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1. sj-docx-1-opp-10.1177_10781552221122026 - Supplemental material for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy

Author

Eliasen, Astrid, Kornholt, J, Mathiasen, R, Brok, J, Rechnitzer, C, Schmiegelow, K, and Dalhoff, K

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-opp-10.1177_10781552221122026 for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy by Astrid Eliasen, J Kornholt, R Mathiasen, J Brok, C Rechnitzer, K Schmiegelow and K Dalhoff in Journal of Oncology Pharmacy Practice

Published
2022
Full Text
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2. sj-docx-2-opp-10.1177_10781552221122026 - Supplemental material for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy

Author

Eliasen, Astrid, Kornholt, J, Mathiasen, R, Brok, J, Rechnitzer, C, Schmiegelow, K, and Dalhoff, K

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-2-opp-10.1177_10781552221122026 for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy by Astrid Eliasen, J Kornholt, R Mathiasen, J Brok, C Rechnitzer, K Schmiegelow and K Dalhoff in Journal of Oncology Pharmacy Practice

Published
2022
Full Text
View/download PDF

3. sj-docx-2-opp-10.1177_10781552221122026 - Supplemental material for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy

Author

Eliasen, Astrid, Kornholt, J, Mathiasen, R, Brok, J, Rechnitzer, C, Schmiegelow, K, and Dalhoff, K

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-2-opp-10.1177_10781552221122026 for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy by Astrid Eliasen, J Kornholt, R Mathiasen, J Brok, C Rechnitzer, K Schmiegelow and K Dalhoff in Journal of Oncology Pharmacy Practice

Published
2022
Full Text
View/download PDF

4. sj-docx-1-opp-10.1177_10781552221122026 - Supplemental material for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy

Author

Eliasen, Astrid, Kornholt, J, Mathiasen, R, Brok, J, Rechnitzer, C, Schmiegelow, K, and Dalhoff, K

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-opp-10.1177_10781552221122026 for Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy by Astrid Eliasen, J Kornholt, R Mathiasen, J Brok, C Rechnitzer, K Schmiegelow and K Dalhoff in Journal of Oncology Pharmacy Practice

Published
2022
Full Text
View/download PDF

5. Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study

Author

Walsh S. L. F., Maher T. M., Kolb M., Poletti V., Nusser R., Richeldi L., Vancheri C., Wilsher M. L., Antoniou K. M., Behr J., Bendstrup E., Brown K., Calandriello L., Corte T. J., Cottin V., Crestani B., Flaherty K., Glaspole I., Grutters J., Inoue Y., Kokosi M., Kondoh Y., Kouranos V., Kreuter M., Johannson K., Judge E., Ley B., Margaritopoulos G., Martinez F. J., Molina-Molina M., Morais A., Nunes H., Raghu G., Ryerson C. J., Selman M., Spagnolo P., Taniguchi H., Tomassetti S., Valeyre D., Wijsenbeek M., Wuyts W., Hansell D., Wells A., Zhu P. S., Yuan Y., Yoshito Fukuda C., Yoshimatsu Y., Xaubet A., Wong A. M., White P., Westney G., West A., Wessendorf T., Waseda Y., Wang C., Vienna J. M., Videnovic Ivanov J., Vicens Zygmunt V., Venero Caceres M. C., Velasquez Pinto G., Veitch E., Vasakova M., Varone F., Varela B. E., Van Hal P., Van De Ven M., Van Der Lee I., Van Den Toorn L., Urrutia Gajate A., Urban J., Ugarte Fornell L. G., Tzouvelekis A., Twohig K., Turner A., Trujillo S., Triani A., Traila D., Torres V., Tomioka H., Tomii K., Tomic R., Toma C., Tokgoz Akyil F., Tobino K., Tobar R., Tiwari A., Tibana R., Tian X., Thillai M., Tham W., Teo F., Tekavec Trkanjec J., Teixeira P., Tarpey D., Tapias L., Tanizawa K., Tanino Y., Takada T., Tabaj G., Szolnoki E., Swarnakar R., Strambu I., Sterclova M., Spinks K., Soo C. I., Soltani A., Solanki S., Sobh E., Soares M. R., Smith J., Smith B., Slocum P., Slabbynck H., Sivokozov I., Shifren A., Shen S. M., Sharp C., Shanmuganathan A., Sebastiani A., Scarlata S., Savas R., Sasaki S., Santeliz J., Santana ANC., Sanchez R., Salinas M., Saito S., Ryan F., Royo Prats J. A., Rosi E., Rokadia H., Robles Perez A., Rivera Ortega P., Rio Ramirez M., Righetti S., Reichner C., Ravaglia C., Ratanawatkul P., Ramalingam V., Rajasekaran A., Radzikowska E., Ra S. W., Quadrelli S., Precerutti J., Prasad J., Popa D., Pizzalato S., Piotrowski W., Pineiro A., Piloni D., Peros Golubicic T., Perez R., Pereira C., Pereira B., Perch M., Patel N., Patel D., Papanikolaou I., Papakosta D., Panselinas E., Pang Y. K., Pandya P., Padrao E., Ozdemir Kumbasar O., Overbeek M. J., Otto Minasian A., O'Riordan D., Ora J., Oldham J., Okutan O., Ohshimo S., Oguzulgen I. K., Ogura T., O'Donnell T., O'Dochartaigh C., O'Beirne S., Novikova L., Novelli L., Noth I., Nogueira Mendes Neto N., Niroumand M., Nieto A., Neves A., Nambiar A., Nair S., Nadama R., Murtagh E., Mura M., Muller Quernheim J., Mukhopadhyay A., Mukherjee S., Morisset J., Moran O., Mooney J., Moller J., Mogulkoc N., Miyamoto A., Milenkovic B., Mette S., Mejia M., Mei F., Mazzei M., Matsuda T., Mason C., Martinez Frances M., Mannarino S., Mancuzo E., Malli F., Malhotra P., Maillo M., Maia J., Mahdavian M., Madsen F., Luckhardt T., Lucht W., Low S. Y., Lopez Miguel C. P., Lipchik R., Levy S., Levin K., Lee K. L., Lederer D., Lammi M. R., Kwan H. Y., Kukreja S., Kruavit A., Kotecki M., Kolilekas L., Knoop H., Kiyan E., Kishaba T., King Biggs M., Khor Y. H., Khan A., Khalil N., Kedia R., Kebba N., Kawano Dourado L., Kapitan K., Kan C. D., Kalyoncu A. F., Kalluri M., Kabasakal Y., Jyothula S., Juretschke M. A., Jovanovic D., Jonkers R., Jo H., Izumi S., Ishii H., Ikeda S., Ibrahim A., Hyldgaard C., Hunninghake G., Huie T., Hufton A., Hu X., Hseih W. C., Hoyos R., Hoyles R., Holguin Rodriguez O., Hogan M. P., Hodgson U., Hilkin Sogoloff H., Herrera E., Henry B. M., Hellemons M., Hecimovic A., Hayashi R., Hart S., Harari S., Haney S., Hambly N., Hakkim R., Gutierrez M., Gripaldo R., Gomez A., Goh N., Godoy R., Gilbert C., Giannarakis I., Gasparini S., Garcha P., Furtado S., Fois A., Flood Page P., Fletcher S., Fiss E., Figueroa Casas J., Figueroa Casas M., Fiddler C. A., Ferrara G., Fernandez Casares M., Felton C., Faverio P., Fabro A. T., Estrada A., Errhalt P., Enomoto N., Enghelmayer J. I., El Kersh K., Eiger G., Dubaniewicz A., Drakopanagiotakis F., Disayabutr S., Dijkstra A., Diaz Patino J. C., Diaz Castanon J. J., Dhooria S., Dhasmana D. J., De Rosa M., De Luca S., Delobbe A., Delgado D., Delgado C., De La Fuente I., De Kruif M., De Gier M., De Andrade J., Davidsen J. R., Daoud B., Dalhoff K., Cotera Solano J. V., Costa A. N., Coronel S., Confalonieri M., Conemans L., Comellas A., Colella S., Clemente S., Clark J., Ciuffreda M., Chung C. L., Chong S. G., Chirita D., Chen P. L., Chaudhuri N., Chambers D., Chalmers G., Chairman D., Chai G. T., Chacon Chaves R., Cetinsu V., Ceruti M., Ceballos Zuniga C. O., Castillo D., Carbone R. G., Caminati A., Callejas Gonzalez F. J., Butler M., Bustos C., Bukowczan M., Buendia I., Brunetti G., Brockway B., Bresser P., Breseghello J., Bouros D., Botero Zaccour J. A., Borzone G., Borie R., Blum H. C., Blank J., Biswas A., Bennett D., Benjamin M., Belaconi I. N., Beirne P., Beckert L., Bastiampillai S., Bascom R., Bartholmai B., Barros M., Ban AYL., Balestro E., Baldi B., Baddini Martinez J., Baburao A., Babu S., Averyanov A., Avdeev S., Athanazio R., Atahan E., Asuquo B., Assayag D., Antuni J., Antillon S., Anderson K. C., Anderson A., Alwani F., Altinisik G., Alsouofi N., Allam J. S., Al Jahdali H., Al Farttoosi A., Alfaro T., Al Busaidi N., Alavi Foumani A., Agreda Vedia M. G., Agarwal A., Afridi F., Adeyeye O. O., Adegunsoye A., Adamali H., Abedini A., Walsh, S. L. F., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., Wilsher, M. L., Antoniou, K. M., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., Corte, T. J., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., Inoue, Y., Kokosi, M., Kondoh, Y., Kouranos, V., Kreuter, M., Johannson, K., Judge, E., Ley, B., Margaritopoulos, G., Martinez, F. J., Molina-Molina, M., Morais, A., Nunes, H., Raghu, G., Ryerson, C. J., Selman, M., Spagnolo, P., Taniguchi, H., Tomassetti, S., Valeyre, D., Wijsenbeek, M., Wuyts, W., Hansell, D., Wells, A., Zhu, P. S., Yuan, Y., Yoshito Fukuda, C., Yoshimatsu, Y., Xaubet, A., Wong, A. M., White, P., Westney, G., West, A., Wessendorf, T., Waseda, Y., Wang, C., Vienna, J. M., Videnovic Ivanov, J., Vicens Zygmunt, V., Venero Caceres, M. C., Velasquez Pinto, G., Veitch, E., Vasakova, M., Varone, F., Varela, B. E., Van Hal, P., Van De Ven, M., Van Der Lee, I., Van Den Toorn, L., Urrutia Gajate, A., Urban, J., Ugarte Fornell, L. G., Tzouvelekis, A., Twohig, K., Turner, A., Trujillo, S., Triani, A., Traila, D., Torres, V., Tomioka, H., Tomii, K., Tomic, R., Toma, C., Tokgoz Akyil, F., Tobino, K., Tobar, R., Tiwari, A., Tibana, R., Tian, X., Thillai, M., Tham, W., Teo, F., Tekavec Trkanjec, J., Teixeira, P., Tarpey, D., Tapias, L., Tanizawa, K., Tanino, Y., Takada, T., Tabaj, G., Szolnoki, E., Swarnakar, R., Strambu, I., Sterclova, M., Spinks, K., Soo, C. I., Soltani, A., Solanki, S., Sobh, E., Soares, M. R., Smith, J., Smith, B., Slocum, P., Slabbynck, H., Sivokozov, I., Shifren, A., Shen, S. M., Sharp, C., Shanmuganathan, A., Sebastiani, A., Scarlata, S., Savas, R., Sasaki, S., Santeliz, J., Santana, Anc., Sanchez, R., Salinas, M., Saito, S., Ryan, F., Royo Prats, J. A., Rosi, E., Rokadia, H., Robles Perez, A., Rivera Ortega, P., Rio Ramirez, M., Righetti, S., Reichner, C., Ravaglia, C., Ratanawatkul, P., Ramalingam, V., Rajasekaran, A., Radzikowska, E., Ra, S. W., Quadrelli, S., Precerutti, J., Prasad, J., Popa, D., Pizzalato, S., Piotrowski, W., Pineiro, A., Piloni, D., Peros Golubicic, T., Perez, R., Pereira, C., Pereira, B., Perch, M., Patel, N., Patel, D., Papanikolaou, I., Papakosta, D., Panselinas, E., Pang, Y. K., Pandya, P., Padrao, E., Ozdemir Kumbasar, O., Overbeek, M. J., Otto Minasian, A., O'Riordan, D., Ora, J., Oldham, J., Okutan, O., Ohshimo, S., Oguzulgen, I. K., Ogura, T., O'Donnell, T., O'Dochartaigh, C., O'Beirne, S., Novikova, L., Novelli, L., Noth, I., Nogueira Mendes Neto, N., Niroumand, M., Nieto, A., Neves, A., Nambiar, A., Nair, S., Nadama, R., Murtagh, E., Mura, M., Muller Quernheim, J., Mukhopadhyay, A., Mukherjee, S., Morisset, J., Moran, O., Mooney, J., Moller, J., Mogulkoc, N., Miyamoto, A., Milenkovic, B., Mette, S., Mejia, M., Mei, F., Mazzei, M., Matsuda, T., Mason, C., Martinez Frances, M., Mannarino, S., Mancuzo, E., Malli, F., Malhotra, P., Maillo, M., Maia, J., Mahdavian, M., Madsen, F., Luckhardt, T., Lucht, W., Low, S. Y., Lopez Miguel, C. P., Lipchik, R., Levy, S., Levin, K., Lee, K. L., Lederer, D., Lammi, M. R., Kwan, H. Y., Kukreja, S., Kruavit, A., Kotecki, M., Kolilekas, L., Knoop, H., Kiyan, E., Kishaba, T., King Biggs, M., Khor, Y. H., Khan, A., Khalil, N., Kedia, R., Kebba, N., Kawano Dourado, L., Kapitan, K., Kan, C. D., Kalyoncu, A. F., Kalluri, M., Kabasakal, Y., Jyothula, S., Juretschke, M. A., Jovanovic, D., Jonkers, R., Jo, H., Izumi, S., Ishii, H., Ikeda, S., Ibrahim, A., Hyldgaard, C., Hunninghake, G., Huie, T., Hufton, A., Hu, X., Hseih, W. C., Hoyos, R., Hoyles, R., Holguin Rodriguez, O., Hogan, M. P., Hodgson, U., Hilkin Sogoloff, H., Herrera, E., Henry, B. M., Hellemons, M., Hecimovic, A., Hayashi, R., Hart, S., Harari, S., Haney, S., Hambly, N., Hakkim, R., Gutierrez, M., Gripaldo, R., Gomez, A., Goh, N., Godoy, R., Gilbert, C., Giannarakis, I., Gasparini, S., Garcha, P., Furtado, S., Fois, A., Flood Page, P., Fletcher, S., Fiss, E., Figueroa Casas, J., Figueroa Casas, M., Fiddler, C. A., Ferrara, G., Fernandez Casares, M., Felton, C., Faverio, P., Fabro, A. T., Estrada, A., Errhalt, P., Enomoto, N., Enghelmayer, J. I., El Kersh, K., Eiger, G., Dubaniewicz, A., Drakopanagiotakis, F., Disayabutr, S., Dijkstra, A., Diaz Patino, J. C., Diaz Castanon, J. J., Dhooria, S., Dhasmana, D. J., De Rosa, M., De Luca, S., Delobbe, A., Delgado, D., Delgado, C., De La Fuente, I., De Kruif, M., De Gier, M., De Andrade, J., Davidsen, J. R., Daoud, B., Dalhoff, K., Cotera Solano, J. V., Costa, A. N., Coronel, S., Confalonieri, M., Conemans, L., Comellas, A., Colella, S., Clemente, S., Clark, J., Ciuffreda, M., Chung, C. L., Chong, S. G., Chirita, D., Chen, P. L., Chaudhuri, N., Chambers, D., Chalmers, G., Chairman, D., Chai, G. T., Chacon Chaves, R., Cetinsu, V., Ceruti, M., Ceballos Zuniga, C. O., Castillo, D., Carbone, R. G., Caminati, A., Callejas Gonzalez, F. J., Butler, M., Bustos, C., Bukowczan, M., Buendia, I., Brunetti, G., Brockway, B., Bresser, P., Breseghello, J., Bouros, D., Botero Zaccour, J. A., Borzone, G., Borie, R., Blum, H. C., Blank, J., Biswas, A., Bennett, D., Benjamin, M., Belaconi, I. N., Beirne, P., Beckert, L., Bastiampillai, S., Bascom, R., Bartholmai, B., Barros, M., Ban, Ayl., Balestro, E., Baldi, B., Baddini Martinez, J., Baburao, A., Babu, S., Averyanov, A., Avdeev, S., Athanazio, R., Atahan, E., Asuquo, B., Assayag, D., Antuni, J., Antillon, S., Anderson, K. C., Anderson, A., Alwani, F., Altinisik, G., Alsouofi, N., Allam, J. S., Al Jahdali, H., Al Farttoosi, A., Alfaro, T., Al Busaidi, N., Alavi Foumani, A., Agreda Vedia, M. G., Agarwal, A., Afridi, F., Adeyeye, O. O., Adegunsoye, A., Adamali, H., Abedini, A., National Institute for Health Research, British Lung Foundation, Walsh, S, Maher, T, Kolb, M, Poletti, V, Nusser, R, Richeldi, L, Vancheri, C, Wilsher, M, Antoniou, K, Behr, J, Bendstrup, E, Brown, K, Calandriello, L, Corte, T, Cottin, V, Crestani, B, Flaherty, K, Glaspole, I, Grutters, J, Inoue, Y, Kokosi, M, Kondoh, Y, Kouranos, V, Kreuter, M, Johannson, K, Judge, E, Ley, B, Margaritopoulos, G, Martinez, F, Molina-Molina, M, Morais, A, Nunes, H, Raghu, G, Ryerson, C, Selman, M, Spagnolo, P, Taniguchi, H, Tomassetti, S, Valeyre, D, Wijsenbeek, M, Wuyts, W, Hansell, D, Wells, A, Zhu, P, Yuan, Y, Yoshito Fukuda, C, Yoshimatsu, Y, Xaubet, A, Wong, A, White, P, Westney, G, West, A, Wessendorf, T, Waseda, Y, Wang, C, Vienna, J, Videnovic Ivanov, J, Vicens Zygmunt, V, Venero Caceres, M, Velasquez Pinto, G, Veitch, E, Vasakova, M, Varone, F, Varela, B, Van Hal, P, Van De Ven, M, Van Der Lee, I, Van Den Toorn, L, Urrutia Gajate, A, Urban, J, Ugarte Fornell, L, Tzouvelekis, A, Twohig, K, Turner, A, Trujillo, S, Triani, A, Traila, D, Torres, V, Tomioka, H, Tomii, K, Tomic, R, Toma, C, Tokgoz Akyil, F, Tobino, K, Tobar, R, Tiwari, A, Tibana, R, Tian, X, Thillai, M, Tham, W, Teo, F, Tekavec Trkanjec, J, Teixeira, P, Tarpey, D, Tapias, L, Tanizawa, K, Tanino, Y, Takada, T, Tabaj, G, Szolnoki, E, Swarnakar, R, Strambu, I, Sterclova, M, Spinks, K, Soo, C, Soltani, A, Solanki, S, Sobh, E, Soares, M, Smith, J, Smith, B, Slocum, P, Slabbynck, H, Sivokozov, I, Shifren, A, Shen, S, Sharp, C, Shanmuganathan, A, Sebastiani, A, Scarlata, S, Savas, R, Sasaki, S, Santeliz, J, Santana, A, Sanchez, R, Salinas, M, Saito, S, Ryan, F, Royo Prats, J, Rosi, E, Rokadia, H, Robles Perez, A, Rivera Ortega, P, Rio Ramirez, M, Righetti, S, Reichner, C, Ravaglia, C, Ratanawatkul, P, Ramalingam, V, Rajasekaran, A, Radzikowska, E, Ra, S, Quadrelli, S, Precerutti, J, Prasad, J, Popa, D, Pizzalato, S, Piotrowski, W, Pineiro, A, Piloni, D, Peros Golubicic, T, Perez, R, Pereira, C, Pereira, B, Perch, M, Patel, N, Patel, D, Papanikolaou, I, Papakosta, D, Panselinas, E, Pang, Y, Pandya, P, Padrao, E, Ozdemir Kumbasar, O, Overbeek, M, Otto Minasian, A, O'Riordan, D, Ora, J, Oldham, J, Okutan, O, Ohshimo, S, Oguzulgen, I, Ogura, T, O'Donnell, T, O'Dochartaigh, C, O'Beirne, S, Novikova, L, Novelli, L, Noth, I, Nogueira Mendes Neto, N, Niroumand, M, Nieto, A, Neves, A, Nambiar, A, Nair, S, Nadama, R, Murtagh, E, Mura, M, Muller Quernheim, J, Mukhopadhyay, A, Mukherjee, S, Morisset, J, Moran, O, Mooney, J, Moller, J, Mogulkoc, N, Miyamoto, A, Milenkovic, B, Mette, S, Mejia, M, Mei, F, Mazzei, M, Matsuda, T, Mason, C, Martinez Frances, M, Mannarino, S, Mancuzo, E, Malli, F, Malhotra, P, Maillo, M, Maia, J, Mahdavian, M, Madsen, F, Luckhardt, T, Lucht, W, Low, S, Lopez Miguel, C, Lipchik, R, Levy, S, Levin, K, Lee, K, Lederer, D, Lammi, M, Kwan, H, Kukreja, S, Kruavit, A, Kotecki, M, Kolilekas, L, Knoop, H, Kiyan, E, Kishaba, T, King Biggs, M, Khor, Y, Khan, A, Khalil, N, Kedia, R, Kebba, N, Kawano Dourado, L, Kapitan, K, Kan, C, Kalyoncu, A, Kalluri, M, Kabasakal, Y, Jyothula, S, Juretschke, M, Jovanovic, D, Jonkers, R, Jo, H, Izumi, S, Ishii, H, Ikeda, S, Ibrahim, A, Hyldgaard, C, Hunninghake, G, Huie, T, Hufton, A, Hu, X, Hseih, W, Hoyos, R, Hoyles, R, Holguin Rodriguez, O, Hogan, M, Hodgson, U, Hilkin Sogoloff, H, Herrera, E, Henry, B, Hellemons, M, Hecimovic, A, Hayashi, R, Hart, S, Harari, S, Haney, S, Hambly, N, Hakkim, R, Gutierrez, M, Gripaldo, R, Gomez, A, Goh, N, Godoy, R, Gilbert, C, Giannarakis, I, Gasparini, S, Garcha, P, Furtado, S, Fois, A, Flood Page, P, Fletcher, S, Fiss, E, Figueroa Casas, J, Figueroa Casas, M, Fiddler, C, Ferrara, G, Fernandez Casares, M, Felton, C, Faverio, P, Fabro, A, Estrada, A, Errhalt, P, Enomoto, N, Enghelmayer, J, El Kersh, K, Eiger, G, Dubaniewicz, A, Drakopanagiotakis, F, Disayabutr, S, Dijkstra, A, Diaz Patino, J, Diaz Castanon, J, Dhooria, S, Dhasmana, D, De Rosa, M, De Luca, S, Delobbe, A, Delgado, D, Delgado, C, De La Fuente, I, De Kruif, M, De Gier, M, De Andrade, J, Davidsen, J, Daoud, B, Dalhoff, K, Cotera Solano, J, Costa, A, Coronel, S, Confalonieri, M, Conemans, L, Comellas, A, Colella, S, Clemente, S, Clark, J, Ciuffreda, M, Chung, C, Chong, S, Chirita, D, Chen, P, Chaudhuri, N, Chambers, D, Chalmers, G, Chairman, D, Chai, G, Chacon Chaves, R, Cetinsu, V, Ceruti, M, Ceballos Zuniga, C, Castillo, D, Carbone, R, Caminati, A, Callejas Gonzalez, F, Butler, M, Bustos, C, Bukowczan, M, Buendia, I, Brunetti, G, Brockway, B, Bresser, P, Breseghello, J, Bouros, D, Botero Zaccour, J, Borzone, G, Borie, R, Blum, H, Blank, J, Biswas, A, Bennett, D, Benjamin, M, Belaconi, I, Beirne, P, Beckert, L, Bastiampillai, S, Bascom, R, Bartholmai, B, Barros, M, Ban, A, Balestro, E, Baldi, B, Baddini Martinez, J, Baburao, A, Babu, S, Averyanov, A, Avdeev, S, Athanazio, R, Atahan, E, Asuquo, B, Assayag, D, Antuni, J, Antillon, S, Anderson, K, Anderson, A, Alwani, F, Altinisik, G, Alsouofi, N, Allam, J, Al Jahdali, H, Al Farttoosi, A, Alfaro, T, Al Busaidi, N, Alavi Foumani, A, Agreda Vedia, M, Agarwal, A, Afridi, F, Adeyeye, O, Adegunsoye, A, Adamali, H, Abedini, A, and Pulmonary Medicine

Subjects
Male, Pediatrics, International Cooperation, Respiratory System, Hospitals, University, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Cohen's kappa, Diagnosis, UK, 030212 general & internal medicine, Medical diagnosis, Referral and Consultation, Pulmonologists, Idiopathic Pulmonary Fibrosi, Interstitial lung disease, 11 Medical And Health Sciences, Middle Aged, respiratory system, Prognosis, Hospitals, humanities, Dimensional Measurement Accuracy, Clinical Competence, Diagnosis, Differential, Diagnostic Techniques, Respiratory System, Female, Humans, Idiopathic Pulmonary Fibrosis, Quality of Health Care, Reproducibility of Results, Human, Cohort study, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Prognosi, education, MEDLINE, Reproducibility of Result, INTERSTITIAL PNEUMONIA, Interstitial Lung Diseases, 03 medical and health sciences, Internal medicine, PARENCHYMAL LUNG-DISEASE, MANAGEMENT, medicine, Idiopathic pulmonary fibrosis, diagnosis, Pulmonologist, University, business.industry, MORTALITY, Original Articles, medicine.disease, respiratory tract diseases, Diagnostic Techniques, IPF Project Consortium, 030228 respiratory system, Differential, INTEROBSERVER AGREEMENT, UPDATE, COOPERAÇÃO INTERNACIONAL, Differential diagnosis, business
Abstract

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53–0.72, p20 years of experience (C-index=0.72, IQR 0.0–0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70–0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72–0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts., Academic status, access to MDT meetings and clinician experience predict accuracy of a clinical diagnosis of IPF http://ow.ly/k43W30cTMg1

Published
2017

6. Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Author

Cottin , V., Bel , E., Bottero , P., Dalhoff , K., Humbert , M., Lazor , R., Sinico , R.A., Sivasothy , P., Wechsler , M.E., Groh , M., Marchand-Adam , S., Khouatra , C., Wallaert , B., Taillé , C., Delaval , P., Cadranel , J., Bonniaud , P., Prévot , G., Hirschi , S., Gondouin , A., Dunogué , B., Chatté , G., Briault , C., Pagnoux , C., Jayne , D., Guillevin , L., Cordier , J.-F., Centre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Department of Pneumology [Lyon], Hospices Civils de Lyon (HCL), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Universität zu Lübeck = University of Lübeck [Lübeck], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université de Lausanne = University of Lausanne (UNIL), Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, University of Colorado Anschutz [Aurora], Pathologies Respiratoires : Protéolyse et Aérosolthérapie, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie et Immuno-Allergologie [CHU LIlle], Pole Cardio-vasculaire et pulmonaire [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Pneumologie [Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Centre de Compétence pour les Maladies Pulmonaires Rares, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Theranoscan, Université Pierre et Marie Curie - Paris 6 (UPMC), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Service des maladies respiratoires [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Protéines de choc thermique : mort cellulaire, différenciation cellulaire et propriétés tumorigéniques (U866, Cancer, équipe 3), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, European Respiratory Society ERS TF 2008-08, Cottin, V, Bel, E, Bottero, P, Dalhoff, K, Humbert, M, Lazor, R, Sinico, R, Sivasothy, P, Wechsler, M, Groh, M, Marchand Adam, S, Khouatra, C, Wallaert, B, Taillé, C, Delaval, P, Cadranel, J, Bonniaud, P, Prévot, G, Hirschi, S, Gondouin, A, Dunogué, B, Chatté, G, Briault, C, Pagnoux, C, Jayne, D, Guillevin, L, Cordier, J, Universität zu Lübeck [Lübeck], Université de Lausanne (UNIL), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Hospices Civils de Lyon ( HCL ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ), Université de Lausanne ( UNIL ), University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Université de Tours-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Pneumologie et Immuno-Allergologie, Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre de Compétence pour les Maladies Pulmonaires Rares, Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Service de pneumologie et réanimation [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Tenon [APHP], Université Pierre et Marie Curie - Paris 6 ( UPMC ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Université Claude Bernard Lyon 1 ( UCBL ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)

Subjects
Adult, Male, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Vasculiti, ANCA, Eosinophilic granulomatosis with polyangiitis, Immunology, Churg-Strauss syndrome, Middle Aged, Prognosis, Asthma, vasculitis, [ SDV.EE ] Life Sciences [q-bio]/Ecology, environment, Treatment Outcome, classification, diagnostic criteria, Eosinophilic granulomatosis with polyangiiti, Humans, Immunology and Allergy, Female, Immunosuppressive Agents, Retrospective Studies
Abstract

International audience; Objective To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. Methods Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease. Results The study population included 157 patients (mean age 49.4 ± 14.1), with a follow-up of 7.4 ± 6.4 years. Patients with ANCA (31%) more frequently had weight loss, myalgias, arthralgias, biopsy-proven vasculitis, glomerulonephritis on biopsy, hematuria, leukocytoclastic capillaritis and/or eosinophilic infiltration of arterial wall on biopsy, and other renal disease. A total of 41% of patients had definite vasculitis manifestations (37%) or strong surrogates of vasculitis (4%), of whom only 53% had ANCA. Mononeuritis multiplex was associated with systemic vasculitis (p = 0.005) and with the presence of ANCA (p

Published
2017

7. Review of the availability of paracetamol sold as over-the-counter drugs in European pharmacies; a descriptive cross sectional study

Author

Morthorst, B, Erlangsen, A, Nordentoft, M, Hawton, K, Hoegberg, L, and Dalhoff, K

Subjects
health services administration, organic chemicals, digestive, oral, and skin physiology
Abstract

Paracetamol is a very frequently used drug for overdose and enquiries to poison information centres (PIC) concerning paracetamol-related poisonings are common. Availability of paracetamol varies in European countries; some have no pack size restriction in pharmacies, while others do. The aim of the study was to describe availability of paracetamol sold over-the counter (OTC) in European pharmacies, secondly to investigate the association between availability and the frequencies of enquiries to PICs concerning poisoning with paracetamol.

Published
2018

8. Pack size restriction of mild analgesics sold as over-the-counter drugs in pharmacies in Denmark: preliminary register findings

Author

Morthorst, B, Erlangsen, A, Hawton, K, Dalhoff, K, and Nordentoft, M

Abstract

Mild analgesics are sold in all European countries, and some countries have observed increased contact with emergency departments due to overdose by these agents, especially paracetamol. There is significant evidence that restricting access to means is an effective suicide prevention strategy, and moreover controlling availability of analgesics has proven to be effective. The aim of the study was to investigate changes in numbers and rates of overdose before and after the pack size restriction on mild analgesics sold over-the-counter (OTC) in pharmacies in Denmark implemented in September 2013, and secondly to investigate potential substitution of self-harming agents.

Published
2018

9. Higher chlorzoxazone clearance in obese children compared with nonobese peers

Author

Gade, C., Dalhoff, K., Petersen, T. S., Riis, T., Schmeltz, C., Chabanova, E., Christensen, H. R., Mikus, G., Burhenne, J., Holm, J. C., and Holst, H.

Subjects
Male, Adolescent, Dose-Response Relationship, Drug, Metabolic Clearance Rate, Administration, Oral, Cytochrome P-450 CYP2E1, Original Articles, Hydroxylation, Body Mass Index, Fatty Liver, Chlorzoxazone, Area Under Curve, Diabetes Mellitus, Humans, Female, Obesity, Child, Letter to the Editor
Abstract

AIMS: To test the in vivo activity of Cytochrome P450 (CYP) 2E1 in obese children vs. nonobese children, aged 11–18 years. Secondly, whether the activity of CYP2E1 in these patients is associated with NALFD, diabetes or hyperlipidaemia. METHODS: Seventy children were divided into groups by body mass index (BMI) standard deviation score (SDS). All children received 250 mg oral chlorzoxazone (CLZ) as probe for CYP2E1 activity. Thirteen blood samples and 20‐h urine samples were collected per participant. RESULTS: Obese children had an increased oral clearance and distribution of CLZ, indicating increased CYP2E1 activity, similar to obese adults. The mean AUC(0–∞) value of CLZ was decreased by 46% in obese children compared to nonobese children. The F was was increased twofold in obese children compared to nonobese children, P

Published
2017

10. Mycoplasma pneumoniae and Chlamydia spp. Infection in Community-Acquired Pneumonia, Germany, 2011-2012

Author

Dumke, Roger, Schnee, Christiane, Armari, I., Stolz, D., Suttorp, N., Schütte, H., Creutz, P., Bauer, T., Weiß, T., Pankow, W., Lies, A., Thiemig, D., Pletz, Mathias W., Hauptmeier, B., Wehde, D., Suermann, M., Ewig, S., Prediger, M., Zernia, G., Höffken, G., Kolditz, M., Welte, T., Barten, G., Rupp, Jan, Abrahamczik, M., Naim, J., Kröner, W., Illig, T., Klopp, N., Kroegel, C., Pletz, M., Dalhoff, K., Schütz, S., Hörster, R., Jacobs, Enno, Rohde, G., Buschmann, H., Kröning, R., Schaberg, T., Hering, I., Schumann, C., Illmann, T., Wallner, M., Sachse, Konrad, Rohde, Gernot, Dreher, M., Cornelissen, Christian, Knüppel, W., Pulmonologie, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Subjects
Male, Mycoplasma pneumoniae, community-acquired pneumonia, Epidemiology, CHLAMYDOPHILA, lcsh:Medicine, urologic and male genital diseases, medicine.disease_cause, CAPNETZ, Community-acquired pneumonia, Chlamydia pneumoniae, Germany, Chlamydia, bacteria, Chlamydia psittaci, biology, Incidence, Incidence (epidemiology), Middle Aged, CAP, Community-Acquired Infections, Infectious Diseases, MICROARRAY-BASED DETECTION, Female, Chlamydial Pneumonia, Adult, Microbiology (medical), EUROPE, Adolescent, Genotype, FRANCE, Mycoplasma pneumoniae and Chlamydia spp. Infection in Community-Acquired Pneumonia, Germany, 2011–2012, lcsh:Infectious and parasitic diseases, Microbiology, molecular diagnostics, Young Adult, bacterial pneumonia, TANDEM-REPEAT ANALYSIS, Pneumonia, Mycoplasma, medicine, Humans, COMPETENCE NETWORK, lcsh:RC109-216, ddc:610, Aged, PATHOGENS, Research, MLVA, STRAINS, lcsh:R, Bacterial pneumonia, ADULTS, medicine.disease, biology.organism_classification, outpatients, Molecular Typing, Pneumonia
Abstract

M. pneumoniae infections showed a strong epidemic peak, but Chlamydia spp. were consistently detected throughout the year., Mycoplasma pneumoniae and Chlamydia spp., which are associated with community-acquired pneumonia (CAP), are difficult to propagate, and can cause clinically indistinguishable disease patterns. During 2011–2012, we used molecular methods to test adult patients in Germany with confirmed CAP for infection with these 2 pathogens. Overall, 12.3% (96/783) of samples were positive for M. pneumoniae and 3.9% (31/794) were positive for Chlamydia spp.; C. psittaci (2.1%) was detected more frequently than C. pneumoniae (1.4%). M. pneumoniae P1 type 1 predominated, and levels of macrolide resistance were low (3.1%). Quarterly rates of M. pneumoniae–positive samples ranged from 1.5% to 27.3%, showing a strong epidemic peak for these infections, but of Chlamydia spp. detection was consistent throughout the year. M. pneumoniae–positive patients were younger and more frequently female, had fewer co-occurring conditions, and experienced milder disease than did patients who tested negative. Clinicians should be aware of the epidemiology of these pathogens in CAP.

Published
2015

11. Isolierung von Chlamydia pneumoniae bei atypischer Pneumonie

Author

Dalhoff K and Maass M

Subjects
medicine.medical_specialty, Chlamydia, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Gastroenterology, respiratory tract diseases, Bronchoalveolar lavage, Bronchoscopy, Atypical pneumonia, Clarithromycin, Internal medicine, Medicine, Bronchitis, business, Chest radiograph, Cefuroxime, medicine.drug
Abstract

A 33-year-old man, who two months previously had been treated for bronchopneumonia with cefuroxime, fell ill again with cough, dyspnoea and fever up to 39.8 degrees C. Auscultation and lung function tests indicated respiratory tract obstruction. The chest radiograph revealed an infiltrate of the left lower lobe and bronchoscopy showed hypertrophic bronchitis. Empirical antibiotic treatment with clarithromycin (initially 500 mg twice daily, continued on half this dose) lead to rapid improvement of clinical symptoms and the patient could be discharged after 9 days. A follow-up examination 3 months later showed no abnormality. A cell culture procedure using bronchoalveolar lavage fluid obtained during bronchoscopy permitted the continuous demonstration of Chlamydia pneumoniae inclusions in HEp-2 host cells by immunofluorescence microscopy. In parallel, Chlamydia pneumoniae DNA was specifically demonstrated in the lavage fluid by use of the polymerase chain reaction. This is the first reported isolation of a replicative Chlamydia pneumoniae strain in Germany.

Published
2008

12. Generalisierte Nokardiose mit Meningoenzephalitis bei einer nicht-immunsupprimierten Patientin

Author

Hannemann J, Lebeau A, Hell W, Dalhoff K, Busch D, and Dalitz M

Subjects
medicine.medical_specialty, business.industry, Nocardiosis, Lymphocytic pleocytosis, Meningoencephalitis, General Medicine, medicine.disease, Gastroenterology, Pneumonia, Internal medicine, medicine, medicine.symptom, business, Meningitis, Rifampicin, Immunodeficiency, Paresis, medicine.drug
Abstract

Four weeks after an attack of pneumonia of unknown aetiology a 40-year-old woman was hospitalized because of a nonpurulent, predominantly basal meningoencephalitis and infratentorial abscesses. She had dysarthria, mild right-sided motor hemiparesis and central paresis affecting the 7th cranial nerve. An area of fluctuating resistance, about 3 cm in diameter, was noticed over the left thigh. Serology indicated inflammatory disease, but there was no immunodeficiency. The CSF showed lymphocytic pleocytosis with mild protein increase but no evidence of infective agent. As tubercular meningitis was suspected she was treated with rifampicin (300 mg i.v. twice daily), isoniazid (300 mg i.v. once daily), streptomycin (800 mg i.m. once daily), cefotaxime (2.0 g i.v. three times daily), fluconazole (200 mg i.v. once daily) and dexamethasone (16-8-8 mg i.v.). She suddenly died two days after admission, probably as the result of central regulatory failure. Generalized nocardiosis involving lung, subcutaneous tissue and brain was revealed at autopsy. Although nocardiosis occurs predominantly in patients under immunosuppression, this infection should be considered in the differential diagnosis of treatment-resistant pneumonia and meningoencephalitis without obvious predisposition.

Published
2008

13. Akutes Nierenversagen unter Psoriasistherapie mit Fumarsäurederivaten

Author

P. Faerber, Dalhoff K, H. Arnholdt, O. Strubelt, and K. Sack

Subjects
medicine.medical_specialty, Creatinine, medicine.diagnostic_test, Nausea, business.industry, Urology, Renal function, General Medicine, urologic and male genital diseases, medicine.disease, Excretion, chemistry.chemical_compound, Tubular proteinuria, chemistry, Psoriasis, medicine, Vomiting, Renal biopsy, medicine.symptom, business
Abstract

24 days after starting treatment of psoriasis with fumaric acid derivatives (0.8-1.0 g orally, plus unknown quantities locally) a 21-year-old woman developed acute oliguric renal failure with a rise of serum creatinine levels to 1094 mumol/l (12.4 mg/dl). Deterioration of renal function had been preceded by severe abdominal symptoms with nausea, vomiting and colicky pain. On admission to hospital she was dehydrated with hyponatraemia and hypokalaemia. There was glomerular microhaematuria, increased excretion of renal epithelia, and tubular proteinuria. Renal biopsy demonstrated acute tubular damage with vacuolization of proximal epithelia, dilated tubules and scattered necroses. After intermittent haemodialysis (13 courses over two weeks) renal function gradually recovered, as demonstrated at a follow-up examination four months after discharge.

Published
2008

14. Randomized double blind placebo-controlled study to demonstrate that antibiotics are not needed in moderate acute exacerbations of COPD--the ABACOPD study

Author

Rohde, Gernot G. U., Koch, Armin, Pankow, W., Lies, A., de Roux, A., Dallwitz, N., Pociuli, O., Zierock, P., Hauptmeier, B., Wehde, D., Herzmann, C., Lange, C., Welte, Tobias, Schaaf, B., Teipel, C., Höffken, G., Kolditz, M., Idzko, M., Seuthe, B., Gläser, S., Ewert, R., Nilius, G., Franke, K. J., ABACOPD study group, Weiss, C., Zelniker, T., Welte, T., Köhnlein, T., Freise, J., Andreas, S., Hammerl, P., Pletz, M., Hagel, S., Dalhoff, K., Dreher, Michael, Drömann, D., Buschmann, H., Kröning, R., Schaberg, T., Göbel, C., Randerath, W., Priegnitz, C., Stieglitz, S., Hagmeyer, S., Rasche, K., Cornelissen, Christian, Leidag, M., Barten, G., Kröner, W., Naim, J., Abrahamczik, M., Koch, A., Gonnermann, A., Stichtenoth, D., von der Leyen, H., Breuer, D., Knüppel, W., Craul, M., Suttorp, N., Stenger, S., Rohde, G., Schütte, H., Rupp, J., Illmann, T., Wallner, M., Dressel, S., Illig, T., Klopp, N., Bauer, S., Bauer, T., Sabha, T., Pulmonologie, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, and Pathologie

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, medicine.drug_class, Prednisolone, VIRUSES, Antibiotics, RESPIRATORY-TRACT INFECTIONS, Placebo-controlled study, medicine.disease_cause, OBSTRUCTIVE PULMONARY-DISEASE, THERAPY, Drug Administration Schedule, law.invention, Pulmonary Disease, Chronic Obstructive, Study Protocol, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Drug Resistance, Bacterial, Humans, Medicine, QUALITY, Hypoxia, Aged, Aged, 80 and over, COPD, Respiratory tract infections, business.industry, Oxygen Inhalation Therapy, Pathogenic bacteria, Sulbactam, Middle Aged, medicine.disease, Bronchodilator Agents, Clinical trial, Treatment Outcome, Research Design, Acute Disease, Disease Progression, Ampicillin, Drug Therapy, Combination, business, medicine.drug
Abstract

BMC Pulmonary Medicine 15, 7 Seiten (2015). doi:10.1186/1471-2466-15-5, Published by BioMed Central, London

Published
2015

15. Failure of Ambulatory Treatment in Cap Patients Leading to Subsequent Hospitalization and its Association to Risk Factors

Author

Bauer T, Dalhoff K, Braun M, Creutz P, Norbert Suttorp, H Kothe, and Welte T

Subjects
Pediatrics, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Mortality rate, Physical examination, Omics, medicine.disease, Community-acquired pneumonia, Internal medicine, Diabetes mellitus, Ambulatory, medicine, Prospective cohort study, business, Kidney disease
Abstract

Background: Outpatient treatment is an increasingly used option in Community-Acquired Pneumonia (CAP). Risk factors for deterioration and subsequent hospitalization are poorly characterized. Material and Methods: A prospective study was conducted to assess risk factors associated with hospitalization of CAP-patients initially treated in an outpatient setting. Clinical history, severity of disease, physical examination findings, laboratory test results, initial treatment and outcome were prospectively documented in both groups. Data derived from a multicenter prospective study initiated by the German competence network for communityacquired pneumonia CAPNETZ. The network includes 10 clinical centers representing hospital and outpatient facilities from all levels of health care. 5431 patients with CAP were screened for inclusion. 1517 of these patients were initially treated as outpatients and included. 1403 patients were treated exclusively in an outpatient setting, 114 (8.1%) were hospitalized after initial outpatient treatment. Results: Compared to patients treated exclusively in an outpatient setting patients with subsequent hospitalization had a significantly higher 28-day mortality rate (4.2% vs. 0.2%, p= 65 years as the only risk factor. Cerebrovascular disease, chronic kidney disease and diabetes mellitus were overrepresented in this patient group. In addition, cephalosporin monotherapy was identified as independent risk factor for hospitalization. Conclusion: In ambulatory CAP patients subsequent hospitalization was observed mainly in low CRB-65 risk classes and was associated with comorbidities and the choice of initial therapy

Published
2013

16. [Epidemiology, diagnosis and treatment of adult patients with nosocomial pneumonia. S-3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy]

Author

Dalhoff, K., Abele-Horn, M., Andreas, S., Bauer, T., Baum, H., Deja, M., Ewig, S., Gastmeier, P., Gatermann, S., Gerlach, H., Grabein, B., Hoffken, G., Kern, W.V., Kramme, E., Lange, C., Lorenz, J., Mayer, K., Nachtigall, I., Pletz, M., Rohde, G., Rosseau, S., Schaaf, B., Schaumann, R., Schreiter, D., Schutte, H., Seifert, H., Sitter, H., Spies, C., Welte, T., Pulmonologie, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Subjects
Adult, Male, Microbiological Techniques, Cross Infection, Germany, Pneumonia, Bacterial, Pulmonary Medicine, Humans, Female, Anti-Bacterial Agents
Abstract

Nosocomial pneumonia (HAP) is a frequent complication of hospital care. Most data are available on ventilator-associated pneumonia. However infections on general wards are also increasing. A central issue are infections with multi drug resistant (MDR) pathogens which are difficult to treat particularly in the empirical setting potentially leading to inappropriate use of antimicrobial therapy. This guideline was compiled by an interdisciplinary group on the basis of a systematic literature review. Recommendations are made according to GRADE giving guidance for the diagnosis and therapy of HAP on the basis of quality of evidence and benefit/risk ratio. The guideline has two parts. First an update on epidemiology, spectrum of pathogens and antiinfectives is provided. In the second part recommendations for the management of diagnosis and treatment are given. Proper microbiologic work up is emphasized for knowledge of the local patterns of microbiology and drug susceptibility. Moreover this is the optimal basis for deescalation in the individual patient. The intensity of antimicrobial therapy is guided by the risk of infections with MDR. Structured deescalation concepts and strict limitation of treatment duration should lead to reduced selection pressure.

Published
2012

17. Cytochrome P450 polymorphism and postoperative cognitive dysfunction

Author

Steinmetz J, Jespersgaard C, Dalhoff K, Paula Hedley, Abildstrøm H, Christiansen M, Ls, Rasmussen, and Ispocd, Group

Subjects
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Middle Aged, Neuropsychological Tests, Cytochrome P-450 CYP2C19, Phenotype, Postoperative Complications, Cytochrome P-450 CYP2D6, Gene Frequency, Humans, Female, Genetic Predisposition to Disease, Aryl Hydrocarbon Hydroxylases, Cognition Disorders, Propofol, Alleles, Anesthetics, Intravenous, Biotransformation, Aged
Abstract

The etiology of postoperative cognitive dysfunction (POCD) remains unclear but toxicity of anesthetic drugs and their metabolites could be important. We aimed to assess the possible association between POCD after propofol anesthesia and various phenotypes owing to polymorphisms in cytochrome P450 encoding genes.We included patients who underwent non-cardiac surgery under total intravenous anesthesia with propofol. POCD was identified using a neuropsychological test-battery administered preoperatively, one week, and three months after surgery. Genotyping of CYP2C19*2, *3, CYP2D6*3, *4, *5 and *6 was performed using pyrosequencing, and patients were characterized according to their phenotype as ultra, extensive, intermediate, or poor metabolizers.In total, 337 patients with a median age of 67 years were included. 30 (9.4%) out of the 319 patients who underwent neuropsychological testing at one week had POCD, and 24 out of 307 (7.8%) had POCD at three months. None of the examined CYP2C19, 2D6 alleles, or various phenotypes were significantly associated with POCD.Polymorphisms in CYP2C19, or 2D6 genes do not seem to be related to the occurrence of cognitive dysfunction after non-cardiac surgery in patients anesthetised with propofol.

Published
2011

18. Infection of human lungs with human-pathogenic, porcine and avian Influenza A virus

Author

Becher, A., Weinheimer, V.K., Hocke, A., Szymanski, K., Dalhoff, K., Drömann, D., Bauer, T., Tönnies, M., Suttorp, N., Wolff, T., and Hippenstiel, S.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Der humane Respirationstrakt ist der primäre Replikationsort human-pathogener Influenzaviren. Während dieses Gewebe für die meisten aviären Viren nicht permissiv ist, replizieren hoch-pathogene aviäre H5N1-Viren effizient. Humane Lungenepithelzellen exprimieren humane und aviäre[for full text, please go to the a.m. URL], 10. Kongress für Infektionskrankheiten und Tropenmedizin (KIT 2010)

Published
2010

19. Role of COX2 and PGE2 in the infection of human lung tissue with Streptococcus pneumoniae

Author

Szymanski, K., Becher, A., Zahlten, J., Schneider, P., Dalhoff, K., Drömann, D., Suttorp, N., Hippenstiel, S., and Hocke, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Die ambulant erworbene Pneumonie (CAP) zählt zu den häufigsten Infektionskrankheiten in industrialisierten Ländern. Ca. 40% werden durch Streptococcus pneumoniae (S.p.) verursacht. Während der CAP ist die Aktivierung der pro-inflammatorischen Antwort entscheidend für die[for full text, please go to the a.m. URL], 10. Kongress für Infektionskrankheiten und Tropenmedizin (KIT 2010)

Published
2010

20. Management der Influenza A/H1N1 - Pandemie im Krankenhaus: Update Januar 2010. Eine Stellungnahme der Deutschen Gesellschaft fur Pneumologie und Beatmungsmedizin

Author

Schaberg, T., Bauer, T., Dalhoff, K., Ewig, S., Kohler, D., Lorenz, J., Rohde, G., Pletz, M.W., Rosseau, S., Schaaf, B., Suttorp, N., Welte, T., Haas, W., Reuss, A., Pulmonologie, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Subjects
virus diseases
Abstract

This update summarized the hospital experience from the first wave of the new influenza A/H1/N1 pandemic.

Published
2010

24. Diagnostic value of bronchoalveolar lavage in patients with opportunistic and nonopportunistic bacterial pneumonia

Author

Wiessmann Kj, Marre R, H. Hollandt, Braun J, Dalhoff K, and Lipp R

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Opportunistic infection, medicine.medical_treatment, Opportunistic Infections, Gastroenterology, Internal medicine, Immunopathology, Medicine, Humans, Prospective Studies, Prospective cohort study, Aged, medicine.diagnostic_test, Bacteria, business.industry, Respiratory disease, Bacterial pneumonia, Immunosuppression, General Medicine, Bacterial Infections, Pneumonia, Middle Aged, medicine.disease, respiratory tract diseases, Anti-Bacterial Agents, Infectious Diseases, Bronchoalveolar lavage, Immunology, Female, business, Bronchoalveolar Lavage Fluid
Abstract

In 29 patients with community-acquired pneumonia, 24 patients with hospital-acquired pneumonia and 35 patients with pneumonia in the immunocompromised host the diagnostic value of bronchoalveolar lavage (BAL) with quantitative bacterial and fungal cultures was studied; 32 patients with noninfectious pulmonary diseases and 14 healthy volunteers served as controls. An infectious etiology could be established in 81% of the pneumonia patients without differences between the three groups; significant infection was associated with colony counts ofor = 10(4) cfu/ml. Prior antibiotic therapy lowered the yield of BAL culture only in community-acquired pneumonia (94% vs 55% positive cultures in untreated vs pretreated patients, p0.02). Furthermore the culture results were related to the radiographic extension of pulmonary infiltrates (92% positive cultures in multilobar vs 54% in lobar or segmental infiltrates, p0.001). Therapeutic consequences of BAL were shown by resistance of the isolated organisms to predefined empiric treatment regimens in 41% community-acquired pneumonia, 43% pneumonia in the immunocompromised host and 67% hospital-acquired pneumonia patients.

Published
1993

25. [Voice therapy according to Smith. Comments on the accent method of treating voice and speech disorders]

Author

Dalhoff K and Kitzing P

Subjects
Voice Disorders, Voice Training, Phonation, Respiration, Voice, Humans, Speech Therapy
Abstract

The accent method (A.M.) is based on the myoelastic and aerodynamic phonatory theory. The aim of the respiration exercises is to establish a predominantly abdominal respiration. Following the exercises of accentuated phonatory pulsations, patients work on reading special texts designed to enable them to become aware of the accentuated or unaccentuated sections. The AM is based on a holistic understanding of the voice and of speech. Whilst the exercise of AM is linked to a physiological phenomenon, such as phonatory aerodynamics and muscular function, the method is to be understood as a therapy aimed at producing an overall change in the behaviour related to oral communication disorders. The aim is not so much to eliminate a given particular defect, but rather to condition a subconscious automatism.

Published
1989

32. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Author

David Jayne, Romain Lazor, Jean-François Cordier, Ulrich Specks, Marc Humbert, Klaus Dalhoff, Wolfgang L. Gross, Vincent Cottin, Peter A. Merkel, Matthieu Groh, Augusto Vaglio, Alfred Mahr, Paolo Bottero, Renato Alberto Sinico, Bertrand Dunogué, J. Charles Jennette, Loïc Guillevin, Christian Pagnoux, Michael E. Wechsler, Julia U Holle, Luc Mouthon, Chiara Baldini, Elisabeth H. Bel, Groh, M, Pagnoux, C, Baldini, C, Bel, E, Bottero, P, Cottin, V, Dalhoff, K, Dunogué, B, Gross, W, Holle, J, Humbert, M, Jayne, D, Jennette, J, Lazor, R, Mahr, A, Merkel, P, Mouthon, L, Sinico, R, Specks, U, Vaglio, A, Wechsler, M, Cordier, J, Guillevin, L, AII - Amsterdam institute for Infection and Immunity, and Pulmonology

Subjects
United State, medicine.medical_specialty, Consensus, Advisory Committees, Churg-Strauss syndrome, MEDLINE, Consensu, Recommendations, Immunosuppressive Agent, Glucocorticoid, Eosinophilic, Eosinophilia, Internal Medicine, Medicine, Humans, Churg–Strauss syndrome, Disease management (health), Glucocorticoids, Churg strauss, Pulmonologists, Advisory Committee, business.industry, Task force, Eosinophilic granulomatosis with polyangiitis, Medicine (all), Granulomatosis with Polyangiitis, Disease Management, Evidence-based medicine, Recommendation, medicine.disease, United States, Asthma, Surgery, Europe, Anti-neutrophil cytoplasm antibody-associated vasculitis, Anti-neutrophil cytoplasm antibody-associated vasculiti, Family medicine, Eosinophilic granulomatosis with polyangiiti, Granulomatosis with Polyangiiti, business, Granulomatosis with polyangiitis, Rituximab, Churg-Strauss Syndrome, Immunosuppressive Agents, Human
Abstract

Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

Published
2015

33. L5. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Author

Romain Lazor, Marc Humbert, Jean-François Cordier, Pasupathy Sivasothy, Loïc Guillevin, Klaus Dalhoff, Vincent Cottin, Renato Alberto Sinico, Paolo Bottero, Michael E. Wechsler, Elisabeth H. Bel, AII - Amsterdam institute for Infection and Immunity, Pulmonology, Cordier, J, Cottin, V, Guillevin, L, Bel, E, Bottero, P, Dalhoff, K, Humbert, M, Lazor, R, Sinico, R, Sivasothy, P, and Wechsler, M

Subjects
Pathology, medicine.medical_specialty, Prognosi, Adrenal cortex hormones, Churg-strauss syndrome, Eosinophil, Churg-Strauss Syndrome, Adrenal Cortex Hormone, Diagnosis, Differential, Immunosuppressive Agent, Adrenal Cortex Hormones, Terminology as Topic, Hypereosinophilic Syndrome, Eosinophilic, Humans, Medicine, Churg strauss, business.industry, Hypereosinophilic syndrome, Medicine (all), General Medicine, Prognosis, medicine.disease, Eosinophils, Differential diagnosis, business, Granulomatosis with polyangiitis, Immunosuppressive Agents, Human
Published
2013

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