99 results on '"Divya Kumari"'
Search Results
2. An Examination of Habitability in Exoplanet Systems
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Divya Kumari
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Automotive Engineering - Published
- 2023
3. AN EXPEDIENT APPROACH TO TREAT ASTHMA THROUGH NON-STEROIDAL, NATURAL TRANSFEROSOMES AEROSOL SYSTEM
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SONAM SHARMA, DIVYA KUMARI, SHARUKH KHAN, PRIYANKA PATHAK, DEEKSHA KATIYAR, and SYED SAIF IMAM
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Marketing ,Pharmacology ,Organizational Behavior and Human Resource Management ,Strategy and Management ,Drug Discovery ,Pharmaceutical Science - Abstract
Asthma is the most common respiratory disease, affecting an estimated 262 million people and resulting in 461,000 fatalities in 2019. The treatment is available on the market, but it is quite expensive, and it also has serious adverse effects due to the high concentration of steroids in the medicine. If given effectively, curcumin, formononetin, and matrine’s anti-inflammatory properties can play a significant role in treatment. To improve the chemical stability and therapeutic potential of these active pharmaceutical ingredients (APIs) in the respiratory tract, a transferosomes system was designed, which encapsulates the APIs inside its vesicular structure and delivers them selectively to the inflamed cells. The DPPC layer will allow for efficient penetration, whereas Tween-80 will aid in deformability and lower interfacial tension, resulting in a small Z-average diameter, allowing for efficient penetration between layers of cells. The APIs’ stability at alkaline pH (7.6) is ensured by the nano-vesicular structure, which significantly increases cellular antioxidant activity and ferric reducing antioxidant power values. On the RAW264.7 cell line, the formulation will be tested for anti-inflammatory activity. Nuclear factor kappa B, tumor necrosis factor, interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, nitric oxide, and cyclooxygenase-2 are all reduced by curcumin, formononetin, and matrine. They also have an inhibitory effect on the MAPK signaling pathway, preventing extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 from causing inflammation. This formulation can effectively treat asthma without the use of steroids, has no adverse effects, and is inexpensive.
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- 2022
4. Role of Interventional Radiology in the Management of Venous Trauma
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Divya Kumari, Daniel H. Kwak, and Jonathan Fergus
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Abstract
Traumatic injury to the large, central venous vasculature, although rare, is associated with high morbidity and mortality rates. Conventional open surgical treatment by repair or ligation can be technically challenging in anatomically difficult areas to expose. Furthermore, open surgical approach can release tension on the venous injury and result in uncontrollable bleeding. Endovascular techniques such as stenting and embolization can be used effectively for the treatment of traumatic venous injury. This article will discuss the morbidity and mortality associated with traumatic venous injuries, venous anatomy, endovascular treatment options, and management of traumatic venous injury.
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- 2022
5. COMMUNITY RELATIONS MANAGEMENT IN CONTEMPORARY CORPORATE HOUSES
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Divya Kumari K P
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Embryology ,Cell Biology ,Anatomy ,Developmental Biology - Abstract
Modern organizations receive land, labor, capital, investors, distributors, consumers, image builders, events managers and other facilitators of organizational development. They are required to establish and maintain a mutually beneficial relationship with the communities since they are at the receiving end. Community relationship management is an important activity undertaken by the modern organizations. These organizations must cultivate civic responsibility and repay their gratitude to the local community. Community involvement is necessary to foster a sense of community teamwork for the sustainable development of the organization. A comprehensive community relations program enhances the visibility of organizations and brings the community closer to the organizational mainstream. Good community relations programs generate series of advantages to the organizations. New business opportunities also crop up on the basis of effective community relations programmes implemented by the modern organizations. The salient features of community relations management are primarily discussed in this paper on the basis of qualitative research methodology.
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- 2022
6. Hybrid CT-angiography (Angio-CT) for combined CT and fluoroscopic procedures in interventional radiology enhances utilization
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Daniel H. Kwak, Osman Ahmed, Hasan Habib, Karan Nijhawan, Divya Kumari, and Mikin Patel
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Radiological and Ultrasound Technology ,Computed Tomography Angiography ,Fluoroscopy ,Urology ,Angiography ,Gastroenterology ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiology, Interventional ,Radiography, Interventional ,Tomography, X-Ray Computed - Abstract
To investigate the utilization of an angiography-CT (Angio-CT) system and its advantages for single patient encounters.Interventions utilizing both CT and fluoroscopy to perform multiple procedures in a single encounter or single interventions using both were identified. Cases were stratified by complexity (defined by RVUs). Comparative analyses of room (TBetween June 2018 and August 2019, 1108 procedures were performed via the Angio-CT system; 10% (114/1108) used both fluoroscopy and CT. 21% (24/114) Involved more than one procedure in a single encounter that required a CT-only and fluoroscopy-only bundled procedure. 59% (67/114) were non-complex, and 70% (80/114) were non-oncologic. 82.5% (14/17) of non-complex bundled procedures demonstrated TThe primary use for the hybrid Angio-CT system was to perform non-oncologic and non-complex cases with potential reduction in T
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- 2022
7. Lessons in IR: Hepatic Abscess after Liver-Directed Therapy
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Divya Kumari
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2023
8. A Novel Method for Predicting Time of Alcohol Use Based on Personality Traits and Demographic Information
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Divya Kumari and Aleena Swetapadma
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Electrical and Electronic Engineering ,Computer Science Applications ,Theoretical Computer Science - Published
- 2022
9. SLP-RRFPR: a source location privacy protection scheme based on random ring and limited hop fake packet routing for wireless sensor networks
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Anurag Shukla, Deepak Singh, Mohit Sajwan, Malay Kumar, Divya Kumari, Ajit Kumar, and Manikant Panthi
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Computer Networks and Communications ,Hardware and Architecture ,Media Technology ,Software - Published
- 2022
10. Lessons in IR: Renal Transplant Artery Guide Wire Perforation Leading to Hematoma and Graft Failure
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Divya Kumari and Brian Funaki
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2023
11. Lessons in IR: Splenic Infarct after Splenic Aneurysm Embolization
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Divya Kumari
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2023
12. Study of the Synergistic Role of Multivalence States of 3d Cations on the Crystal Lattice Distortion and Magnetic Behavior of Sr2fecoo6-Δ: A Spectroscopic Study
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Divya Kumari, Digvijay N. Singh, Md. Kashif Shamim, Sourav Choudhary, R. J. Choudhary, and Seema Sharma
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- 2023
13. Accelerating the Race to Autonomous Cars – A Case Study
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Divya Kumari and Subrahmanya Bhat
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Machine Learning ,Deep Learning ,ABCD Analysis ,Artificial Intelligence in autonomous car ,Autopilot ,Autonomous Vehicles ,Driverless cars ,Self-driving - Abstract
Background/Purpose: Every automaker is racing to generate self-driving innovations and some slew of fantastic tech firms and start-ups doing the same. The vehicle industry has a long history of implementing cutting-edge technologies to bring efficient, creative, and reliable vehicles to market, all while working to reduce production costs. Such innovations involve machine learning and computational intelligence, which are essential to automobiles progress. Machine learning (AI) technologies have made the innovative concept of self-driving vehicles an actuality. Today, global automotive rulers such as BMW, Volvo, and Tesla use intelligent automation to enhance production, raise production efficiency, and actually drive secure, extra relaxed, expanding, and increasingly enjoyable.This article provides a comprehensive analysis of Companies in the development of Autonomous vehicles and used ABCD analysis to examine the key parameters. Objective: Analyses the technology and business strategies of the companies in the Race of Autonomous cars. Design/Methodology/Approach: The information for this case study were gathered from various scholarly articles and websites. Findings/Result: The technological details of Artificial Intelligence, Self-driving car companies, laws and restrictions of different companies for using Self-driving vehicles, Autopilot driving features, sales volume and financial expansion, Impact of COIVID-19 on Autonomous vehicles business are studied. The impacts of COVID-19 on the autonomous car business are analysed using the ABCD framework. Originality/Value: The result provides a brief overview of different self-driving vehicle companies and self-driving technology building companies in the competitive race. Paper type: A Research Case study paper - focuses on companies in a race of producing Autonomous vehicles and the growth of those companies.
- Published
- 2021
14. Exploring the potential role of quercetin in corrosion inhibition of aluminium alloy 6063 in hydrochloric acid solution by experimental and theoretical studies
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Pushyaraga P Venugopal, Divya Kumari, Debashree Chakraborty, and P. D. Reena Kumari
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Materials science ,Acid inhibition ,Potentiodynamic polarization ,Hydrochloric acid ,Surfaces and Interfaces ,General Chemistry ,Surfaces, Coatings and Films ,Corrosion ,Dielectric spectroscopy ,Corrosion inhibitor ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,visual_art ,Materials Chemistry ,Aluminium alloy ,visual_art.visual_art_medium ,Quercetin ,Nuclear chemistry - Abstract
Quercetin was evaluated as corrosion inhibitor for AA6063 in 0.5 M HCl solution by employing weight-loss, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), Scanning Electr...
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- 2021
15. Examination of Habitability in Exoplanet Systems
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Divya Kumari
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- 2022
16. Risk Factors for Abscess Development Following Percutaneous Microwave Ablation Therapy of Hepatic Tumors
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Daniel H. Kwak, Qian Yu, Mira Malavia, Emily Sellers, Adam Said, Mikin Patel, Divya Kumari, and Osman Ahmed
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Abstract
To investigate risk factors associated with post-microwave ablation (MWA) abscess development.A retrospective case-control analysis was conducted to identify hepatic MWA performed at a single tertiary medical center between January 2010 and January 2022. Case and control patients were defined as those who did or did not develop intrahepatic abscess within 3 months following MWA, respectively. Correlations between risk factors and post-MWA abscess development were assessed by Fisher's exact test.Between 2010 and 2022, 253 patients underwent 376 MWA sessions with post-ablation abscess complication rate of 1.1% (4/376). Complications associated with intrahepatic abscess included bacteremia, empyema, pleural abscess, subcutaneous abscess, cholangitis, bile leak, biliocutaneous and arterio-biliary fistulae, and pseudoaneurysm. One patient expired from septic shock 5 days post-ablation. All abscesses were treated by percutaneous drainage and antibiotics. One patient required concomitant placement of a biliary stent and embolization of a biliocutaneous tract. History of Sphincter of Oddi manipulation (p 0.01), cholangiocarcinoma (p 0.05), transarterial radioembolization (TARE) to the index lesion (p 0.05), and abnormal serum alkaline phosphatase levels (p 0.05) were significantly correlated with post-MWA abscess. The risk of developing post-MWA abscesses for patients with a history of cholangiocarcinoma or a history of Sphincter of Oddi manipulation were 20.0% and 27.2%, respectively.Patients with prior Sphincter of Oddi manipulation, cholangiocarcinoma, or TARE are at greater risk of developing post-MWA abscess.
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- 2022
17. Severity Scoring Cutoff for MLPA and Its Diagnostic Yield in 332 North Indian Children with Developmental Delay
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Priyanka Srivastava, Parminder Kaur, Roshan Daniel, Chakshu Chaudhry, Anit Kaur, Saurabh Seth, Divya Kumari, Anupriya Kaur, and Inusha Panigrahi
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Pediatrics, Perinatology and Child Health ,Genetics (clinical) - Abstract
Chromosomal aberrations/rearrangements are the most common cause of intellectual disability (ID), developmental delay (DD), and congenital malformations. Traditionally, karyotyping has been the investigation of choice in such cases, with the advantage of being cheap and easily accessible, but with the caveat of the inability to detect copy number variations of sizes less than 5 Mb. Chromosomal microarray can solve this problem, but again the problems of expense and poor availability are major challenges in developing countries. The purpose of this study is to find the utility of multiplex ligation-dependent probe amplification (MLPA) as a middle ground, in a resource-limited setting. We also attempted to establish an optimum cutoff for the de Vries score, to enable physicians to decide between these tests on a case-to-case basis, using only clinical data. A total of 332 children with DD/ID with or without facial dysmorphism and congenital malformations were studied by MLPA probe sets P245. Assessment of clinical variables concerning birth history, facial dysmorphism, congenital malformations, and family history was done. We also scored the de Vries scoring for all the patients to find a suitable cutoff for MLPA screening. In our study, the overall detection rate of MLPA was 13.5% (45/332). The majority of patients were DiGeorge's syndrome with probe deletion in 22q11.21 in 3.3% (11/332) followed by 15q11.2 del in 3.6% (12/332, split between Angelman's and Prader–Willi's syndromes). Also, 3.0% (10/332) of patients were positive for Williams–Beuren's syndrome 7q11.23, 1.8% (6/332) for Wolf–-Hirschhorn's syndrome 4p16.3, 1.2% (4/332) for 1p36 deletion, and 1% for each trichorhinophalangeal syndrome type I 8q23.3 duplication syndrome and cri du chat syndrome. The optimum cutoff of de Vries score for MLPA testing in children with ID and/or dysmorphism came out to be 2.5 (rounded off to 3) with a sensitivity of 82.2% and specificity of 66.7%. This is the largest study from India for the detection of chromosomal aberrations using MLPA common microdeletion kit P245. Our study suggests that de Vries score with a cutoff of 3 or more can be used to offer MLPA as the first tier test for patients with unexplained ID, with or without facial dysmorphism and congenital malformations.
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- 2022
18. A systematic review of the monogenic causes of Non-Syndromic Hearing Loss (NSHL) and discussion of Current Diagnosis and Treatment options
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Nandita Sharma, Divya Kumari, Inusha Panigrahi, and Preeti Khetarpal
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Genetics ,Genetics (clinical) - Abstract
Hearing impairment is one of the most widespread inheritable sensory disorder affecting at least 1 in every 1000 born. About two-third of hereditary hearing loss (HHL) disorders are non-syndromic. To provide comprehensive update of monogenic causes of non-syndromic hearing loss (NSHL), literature search has been carried out with appropriate keywords in the following databases-PubMed, Google Scholar, Cochrane library, and Science Direct. Out of 2214 papers, 271 papers were shortlisted after applying inclusion and exclusion criterion. Data extracted from selected papers include information about gene name, identified pathogenic variants, ethnicity of the patient, age of onset, gender, title, authors' name, and year of publication. Overall, pathogenic variants in 98 different genes have been associated with NSHL. These genes have important role to play during early embryonic development in ear structure formation and hearing development. Here, we also review briefly the recent information about diagnosis and treatment approaches. Understanding pathogenic genetic variants are helpful in the management of affected and may offer targeted therapies in future.
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- 2022
19. Reinforced NMT for Sentiment and Content Preservation in Low-resource Scenario
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Rejwanul Haque, Asif Ekbal, Andy Way, Divya Kumari, and Pushpak Bhattacharyya
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050101 languages & linguistics ,neural machine translation ,sentiment preservation ,actor-critic ,reinforcement learning ,BERT ,General Computer Science ,Machine translation ,business.industry ,Computer science ,05 social sciences ,Context (language use) ,02 engineering and technology ,Semantics ,computer.software_genre ,0202 electrical engineering, electronic engineering, information engineering ,Reinforcement learning ,Domain knowledge ,020201 artificial intelligence & image processing ,0501 psychology and cognitive sciences ,Source text ,Artificial intelligence ,business ,Machine translating ,computer ,Classifier (UML) ,Sentence ,Natural language processing - Abstract
The preservation of domain knowledge from source to the target is crucial in any translation workflows. Hence, translation service providers that use machine translation (MT) in production could reasonably expect that the translation process should transfer both the underlying pragmatics and the semantics of the source-side sentences into the target language. However, recent studies suggest that the MT systems often fail to preserve such crucial information (e.g., sentiment, emotion, gender traits) embedded in the source text in the target. In this context, the raw automatic translations are often directly fed to other natural language processing (NLP) applications (e.g., sentiment classifier) in a cross-lingual platform. Hence, the loss of such crucial information during the translation could negatively affect the performance of such downstream NLP tasks that heavily rely on the output of the MT systems. In our current research, we carefully balance both the sides (i.e., sentiment and semantics) during translation, by controlling a global-attention-based neural MT (NMT), to generate translations that encode the underlying sentiment of a source sentence while preserving its non-opinionated semantic content. Toward this, we use a state-of-the-art reinforcement learning method, namely, actor-critic , that includes a novel reward combination module, to fine-tune the NMT system so that it learns to generate translations that are best suited for a downstream task, viz. sentiment classification while ensuring the source-side semantics is intact in the process. Experimental results for Hindi–English language pair show that our proposed method significantly improves the performance of the sentiment classifier and alongside results in an improved NMT system.
- Published
- 2021
20. No Association was Detected between Polymorphism of COL1A2 Genes and Occurrence of Dental Fluorosis Among the Subjects Living in a Fluorosis-Endemic Area of India
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Mohammed S Mustak, Chitta Chowdhury, Shahnawaz Khijmatgar, Avidyuti Chowdhury, Divya Kumari P, Edward Lynch, and Martin Grootveld
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education.field_of_study ,business.industry ,Population ,Physiology ,Endemic area ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Polymorphism (computer science) ,Genotype ,Medicine ,business ,Male to female ,education ,Fluoride ,Dental fluorosis ,Genetic association - Abstract
Objective: To determine any genetic association of COL1A2 polymorphism and the occurrence of dental fluorosis within an Indian human dental fluorosis population. Material and Methods: Fifty-six (56) subjects from two groups i.e. cases with dental fluorosis from the Pavagada population (n=29) and a control group (n=27) without fluorosis, were explored. The ages ranged between 15 and 76 years (mean 50.8 years) were included, and the male to female ratio was 70:30. The severity of dental fluorosis was graded using WHO’s Thylstrup-Fejerskov index (TF), and the concentration of fluoride was determined by a fluoride ion selective electrode (ISE). Genomic DNA was extracted using the standard phenol-chloroform method. The rs412777 and rs414408 polymorphism in COL1A2 were genotyped using the Sanger sequence method. Results: Genotype distributions for rs412777 within each group were: AA 41%, AC 51%, and CC 7% for dental fluorosis participants, and AA 56%, AC 46%, and CC 0% for the control participants. Conclusions: The rs412777 and rs414408 polymorphisms in the COL1A2gene showed no significant association between COL1A2 and the occurrence of dental fluorosis amongst this Indian population.
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- 2021
21. Organo-Facies and Mineral Effects on Sorption Capacity of Low-Maturity Permian Barakar Shales from the Auranga Basin, Jharkhand, India
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Shailesh Agrawal, Divya Kumari Mishra, Bhagwan D. Singh, Paul C. Hackley, Atul Kumar Varma, and Vinod Atmaram Mendhe
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Maturity (geology) ,Fuel Technology ,Mineral ,Permian ,General Chemical Engineering ,Facies ,Geochemistry ,Energy Engineering and Power Technology ,Sorption ,Structural basin ,Geology - Published
- 2021
22. The impact of environmental, social and governance score on shareholder wealth: A new dimension in investment philosophy
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Abhishek Parikh, Divya Kumari, Maria Johann, and Dušan Mladenović
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Economics and Econometrics ,Environmental Engineering ,Renewable Energy, Sustainability and the Environment ,Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Environmental Science (miscellaneous) ,Social Sciences (miscellaneous) - Published
- 2023
23. STUDY ON ANTIVIRAL DRUGS RAISENEW HOPES FOR RECOVERY ON SARS-COV-2
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Chaitanya Krishna Kommineni , Krishna Keethika Oruganti , Narasimha Vakkalagadda , Venkata Sai Yogesh Konakandla , Divya Kumari Muppa , Kumudwati Kakani , Sai Neeraj Krishna Vedantam and Praveen Kumar Vemuri
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SARS-CoV-2 Viral Drugs Disease COVID-19 Medicine ,viruses - Abstract
The goal of this study is to perform a systematic assessment of the literature to determine the effectiveness and safety of molnupiravir and paxlovid oral antiviral drugs in COVID-19 patients.These Drugs has shown consistent efficacy against the SARS-CoV-2 viruss Gamma, Delta, and Mu versions, the firm has yet to release data on the drugs action against Omicron. COVID-19, a worldwide pandemic produced by the SARS-CoV-2 virus, has already wreaked havoc on human life and the global economy. In this study, an attempt is made to comprehend the SARS-CoV-2 life cycle, and prospective druggable targets against SARS-CoV-2 are outlined based on this knowledge. COVID-19, there are more vaccine candidates in the pipeline at the same time than there haveever been for an infectious illness. Theyre all attempting to accomplish the same goal: viral immunity, and some may even be able to block transmission. Whole virus, protein subunit, viral vector, and nucleic acid are the four types of vaccines now being tested in clinical studies.  
- Published
- 2022
- Full Text
- View/download PDF
24. RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation
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Pavan Kumar Mysuru Shivalingappa, Divya Kumari Singh, Vaishali Sharma, Vivek Arora, Anjali Shiras, and Sharmila Bapat
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General Medicine - Abstract
RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are involved in each step of RNA metabolism. Several RBPs are essential for viable growth and development in mammals. RNA-binding motif 47 (RBM47) is an RRM-containing RBP whose role in mammalian embryonic development is poorly understood yet deemed to be essential since its loss in mouse embryos leads to perinatal lethality. In this study, we attempted to elucidate the significance of RBM47 in cell-fate decisions of mouse embryonic stem cells (mESCs). Downregulation of Rbm47 did not affect mESC maintenance and the cell cycle but perturbed the expression of primitive endoderm (PrE) markers and increased GATA4 + PrE-like cells. However, the PrE misregulation could be reversed by either overexpressing Rbm47 or treating the knockdown mESCs with the inhibitors of FGFR or MEK, suggesting an implication of RBM47 in regulating FGF-ERK signaling. Rbm47 knockdown affected the multi-lineage differentiation potential of mESCs as it regressed teratoma in NSG mice and led to a skewed expression of differentiation markers in serum-induced monolayer differentiation. Further, lineage-specific differentiation revealed that Rbm47 is essential for proper differentiation of mESCs towards neuroectodermal and endodermal fate. Taken together, we assign a hitherto unknown role(s) to RBM47 in a subtle regulation of mESC differentiation.
- Published
- 2022
25. NSG-70, a new glioblastoma cell line with mixed proneural-mesenchymal features associates NOTCH1-WNT5A signaling with stem cell maintenance and angiogenesis
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Divya Kumari Singh, Pavan Kumar Mysuru Shivalingappa, Aman Sharma, Abir Mondal, Dattatraya Muzumdar, Anjali Shiras, and Sharmila A. Bapat
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Cancer Research ,endocrine system ,Neovascularization, Pathologic ,Brain Neoplasms ,fungi ,Glioma ,Wnt-5a Protein ,Cell Line ,Neurology ,Oncology ,Cell Line, Tumor ,embryonic structures ,Neoplastic Stem Cells ,Humans ,Neurology (clinical) ,sense organs ,Receptor, Notch1 ,Glioblastoma - Abstract
BackgroundGlioblastoma initiation and progression is believed to be driven by Glioma stem cells (GSCs). Activation of NOTCH1 and WNT, and more recently, non-canonical WNT5A signaling, has been demonstrated to regulate self-renewal and differentiation of the GSCs crucially. High expression levels of NOTCH1 and WNT in GBM tumors contribute to the sustenance of GSCs and mediate characteristic phenotypic plasticity, which is reflected by the different subtypes and tremendous intra-tumor heterogeneity. However, the coregulation of NOTCH1 and WNT5A is not well understood. Here, we studied the role of these molecules in regulating the characteristics of different GSC subtypes. MethodsWe established a novel GSC-enriched cell model, referred to as NSG-70, from a patient with recurrent GBM. NSG-70 cells harbor a unique cytogenetic feature, viz. isochromosome 9q. At the same time, its expression profiles indicate it to represent a mixed lineage comprising of proneural and mesenchymal subtypes. We examined the relevance of NOTCH1 and WNT5A signaling and their coordinated action in GBM using these cells and other patient-derived models representing different GSC subtypes. ResultsOur data revealed that the downregulation of NOTCH1 resulted in the suppression of stem cell and mesenchymal markers and significantly reduced the levels of WNT5A. NOTCH1 knockdown also led to a notable reduction in the vasculogenic mimicry of GSCs. Interestingly, knockdown of WNT5A exhibited similar effects and drove quiescent GSC towards proliferation. In a complementary manner, ectopic expression of WNT5A or rhWNT5A treatment rescued the effects of NOTCH1 knockdown. ConclusionsGiven the resistance of GSCs towards conventional therapies in part due to subtype, interconversion demands therapies targeting specific GSC subtype. Our study suggests the need for a combinatorial approach that could effectively target the NOTCH1-WNT5A signaling axis towards eliminating GSCs.
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- 2022
26. Alteration of Zinc Transporter mRNA Expression in Zinc Depleted Condition by TPEN{N,N,Na2,Na2-Tetrakis(2-Pyridylmethyl)Ethylenediamine}: A Cell-Line Based Study
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Arnab Chatterjee, Divya Kumari, Virendra V. Panpatil, Sandeep Kumar, and Sudip Ghosh
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Nutrition and Dietetics ,Monocyte ,Medicine (miscellaneous) ,Skeletal muscle ,chemistry.chemical_element ,Ethylenediamine ,Transporter ,Zinc ,medicine.disease ,Molecular biology ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Cell culture ,medicine ,Zinc deficiency ,Chelation - Abstract
Zinc deficiency is rapidly emerging as one of the important concerns in public health nutrition. Early diagnosis of zinc deficiency remains a major challenge. We investigated the expression level of different zinc transporters in zinc-deficient condition induced by TPEN, an intracellular zinc chelator in different cell lines like human monocyte (THP-1), skeletal muscle (RD), bone (Saos-2), liver (HepG2), representing different tissues which play key roles in zinc homeostasis. Cells were exposed to TPEN at various concentrations (2, 5, 10 μM) for 2 to12 h and mRNA levels of ZnT1 and MT were analyzed using qPCR. Statistical analysis was carried out using one-way ANOVA. ZnT1 expression was significantly different at 4 h with TPEN concentration of 2 μM and 5 μM as compared to untreated controls in THP-1, whereas in HepG2, significant differences were observed at 5 μM and 10 μM TPEN concentration after 6 h. In RD, significant differences were observed at 4 h in presence of 2 μM TPEN and in Saos2 expression was significantly different at 2 h with 2 μM, 5 μM, and 10 μM TPEN as compared to respective controls. Expression of MT in THP1 was significantly different at 2 h and 12 h control in presence of 2 μM, 5 μM and 10 μM TPEN, whereas in HepG2 significant differences were found at 2 μM, 5 μM, and 10 μM TPEN after 6 h of treatment. RD MT expression was significantly different in 10 μM for 12 h. Similarly, Saos2 expression was significantly different in the presence of 5 μM and 10 μM TPEN. Conclusions: This study may help in understanding the molecular cross talks among different zinc tissue storage depots during zinc deficiency and identification of early biomarkers for zinc deficiency.
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- 2020
27. ReviewMT: Sentiment Preserved E-Commerce Review Translation System
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Kamal Kumar Gupta, Divya Kumari, Soumya Chennabasavraj, Nikesh Garera, and Asif Ekbal
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- 2022
28. Genome survey sequencing and mining of genome-wide microsatellite markers in yellow-billed babbler (Turdoides affinis)
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Trisha Mondal, Prateek Dey, Divya Kumari, Swapna Devi Ray, Goldin Quadros, Venkata Hanumat Sastry Kochiganti, and Ram Pratap Singh
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Multidisciplinary - Published
- 2023
29. Biodegradable Packaging: A Sustainable Approach for Packaging of Fruits and Vegetables
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Divya Kumari Keshari, Kamlesh Kumar Maurya, Arpit Shrivastava, Tanweer Alam, and Abhishek Dutt Tripathi
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Fruits and vegetables ,Food science ,Business - Published
- 2021
30. Chromosome 1p36 Deletion Syndrome: Four Patients with Variable Presentations
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Chakshu Chaudhry, Divya Kumari, Inusha Panigrahi, and Parminder Kaur
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Pediatrics ,medicine.medical_specialty ,1p36 deletion syndrome ,Microarray ,Heart disease ,business.industry ,Chromosome ,medicine.disease ,Short stature ,Hypotonia ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Renal abnormalities ,Pediatrics, Perinatology and Child Health ,Intellectual disability ,medicine ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Genetics (clinical) - Abstract
Chromosome 1p36 deletion accounts for around 1% of cases of intellectual disability. The pattern of clinical features includes developmental delay, hypotonia, seizures, short stature, intellectual disability, vision and hearing deficits, congenital heart disease, and renal abnormalities. The size of deletion can be variable. We report four cases of 1p36 deletion syndrome detected in the past 3 years in a genetic clinic. One patient was detected by next-generation sequencing, another by chromosomal microarray, and the remaining two by multiplex ligation-dependent probe amplification. We discuss the variable presentations in the four children. Early diagnosis enables better prognostication and further reproductive planning.
- Published
- 2021
31. Single gene variants causing deafness in Asian Indians
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Inusha Panigrahi, Divya Kumari, and B N Anil Kumar
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Adult ,Male ,Adolescent ,MYO7A ,Hearing loss ,Hearing Loss, Sensorineural ,Population ,Fibroblast Growth Factor 3 ,India ,Prenatal diagnosis ,Biology ,Deafness ,Young Adult ,otorhinolaryngologic diseases ,Genetics ,medicine ,Ethnicity ,Prelingual deafness ,Humans ,Genetic Predisposition to Disease ,Allele ,education ,Gene ,education.field_of_study ,DNA Helicases ,Membrane Proteins ,medicine.disease ,Connexin 26 ,DNA-Binding Proteins ,Child, Preschool ,Myosin VIIa ,Trans-Activators ,Sensorineural hearing loss ,Female ,medicine.symptom - Abstract
Congenital deafness is one of the common disorders, with some common genes accounting for most of the cases. One in 1000 children are born with sensorineural hearing loss, and of that 50% are hereditary. In the Mediterranean Europeans, 80% of the nonsyndromic recessive deafness is due to homozygous mutation in GJB2, the 35del G allele. InWestern population, the GJB2 variation have been found in up to 30-40% cases. In Indians, the GJB2 variants have been found in up to 20% cases, mostly from central and southern India. In the present study, DNA was extracted from blood using standard methods. This was used to perform targeted gene capture using a custom capture kit. Multiple genes causing deafness were sequenced by next-generation sequencing to mean >80-100x coverage on Illumina sequencing platform. We found variants in GJB2, WFS1, FGF3, EYA4, MYO7A. and CHD7 genes. Most of these variants were pathogenic and novel, and possibly causative. Deafness is most commonly due to the autosomal dominant genes but in severe cases of early onset deafness, autosomal recessive genes may contribute in our population. In selected families of severe prelingual deafness, prenatal diagnosis can be done.
- Published
- 2021
32. A code search tool using text-based approach
- Author
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Tankala Divya Kumari and T. Venu Gopal
- Subjects
Code search, Code clones, code detection techniques - Abstract
Code reuse becomes an important opportunity for a software development organization, which helps in the reuse of software components or code snippets which are already developed and well-tested. It helps in reducing the cost and time in the development of software. When effective and efficient, a code search can boost programmer productivity; however, the search effectiveness depends on the programmer's ability to specify a query that captures how the desired code may have been implemented. Further, the results often include many irrelevant matches that must be filtered manually. Our proposed code search tool can help better as it is language-specific and also users can contribute their code fragments using this tool so that others can be fetched.
- Published
- 2021
- Full Text
- View/download PDF
33. Thoracic Duct Embolization Using Direct Hybrid Angiography/Computed Tomography‑Guided Cisterna Chyli Access for the Treatment of Chylous Leak Secondary to Partial Glossectomy and Neck Dissection
- Author
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Divya Kumari, Osman Ahmed, Brian Funaki, and Karan Nijhawan
- Subjects
Leak ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,chylous leak ,R895-920 ,Partial glossectomy ,Cisterna chyli ,Neck dissection ,Computed tomography ,Thoracic duct ,Medical physics. Medical radiology. Nuclear medicine ,cisterna chyli ,medicine.anatomical_structure ,Angiography ,medicine ,hybrid angiography/computed tomography ,Radiology ,Embolization ,thoracic duct embolization ,business - Abstract
Thoracic duct embolization (TDE) is a minimally invasive alternative to surgery for the treatment of postoperative chylous leaks that fail conventional medical management. TDE can be a technically challenging procedure that requires real-time image guidance to visualize the thoracic duct. This case report describes using hybrid angiography/computed tomography technology to perform TDE through direct access of the cisterna chyli, potentially eliminating the need for intranodal lymphangiography, and reducing procedure length.
- Published
- 2020
34. Management of attention deficit hyperactivity disorder (ADHD) through yoga
- Author
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Divya Kumari
- Subjects
DSM-5criteria ,medicine.medical_specialty ,business.industry ,Yoga ,education ,medicine.disease ,humanities ,Asana ,Ayurved ,Environmental sciences ,mental disorders ,Surya Namaskar ,medicine ,ADHD ,Attention deficit hyperactivity disorder ,GE1-350 ,business ,Psychiatry ,human activities - Abstract
Yoga is our ancient science. Yoga provides treatment modalities for many diseases without any bad effect on the body. ADHD is a commonest disorder of childhood in which child shows hyperactivity, impulsiveness and inattentiveness that is inappropriate for age. In modern there are some drugs that are used in ADHD but all the drugs have bad effect on the body. Yoga and ayurveda are two treatment modalities that may be used in the management of ADHD without any bad effect on the health. Yoga is a type of therapy that is used without medication. Yoga benefits children with ADHD as it uses asanas (physical posture), surya namaskar, pranayam and deep relaxation techniques to calm the senses decrease hyperactivity. Many studies showed beneficial effect of yoga in relieving the symptoms of ADHD like hyperactivity, impulsiveness and inattentiveness.
- Published
- 2019
35. Factors influencing fluoride release in atraumatic restorative treatment (ART) materials: A review
- Author
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Shahnawaz Khijmatgar, Chitta Ranjan Chowdhury, P. Divya Kumari, Avidyuti Chowdhury, and Edward Lynch
- Subjects
Cement ,Materials science ,business.industry ,Glass ionomer cement ,Dentistry ,Resin modified ,030206 dentistry ,Article ,Restorative treatment ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Search terms ,Otorhinolaryngology ,chemistry ,Fluoride release ,030220 oncology & carcinogenesis ,business ,General Dentistry ,Fluoride ,Minimally invasive procedures - Abstract
Objectives The purpose of this article was to review the fluoride release and uptake ability of some restorative materials which are used for minimally invasive procedures. Methods The literature search on published researches and review articles were carried out by using PubMed, Trip and Cochrane library databases. The search terms used were fluoride, restorative materials, atraumatic restorative treatment or ART, glass ionomer or GIC, resin modified glass ionomer cement or RMGIC. The articles included were between 2000 and 2015. Conclusion Fluoride release varies with m factors including the type of restorative materials used and also the media in which it is stored. Fluoride uptake is dependent on the type of the cement and the availability of fluoride including fluoride releasing capacity in the material.
- Published
- 2019
36. Antibacterial activity of new atraumatic restorative treatment materials incorporated with Azadirachta indica (Neem) against Streptococcus mutans
- Author
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Shahnawaz Khijmatgar, Avidyuti Chowdhury, P. Divya Kumari, Chitta Ranjan Chowdhury, Edward Lynch, and Shilpa M. Shenoy
- Subjects
Antibacterial property ,biology ,Traditional medicine ,Chemistry ,Neem extract ,030206 dentistry ,Azadirachta ,biology.organism_classification ,Streptococcus mutans ,Restorative treatment ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Agar diffusion test ,Antibacterial activity ,General Dentistry - Abstract
Background The antibacterial property of new atraumatic restorative treatment (ART) materials incorporated with Azadirachta indica (Neem) on Streptococcus mutans was carried out. Materials and methods The study was carried out by using the agar diffusion method to determine the antibacterial property of ART materials (ART-I and ART-II). The zone of inhibition was tabulated, and the data was statistically analyzed using the student t-test. The minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the ethanolic extract of Neem were recorded. Results The MIC and MBC of the mixture of the ethanolic extract of Neem was 3.13% and 12.5% respectively. The zone of inhibition of ART-I and ART-II was 11.81 mm and 11.97 mm respectively. Significant differences were observed between these two ART materials (P = 0,08). Conclusion Both the new ART materials i.e. ART-I and ART–II have considerable antibacterial activity against S. mutans.
- Published
- 2019
37. Water Stress Revealed Physiological and Biochemical Variations in Taro [Colocasia esculenta (L.) Schott] Varieties/Genotypes
- Author
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S. Divya Kumari, V Ravi, J. Suresh Kumar, and Sanket J. More
- Subjects
Colocasia esculenta ,Horticulture ,Water stress ,Genotype ,Biology - Published
- 2019
38. An improved method using supervised learning technique for diabetic retinopathy detection
- Author
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Divya Kumari, Aleena Swetapadma, Sabyasachi Chakraborty, and Gopal Chandra Jana
- Subjects
Computer Networks and Communications ,Computer science ,Computer Science::Neural and Evolutionary Computation ,Improved method ,02 engineering and technology ,Artificial Intelligence ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Electrical and Electronic Engineering ,Medical diagnosis ,Artificial neural network ,business.industry ,Applied Mathematics ,Supervised learning ,020206 networking & telecommunications ,Pattern recognition ,Diabetic retinopathy ,equipment and supplies ,medicine.disease ,Computer Science Applications ,body regions ,ComputingMethodologies_PATTERNRECOGNITION ,Feed forward back propagation neural network ,Computational Theory and Mathematics ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,Classifier (UML) ,Information Systems - Abstract
Now a day’s intelligent diagnoses approaches are massively accepted for the purpose of advance analysis and detection of several diseases. In this work a supervised learning based approach using artificial neural network (ANN) has been proposed to achieve more accurate diagnoses outcomes for the case of diabetic retinopathy. Features extracted from the retina images are used as input to the ANN based classifier. Customized ANN architecture by estimating several entities of traditional ANN has been used to improve the accuracy of the method. The ANN architecture used in this work is feed forward back propagation neural network. Accuracy obtained for the proposed method is found to be 97.13%. The results suggest that proposed method can be used to detect diabetic retinopathy effectively.
- Published
- 2019
39. Geochemical attributes, pore structures and fractal characteristics of Barakar shale deposits of Mand-Raigarh Basin, India
- Author
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Susheel Kumar, Alka Damodhar Kamble, Mollika Bannerjee, J. Buragohain, Vinod Atmaram Mendhe, Divya Kumari Mishra, Atul Kumar Varma, and Amal Kishore Prasad
- Subjects
chemistry.chemical_classification ,010504 meteorology & atmospheric sciences ,Stratigraphy ,chemistry.chemical_element ,Mineralogy ,Geology ,Weathering ,010502 geochemistry & geophysics ,Oceanography ,01 natural sciences ,Fractal dimension ,Matrix (geology) ,Geophysics ,chemistry ,Facies ,Economic Geology ,Organic matter ,Carbon ,Oil shale ,Dissolution ,0105 earth and related environmental sciences - Abstract
Pore structures in the shale matrix are an essential factor affecting the storage capacity of gas of shale beds as well as production performance. Twenty organic-rich shale samples at different depths were collected from Barakar Formation of Mand-Raigarh basin, to examine the pore structure and their fractal characteristic. Fractal dimension was calculated by following FHH theory to investigate the complexity of pore surfaces, storage mechanism and the pore network system. The complex pore system influenced by thermal cracking of organic matter, pore dissolution during geochemical weathering and tectonics of the basins having surface area 5.56–23.94 m2/g (avg. 14.21 m2/g). Whereas, the pore volume determined using the BJH model varying from 0.035 to 0.076 cc/g (avg. 0.053 cc/g). FTIR spectrum demonstrated that significant presence of aliphatic side chains and aromatic carbon structures existing in studied shale influencing the pore volume. It is summarized that pores and matrix of shale are built by complex mixtures of organic and inorganic content. Further, the pores are categorized into organic pores evolved during thermal cracking, inter-granular, intra-granular and inter-crystalline due to the large content of altered clays and minerals showing fissile nature. The SEM-EDX derived facies indicating the involvement of different chemical constituents following the trend of alteration as well as carbon enrichment. The D1 and D2 values obtained through FHH model range from 1.17 to 2.45 and 2.54–2.70, the fractal values particularly D2 are ∼3 demonstrating the pore surfaces and structure of studied shales beds are complex and heterogeneous. This study helps to enhance the exploration and advancement in the shale gas resources from Ib-River of Mand-Raigarh Basin, India.
- Published
- 2019
40. Protective Effect of Turmeric against Bisphenol-A Induced Genotoxicity in Rats
- Author
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Divya Kumari, Arnab Chatterjee, Vidhyacharan Bhaskar, Kalpagam Polasa, Virendra V. Panpatil, Sandeep Kumar, and Sudip Ghosh
- Subjects
0301 basic medicine ,endocrine system ,medicine.medical_specialty ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,medicine.disease_cause ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Curcuma ,Internal medicine ,Malondialdehyde ,medicine ,Deoxyguanosine ,Animals ,Rats, Wistar ,Carcinogen ,Kidney ,030109 nutrition & dietetics ,Nutrition and Dietetics ,urogenital system ,Rats ,Comet assay ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Endocrine disruptor ,Liver ,Micronucleus test ,Genotoxicity ,DNA Damage - Abstract
In this study, the protective role of turmeric on genotoxic effects of Bisphenol-A exposure in Wistar rats by in vivo experiment were investigated. Bisphenol-A is a known endocrine disruptor and suspected carcinogen, that comes diet through plastics for food packaging and food processing. In this study, rats were divided into three groups of twelve animals each and were administered with Bisphenol-A by oral gavage with levels of 0, 50 and, 100 μg. Half of the animals in each group were fed with feed which contained 3% turmeric (wt/wt), for a period of 4 wk, while the rest of the rats received the same diet treatment without the addition of turmeric. At the end of the experiment, all rats were terminated and the internal organs such as liver, kidney, femurs were collected and analyzed. Mean and SD values were compared by one-way ANOVA and Kruskal-Wallis-Wilcoxon test, the formation of micronuclei was compared using Mann-Whitney U-test. Significant decrease in serum malondialdehyde and urinary 8-hydroxy-2'-deoxyguanosine levels were observed in Bisphenol-A+turmeric groups as compared to Bisphenol-A groups. Bisphenol-A groups exhibited significantly higher mean levels of DNA damage in liver and kidney as compared to the untreated control group. Bisphenol-A group showed significant increase in the formation of micronuclei which was approximately threefold higher as compared to the control group. A significant decrease in DNA migration was observed in Bisphenol-A+turmeric fed groups in liver and kidney. Turmeric feeding significantly inhibited the micronuclei formation induced by Bisphenol-A. The study results indicate that turmeric can protect against Bisphenol-A induced genotoxicity in rats.
- Published
- 2021
41. Alteration of Zinc Transporter mRNA Expression in Zinc Depleted Condition by TPEN{N,N,Na
- Author
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Divya, Kumari, Arnab, Chatterjee, Virendra, Panpatil, Sandeep, Kumar, and Sudip, Ghosh
- Subjects
Zinc ,Humans ,RNA, Messenger ,Ethylenediamines ,Cation Transport Proteins ,Cell Line - Abstract
Zinc deficiency is rapidly emerging as one of the important concerns in public health nutrition. Early diagnosis of zinc deficiency remains a major challenge. We investigated the expression level of different zinc transporters in zinc-deficient condition induced by TPEN, an intracellular zinc chelator in different cell lines like human monocyte (THP-1), skeletal muscle (RD), bone (Saos-2), liver (HepG2), representing different tissues which play key roles in zinc homeostasis. Cells were exposed to TPEN at various concentrations (2, 5, 10 μM) for 2 to12 h and mRNA levels of ZnT1 and MT were analyzed using qPCR. Statistical analysis was carried out using one-way ANOVA. ZnT1 expression was significantly different at 4 h with TPEN concentration of 2 μM and 5 μM as compared to untreated controls in THP-1, whereas in HepG2, significant differences were observed at 5 μM and 10 μM TPEN concentration after 6 h. In RD, significant differences were observed at 4 h in presence of 2 μM TPEN and in Saos2 expression was significantly different at 2 h with 2 μM, 5 μM, and 10 μM TPEN as compared to respective controls. Expression of MT in THP1 was significantly different at 2 h and 12 h control in presence of 2 μM, 5 μM and 10 μM TPEN, whereas in HepG2 significant differences were found at 2 μM, 5 μM, and 10 μM TPEN after 6 h of treatment. RD MT expression was significantly different in 10 μM for 12 h. Similarly, Saos2 expression was significantly different in the presence of 5 μM and 10 μM TPEN. Conclusions: This study may help in understanding the molecular cross talks among different zinc tissue storage depots during zinc deficiency and identification of early biomarkers for zinc deficiency.
- Published
- 2021
42. Genetic Defects in Children with Cardiac Anomalies/Malformations: Noonan and CFC Syndromes
- Author
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Inusha Panigrahi, Manoj Kumar Rohit, Divya Kumari, and Deepti Chaudhary
- Subjects
0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Juvenile myelomonocytic leukemia ,medicine.diagnostic_test ,Genetic heterogeneity ,business.industry ,030204 cardiovascular system & hematology ,medicine.disease ,Malignancy ,Short stature ,Tertiary care ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Cardiac defects ,medicine.symptom ,Ultrasonography ,business ,Fetal echocardiography ,Genetics (clinical) - Abstract
Cardiac defects presenting in childhood show significant phenotypic and genetic heterogeneity. With availability of advanced genetic technologies, these can be detected early using specialized testing. Prenatal testing is currently feasible with improved ultrasonography and fetal echocardiography. Here, we report two cases of Noonan's and cardiofaciocutaneous syndromes in patients seen in the genetic unit of a tertiary care center presenting with cardiac defect with or without developmental delay, short stature, and dysmorphism. In these conditions, there is also increased risk of malignancy such as juvenile myelomonocytic leukemia. With the advent of next-generation sequencing, definitive diagnosis and counseling is possible in this group of conditions.
- Published
- 2020
43. Radionuclide activity concentration in soil, granites and water in a fluorosis endemic area of India: An oral health perspective
- Author
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Shahnawaz Khijmatgar, Divya Kumari P, Edward Lynch, Chitta Ranjan Chowdhury, Avidyuti Chowdhury, and Martin Gootveld
- Subjects
Veterinary medicine ,Radionuclide ,Endemic area ,030206 dentistry ,Oral health ,medicine.disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Otorhinolaryngology ,chemistry ,030220 oncology & carcinogenesis ,Activity concentration ,medicine ,Environmental science ,Hpge detector ,General Dentistry ,Fluoride ,Dental fluorosis ,Research Paper - Abstract
Background The idea that hilly areas have a high background radiation which in turn is linked to dental fluorosis is widely held by many in India. There is little evidence to confirm this. Objective The study aimed to investigate the level of environmental radionuclide in order to determine any interrelationship between radionuclide and dental fluorosis in Pavagada, a fluorosis endemic area of Karnataka, India. Methods Gamma radionuclides (Th232, Ra226 and K40) were determined by high purity germanium (HPGe) gamma-ray spectrometer (Bq Kg-1) using a 50% relative efficiency p-type broad energy HPGe detector. Fluoride was estimated using fluoride Ion-selective electrode (ISE). Fluorosis was assessed using WHO diagnostic criteria. Results The average mean +_SD activity concentration in soil for K40 was detected between 416.6 ± 9.3 and 769.1 ± 15.0. Th232 was estimated between 13.6 ± 0.6 and 57.6 ± 1.3; and Ra226 was found between 6.4 ± 0.4 and 21.6 ± 0.7. Similarly, the mean activity concentration detected (Bq kg-1) in granite for K40 ranged between 259.8 ± 6.9 and 1608.5 ± 26.9. The activity concentration of Th232 ranged between 26.4 ± 0.8 and 57.6 ± 1.3: and that of Ra226 was between 6.6 ± 0.3 and 21.6 ± 07. Drinking water contains 2.98 ppm of fluoride. Dental fluorosis was diagnosed as mild to moderate. Conclusion The radionuclide activity in water, soil and granites were below the detection limit. Hence, the study revealed no association of fluorosis and radionuclide level in Pavagada, Karnataka, India. This helps resolve an ambiguity.
- Published
- 2020
44. Clinical outcome and course of Tenon's patch graft in corneal perforation and descemetocele
- Author
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Rakhi Kusumesh, Anita Ambastha, Ankita Singh, Divya Kumari, Nilesh Mohan, BibhutiP Sinha, and LalanK Arya
- Subjects
Cicatrix ,Ophthalmology ,Corneal Perforation ,Anterior Chamber ,Humans ,Eye Infections, Viral ,Retrospective Studies - Abstract
To assess the efficacy and clinical outcome of Tenon's patch graft (TPG) in corneal perforation and descemetocele.In this retrospective study, medical records of 83 patients (85 eyes) who underwent TPG for corneal perforation (58, 68%) or descemetocele (27, 32%) between July 2018 and October 2021 were reviewed. Clinical examination and anterior segment optical coherence tomography (AS-OCT) were performed on every follow-up visit. Anatomical success was considered as the restoration of the structural integrity with the formation of scar and anterior chamber (AC).The mean size of the corneal lesions (corneal perforation or descemetocele) was 4.20 ± 1.01 mm. The mean follow-up period was 9.2 ± 5.48 months. The common underlying etiologies were infectious keratitis in 48% and autoimmune disorders in 35% of cases. TPG successfully restored the globe integrity in 74 (87%) eyes (83% in perforation and 96% in descemetocele). Anatomical failure occurred in 11 eyes (13%). The failures were due to graft dehiscence (8 eyes), graft ectasia (1 eye), and scarring with flat AC (2 eyes). The median time to epithelialization and scar formation were 3 and 15 weeks, respectively. Logistic regression analysis showed few predictors for a successful outcome: descemetoceles, noninfective causes, viral keratitis in infectious etiology, and paracentral or peripheral lesions.TPG can be considered an effective and inexpensive treatment for restoring the structural integrity in the eyes with perforations and descemetoceles, particularly when the donor tissue is unavailable. AS-OCT is a valuable noninvasive tool for monitoring the graft status.
- Published
- 2022
45. Evaluation of gas resource potentiality, geochemical and mineralogical characteristics of Permian shale beds of Latehar-Auranga Coalfield, India
- Author
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Vivekanand Kumar, Jaywardhan Kumar, Vinod Atmaram Mendhe, Mollika Bannerjee, Bhagwan D. Singh, Divya Kumari Mishra, Atul Kumar Varma, Suresh Kumar Samad, Vinod Kumar Saxena, Sadanand Sharma, Subhashree Mishra, and Alka Damodhar Kamble
- Subjects
Materials science ,020209 energy ,Stratigraphy ,Mineralogy ,Geology ,02 engineering and technology ,engineering.material ,010502 geochemistry & geophysics ,01 natural sciences ,Catagenesis (geology) ,Diagenesis ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,Illite ,0202 electrical engineering, electronic engineering, information engineering ,engineering ,Kerogen ,Kaolinite ,Economic Geology ,Gas composition ,Van Krevelen diagram ,Oil shale ,0105 earth and related environmental sciences - Abstract
The shale beds associated with Permian coal-bearing Barakar Formation of the Latehar-Auranga coalfield (north Koel Valley), India have been investigated for the hydrocarbon prospects and their critical reservoir properties. The shale core samples were collected from boreholes drilled in three different blocks like Gowa, Jagaldaga and Banhardih. The shale core samples are examined for in-situ gas content, desorbed gas composition, geochemical, Rock-Eval, scanning electron microscopy (SEM), X-ray diffraction (XRD), high pressure CH4 adsorption isotherm, porosity and permeability aspects. The shales are rich in carbonaceous and silty materials with alternate bands of intercalations; suggesting deposition of the sediments and organic matters by slow or wavering river currents under the reducing environment. The van Krevelen diagram of H/C and O/C atomic ratio of the shales has demonstrated type III/IV kerogens; specifying that organic matters transformed from the fluvio-terrestrial depositional conditions to the diagenesis and catagenesis stages and placed in wet to dry gas window (H/C ratio The plots of hydrogen index (39.54–821.45 mg HC/g TOC) with calculated VRo (0.29–1.05%) and Tmax (414–456 °C) are signifying types I, II, III and IV kerogen in the shales prone to generate oil, wet and dry gas placed in immature to mature regions. The positive linear correlation of the VL with kaolinite and illite contents suggests that mainly clays contribute to the formation of shale matrix. The SEM images show six types of pore: i) lenticular open pores along the fissility, ii) altered pores due to weathering, iii) intergranular pores, iv) intermingled pores between crystal lattices, v) partially filled pores associated with clays and minerals, and vi) evolved pores by cracking of the organic compounds. The values of porosity and permeability have been measured under reservoir simulated confining pressure, and are ranging from 0.87–8.18% and 0.08–1.45 mD, respectively. This shows poor connectivity between the pores and fracture mechanisms controlled by the clay and minerals. It is summarized that the studied shales of Latehar-Auranga Coalfield have a low to moderate gas potential, based on their in-situ gas, TOC content (1.28–16.26 wt%), sorption capacity, Tmax values and thermal maturity. Moreover, the significant residual volume, low porosity and low permeability are the most critical properties for shale gas resource development at the Latehar-Auranga coalfield.
- Published
- 2018
46. Experimental and Theoretical Evaluation of Rutin as Eco-Friendly Corrosion Inhibitor for Aluminum 6063 Alloy in Acidic Medium
- Author
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P. D. Reena Kumari and Divya Kumari
- Subjects
Materials science ,Mechanical Engineering ,Inorganic chemistry ,Entropy of activation ,02 engineering and technology ,Activation energy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Dielectric spectroscopy ,Corrosion ,Corrosion inhibitor ,chemistry.chemical_compound ,Rutin ,Adsorption ,chemistry ,Mechanics of Materials ,Chemisorption ,General Materials Science ,0210 nano-technology ,Safety, Risk, Reliability and Quality - Abstract
The corrosion inhibition characteristics of rutin a natural flavonoid glycoside has been studied as an eco-friendly green inhibitor for corrosion control of aluminum alloy AA6063 in 0.5 M HCl medium at a temperature range of 30–60 °C by weight loss method, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) techniques. The inhibition efficiency increased with the increase in concentration of the inhibitor and also with increase in temperature. The surface morphologies of the polished, corroded and inhibited surfaces were scanned using the scanning electron microscope images. The activation parameters like energy of activation, enthalpy of activation and entropy of activation were calculated and analyzed. Thermodynamic parameters for the adsorption of the inhibitor on the metal alloy surface were calculated and analyzed. The inhibitor acted as a mixed inhibitor. The mechanism of adsorption deduced from the variation of inhibition efficiency with temperature as well as kinetic and activation parameters suggests significant chemisorption of the inhibitor on the metal surface. The mechanism of inhibition can partly be attributed to the possible coordination of rutin to form stable aluminum–rutin complex. The maximum inhibition efficiency was found to be 95.1 and 94.45% by PDP and EIS studies, respectively, at 60 °C. Density functional theory calculations under the level B3LYP/6-311G(d) is utilized for the calculation of quantum chemical parameters.
- Published
- 2018
47. Ecofriendly Fruit Switches: Graphene Oxide-Based Wrapper for Programmed Fruit Preservative Delivery To Extend Shelf Life
- Author
-
Pulkit Bindra, Divya Kumari, Sandeep Kr. Sharma, Tsering Stobdan, Vijayakumar Shanmugam, Badal Kumar Biswal, and Satish Kumar
- Subjects
Preservative ,Materials science ,Vacuum ,Graphene ,Hydrazine ,Oxide ,02 engineering and technology ,Chloroformate ,010501 environmental sciences ,021001 nanoscience & nanotechnology ,Shelf life ,Pulp and paper industry ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,Acid labile ,chemistry ,law ,Food Preservation ,Fruit ,Graphite ,General Materials Science ,Fruit juice ,0210 nano-technology ,0105 earth and related environmental sciences - Abstract
According to Food and Agriculture Organization 2015 report, post-harvest agricultural loss accounts for 20-50% annually; on the other hand, reports about preservatives toxicity are also increasing. Hence, preservative release with response to fruit requirement is desired. In this study, acid synthesized in the overripe fruits was envisaged to cleave acid labile hydrazone to release preservative salicylaldehyde from graphene oxide (GO). To maximize loading and to overcome the challenge of GO reduction by hydrazine, two-step activation with ethylenediamine and 4-nitrophenyl chloroformate respectively, are followed. The final composite shows efficient preservative release with the stimuli of the overripe fruit juice and improves the fruit shelf life. The composite shows less toxicity as compared to the free preservative along with the additional scope to reuse. The composite was vacuum-filtered through a 0.4 μm filter paper, to prepare a robust wrapper for the fruit storage.
- Published
- 2018
48. Pore geometrical complexity and fractal facets of Permian shales and coals from Auranga Basin, Jharkhand, India
- Author
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Divya Kumari Mishra, Vinod Atmaram Mendhe, Suresh Kumar Samad, and Atul Kumar Varma
- Subjects
Total organic carbon ,Chemistry ,business.industry ,020209 energy ,Energy Engineering and Power Technology ,Mineralogy ,Sorption ,02 engineering and technology ,010502 geochemistry & geophysics ,Geotechnical Engineering and Engineering Geology ,01 natural sciences ,chemistry.chemical_compound ,Fuel Technology ,Adsorption ,Desorption ,0202 electrical engineering, electronic engineering, information engineering ,Kerogen ,Coal ,business ,Pyrolysis ,Oil shale ,0105 earth and related environmental sciences - Abstract
The pore system is a significant factor for the hydrocarbon generation, storage and production. Several studies had been carried earlier by distinguished researchers on pore system characterization, where little information regarding a thermally immature basin has been discussed so far. To understand these, total fifty-one samples including 41-shales and 10-coals are taken for study from Barakar (L.Sakmarian-Kungurian) Formation of Auranga basin to investigate the pore characteristics of a low mature substance. This work provides information regarding a low mature basin having oil generation potential. For this, authors have carried low pressure N2 sorption, FE-SEM/EDX with rock eval pyrolysis, total organic carbon (TOC), ash yield, vitrinite reflectance and clay content. The low-pressure N2 sorption: BET (Brunauer-Emmett-Teller) and BJH (Barrett-Joyner-Halenda) are employed to analyze the pore size, area, geometry and its distribution. Shale samples have shown variation in the specific surface areas (BET) and pore volume from 7.43 to 30.36 m2/g and 0.019–0.069 cm3/g respectively; whereas coal samples exhibits these properties ranging from 3.13 to 17.2 m2/g and 0.08–0.31 cm3/g respectively. Here, two kinds of desorption curve have been observed: (a) sub-hysteresis types H2′ where rapid desorption (lacking a plateau at high pressure) indicating pipette shaped pore (b) hysteresis type H3 having slow rate of desorption suggesting slit shaped pore. The subtype H2′ i.e. lacking the plateau at high pressure has been distinguished under H2 hysteresis. The dominance of mesopores to macropores are deduced from BJH and presence of micropores were also observed in few samples from t-plot method. The Type II isotherms are observed dominantly in shales and few coal samples (27-shales; 3-coals) whereas Type IV isotherms (13 shales; 7 coals) are mainly noticed in coals and in limited number of shales. Moreover, the total organic carbon (TOC) content of the shale and coal samples ranges from 1.35 to 29.42 wt% and 32.38–63.46 wt% respectively. Tmax [temperature under S2 to release maximum amount of pyrolyzate from the kerogen under rock eval pyrolysis (REP)] range from 409 to 468 °C and 420–426 °C of shales and coals respectively indicating of immature to early mature stage of the sample. The TOC normalized-BET (BET*) in relation to ash yield exhibits the significance of mineral matter in the shales for pore formation. The relation of pyrolysis parameters (S1and S2) with BET* gives the indication of bitumen retention in the pore spaces of organic matter, which reduces their surface area in coals. Fractal geometry of the samples were also studied. The surface fractal dimensions viz. D1 (P/Po = 0.0–0.5) and D2 (P/Po = 0.5–1.0) both are calculated for the basin. The D1 (pore surface) varies from 1.9888 to 2.5530 and 1.8190–2.4430 for shales and coals respectively pointing towards surface heterogeneity and ruggedness of the surface favorable for increasing the adsorption capability. However, D2 (pore structure) for the shales and coals are placed in the range of 2.570–2.759 and 2.6150–2.7530 respectively indicating large heterogeneity of the pore structure causing high capillary condensation that reduces the adsorption ability. The FE-SEM with EDX study supports the analysis of pore structure, characteristics and fractal behaviour of shales and coals.
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- 2018
49. Twin Function of Zein–Zinc Coordination Complex: Wheat Nutrient Enrichment and Nanoshield against Pathogenic Infection
- Author
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Sandeep Sharma, Nitin Kumar Singhal, Tsering Stobdan, Divya Kumari, Vijayakumar Shanmugam, Mahmoud El Sadany, Badal Kumar Biswal, and Poonam Sagar
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chemistry.chemical_classification ,010405 organic chemistry ,Renewable Energy, Sustainability and the Environment ,Grain moisture ,General Chemical Engineering ,food and beverages ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Zinc ,Microbial contamination ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Coordination complex ,Nutrient ,chemistry ,Environmental Chemistry ,Food science ,0210 nano-technology ,Nutrient deficiency ,Function (biology) - Abstract
Cereal grains undergo a huge loss in storage, which is significantly due to microbial contamination; on the other hand, nutrient deficiency also coexists. Grain moisture is key for microbial contam...
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- 2018
50. Geochemical and organo-petrographic characterization for hydrocarbon generation from Barakar Formation in Auranga Basin, India
- Author
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Bhagwan D. Singh, Amal Kishore Prasad, Durga Charan Panigrahi, Atul Kumar Varma, Vinod Atmaram Mendhe, Divya Kumari Mishra, and Suresh Kumar Samad
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Total organic carbon ,Chemistry ,020209 energy ,Stratigraphy ,Maceral ,Mineralogy ,Geology ,02 engineering and technology ,Sporinite ,010502 geochemistry & geophysics ,01 natural sciences ,chemistry.chemical_compound ,Fuel Technology ,Inertinite ,0202 electrical engineering, electronic engineering, information engineering ,Kerogen ,Economic Geology ,Alginite ,Vitrinite ,Oil shale ,0105 earth and related environmental sciences - Abstract
Keeping in pace with global studies of shale gas/oil, the authors had selected fifty-one (41 shales and 10 coal) core samples of Barakar Formation (lower Sakmarian–Kungurian) from four boreholes of Auranga basin, to understand hydrocarbon generation potential. The Rock-Eval pyrolysis along with total organic carbon content (TOC), organo-petrographic, vitrinite reflectance, Fourier Transform infrared spectroscopy (FTIR), X-ray fluorescence (XRF) analyses were carried. These studies indicate that all the samples (coal and shale) have fair to excellent hydrocarbon generation in respect of TOC and S2 (under Rock-Eval pyrolysis). Further, the thermal maturity (Tmax) of shales and coals are placed in ranges from 409 to 468 and 420–426 °C respectively. However, vitrinite grains having reflectance > 0.60% (↑ Vt60%) may indicate the onset of thermogenic oil generation could possible in the majority of the samples. The presence of alginite, sporinite, resinite, liptodetrinite and suberinite along with perhydrous vitrinite and inertinite macerals is observed. The linear relationship of total maceral content (TMC) with TOC may help in their determination empirically. Multiple regression analysis denote maceral reactivity in the generation of S2. In addition, A-factor (aliphatic/aromatic peak intensity) and C-factor (carbonyl/aromatic peak intensity) under FTIR spectra, suggest dominance of kerogen type III, IV and II/III. The geochemical indices like CIA (chemical index of alteration), CIW (chemical index of weathering) and ICV (index of compositional variation) indicate strong to intermediate weathering, under passive continental margin depositional environment supporting luxurious vegetation and organic matter preservation.
- Published
- 2018
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