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1. Erwachsene mit angeborenen Herzfehlern im Notaufnahmedienst

Author

Mair, J, Diller, G-P, Geiger, H, Greutmann, M, Hessling, G, Tobler, D, University of Zurich, and Mair, J

Subjects
2724 Internal Medicine, 10209 Clinic for Cardiology, 610 Medicine & health, 2711 Emergency Medicine, 2706 Critical Care and Intensive Care Medicine, 2907 Emergency Nursing
Published
2022

2. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabes, J. A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A. J. S., Deharo, J. -C., Delgado, V., Diller, G. -P., Israel, C. W., Keren, A., Knops, R. E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Thylen, I., Tolosana, J. M., Leyva, F., Linde, C., Abdelhamid, M., Aboyans, V., Arbelo, E., Asteggiano, R., Baron-Esquivias, G., Bauersachs, J., Biffi, M., Birgersdotter-Green, U., Bongiorni, M. G., Borger, M. A., Celutkiene, J., Cikes, M., Daubert, J. -C., Drossart, I., Ellenbogen, K., Elliott, P. M., Fabritz, L., Falk, V., Fauchier, L., Fernandez-Aviles, F., Foldager, D., Gadler, F., De Vinuesa, P. G. G., Gorenek, B., Guerra, J. M., Hermann Haugaa, K., Hendriks, J., Kahan, T., Katus, H. A., Konradi, A., Koskinas, K. C., Law, H., Lewis, B. S., Linker, N. J., Lochen, M. -L., Lumens, J., Mascherbauer, J., Mullens, W., Nagy, K. V., Prescott, E., Raatikainen, P., Rakisheva, A., Reichlin, T., Ricci, R. P., Shlyakhto, E., Sitges, M., Sousa-Uva, M., Sutton, R., Suwalski, P., Svendsen, J. H., Touyz, R. M., Van Gelder, I. C., Vernooy, K., Waltenberger, J., Whinnett, Z., Witte, K. K., Qoriany, A., Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Pacemaker, Artificial, Cardiac pacing, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], cardiac resynchronization therapy, heart failure, temporary pacing, law.invention, law, atrial fibrillation, 610 Medicine & health, ComputingMilieux_MISCELLANEOUS, biology, Cardiac Pacing, Artificial, Syncope (genus), Atrial fibrillation, syncope, Cardiology, cardiovascular system, medicine.symptom, guidelines, cardiac pacing, pacemaker, conduction system pacing, pacing indications, alternate site pacing, complications, pacing in TAVI, bradycardia, Cardiology and Cardiovascular Medicine, Bradycardia, medicine.medical_specialty, Cardiac resynchronization therapy, Guidelines, Physiology (medical), Internal medicine, medicine, Humans, Task force, business.industry, Stroke Volume, 1103 Clinical Sciences, medicine.disease, biology.organism_classification, Heart Rhythm, Cardiovascular System & Hematology, Heart failure, Artificial cardiac pacemaker, business, Atrioventricular block
Abstract

These are the clinical practice guidelines of the European Society of Cardiology on cardiac pacing and cardiac resynchronization therapy, from 2021.

Published
2022
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3. 2020 ESC Guidelines for the management of adult congenital heart disease

Author

Baumgartner, H., De Backer, J., Babu-Narayan, S. V., Budts, W., Chessa, M., Diller, G. -P., Lung, B., Kluin, J., Lang, I. M., Meijboom, F., Moons, P., Mulder, B. J. M., Oechslin, E., Roos-Hesselink, J. W., Schwerzmann, M., Sondergaard, L., Zeppenfeld, K., Ernst, S., Ladouceur, M., Aboyans, V., Alexander, D., Christodorescu, R., Corrado, D., D'Alto, M., De Groot, N., Delgado, V., Di Salvo, G., Dos Subira, L., Eicken, A., Fitzsimons, D., Frogoudaki, A. A., Gatzoulis, M., Heymans, S., Horer, J., Houyel, L., Jondeau, G., Katus, H. A., Landmesser, U., Lewis, B. S., Lyon, A., Mueller, C. E., Mylotte, D., Petersen, S. E., Sonia Petronio, A., Roffi, M., Rosenhek, R., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Torp-Pedersen, C. T., Touyz, R. M., Van De Bruaene, A., Iung, B., Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Heart Defects, Congenital, Adult, medicine.medical_specialty, Patient follow up, Heart disease, diagnosis, [SDV]Life Sciences [q-bio], Cardiology, Disease, 030204 cardiovascular system & hematology, Guidelines, adult, catheter intervention, congenital cardiac surgery, congenital heart disease, disease, imaging, late complications, medicaltreatment, patient follow-up, recommendations, Humans, 03 medical and health sciences, Congenital, 0302 clinical medicine, medicine.artery, Internal medicine, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Heart Defects, Aorta, Lung, Medical treatment, business.industry, Cardiac arrhythmia, medicine.disease, Shunt (medical), medicine.anatomical_structure, Cardiology and Cardiovascular Medicine, business
Abstract

International audience

Published
2021
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4. 2020 ESC Guidelines for the management of adult congenital heart disease: The Task Force for the management of adult congenital heart disease of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Adult Congenital Heart Disease (ISACHD)

Author

Baumgartner, H., De Backer, J., Babu-Narayan, S. V., Budts, W., Chessa, M., Diller, G. -P., Iung, B., Kluin, J., Lang, I. M., Meijboom, F., Moons, P., Mulder, B. J. M., Oechslin, E., Roos-Hesselink, J. W., Schwerzmann, M., Sondergaard, L., Zeppenfeld, K., Ernst, S., Ladouceur, M., Aboyans, V., Alexander, D., Christodorescu, R., Corrado, D., D'Alto, M., de Groot, N., Delgado, V., Di Salvo, G., Dos Subira, L., Eicken, A., Fitzsimons, D., Frogoudaki, A. A., Gatzoulis, M., Heymans, S., Horer, J., Houyel, L., Jondeau, G., Katus, H. A., Landmesser, U., Lewis, B. S., Lyon, A., Mueller, C. E., Mylotte, D., Petersen, S. E., Petronio, A. S., Roffi, M., Rosenhek, R., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Torp-Pedersen, C. T., Touyz, R. M., and Van De Bruaene, A.

Published
2021

5. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J., Katritsis, D. G., Arbelo, E., Arribas, F., Bax, J. J., Blomstrom-Lundqvist, C., Calkins, H., Corrado, D., Deftereos, S. G., Diller, G. -P., Gomez-Doblas, J. J., Gorenek, B., Grace, A., S. Y., Ho, Kaski, J. -C., Kuck, K. -H., Lambiase, P. D., Sacher, F., Sarquella-Brugada, G., Suwalski, P., Zaza, A., De Potter, T., Sticherling, C., Aboyans, V., Basso, C., Bocchiardo, M., Budts, W., Delgado, V., Dobrev, D., Fitzsimons, D., Gevaert, S., Heidbuchel, H., Hindricks, G., Hlivak, P., Kanagaratnam, P., Katus, H., Kautzner, J., Kriebel, T., Lancellotti, P., Landmesser, U., Leclercq, C., Lewis, B., Lopatin, Y., Merkely, B., Paul, T., Pavlovic, N., Petersen, S., Petronio, A. S., Potpara, T., Roffi, M., Scherr, D., Shlyakhto, E., Simpson, I. A., Zeppenfeld, K., Windecker, S., Baigent, C., Collet, J. -P., Dean, V., Gale, C. P., Grobbee, D. E., Halvorsen, S., Iung, B., Juni, P., Lettino, M., Mueller, C., Richter, D. J., Sousa-Uva, M., Touyz, R. M., Amara, W., Grigoryan, S., Podczeck-Schweighofer, A., Chasnoits, A., Vandekerckhove, Y., Sokolovich, S., Traykov, V., Skoric, B., Papasavvas, E., Riahi, S., Kampus, P., Parikka, H., Piot, O., Etsadashvili, K., Stellbrink, C., Manolis, A. S., Csanadi, Z., Gudmundsson, K., Erwin, J., Barsheshet, A., De Ponti, R., Abdrakhmanov, A., Jashari, H., Lunegova, O., Jubele, K., Refaat, M. M., Puodziukynas, A., Groben, L., Grosu, A., Ibtissam, F., Trines, S. A., Poposka, L., Haugaa, K. H., Kowalski, O., Cavaco, D., Dobreanu, D., Mikhaylov, E. N., Zavatta, M., Nebojsa, M., Ferreira-Gonzalez, I., Juhlin, T., Reichlin, T., Haouala, H., Akgun, T., Gupta, D., Brugada, J, Katritsis, D, Arbelo, E, Arribas, F, Bax, J, Blomstrom-Lundqvist, C, Calkins, H, Corrado, D, Deftereos, S, Diller, G, Gomez-Doblas, J, Gorenek, B, Grace, A, Ho, S, Kaski, J, Kuck, K, Lambiase, P, Sacher, F, Sarquella-Brugada, G, Suwalski, P, Zaza, A, De Potter, T, Sticherling, C, Aboyans, V, Basso, C, Bocchiardo, M, Budts, W, Delgado, V, Dobrev, D, Fitzsimons, D, Gevaert, S, Heidbuchel, H, Hindricks, G, Hlivak, P, Kanagaratnam, P, Katus, H, Kautzner, J, Kriebel, T, Lancellotti, P, Landmesser, U, Leclercq, C, Lewis, B, Lopatin, Y, Merkely, B, Paul, T, Pavlovic, N, Petersen, S, Petronio, A, Potpara, T, Roffi, M, Scherr, D, Shlyakhto, E, Simpson, I, Zeppenfeld, K, Windecker, S, Baigent, C, Collet, J, Dean, V, Gale, C, Grobbee, D, Halvorsen, S, Iung, B, Juni, P, Lettino, M, Mueller, C, Richter, D, Sousa-Uva, M, Touyz, R, Amara, W, Grigoryan, S, Podczeck-Schweighofer, A, Chasnoits, A, Vandekerckhove, Y, Sokolovich, S, Traykov, V, Skoric, B, Papasavvas, E, Riahi, S, Kampus, P, Parikka, H, Piot, O, Etsadashvili, K, Stellbrink, C, Manolis, A, Csanadi, Z, Gudmundsson, K, Erwin, J, Barsheshet, A, De Ponti, R, Abdrakhmanov, A, Jashari, H, Lunegova, O, Jubele, K, Refaat, M, Puodziukynas, A, Groben, L, Grosu, A, Ibtissam, F, Trines, S, Poposka, L, Haugaa, K, Kowalski, O, Cavaco, D, Dobreanu, D, Mikhaylov, E, Zavatta, M, Nebojsa, M, Ferreira-Gonzalez, I, Juhlin, T, Reichlin, T, Haouala, H, Akgun, T, and Gupta, D

Subjects
Focal, Supraventricular, Atrioventricular, Nodal, Guidelines, Ablation, Flutter, Guideline, Tachycardia, Re-entrant, Arrhythmia, Junctional, Macrore-entrant, Pre-excitation
Abstract

E' una "linea-guida" non esiste abstract.

Published
2020

6. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J. Katritsis, D.G. Arbelo, E. Arribas, F. Bax, J.J. Blomstrom-Lundqvist, C. Calkins, H. Corrado, D. Deftereos, S.G. Diller, G.-P. Gomez-Doblas, J.J. Gorenek, B. Grace, A. Ho, S.Y. Kaski, J.-C. Kuck, K.-H. Lambiase, P.D. Sacher, F. Sarquella-Brugada, G. Suwalski, P. Zaza, A. De Potter, T. Sticherling, C. Aboyans, V. Basso, C. Bocchiardo, M. Budts, W. Delgado, V. Dobrev, D. Fitzsimons, D. Gevaert, S. Heidbuchel, H. Hindricks, G. Hlivak, P. Kanagaratnam, P. Katus, H. Kautzner, J. Kriebel, T. Lancellotti, P. Landmesser, U. Leclercq, C. Lewis, B. Lopatin, Y. Merkely, B. Paul, T. Pavlović, N. Petersen, S. Petronio, A.S. Potpara, T. Roffi, M. Scherr, D. Shlyakhto, E. Simpson, I.A. Zeppenfeld, K. Windecker, S. Baigent, C. Collet, J.-P. Dean, V. Gale, C.P. Grobbee, D.E. Halvorsen, S. Iung, B. Jüni, P. Lettino, M. Mueller, C. Richter, D.J. Sousa-Uva, M. Touyz, R.M. Amara, W. Grigoryan, S. Podczeck-Schweighofer, A. Chasnoits, A. Vandekerckhove, Y. Sokolovich, S. Traykov, V. Skoric, B. Papasavvas, E. Riahi, S. Kampus, P. Parikka, H. Piot, O. Etsadashvili, K. Stellbrink, C. Manolis, A.S. Csanádi, Z. Gudmundsson, K. Erwin, J. Barsheshet, A. De Ponti, R. Abdrakhmanov, A. Jashari, H. Lunegova, O. Jubele, K. Refaat, M.M. Puodziukynas, A. Groben, L. Grosu, A. Ibtissam, F. Trines, S.A. Poposka, L. Haugaa, K.H. Kowalski, O. Cavaco, D. Dobreanu, D. Mikhaylov, E.N. Zavatta, M. Nebojša, M. Ferreira-Gonzalez, I. Juhlin, T. Reichlin, T. Haouala, H. Akgun, T. Gupta, D. The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC), Association for European Paediatric Congenital Cardiology (AEPC)

Published
2020

8. NYHA classification in adults with congenital heart disease: Relation to objective measures of exercise and outcome

Author

Bredy, C, Ministeri, M, Kempny, A, Alonso-Gonzalez, R, Swan, L, Uebing, A, Diller, G-P, Gatzoulis, MA, and Dimopoulos, K

Subjects
congenital heart diseases, prognosis, Mortality, NYHA, Cardiopulmonary exercise test
Abstract

Aims The New York Heart Association functional classification (NYHA class) is often used to describe the functional capacity of adults with congenital heart disease (ACHD), albeit with limited evidence on its validity in this heterogeneous population. We aimed to validate the NYHA functional classification in ACHD by examining its relation to objective measures of limitation using cardiopulmonary exercise testing (CPET) and mortality. Methods and results This study included all ACHD patients who underwent a CPET between 2005 and 2015 at the Royal Brompton, in whom functional capacity was graded according to the NYHA classification. Congenital heart diagnoses were classified according to the Bethesda score. Time to all-cause mortality from CPET was recorded in all 2781 ACHD patients (mean age 33.8 ± 14.2 years) enrolled in the study. There was a strong relation between NYHA class and peak oxygen consumption (peak VO2), ventilation per unit in carbon dioxide production (VE/VCO2) slope and the Bethesda classification (P

Published
2017

9. Immediate and midterm cardiac remodeling after surgical pulmonary valve replacement in adults with repaired tetralogy of fallot: A prospective cardiovascular magnetic resonance and clinical study

Author

Heng, E. L., Gatzoulis, M. A., Uebing, A., Sethia, B., Uemura, H., Smith, G. C., Diller, G. -P., Mccarthy, K. P., S. Y., Ho, Li, W., Wright, P., Spadotto, V., Kilner, P. J., Oldershaw, P., Pennell, D. J., Shore, D. F., and Babu-Narayan, S. V.

Subjects
Adult, Male, Heart Valve Prosthesis Implantation, Pulmonary Valve, Ventricular Remodeling, Heart Valve Prosthesis, Tetralogy of Fallot, Humans, Female, Stroke Volume, Magnetic Resonance Imaging, Magnetic resonance imaging, Pulmonary valve, Ventricular remodeling, Follow-Up Studies
Published
2017

10. Risk of Pregnancy in Moderate and Severe Aortic Stenosis: From the Multinational ROPAC Registry

Author

Orwat, S, Diller, G-P, Van Hagen, IM, Schmidt, R, Tobler, D, Greutmann, M, Jonkaitiene, R, Elnagar, A, Johnson, MR, Hall, R, Roos-Hesselink, JW, Baumgartner, H, University of Zurich, Baumgartner, Helmut, and Cardiology

Subjects
Adult, ROPAC Investigators, Cardiac & Cardiovascular Systems, Internationality, Pregnancy Complications, Cardiovascular, MULTICENTER, fetal outcome, ESC, heart failure, 610 Medicine & health, HEART-DISEASE, COLLABORATION, GUIDELINES, Risk Assessment, Severity of Illness Index, 2705 Cardiology and Cardiovascular Medicine, 1117 Public Health and Health Services, ECHOCARDIOGRAPHIC-ASSESSMENT, Pregnancy, FAILURE, Humans, risk factors, Prospective Studies, Registries, 1102 Cardiorespiratory Medicine and Haematology, OUTCOMES, Science & Technology, Pregnancy Outcome, WOMEN, Aortic Valve Stenosis, maternal outcome, EUROPEAN-SOCIETY, Fetal Diseases, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, 10209 Clinic for Cardiology, Female, Life Sciences & Biomedicine
Abstract

BACKGROUND Controversial results on maternal risk and fetal outcome have been reported in women with aortic stenosis (AS). OBJECTIVES The authors sought to investigate maternal and fetal outcomes in patients with AS in a large cohort. METHODS The Registry on Pregnancy and Cardiac Disease (ROPAC) is a global, prospective observational registry of women with structural heart disease, providing a uniquely large study population. Data of women with moderate (peak gradient 36 to 63 mm Hg) and severe AS (peak gradient $64 mm Hg) were analyzed. RESULTS Of 2,966 pregnancies in ROPAC, the authors identified 96 women who had at least moderate AS (34 with severe AS). No deaths were observed during pregnancy and in the first week after delivery. However, 20.8% of women were hospitalized for cardiac reasons during pregnancy. This was significantly more common in severe AS compared with moderate AS (35.3% vs. 12.9%; p ¼ 0.02), and reached the highest rate (42.1%) in severe, symptomatic AS. Pregnancy was complicated by heart failure in 6.7% of asymptomatic and 26.3% of symptomatic patients, but could be managed medically, except for 1 patient who was symptomatic before pregnancy and underwent balloon valvotomy. Children of patients with severe AS had a significantly higher percentage of low birth weight (35.0% vs. 6.0%; p ¼ 0.006). CONCLUSIONS Mortality in pregnant women with AS, including those with severe AS, appears to be close to zero in the current era. Symptomatic and severe AS does, however, carry a substantial risk of heart failure and is associated with high rates of hospitalization for cardiac reasons, although heart failure can nearly always be managed medically. The results highlight the importance of appropriate pre-conceptional patient evaluation and counseling. (J Am Coll Cardiol 2016;68:1727–37) © 2016 by the American College of Cardiology Foundation.

Published
2016

11. Exercise Induced Systemic Venous Hypertension in the Fontan Circulation

Author

Navaratnam, D, Fitzsimmons, S, Grocott, M, Rossiter, HB, Emmanuel, Y, Diller, G-P, Gordon-Walker, T, Jack, S, Sheron, N, Pappachan, J, Pratap, JN, Vettukattil, J, and Veldtman, G

Abstract

Increasingly end-organ injury is being demonstrated late after institution of the Fontan circulation, particularly liver fibrosis and cirrhosis. The exact mechanisms for these late phenomena remain largely elusive. Hypothesizing that exercise induces precipitous systemic venous hypertension and insufficient cardiac output for the exercise demand, i.e. a possible mechanism for end-organ injury, we sought to demonstrate the dynamic exercise responses in systemic venous (SVP) and concurrent end organ perfusion. Ten stable Fontan patients and 9 control subjects underwent incremental cycle ergometry based cardiopulmonary exercise testing. SVP was monitored in the right upper limb and regional tissue oxygen saturation was monitored in the brain and kidney using Near Infrared Spectroscopy. SVP rose profoundly in concert with workload in the Fontan group, described by the regression equation 15.97+0.073 Watts per mm Hg. In contrast SVP did not change in healthy controls. Regional renal (p

Published
2016

13. Multivariable mortality risk stratification in adult patients with eisenmenger syndrome

Author

Kempny, A., Dimopoulos, K., Alonso-Gonzalez, R., Swan, L., Li, W., Szostek, K., Anselm Uebing, Diller, G. P., Wort, S. J., and Gatzoulis, M. A.

Subjects
Science & Technology, Cardiac & Cardiovascular Systems, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, Life Sciences & Biomedicine, 1102 Cardiovascular Medicine And Haematology

23. Emergency department management of patients with adult congenital heart disease: a consensus paper from the ESC Working Group on Adult Congenital Heart Disease, the European Society for Emergency Medicine (EUSEM), the European Association for Cardio-Thoracic Surgery (EACTS), and the Association for Acute Cardiovascular Care (ACVC)

Author

Jolien W. Roos-Hesselink, Martin Möckel, G.P. Diller, Oktay Tutarel, Susana Price, Michael A. Gatzoulis, Alessandro Giamberti, Lorenzo Galletti, Wilhelm Behringer, Konstantinos Dimopoulos, Margarita Brida, Pastora Gallego, Helmut Baumgartner, M Chessa, Cardiology, Chessa, M., Brida, M., Gatzoulis, M. A., Diller, G. -P., Roos-Hesselink, J. W., Dimopoulos, K., Behringer, W., Mockel, M., Giamberti, A., Galletti, L., Price, S., Baumgartner, H., Gallego, P., and Tutarel, O.

Subjects
Adult, Heart Defects, Congenital, medicine.medical_specialty, Consensus, Heart disease, Population, Cardiovascular care, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary management, medicine, Humans, 030212 general & internal medicine, education, education.field_of_study, business.industry, Thoracic Surgery, Emergency department, medicine.disease, ?Congenital heart disease, Cardiothoracic surgery, Emergency, Emergency medicine, Emergency Medicine, Emergency Service, Hospital, Cardiology and Cardiovascular Medicine, business
Abstract

Adult congenital heart disease (ACHD) patients represent a growing population with increasing use of acute emergency department (ED) care. Providing comprehensive ED care necessitates an understanding of the most common clinical scenarios to improve morbidity and mortality in this population. The aim of this position document is to provide a consensus regarding the management of the most common clinical scenarios of ACHD patients presenting to the ED.

Published
2021
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24. Coronavirus disease 2019 in adults with congenital heart disease

Author

Jolien W. Roos-Hesselink, Adrienne H. Kovacs, Jamil Aboulhosn, G P Diller, Massimo Chessa, Margarita Brida, Markus Schwerzmann, Craig S. Broberg, Michael A. Gatzoulis, Cardiology, Diller, G. -P., Gatzoulis, M. A., Broberg, C. S., Aboulhosn, J., Brida, M., Schwerzmann, M., Chessa, M., Kovacs, A. H., and Roos-Hesselink, J.

Subjects
Adult, Heart Defects, Congenital, Pediatrics, medicine.medical_specialty, Heart disease, Hemodynamics, Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, 03 medical and health sciences, Special Article, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Pandemic, Medicine, Humans, AcademicSubjects/MED00200, Adult congenital heart disease, Position paper, 030212 general & internal medicine, 610 Medicine & health, Pandemics, Coronavirus, Pregnancy, business.industry, SARS-CoV-2, Congenital Heart Disease, COVID-19, medicine.disease, Pathophysiology, Cardiovascular Diseases, Corona, business, Cardiology and Cardiovascular Medicine, Psychosocial
Abstract

We are witnessing an unparalleled pandemic caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) associated with coronavirus disease 2019 (COVID-19). Current data show that SARS-CoV-2 results in mild flu-like symptoms in the majority of healthy and young patients affected. Nevertheless, the severity of COVID-19 respiratory syndrome and the risk of adverse or catastrophic outcomes are increased in patients with pre-existing cardiovascular disease. Patients with adult congenital heart disease (ACHD)—by definition—have underlying cardiovascular disease. Many patients with ACHD are also afflicted with residual haemodynamic lesions such as valve dysfunction, diminished ventricular function, arrhythmias or cyanosis, have extracardiac comorbidities, and face additional challenges regarding pregnancy. Currently, there are emerging data of the effect of COVID-19 on ACHD patients, but many aspects, especially risk stratification and treatment considerations, remain unclear. In this article, we aim to discuss the broad impact of COVID-19 on ACHD patients, focusing specifically on pathophysiology, risk stratification for work, self-isolation, hospitalization, impact on pregnancy, psychosocial health, and longer-term implications for the provision of ACHD care.

Published
2021
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