chemistry ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2017
6. Effect of surfactant on structure thermal behavior of cetyl stearyl alcohols
- Author
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Wunsch, Karl, Relkin, Perla, Cuvelier, Gérard, Clement, Franck, Nicolas-Morgantini, Luc, Benkhelifa, Hayat, Flick, Denis, Ingénierie, Procédés, Aliments (GENIAL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and L’Oréal Research and Innovation
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Lamellar phase ,[SDV]Life Sciences [q-bio] ,Cetyl stearyl alcohols ,Cetyl trimetyl ammonium chloride ,Crystallization - Abstract
The thermal behaviors of cetyl (C16OH) and stearyl (C18OH) alcohols, alone or in mixture (C16/18OH), or flooded with water in the absence or presence of cetyl trimetyl ammonium chloride (CTAC), have been investigated using differential scanning calorimetry and X-ray scattering. Additional endothermic temperature transitions were observed at 16.9, 58.8, and 70.7 A degrees C and also an unusual exothermic transition at 63.5 A degrees C, when C16/18OH is in the presence of CTAC. The two first transitions at 16.9 and 58.8 A degrees C seems to be, respectively, linked to the hydration mechanism and the melting of long-chain alcohols, while the exothermic one at 63.5 A degrees C is corresponding to the crystallization of a swollen lamellar phase L (beta) . The crystallized swollen lamellar phase L (beta) melts at 70.7 A degrees C into a L (alpha) swollen liquid lamellar mesomorph phase, inducing an endothermic transition. This L (beta) -> L (alpha) transition is reversible upon cooling and reheating. Those data are key information to control the dispersion state of swollen lamellar crystals of long-chain alcohols.
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- 2016
7. Highlighting gas hydrate formation by high resolution optical microscopy
- Author
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Baños, M.L., Hobeika, Nelly, Bouriat, Patrick, Broseta, Daniel, Clement, Franck, Brown, Ross, Laboratoire des Fluides Complexes et leurs Réservoirs (LFCR), TOTAL FINA ELF-Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), and Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
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[PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,[SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph] ,[SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,[PHYS.MECA.GEME]Physics [physics]/Mechanics [physics]/Mechanical engineering [physics.class-ph] ,ComputingMilieux_MISCELLANEOUS ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] - Abstract
COM; International audience
- Published
- 2016
8. Impact of cetyl trimethyl ammonium chloride on melting behaviour of long chain alcohols
- Author
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Wunsch, Karl, Relkin, Perla, Cuvelier, Gerard, Clement, Franck, Nicolas-Morgantini, Luc, Benkhelifa, Hayat, Flick, Denis, Ingénierie, Procédés, Aliments (GENIAL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, L’Oréal Research and Innovation, and AgroParisTech. FRA.
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[SDV]Life Sciences [q-bio] ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2015
9. In situ-observations of rheology and conductivity changes in mixture of long chain alcohols with surfactant and water: impact of process heating and cooling steps
- Author
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Wunsch, Karl, Benkhelifa, Hayat, Alvarez, Graciela, Clement, Franck, Nicolas-Morgantini, Luc, Flick, Denis, Ingénierie, Procédés, Aliments (GENIAL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, L’Oréal Research and Innovation, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and AgroParisTech. FRA.
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[SDV]Life Sciences [q-bio] ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2015
10. Study of Reactive Oxygen or/and Nitrogen Species Binding Processes on E. coli Bacteria with Mass Spectrometry Isotopic Nanoimaging
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Duday, David, Clement, Franck, Lecoq, Elodie, Penny, Christian, Audinot, Jean-Nicolas, Belmonte, Thierry, Kutasi, Kinga, Cauchie, Henry-Michel, Choquet, Patrick, Centre de Recherche Public - Gabriel Lippmann (LUXEMBOURG), Institut Pluridisciplinaire de Recherche sur l'Environnement et les Matériaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Hungarian Academy of Sciences (MTA)
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[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering - Abstract
International audience; Today, it is necessary to better understand the role of reactive species in plasmas on biological objects in order to use plasma processes for biomedical applications. Even when well-known plasma set-ups producing one main reactive species in a controlled environment are used, it is still difficult to understand reactive species interaction processes with biological systems. In this study, nanoimaging with the most sensitive mass spectrometry technology, and the use of isotopic 15N2 or/and 18O2 containing-Ar gas mixtures to produce the plasma is proposed in order to obtain isotopic and elemental data on microwave late afterglow treated Escherichia coli bacteria. By this way, new data dealing with reactive species binding processes on plasma treated bacteria by using NanoSIMS50 mass spectrometer are obtained.
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- 2013
11. Experimental investigation of an atmospheric pressure DBD under bi-polar pulsed high voltage excitation
- Author
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Panousis, E., Clement, Franck, Lecoq, E., Loiseau, J.-F., Held, B., Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Clément, Franck
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[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,[SPI.PLASMA] Engineering Sciences [physics]/Plasmas - Abstract
International audience; This work presents a primary experimental study of a custom-made coaxial DBD reactor driven by a bipolar pulsed High Voltage supply. The reactor is fed by nitrogen or air at atmospheric pressure conditions and uses a dielectric coating on the HV electrode. The High Voltage generator delivers a "pulse-like" bipolar signal in the 10-50 kHz frequency range. This set-up has been conceived for surface treatment applications in afterglow conditions. Electrical and optical diagnostics are employed for the investigation of the nitrogen and air DBD while varying the frequency of the HV bipolar signal and the maximum applied voltage. Current and voltage oscillogrammes are used in order to derive the mean plasma power injected in the gap. Photomultiplier scans reveal the discharge's filamentary character whereas Optical Emission Spectroscopy (OES) shows the excited species present in such conditions. Comparisons between electrical and OES results show a correlation between the mean plasma power and the production of active species.
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- 2008
12. Two dimensional modeling of ionization waves in a dielectric barrier discharge (DBD) in nitrogen at atmospheric pressure
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Papageorghiou, L., Panousis, E., Loiseau, J.-F., Clement, Franck, Held, B., Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), and Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
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[SPI.PLASMA]Engineering Sciences [physics]/Plasmas - Abstract
International audience; The formation and propagation of ionization waves (streamers) in the filamentary mode of a barrier discharge in Nitrogen at atmospheric pressure is examined. The role of photoemission as well as of photoionization is analysed via a two dimensional finite element flux corrected transport (FEM-FCT) [1] model. Numerical investigations show how the photoemission coefficient influences the formation and propagation of ionization waves into the gas gap. In addition, an attempt is made to elucidate the way the streamer interacts with the dielectric basically by considering the surface charge accumulation in the dielectric material.
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- 2008
13. Amélioration de la mouillabilité du polycarbonate par plasma BF pulsé dans l'azote. Diagnostics par mesure de l'angle de contact
- Author
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Clement, Franck, Soulem, Nicolas, Held, B., Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), and Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
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[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; no abstract
- Published
- 1999
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