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IntroductionApproaches to economic evaluations of stroke therapies are varied and inconsistently described. An objective of the European Stroke Organisation (ESO) Health Economics Working Group is to standardise and improve the economic evaluations of interventions for stroke.MethodsThe ESO Health Economics Working Group and additional experts were contacted to develop a protocol and a guidance document for data collection for economic evaluations of stroke therapies. A modified Delphi approach, including a survey and consensus processes, was used to agree on content. We also asked the participants about resources that could be shared to improve economic evaluations of interventions for stroke.ResultsOf 28 experts invited, 16 (57%) completed the initial survey, with representation from universities, government, and industry. More than half of the survey respondents endorsed 13 specific items to include in a standard resource use questionnaire. Preferred functional/quality of life outcome measures to use for economic evaluations were the modified Rankin Scale (14 respondents, 88%) and the EQ-5D instrument (11 respondents, 69%). Of the 12 respondents who had access to data used in economic evaluations, 10 (83%) indicated a willingness to share data. A protocol template and a guidance document for data collection were developed and are presented in this article.ConclusionThe protocol template and guidance document for data collection will support a more standardised and transparent approach for economic evaluations of stroke care.

Supplemental material, ESO897466 Supplemental Figure for Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group by Dominique A Cadilhac, Joosup Kim, Alastair Wilson, Eivind Berge, Anita Patel, Myzoon Ali, Jeffrey Saver, Hanne Christensen, Matthieu Cuche, Sean Crews, Olivia Wu, Marine Provoyeur, Peter McMeekin, Isabelle Durand-Zaleski, Gary A Ford, Natalia Muhlemann, Philip M Bath, Azmil H Abdul-Rahim, Katharina Sunnerhagen, Atte Meretoja, Vincent Thijs, Christian Weimar, Ayrton Massaro, Annemarei Ranta and Kennedy R Lees; on behalf of the ESO Health Economics Working group in European Stroke Journal

Additional file 5: Hyper-acute stroke units - number of new full-time equivalents and associated cost by year. Year-by-year results of staff requirements in hyper-acute stroke units and estimated total cost.

Additional file 7: Inpatient rehabilitation - number of new full-time equivalents and associated cost by year. Year-by-year results of staff requirements for inpatient rehabilitation services and estimated total cost.

Additional file 2: Canadian recommendations on staffing levels for acute stroke units and inpatient rehabilitation. Full-time equivalents recommended for acute stroke units and inpatient rehabilitation services.

Additional file 6: Acute stroke units - number of new full-time equivalents and associated cost by year. Year-by-year results of staff requirements in acute stroke units and estimated total cost.

Additional file 1: United Kingdom clinical guidelines on minimum staffing levels for hyper-acute stroke units and acute stroke units. Full-time equivalents recommended in hyper-acute and acute stroke units.

Additional file 3: Australian recommendations on staff-to-patient ratios for inpatient rehabilitation services. Full-time equivalents recommended for each staff type for inpatient rehabilitation.

Supplemental Material for A national economic and clinical model for ischemic stroke care development in Saudi Arabia: A call for change by Fahmi Al-Senani, Mohammed Al-Johani, Mohammad Salawati, Souda ElSheikh, Maha AlQahtani, Jamal Muthana, Saeed AlZahrani, Judith Shore, Matthew Taylor, Valeska S Ravest, Simon Eggington, Matthieu Cuche, Heather Davies, Kyriakos Lobotesis and Jeffrey L Saver in International Journal of Stroke