1. Radiotherapy of Prostate Carcinoma: A Comparison of the Predictive Role of EAU Versus NCCN Risk Stratification Systems
- Author
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Vincenzo Valentini, Gabriella Macchia, M. Ntreta, Milly Buwenge, Silvia Bisello, Anna Rita Alitto, Alessio G. Morganti, Francesco Deodato, Savino Cilla, Naama Dominsky, Giambattista Siepe, Buwenge M., Deodato F., Dominsky N., Ntreta M., Cilla S., Siepe G., Alitto A.R., Bisello S., Valentini V., Macchia G., and Morganti A.G.
- Subjects
Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Prostate neoplasm ,Risk Assessment ,Prostate cancer ,Retrospective Studie ,Internal medicine ,Humans ,Multicenter Studies as Topic ,Medicine ,Prostate neoplasms ,Risk stratification systems ,Definitive radiotherapy ,Adjuvant ,Retrospective Studies ,Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA ,NCCN ,Aged ,Salvage Therapy ,Radiotherapy ,business.industry ,Prostatic Neoplasms ,Cancer ,Radiotherapy Dosage ,Kallikrein ,General Medicine ,Prostate carcinoma ,Prostate-Specific Antigen ,medicine.disease ,Survival Analysis ,Risk stratification system ,Radiation therapy ,Observational Studies as Topic ,Treatment Outcome ,EAU ,Prostatic Neoplasm ,Risk stratification ,Kallikreins ,Radiotherapy, Adjuvant ,Survival Analysi ,business ,Human - Abstract
Background/aim To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer. Patients and methods One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. Results Both systems significantly predicted biochemical-relapse-free-survival, metastasis-free-survival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. Conclusion This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.
- Published
- 2020
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