1. Effect of polysaccharides from adlay seed on anti-diabetic and gut microbiota
- Author
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Li-Chun Chen, Shi-Yu Zhang, Hong-Yu Wang, Dong-Cheng Wen, and Zhong-Yang Fan
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,endocrine system diseases ,Gut flora ,Polysaccharide ,Streptozocin ,Diabetes Mellitus, Experimental ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Insulin resistance ,Glucagon-Like Peptide 1 ,Polysaccharides ,RNA, Ribosomal, 16S ,Internal medicine ,Diabetes mellitus ,medicine ,Animals ,Hypoglycemic Agents ,Insulin ,Pancreas ,Triglycerides ,Glycated Hemoglobin ,chemistry.chemical_classification ,Mice, Inbred ICR ,Amyloid beta-Peptides ,030109 nutrition & dietetics ,Triglyceride ,biology ,Chemistry ,General Medicine ,medicine.disease ,biology.organism_classification ,Peptide Fragments ,Gastrointestinal Microbiome ,Metabolic pathway ,Cholesterol ,030104 developmental biology ,Endocrinology ,Hyperglycemia ,Coix ,Seeds ,Hemoglobin ,Insulin Resistance ,Food Science - Abstract
Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance and β-cell dysfunction. This study aims to examine the effects of polysaccharides from adlay seeds (PAS) on hyperglycemia and gut microbiota in streptozocin (STZ)-induced diabetic mice. The administration of PAS in diabetic mice caused a significant decrease in the glucose level and serum levels of glycosylated hemoglobin (HbA1c). Similarly, PAS also showed decreased total cholesterol (TC) and triglyceride (TG) concentrations. Furthermore, a significant increase in the concentrations of glucagon-like peptide 1 (GLP-1) was observed. Unexpectedly, PAS reduced the concentrations of anti-amyloid beta (Aβ1-42) protein. Also, histopathological examination showed that PAS contributed to the reduction of STZ-lesioned pancreatic cells. Metformin treatment significantly reduced the diversity of the gut microbiota, while PAS treatment altered the diversity and composition of the microbiota. Collectively, our findings demonstrate that the hypoglycemic effects of PAS in type-2 diabetic mice (T2D) may be associated with the regulation of the intestinal microbiota and its metabolic pathways.
- Published
- 2019