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21 results on '"DeMarco F"'

3. Dental pulp tissue engineering

Author

Demarco, F. F., Marcus Cristian Muniz Conde, Cavalcanti, B. N., Casagrande, L., Sakai, V. T., and Nör, J. E.

15. Mechanical properties of transparent funcional thin films for flexible displays

Author

Leterrier, Y., Fischer, C., Médico, L., Demarco, F., Månson, J.-A. E., Bouten, P. C. P., de Goede, J., Nisato, G., and Nairn, J. A.

Subjects
flexible polymer-based displays, adhesion, transparent conductive coatings, permeation barrier coatings
Abstract

The present work investigates the mechanical integrity of multilayer films developed for flexible displays. The layers comprise tin-doped indium oxide (ITO) conductive coatings and alumina barrier coatings sputtered onto high temperature aromatic polyesters. The onset strain for tensile failure and related cohesive strength of the coatings, and their adhesion to the polymer substrate, are analyzed by means of bending tests and fragmentation tests. The former test enables accurate electrical resistivity measurements during bending of film specimens, and correlates the failure of the ITO coating to the abrupt increase of resistivity. In the fragmentation test, the progressive failure of the thin coating is examined in situ in an optical microscope as a function of tensile strain, with simultaneous measurement of the electrical resistance, for the ITO coatings. The results and their analysis enable to determine the influence of internal stresses and layer thickness on the failure mechanisms of the multilayer composite films, despite the occurrence of coupled failure processes between adjacent layers.

21. Prospective Multicenter Evaluation of the Direct Flow Medical Transcatheter Aortic Valve

Author

Silvio Klugmann, Michael Schmoeckel, Karl Eugen Hauptmann, Georg Nickenig, Joachim Schofer, Ivar Friedrich, Azeem Latib, Martyn Thomas, Simon Redwood, Michael J. Mullen, Didier Tchetche, Antonio Colombo, Federico DeMarco, Charles J. Davidson, Christopher Young, Francesco Maisano, Klaudija Bijuklic, Jean Fajadet, Thierry Lefèvre, Neil J. Weissman, Reginald I. Low, Giuseppe Bruschi, Jan Malte Sinning, Michael Lauterbach, John Yap, Eberhard Grube, Schofer, J, Colombo, A, Klugmann, S, Fajadet, J, Demarco, F, Tchetche, D, Maisano, F, Bruschi, G, Latib, A, Bijuklic, K, Weissman, N, Low, R, Thomas, M, Young, C, Redwood, S, Mullen, M, Yap, J, Grube, E, Nickenig, G, Sinning, Jm, Hauptmann, Ke, Friedrich, I, Lauterbach, M, Schmoeckel, M, Davidson, C, and Lefevre, T

Subjects
Male, Cardiac Catheterization, medicine.medical_specialty, Transcatheter aortic, TAVR, Direct flow, Cohort Studies, medicine, Animals, Humans, Prospective Studies, Aged, Aged, 80 and over, Heart Valve Prosthesis Implantation, High risk patients, business.industry, transfemoral, Aortic Valve Stenosis, Middle Aged, medicine.disease, aortic regurgitation, Surgery, Aortic Valve, Heart Valve Prosthesis, Aortic valve stenosis, Cattle, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

ObjectivesThe study sought a prospective multicenter nonrandomized evaluation of the Direct Flow Medical (DFM) system for the treatment of severe aortic stenosis.BackgroundThe DFM transcatheter aortic valve system is a nonmetallic design with a pressurized support structure that allows precise positioning, retrieval, and assessment of valve performance prior to permanent implantation.MethodsOne hundred high surgical risk patients with severe aortic stenosis were evaluated for the primary endpoint. There were 75 patients in the group evaluable for the secondary endpoints and 25 in the pre-specified roll-in training phase. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events adjudicated by clinical event committee and classified according to Valve Academic Research Consortium (VARC) criteria.ResultsThere was 99% freedom from all cause mortality at 30 days (primary endpoint). VARC criteria defined 30 day combined freedom from patient safety event rate was 91% and overall device success was 93%. The post-implantation echocardiography results demonstrated mild or no aortic regurgitation in 99% (73 of 74) with a mean gradient of 12.6 ± 7.1 mm Hg (n = 72) and effective orifice area of 1.50 ± 0.56 cm2 and New York Heart Association functional class was I or II in 92% of cases.ConclusionsThe present study demonstrates the safety and efficacy of the DFM system in surgical high risk patients with severe aortic stenosis and complex anatomy aortic regurgitation was less than moderate in 99% of patients.

Published
2014

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