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3. Rheological effects of air drilling fluids on cuttings transportation in underbalanced drilling

Author

null Hudaifa A. Kassim, null Elhassan M. Abdallah, null Faleh H.M. Almahdawi, and null Yasir M. F. Mukhtar

Subjects
General Medicine
Abstract

This research investigates factors influencing cuttings transport efficiency in air drilling operations, aiming to understand the underlying mechanisms, identify critical factors, and optimize drilling parameters for enhanced performance. The methodology includes a literature review, computational fluid dynamics (CFD) simulations, and sensitivity analysis of air velocity, drilling fluid properties, cuttings size, and outlet pressure. CFD simulations were employed to model the multi-phase flow in the annulus during air drilling, examining the effects of varying air velocities, cuttings sizes, and outlet pressures on cuttings transport and hole cleaning efficiency. Results show that increased air velocity improves cuttings transport and hole cleaning but may cause higher pressure drops and borehole erosion. Air drilling fluids' unique rheological properties significantly impact cuttings transportation, requiring careful consideration of factors like air velocity, aerodynamic lift, hole cleaning efficiency, annular pressure losses, and potential cuttings accumulation. The study reveals that cuttings size is crucial for transport efficiency, with larger cuttings necessitating higher air velocities for effective transport and being more prone to settling and accumulation. Moreover, the research demonstrates that increasing outlet pressure typically enhances cuttings transport efficiency in horizontal wells. In conclusion, this study offers valuable insights into factors affecting cuttings transport efficiency in air drilling operations, providing recommendations for optimizing drilling parameters to balance efficient cuttings removal, hole cleaning, and minimal pressure drop. The findings hold practical implications for air drilling operations' design and execution, with the potential to improve drilling performance and reduce operational risks.

Published
2023

6. Assessment of Male Medical Students' Knowledge and Attitudes About Prostate Cancer and Screening at the University of Khartoum

Author

Kamal Elhassan, Mohammed Mohammed, Nimat Elhassan, Abd Altoum, Asaad Babker, Ayman Alfeel, Ahmed Osman, and Salah Hussein

Subjects
General Immunology and Microbiology, General Neuroscience, General Biochemistry, Genetics and Molecular Biology
Abstract

Background: Prostate cancer (PC) is the most common cancer among men in Sudan. It was ranked fourth among all cancer treatment centers in Khartoum. This study aimed to assess knowledge and attitude toward PC among male medical students in their final and semifinal years at the University of Khartoum. Methods and Results: A descriptive cross-sectional online survey was conducted at the University of Khartoum (Faculty of Medicine) on semifinal and final-year male medical students from March 2022 until May 2022. Data were collected from medical students, using a standardized, pretested, coded questionnaire that contained close-ended questions. The questionnaire was distributed online to the medical students using Google Forms. Knowledge levels were determined using 10 questions on risk factors, signs and symptoms, prevention, treatment, and complications of PC. A total of 131 participants received questionnaires, and the response rate was 100%. The results are presented in chronological order in the way they were analyzed, starting with sociodemographic characteristics of the participants, sources of information on PC, knowledge levels (low, medium, and high) of PC, and attitude levels (positive, negative) relating to the year of study. All medical students in the last 2 years have heard about PC, and medical students overwhelmingly (88.5%) believe that early detection of PC through screening improves survival. Almost all the respondents in our study indicated their willingness to go for PC screening (87.8%), and the rest of the respondents’ attitudes about the importance of PC and treatment were positive. Conclusion: Most students have sufficient knowledge about prostate cancer, its risk factors, complications, and treatment. Medical students are an important population in studying the determinants of screening for prostate cancer.

Published
2022

9. Bitumen Stabilised Open Graded Base Materials

Author

Cheah Nelson, Jayakumar Muthuramalingam, Saad Hamad Elhassan, and Nicholas Tam

Abstract

Roads play a crucial role in fostering economic growth and providing social advantages in every nation. However, over time, road infrastructure can become outdated. According to studies conducted by World Highways, a road may seem to be in good condition on the surface while hiding a severe issue beneath. As a result, periodic maintenance, repairs, or modernization may be necessary for road structures. The primary purpose of this project was to investigate the effects of permeability on road base materials by removing particles and restoring strength through stabilization with bitumen. Optimum grade 60/70 bitumen was used in compliance with Malaysia JKR specifications to create a realistic case scenario. The formulation excluded open-graded road base material with particles smaller than 1.18 mm or 2.0 mm, and bitumen stabilization levels of 0%, 2%, 2.5%, and 3% were implemented to reduce the decrease in mechanical strength. The mechanical strength was determined using the California Bearing Ratio (CBR) test, while a Constant Head Method Permeability test was conducted to identify the optimal design mix with the maximum achievable permeability coefficient. The results showed that bitumen stabilization increased the mechanical strength of the road base material, with the highest result compensating for the drop by 8.7%. With open-graded road base material, the permeability can be increased by up to 17.2%. Therefore, open-graded road foundation material with bitumen as a binder for stabilization can be used in the construction of pavements in Malaysia, an area with relatively high rainfall intensity.

Published
2023

10. Detection of Microbiological Activity in Some Collected Water Samples near Dumping Site of Solid Waste, Khartoum North, Sudan

Author

Omer Abbass Elamin Abbass, Abdelelah Mohamed Elhassan, Abdelgadir Elfadil Abdelgadir, and Mariam Hamdan Mohamed

Abstract

A study was conducted at the Wadafiea landfill in Al Khartoum Bahri (North), Sudan, to determine the level of microbial contamination in water samples collected from nearby areas around the landfill. The purpose of this study was to evaluate the impact of solid waste disposal in open dumps and assess the associated risks to water. The study tested for coliform bacteria (E.coli) and compared the seasonal differences between the samples collected during the dry and rainy seasons. The results indicated higher levels of E.coli contamination in each season, with the rainy season samples showing particularly high levels (66.03 × 10⁴ cfu/ml) compared to the dry season (31.93 × 10⁴ cfu/ml). It was concluded that the groundwater was highly polluted due to the current landfill location. The local authorities and the department of solid waste management were advised to close this landfill and relocate it to the outskirts of Al Khartoum Bahri (North) city. Additionally, it was recommended that international regulations for standard landfills should be maintained and implemented.

Published
2023

12. Evaluation of Genetic Diversity of Sesame (Sesamum indicum L.) Genotypes, Using Agro Morphological and Molecular Markers (RAPD)

Author

Atif Elsadig Idris, Atif Ibrahim Abuali, Marmar A. El Siddig, Abdelsalam Kamil Abdelsalam, Bakri Mohammed Elhassan Osman, and Omer Ahamed Mohamed Omer

Subjects
General Medicine
Abstract

The purpose of this study was to look at the genetic variation in seventeen genotypes of sesame (Sesamum indicum L.) from different agro-climatic regions of Sudan, using both agro-morphological traits and RAPD markers. From July 13 to November 2013, the field experiment was conducted on the experimental farm of the College of Agricultural Studies, Sudan University of Science and Technology, Shambat. A randomized complete block design (RCBD) with three replications was employed in this investigation. The seventeen sesame genotypes had their nine growths and yield parameters assessed, the number of branches, the height of the first capsules, the number of capsules per plant, and the weight of 1000 seeds all showed a highly significant difference. There were no statistically significant differences between the two groups (p≥0.05). The plant's height and days to 50% flowering were counted. The number of capsules per plant and seed weight showed the largest genotypic and phenotypic variance. The heritability value was greater when 1000 seeds were used. On the other hand, plant height had the lowest rating. The Highland genotype had the maximum yield (0.2506 ton/ha). Seed yield (ton/ha) was found to be highly associated with seed output per plant, capsule number per plant, and stem diameter. However, there was a non-significant, inverse relationship between height to first capsule and days to flowering. Molecular DNA marker (RAPD) analysis revealed that three RAPD primers chosen for molecular analysis had 170 bands, 130 of which were polymorphic (76.47%). The results based on high genetic variation for agro-morphological traits and polymorphism at DNA level indicating that, the techniques was efficient in determining diversity among sesame genotypes and this information will be useful for collection, conversation and breeding program in the future.

Published
2023

13. Corneal Abscess on Mini-scleral Contact Lens: Clinical Case

Author

Akannour Younes, Akhdari Meryem, Khalil Mrad, Kamal Elmajdoubi Idrissi Louai Serghini, Abdallah Elhassan, and Berraho Amina

Subjects
Immunology
Abstract

Mini-scleral lens’ are large diameter rigid lenses that are used to rehabilitate vision when the corneal shape is distorted from disease, scarring or after a corneal graft procedure, however, there are relatively few reports regarding their potential complications, in this case we describe the case of a corneal abscess in a mini-scleral lens wearer with keratoconus in order to determine whether this type of contact lens presents an increased risk of infection.

Published
2023

17. A Study of Some Properties of Fuzzy Laplace Transform with Their Applications in Solving the Second-Order Fuzzy Linear Partial Differential Equations

Author

Elhassan Eljaoui and Said Melliani

Subjects
Computational Mathematics, Control and Optimization, Article Subject, Control and Systems Engineering
Abstract

In this paper, several results and theorems about the high-order strongly generalized Hukuhara differentiability of function defined via the fuzzy Riemann improper integral (in the sense of Wu) have been established. Then, some properties dealing with the partial derivatives of fuzzy Laplace transform for a fuzzy function of two real variables have been proved. Afterwards, an algorithm of fuzzy Laplace transform for solving second-order fuzzy partial differential equations has been proposed. Finally, two numerical examples, including the heat equation under fuzzy initial conditions, have been studied to justify the efficiency of the algorithm.

Published
2023

18. Assessment of the Physiochemical Characteristics of Water Samples from Vicinity Area of Wadafiae Landfill, Khartoum North, Sudan

Author

Omer Abbass Elamin, Abdelelah Mohamed Elhassan, Abdelgadir Elfadil Abdelgadir, and Mariam Hamdan Ahmed

Abstract

The rapid increase in population, urbanization, industrialization, and changes in consumption patterns have given rise to many environmental problems, which mainly include air, land, and water pollution. In Khartoum North, Khartoum State, Sudan, there was a lack of a compatible solid waste management system. These resulted in a decline in environmental health, and the majority of the yards were turned into dumps (kusha). The current study focused on the effects of uncontrolled dumping of municipal solid waste on groundwater, as well as assessing the risk of physiochemical concentrations in the water around the dumpsite and comparing the differences between the dry and rainy seasons in water samples at Wadafiea Dumpsite, Khartoum North, Sudan. Water parameters such as TSS, Cl⁻, TDS, Ca, Mg, SAR, and Na exceeded the controlled 1 (1.333) and 2 (1.332) levels of water and were within the Sudanese Maximum Values, the bounds of Canadian Guideline Values, and WHO Values.

Published
2023

19. Adipose tissue function and insulin sensitivity in syndromic obesity of Bardet-Biedl syndrome

Author

Shanat Baig, Subadra Wanninayake, Lukas Foggensteiner, Yasir S Elhassan, Konstantinos Manolopoulos, Sadaf Ali, Pierre Bel Lassen, Karine Clément, Richard P Steeds, Jeremy W Tomlinson, and Tarekegn Geberhiwot

Subjects
Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)
Abstract

ContextBardet–Biedl syndrome (BBS) is a rare autosomal recessive syndromic obesity of childhood onset among many other features. To date, the excess risk of metabolic complications of severe early-onset obesity in BBS remains controversial. In-depth investigation of adipose tissue structure and function in link with detailed metabolic phenotype has not been investigated yet.ObjectiveTo investigate adipose tissue function in BBSDesignA prospective cross-sectional study.Main outcome measureTo determine if there are differences in insulin resistance, metabolic profile, adipose tissue function and gene expression in patients with BBS compared to BMI-matched polygenic obese controls.Method9 adults with BBS and 10 controls were recruited from the national centre for BBS, Birmingham, UK. An in-depth study of adipose tissue structure and function along with insulin sensitivity was performed using hyperinsulinemic-euglycemic clamp studies, adipose tissue microdialysis, histology and RNA sequencing, and measurement of circulating adipokines and inflammatory biomarkers.ResultsAdipose tissue structure, gene expression and in-vivo functional analysis between BBS and polygenic obesity cohorts were similar. Using hyperinsulinemic-euglycemic clamp and surrogate markers of insulin resistance, we found no significant differences in insulin sensitivity between BBS and obese controls. Furthermore, no significant changes were noted in an array of adipokines, cytokines and pro-inflammatory markers.ConclusionAlthough childhood-onset extreme obesity is a feature of BBS, detailed studies of insulin sensitivity and adipose tissue structure and function are similar to common polygenic obesity. This study adds to the literature by suggesting that it is the quality and quantity of adiposity not the duration that drives the metabolic phenotype.

Published
2023

20. Evaluation of Teachers Awareness Regarding Common Behavioral Problems among School Age Children in Shendi Town (Ashagalwa Village)

Author

Shireen Ebdelfatah Mohammed Aloob, Fatima OsmanAli, Marim Elnageeb, Lyma Alhadi, Fiza Ahmed Seed, Asgad Fath Alrhman Hassan, Namarig Hamid Ahmed, Malak Mohamed Elhassan, and Shema Mohammed

Subjects
General Energy
Abstract

Background: One of the most challenging aspects of teaching is dealing with students' behavioral issues because they interfere with lessons and produce an unsuitable learning environment. All students have a variety of emotional and personal struggles when they first enter school, which can make their behavior undesirable and challenging to change. Objectives: The main goal of this study to evaluate teachers awareness regarding common behavioral problems among school age children. Methods: Descriptive cross sectional community based study done to assess teachers awareness regarding Common behavioral Problems among school age Children in Al shaqalwa village during period extended from November to June 2022 , the enrolled (52) teachers through multi stage simple random sampling ,questionnaire use for data collection composed of (23) questions finally the data was analyzed by statistical package for social science (SPSS) version (21) then the data was represented in form tables and figures. Results: The result of the present study showed that more than half (55.8%) of study group had poor knowledge about behavioral Problems only (11.5%) of study group had good knowledge about the causes of behavioral Problems and (28.8%) of them had fair knowledge about the causes of behavioral Problems inside the School. Conclusion: The study concluded that studied teachers awareness regarding common behavior problems in (55.8%) was poor also (17%) fair about causes of behavioral problem and only (7.7%) had was good awareness regarding dealing with difficult behavior.

Published
2023

22. The liberal use of magnetic resonance cholangiopancreatography can be switched over to its selective use to detect choledocholithiasis

Author

Altaf G. Haji, null Ali M. Elhassan, Mahmoud Elkadi, Naveen Sivakumar, Aftab Ahmad, null Syed I. Haider, Bala Piramanayagam, and Amitabh Palit

Subjects
General Medicine
Abstract

Background: Gallstone disease is known in 10-15% of adults in Western populations. Magnetic resonance cholangiopancreatography (MRCP) is the investigation of choice for choledocholithiasis; however, its use is varied, and guidelines are not well defined. The National Institute for Health and Care (NICE) guidelines recommends MRCP to be done when common bile duct (CBD) dilatation ≥8 mm or liver function tests (LFTs) are abnormal but do not quantify this further. The liberal use of MRCP is gaining popularity as a roadmap prior to cholecystectomy, aiming to assess primarily for the presence of migrated gallstones within the cystic duct or common bile duct, as well as providing information regarding the anatomical features of the extrahepatic biliary tree on an individualised basis. Due to these reasons MRCP at times is done unnecessarily which creates economic burden and restricts access to patients in real need of imaging slots. Methods: It is hospital based retrospective observational study. Time frame was July 2021 to July 2022 and sample size was 230 patients. Results: Our study showed that isolated elevated alanine aminotransferase (ALT) level should not be reason to evaluate patients for choledocholithiasis. It concluded that elevated serum bilirubin levels, alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) are the strongest predictors of CBD stones in patients with gallstone disease and hence can be used to triage patients for undergoing MRCP. Conclusions: To conclude elevated serum bilirubin levels, ALP and GGT are the strongest predictors of CBD stones in patients with gallstone disease and hence can be used to triage patients for undergoing MRCP. Isolated elevated ALT should not be a reason to evaluate patients for CBD stones.

Published
2023

27. The Relationship Between FoxP3 and SOCs3 Gene Expressions and Disease Activity in Rheumatoid Arthritis

Author

Haneya A. A. Anani, Amany M. Tawfeik, Omnia A. El-dydamoni, Hend M. Maghraby, Eman Elshohat, Nora Seliem, Hanaa A. Abou elhassan, and Eman A. Kassem

Subjects
Rheumatology
Abstract

Background: Immune dysregulation plays an important role in the pathogenesis of rheumatoid arthritis (RA). The CD4+CD25 high FoxP3+ subset of regulatory T cells plays an essential role in preventing autoimmunity and maintaining immune homeostasis. Negative regulation of JAK/STAT signaling is controlled by Suppressor of Cytokine Signaling (SOCs3) proteins. SOCs is produced at lower levels in RA. Our aim was to evaluate the expressional dysregulation of SOCs3 and FoxP3 genes in RA patients in relation to disease activity. Methods: We have recruited 90 patients with RA and 60 healthy controls in case control study. Whole blood samples were collected from RA patients and healthy subjects. The measurement of FoxP3 and SOCs3 gene expression was performed by real-time PCR (qPCR). Results: Patients with RA had significantly decreased expression levels of FoxP3 and SOCs3 genes in comparison with controls (P Conclusion: FoxP3 and SOCs3 genes showed significant defects in rheumatoid arthritis patients with no significant difference in disease activity.

Published
2023

28. Monumental Stone Structure Archaeology in Northwest Saudi Arabia: New Investigations from the Al Ha’it Oasis

Author

Ahmed Nassr, Ahmed Elhassan, Ali Tueaiman, and Mohammed al-Hajj

Subjects
Archeology, Conservation
Abstract

Increased archaeological fieldwork in Saudi Arabia is contributing toward a more precise general idea about ancient Arabia. Moreover, the history of Arabian archaeology demonstrates that major discoveries and advances have been achieved as a result of systematic field enterprises. However, several regions in Saudi Arabia remain unstudied. One such major area is Ha’il in the north. Our intensive desktop-archaeological survey using remote sensing revealed the region’s archaeological richness. Several monumental structures were observed in the al Ha’it oasis. Based on those findings, we conducted an archaeological survey and excavations, resulting in the discovery of eight new archaeological sites. Three major types of funerary stone structures identified in this area include pendants, tumuli, and tower tombs. In addition, we encountered mustatils and kites of the Neolithic and Bronze Age. This article presents the investigations carried out in these new sites and places them within the context of Arabian archaeology.

Published
2023

29. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Author

Global Health Research Unit on Global Surgery, National Institute for Health and Care Research, Adisa, Adewale, Bahrami-Hessari, Michael, Bhangu, Aneel, George, Christina, Ghosh, Dhruv, Glasbey, James, Haque, Parvez, Ingabire, J C Allen, Kamarajah, Sivesh Kathir, Kudrna, Laura, Ledda, Virginia, Li, Elizabeth, Lillywhite, Robert, Mittal, Rohin, Nepogodiev, Dmitri, Ntirenganya, Faustin, Picciochi, Maria, Simões, Joana Filipa Ferreira, Booth, L, Elliot, R, Kennerton, A S, Pettigrove, K L, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, John W D, Smith, A, Sayed, A Emad, Goswami, Aakansha Giri, Malik, Aamer, Mclean, Aaron Lawson, Hassan, Abbas, Nazimi, Abd Jabar, Aladna, Abdallah, Abdelgawad, Abdalrahman, Saed, Abdel, Abdelmageed, Abdelfatah, Ghannam, Abdelilah, Mahmoud, Abdelrahman, Alvi, Abdul, Ismail, Abdulaziz, Adesunkanmi, Abdulhafiz, Ebrahim, Abdulla, Al-Mallah, Abdullah, Alqallaf, Abdullah, Durrani, Abdullah, Gabr, Abdullah, Kirfi, Abdullahi Musa, Altaf, Abdulmalik, Almutairi, Abdulmjeed, Sabbagh, Abdulrahman J, Ajiya, Abdulrazak, Haddud, Abdurrahman, Alnsour, Abed Alfattah Mahmoud, Singh, Abhinav, Mittal, Abhishek, Semple, Abigail, Adeniran, Abiodun, Negussie, Abraham, Oladimeji, Abraham, Muhammad, Abubakar Bala, Yassin, Abubaker, Gungor, Abuzer, Tarsitano, Achille, Soibiharry, Adaiah, Dyas, Adam, Frankel, Adam, Peckham-Cooper, Adam, Truss, Adam, Issaka, Adamu, Ads, Adel Mohamed, Aderogba, Adeleke Akeem, Adeyeye, Ademola, Ademuyiwa, Adesoji, Sleem, Adham, Papa, Adrian, Cordova, Adriana, Appiah-Kubi, Adu, Meead, Adullah, Nacion, Aeris Jane D, Michael, Afieharo, Forneris, Agustin Albani, Duro, Agustin, Gonzalez, Agustin Rodriguez, Altouny, Ahmad, Ghazal, Ahmad, Khalifa, Ahmad, Ozair, Ahmad, Quzli, Ahmad, Haddad, Ahmad, Othman, Ahmad Faidzal, Yahaya, Ahmad Shuib, Elsherbiny, Ahmed, Nazer, Ahmed, Tarek, Ahmed, Abu-Zaid, Ahmed, Al-Nusairi, Ahmed, Azab, Ahmed, Elagili, Ahmed, Elkazaz, Ahmed, Kedwany, Ahmed, Nuhu, Ahmed Mohammed, Sakr, Ahmed, Shehta, Ahmed, Shirazi, Ahmed, Mohamed, Ahmed Mohamed Ibrahim, Sherif, Ahmed Elshawadfy, Awad, Ahmed K, Abbas, Ahmed M, Abdelrahman, Ahmed Saber, Ammar, Ahmed Siddique, Azzam, Ahmed Y, Ciftci, Ahmet Burak, Dural, Ahmet Cem, Sanli, Ahmet Necati, Rahy-Martín, Aida Cristina, Tantri, Aida Rosita, Khan, Aimal, Al-Touny, Aiman, Tariq, Aiman, Gmati, Aimen, Costas-Chavarri, Ainhoa, Auerkari, Aino, Landaluce-Olavarria, Aitor, Puri, Ajay, Radhakrishnan, Ajay, Ubom, Akaninyene Eseme, Pradhan, Akhilesh, Turna, Akif, Adepiti, Akinfolarin, Kuriyama, Akira, Kassam, Al-Faraaz, Hassouneh, Ala, El-Hussuna, Alaa, Habeebullah, Alaa, Ads, Alaa Mohamed, Mousli, Alaa, Biloslavo, Alan, Hoang, Alan, Kirk, Alan, Santini, Alasdair, Melero, Alba Vazquez, Calvache, Albaro José Nieto, Baduell, Albert, Chan, Albert, Abrate, Alberto, Balduzzi, Alberto, Sánchez, Alberto Cabañero, Navarrete-Peón, Alberto, Porcu, Alberto, Brolese, Alberto, Barranquero, Alberto G, Saibene, Alberto Maria, Adam, Albushra Altayeb, Vagge, Aldo, Maquilón, Alejandra Jara, Leon-Andrino, Alejandro, Sekulić, Aleksandar, Trifunovski, Aleksandar, Mako, Aleksandro, Bedada, Alemayehu Ginbo, Broglia, Alessandro, Coppola, Alessandro, Giani, Alessandro, Grandi, Alessandro, Iacomino, Alessandro, Moro, Alessandro, D’amico, Alessia, Malagnino, Alessia, Tang, Alethea, Doyle, Alex, Alfieri, Alex, Haynes, Alex, Wilkins, Alex, Baldwin, Alexander, Heriot, Alexander, Laird, Alexander, Lazarides, Alexander, O'connor, Alexander, Trulson, Alexander, Rokohl, Alexander Christopher, Caziuc, Alexandra, Triantafyllou, Alexandra, Anesi, Alexandre, Nikova, Alexandrina, Andrianakis, Alexandros, Charalabopoulos, Alexandros, Tsolakidis, Alexandros, Chirca, Alexandru, Arnaud, Alexis P, Narvaez-Rojas, Alexis Rafael, Kavalakat, Alfie, Spina, Alfio, Recordare, Alfonso, Annicchiarico, Alfredo, Conti, Alfredo, Mohammed, Alhassan Datti, Kocataş, Ali, Almhimid, Ali, Arnaout, Ali, Fahmy, Ali, Mangi, Ali, Modabber, Ali, Ulas, Ali Bilal, Mohamedahmed, Ali Yasen Y, Frontali, Alice, Moynihan, Alice, Yunus, Alif, Ahmad, Aline, Kent, Alistair J, Khamees, Almu'atasim, Ugwu, Aloy Okechukwu, Turan, Alparslan, Mohammed, Alsnosy Abdullah Khalefa, Navarro-Barrios, Alvaro, Yebes, Alvaro, De Sousa, Álvaro Francisco Lopes, Moreno, Amabelle, Sethi, Aman, Dawson, Amanda Caroline, Othman, Amani Alsayd Abdulsalam, Kaur, Amanjot, Wolde, Amanuel, Antonelli, Amedeo, Scifo, Amedeo, Alhamad, Ameen, Davis, Amelia, Alderazi, Amer, Harky, Amer, Mohammed-Durosinlorun, Amina, Seguya, Amina, Okhakhu, Amina, Chamakhi, Amine, Sebai, Amine, Souadka, Amine, Asla, Amir, Agrawal, Amit, Persad, Amit, Gupta, Amit, Elgazar, Amr, Kulkarni, Amruta, Coates, Amy, Bellés, Ana Ciscar, Hadzibegovic, Ana Danic, Jotic, Ana, Kowark, Ana, Martins, Ana, Pineda, Ana Mejía, Peral, Ana, Gollarte, Ana Sánchez, Senent-Boza, Ana, Camarena, Ana Isabel Avellaneda, Castaño-Leon, Ana M, Bravo, Ana Maria Minaya, Moro, Ana María Gimeno, Musina, Ana-Maria, Tapia-Herrero, Ana-María, Kothari, Anai, Gupta, Anand, Raja, Anand, Aljaiuossi, Anas, Taha, Anas, Majbar, Anass Mohammed, Prodromidou, Anastasia, Kanatas, Anastasios, Gupte, Anaya, Zakaria, Andee Dzulkarnaen, Balla, Andrea, Barberis, Andrea, Bondurri, Andrea, Bottari, Andrea, Costantino, Andrea, Figus, Andrea, Lauretta, Andrea, Mingoli, Andrea, Romanzi, Andrea, Sagnotta, Andrea, Scacchi, Andrea, Picchetto, Andrea, Valadez, Andrea Estefania Cueto, Luzzi, Andrea-Pierre, Älgå, Andreas, Fontalis, Andreas, Hecker, Andreas, Demetriades, Andreas K, Serban, Andreea-Madalina, Văcărașu, Andrei Bogdan, Cokan, Andrej, Isaza-Restrepo, Andres, Beamish, Andrew, Schache, Andrew, Stevenson, Andrew, Yiu, Andrew, Cockbain, Andrew J, Litvin, Andrey, Abad-Motos, Ane, Becerra, Angel, Ramos, Ángel Cilleruelo, Chiaradia, Angela, Dell, Angela, Romano, Angela, Pascale, Angelo, Marra, Angelo Alessandro, Dimas, Angelos, Kolias, Angelos, Cerovac, Anis, Koneru, Anish, Tidjane, Anisse, Agbeko, Anita Eseenam, Bajaj, Ankur, Gosain, Ankush, Allan, Anna, Carreras-Castañer, Anna, D'amore, Anna, Dare, Anna, Maffioli, Anna, Palepa, Anna, Paspala, Anna, Konney, Anna, Gatta, Anna Nunzia Della, Ezanno, Anne-Cecile, Yiallourou, Anneza, Kinnair, Anthony, Rayner, Anthony, Scafa, Anthony Kevin, Bowan, Antoinette Bediako, Veglia, Antonella, Russo, Antonino, Maniaci, Antonino, Castaldi, Antonio, Gil-Moreno, Antonio, Maffuz-Aziz, Antonio, Meola, Antonio, Nenna, Antonio, Ferrer, Antonio Perez, Bonilla, Antonio Ramos, Ramos-De La Medina, Antonio, Infante, Antonio Rodriguez, Santoro, Antonio, Laganà, Antonio Simone, Bateman, Antony, Michael, Antony Louis Rex, Abozid, Anwaar, Seidu, Anwar Sadat, Lowery, Aoife, Tantraworasin, Apichat, Rasheed, Aqsa, Picciariello, Arcangelo, Isik, Arda, Saif, Areeba, Anjum, Arfa, Ioannidis, Argyrios, Abeldaño, Ariel, Hussain, Arif, Nathan, Arjun, Bedzhanyan, Arkady, Perfecto, Arkaitz, De Virgilio, Armando, Galvan, Armando, Sablotzki, Armin, Böttcher, Arne, Pellacani, Arrigo, Gatti, Arthur, Ibrahimli, Arturan, Menon, Arun, Sahni, Arun, Mwenda, Aruyaru Stanley, Choudhry, Asad, Jayawardane, Asanka, Gupta, Ashish, Ramasamy, Ashok, Mitul, Ashrarur Rahman, Bawa, Ashvind, Nugur, Ashwani, Rammohan, Ashwin, Sachdeva, Ashwin, Mehraj, Asif, Yildirim, Asif, Alqaseer, Asma, Radwan, Asmaa, Sallam, Asser, Syllaios, Athanasios, Tampakis, Athanasios, Alwael, Athari, Samara, Athina, Eroglu, Atilla, Rahman, Atiqur, Ulkucu, Attila, Zaránd, Attila, Dulskas, Audrius, Tawiah, Augustine, Zani, Augusto, Vas, Aurelia, Lukosiute-Urboniene, Ausra, Adamu, Auwal, Aujayeb, Avinash, Malik, Awais Amjad, İplikçi, Ayberk, Mahmud, Ayesha, Cil, Aylin Pelin, Makanjuola, Ayomide, Akwaisah, Ayoub, Galandarova, Aysuna, Saracoglu, Ayten, Regan, Azel, Barlas, Aziz Mutlu, Alhassan, Baba Alhaji Bin, Mostafa, Badr, Hamida, Baha Ben, Torun, Bahar Canbay, Abdullah, Bahiyah, Balagobi, Balasingam, Banky, Balazs, Singh, Baljit, Alegbeleye, Bamidele, Yigit, Banu, Hajjaj, Baraa Nabil, Burgos-Blasco, Barbara, Seeliger, Barbara, Alayande, Barnabas, 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R, Mohan, R, Singh, R, Sivaprakasam, R, Seenivasagam, R, Rajendram, R, Radulescu, R, Goicea, R, Seshadri, R, Sarı, R, Nataraja, R, Aslam, R, Abdelemam, R, Shrestha, R, Bharathan, R, Pellini, R, Guevara, R, Agarwal, R, Vissapragada, R, Alharmi, R, Sayyed, R, Browning, R, Critchley, R, Mallick, R, Alarabi, R, Beron, R, Függer, R, Othman, R, Saad, R, Amores, R, Colombari, R, Radivojević, R, Patrone, R, Novysedlák, R, Huatuco, R, Baertschiger, R, Liang, R, Luckwell, R, Escrevente, R, Rezende, R, Cruz, R, Lenzi, R, Rosati, R, Donovan, R, Egan, R, Morris, R, Page, R, Seglenieks, R, Unsworth, R, Wilkin, R, Skipworth, R, Davies, R, Bezirci, R, Talwar, R, Azami, R, Bohmer, R, Crichton, R, Fruscio, R, Hooker, R, Jach, R, Parker, R, Pillerstorff, R, Sinnerton, R, Stabler, R, O'Connell, R, Ragozzino, R, Tutino, R, Angelico, R, Cammarata, R, Colasanti, R, Macchiavello, R, Peltrini, R, Pirrello, R, Vaschetti, R, Pires, R, Papalia, R, Arrangoiz, R, Hompes, R, Salah, R, Pinto, R, Flumignan, R, Callan, R, Cuthbert, R, Dennis, R, Scaramuzzo, R, Macías, R, Sánchez, R, Ogu, R, Ramely, R, Sgarzani, R, Ramli, R, Hillier, R, Thumbadoo, R, Ooi, R, Abdus-Salam, R, Masri, R, Hodgson, R, Mathew, R, Wade, R, D'Archi, S, Khan, S, Ngaserin, S, Kale, S, Hassan, S, Merghani, S, Benamar, S, Muhammad, S, Badran, S, Elsahli, S, Heta, S, Hammouche, S, Baeesa, S, Paiella, S, Eldeen, S, Arkani, S, Mittal, S, Hirji, S, Tebha, S, Emile, S, Dbouk, S, Bandyopadhyay, S, Olori, S, Asirifi, S, Hailu, S, Ling, S, Newman, S, Ross, S, Wanjara, S, Kumar, S, Seneviratne, S, Tamburello, S, Suarez, S, Ingallinella, S, Irshaidat, S, Konswa, S, Mambrilla, S, Nasser, S, Parini, S, Pitoni, S, Ornaghi, S, Rodrigues, S, Abdelmohsen, S, Aitken, S, Tian, S, Badiani, S, Ahmad, S, Swed, S, Muthu, S, Lakpriya, S, Alzahrani, S, Mikalauskas, S, Lasrado, S, Satoskar, S, Bawa, S, Altiner, S, Garcia, S, Stevens, S, Demir, S, Ken-Amoah, S, Tranca, S, Ziemann, S, Awad, S, Atici, S, Subramaniam, S, Erel, S, Jiang, S, Efetov, S, Efremov, S, Katorkin, S, Valladares, S, Contreras, S, Meriç, S, Zenger, S, Safi, S, Leventoğlu, S, Elsalhawy, S, Shaikh, S, Sheik, S, Islam, S, Shamim, S, Waqar, S, Farid, S, Seraj, S, Sundarraju, S, Karandikar, S, Sambhwani, S, Chopra, S, Chowdhury, S, Laura, S, Ahmed, S, Wason, S, Tan, S, Fraser, S, Williams, S, Ghozy, S, Abdelmawgoud, S, Shehata, S, Sharma, S, Al-Touny, S, Ramzanali, S, Nah, S, Jansen, S, Rajan, S, Dindyal, S, Amin, S, Shoukrie, S, Karar, S, Patkar, S, Abdulsalam, S, Lin, S, Hegde, S, Fiorelli, S, Quaresima, S, Redondo, S, Palmisano, S, Ruggiero, S, Balogun, S, Cais, S, Cole, S, Federer, S, Le Roux, S, Ippoliti, S, Meneghini, S, Viola, S, Manfredelli, S, Novello, S, Gananadha, S, Mesli, S, Tani, S, Malik, S, Anastasiadou, S, Boligo, S, Esposito, S, Valanci, S, Xenaki, S, Pejkova, S, Trungu, S, Basu, S, Alkhatib, S, Pérez-Bertólez, S, Flores, S, Donoghue, S, Lunca, S, Orsoo, S, Potamianos, S, Devarakonda, S, Suresh, S, Croghan, S, Turi, S, Capella, S, Lucchini, S, Magnone, S, Salizzoni, S, Scabini, S, Scaringi, S, Cioffi, S, Seyfried, S, Degener, S, Potten, S, Taha-Mehlitz, S, Ali, S, Angamuthu, S, Mcaleer, S, Knight, S, White, S, Mantziari, S, Kykalos, S, Goh, S, Ibrahim, S, Elzwai, S, Bansal, S, Tripathy, S, Amrayev, S, Anwar, S, Banerjee, S, Thakar, S, Saeed, S, Venkatappa, S, Das, S, Techapongsatorn, S, Dube, S, Lee, S, González-Suárez, S, Henriques, S, Konjevoda, S, Gisbertz, S, Bravo, S, Mannan, S, Bukhari, S, Zafar, S, Batista, S, Chin, S, Arif, T, Lawal, T, Aktokmakyan, T, Osborn, T, Szakmany, T, Sztipits, T, Triantafyllou, T, Valadez, T, Singh, T, Khaliq, T, Patel, T, Fadalla, T, Jichi, T, Sammour, T, Al-Shaiji, T, Naggs, T, Barišić, T, Nikolouzakis, T, Bisgin, T, Perra, T, Uprak, T, Dagklis, T, Liakakos, T, Sidiropoulos, T, Adjeso, T, Dölker, T, Oung, T, Aherne, T, Diehl, T, Pinkney, T, Raymond, T, Rhomberg, T, Schmitz-Rixen, T, Madhuri, T, Lohmann, T, Yeoh, T, Zaimis, T, Bright, T, Vilz, T, Glowka, T, Board, T, Hardcastle, T, Cohnert, T, Mahečić, T, William, T, Klatte, T, Abbott, T, Watcyn-Jones, T, Mendes, T, Kulis, T, Sečan, T, Campagnaro, T, Frisoni, T, Simoncini, T, Violante, T, Safranovs, T, Risteski, T, Pang, T, Akinyemi, T, Yotsov, T, Laeke, T, Kochiyama, T, Sholadoye, T, Alekberli, T, Ezomike, U, Giustizieri, U, Grossi, U, Köksoy, Ü, Bork, U, Kisser, U, Ronellenfitsch, U, Saeed, U, Bracale, U, Jayarajah, U, Rauf, U, Bumbasirevic, U, Ferrer, U, Ahmed, U, Bello, U, Jogiat, U, Sadia, U, Galandarov, V, Narayanan, V, Calu, V, Bianchi, V, Ciniero, V, Tonini, V, Silvestri, V, Vijay, V, Dewan, V, Lohsiriwat, V, Thuduvage, V, Mousafeiris, V, Dragisic, V, Sasireka, V, Santric, V, Kusuma, V, Kolli, V, Alonso, V, De Simone, V, Picotti, V, Martínez, V, Panduro-Correa, V, Kakotkin, V, Angulo, V, Turrado-Rodriguez, V, Krishnamoorthy, V, Ban, V, Shah, V, Maiola, V, Giordano, V, La Vaccara, V, Lizzi, V, Papagni, V, Schiavone, V, Satchithanantham, V, Garcia-Virto, V, Jimenez, V, Kumar, V, Shelat, V, Bhat, V, Sodhai, V, Graziadei, V, 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Subjects
general surgery, acute care surgery, Settore MED/18 - CHIRURGIA GENERALE, climate change, trauma, Settore MED/40 - Ginecologia E Ostetricia, environmental impact, surgery, Settore MED/31 - Otorinolaringoiatria, None, Medicine and Health Sciences, Surgery, operating theatre, environment
Abstract

Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.

Published
2023

30. Crystal structure of barium dinickel(II) iron(III) tris[orthophosphate(V)], BaNi2Fe(PO4)3

Author

Said Ouaatta, Adam Bouraima, Elhassan Benhsina, Jamal Khmiyas, Abderrazzak Assani, Mohamed Saadi, and Lahcen El Ammari

Subjects
General Materials Science, General Chemistry, Condensed Matter Physics
Abstract

The orthophosphate BaNi2Fe(PO4)3 has been synthesized by a solid-state reaction route and characterized by single-crystal X-ray diffraction and energy-dispersive X-ray spectroscopy. The crystal structure comprises (100) sheets made up of [Ni2O10] dimers that are linked to two PO4 tetrahedra via common edges and vertices and of linear infinite [010] chains of corner-sharing [FeO6] octahedra and [PO4] tetrahedra. The linkage of the sheets and chains into a framework is accomplished through common vertices of PO4 tetrahedra and [FeO6] octahedra. The framework is perforated by channels in which positionally disordered Ba2+ cations are located.

Published
2023

31. Combining Sunitinib and Bevacizumab for the Management of Advanced Renal Cell Carcinoma: A Phase I/II Trial

Author

Shouki Bazarbashi, Ahmed Alzahrani, Ali Aljubran, Mahmoud Elshenawy, Ahmed Mostafa Gad, Fatima Maraiki, Noura Alzannan, Tusneem Elhassan, and Ahmed Badran

Subjects
Cancer Research, Oncology
Abstract

Background Tyrosine kinase inhibitors remain a cornerstone in managing metastatic clear cell renal cell carcinoma (RCC). The 4 weeks on/2 weeks off intermittent sunitinib schedule could result in rebound angiogenesis and tumor progression in the 2-week rest period. We propose using bevacizumab during this period for continuous antiangiogenic effects. Method This was a phase I/II study of patients with advanced clear cell RCC. Sunitinib was given 50 mg daily on a 4-week on/2-week off schedule. Bevacizumab was given on day 29 of each sunitinib cycle. The bevacizumab starting dose was 5 mg/kg, and the dose was escalated to 10 mg if there was no dose-limiting toxicity. The primary endpoints were response rate and progression-free survival (PFS). Results Twenty-five patients were recruited. The study was closed prematurely because of poor accrual. No dose-limiting toxicity was observed with 5 mg bevacizumab. One patient achieved a complete response, and 12 achieved a partial response (52% response rate). At a median follow-up of 42.2 months (95%, confidence interval (CI) 32.9 to 51.4), the median PFS duration was 16.5 months (95% CI 4.1-28.8), and the median overall survival time was 33.3 months (95% CI 19.4-47.3). Twenty-two patients (88%) had at least one grade 3 or 4 toxicity; the most common were thrombocytopenia (32%), lymphopenia (32%), hypertension (28%), and fatigue (24%). Conclusion Continuous angiogenesis blockade by adding bevacizumab to the sunitinib on/off regimen for advanced RCC yields significant antitumor activity with manageable increased toxicity.

Published
2023

32. Never reported complication of open right hemicolectomy-right external iliac artery pseudoaneurysm with arterio colonic fistulae presenting as delayed postoperative anastomotic bleeding: a case report and review of literature

Author

Altaf Gauhar Haji, Ali Elhassan, Aravindan Narayanan, Bala Piramanayagam, Srinivasamurthy Devraj, and Hassan Abedi Farhad Syed

Subjects
General Medicine
Abstract

Anastomotic bleeding is well known complication after gastrointestinal resection and anastomosis procedures. The percentage of patients experiencing this complication is between 0.5% to 9.6%. Delayed postoperative anastomotic bleeding is even more rare, herein, we report a case of pseudoaneurysm of right external iliac artery with arterio-colonic fistulae in a patient who underwent open right hemicolectomy and presented as delayed postoperative anastomotic bleeding-a complication never reported before related to this procedure.

Published
2023

43. The Occupied Marginal Space and Rebuilding Memory in the North Moroccan Novels

Author

Said Elaimari and Elhassan Hjjij

Subjects
Arts and Humanities (miscellaneous), General Social Sciences
Abstract

This article aims to explore the patterns marking the occupied marginal space in Mohamed Ankar’s novel “Barrio Málaga” from an aesthetic and artistic perspective that tracks the role of memory in shaping the occupied marginal space and reveals its realistic connotations and its sociological and ideological dimensions without digging deep into the historical aspects of the Spanish colonial period in the North of Morocco. Furthermore, the article seeks to highlight the historical dimensions of the novel from an interpretive perspective that considers the novel as a mirror reflecting another untold history, which is the history of the margin and its people as shaped in the memory, which is a mechanism for storing and rereading perspectives and attitudes according to a perceptual process that goes beyond the obsession of laying emphasis on the colonizer and the forms of resistance to its occupation and aims at highlighting the roles of this space in exposing the aspects of authoritarianism, oppression and injustice of the colonizer. Accordingly, the research findings reaffirm that both identifying the aspects of the marginal space in this novel and highlighting its working mechanisms and role in providing an imaginary portrayal of this space are likely to contribute to rebuilding the memory and identifying the aspects of correlation between the realistic and the imaginary to identify the symbolic and cultural connotations behind taking the margin as a framework for building an indicative process based on the space, which is not separate from the other narrative elements marking the narrative discourse.

Published
2022

44. Atrioventricular Conduction Disorders as a Complication of Inferior ST-Elevation Myocardial Infarction in Patients with COVID-19 Infection

Author

Yaser Alahmad, Hassan Al-Tamimi, Fadi Khazaal, Mawahib Elhassan, Abdulrahman Arabi, Jassim Al Suwaidi, Awad AlQahtani, and Nidal Asaad

Subjects
Cardiology and Cardiovascular Medicine
Abstract

This case series demonstrates how COVID-19 infection might affect the heart in the context of acute myocardial infarction. Atrioventricular (AV) block might appear as one of the significant cardiac complications of acute MI in patients who tested COVID-19 PCR positive regardless of the presence of CVOID-19 infection symptoms. In our series, conduction disorders as a complication of acute inferior STEMI are more common in patients who tested positive for the COVID-19 infection. 11 patients out of 18 inferior STEMI patients who have tested positive for the COVID-19 infection have atrioventricular block disorders.

Published
2022

47. Seroprevalence and clinical outcome of hepatitis D infection in Qatar

Author

Tasneem, Abdallah, Tawheeda, Ibrahim, Muhammed, Hajmusa, Mohammed, Abdulgayoom, Afra, Elhassan, Alyaa, Abusabeib, Mona, Babikir, Shaimaa, Abdelrahim, Joanne, Daghfal, and Moutaz, Derbala

Subjects
General Medicine
Abstract

Worldwide, 5-10% of people with chronic hepatitis B virus infection are co-infected with hepatitis D virus. In Qatar, there are no data on hepatitis D virus infection among patients positive for hepatitis B surface antigen (HBsAg).To determine the seroprevalence of hepatitis D virus infection among patients with chronic hepatitis B virus infection in Qatar and assess the characteristics of these patients.This was a retrospective cohort study of all HBsAg-positive individuals tested for hepatitis D virus between 1 January 2010 and 29 December 2019 within the Hamad Medical Corporation. Data were retrieved from electronic records and included demographic and clinical information of the patients.Of the 2348 HBsAg-positive patients, 125 were positive for hepatitis D virus (seroprevalence 5.3%). The median age of hepatitis D positive patients was significantly higher than for hepatitis D negative patients (P = 0.001). Most of the patients with hepatitis D had a hepatitis B viral load2000 IU/mL (53.6%) and were negative for hepatitis B e antigen (93.6%). A significantly greater proportion of hepatitis D positive patients than hepatitis D negative patients were infected with hepatitis C virus (P0.001), and had liver cirrhosis (P0.001) and hepatocellular carcinoma (P = 0.006).Hepatitis D virus infection is associated with lower hepatitis B virus viraemia and more advanced liver disease in the study population.الانتشار المصلي والنتائج السريرية للعدوى بالتهاب الكبد D في قطر.تسنيم عبد الله، توحيدة إبراهيم، محمد حاج موسى، محمد عبد القيوم، عفراء الحسن،، علياء أبو سبيب، مني بابكر، شيماء عبد الرحيم، جوان دغفل، معتز دربالة.لقد وجد أن 5–10٪ من المصابين بعدوى مزمنة بفيروس التهاب الكبد B على مستوى العالم، مصابون أيضًا بفيروس التهاب الكبد D. ولكن في قطر لا توجد بيانات عن عدوى فيروس التهاب الكبد D بين المرضى الإيجابيين للمستضد السطحي لالتهاب الكبد B (HBsAg).هدفت هذه الدراسة الى تحديد الانتشار المصلي لعدوى فيروس التهاب الكبد D بين المصابين بعدوى مزمنة بفيروس التهاب الكبد B في قطر، وتقييم السمات المميزة لهؤلاء المرضى.هذه الدراسة دراسة أترابية استعادية لجميع الأشخاص الإيجابيين للمستضد السطحي لالتهاب الكبد B، الذين أُجري لهم اختبار الكشف عن فيروس التهاب الكبد D بين 1 يناير / كانون الثاني 2010 و29 ديسمبر / كانون الأول 2019 ضمن مؤسسة حمد الطبية. وقد استُُرجعت البيانات من السجلات الإلكترونية وشملت السمات السكانية والبيانات السريرية للمرضى.من بين المرضى الإيجابيين للمستضد السطحي لالتهاب الكبد B، البالغ عددهم 2348 مريضًا، كان هناك 125 مريضًا إيجابيًّا لفيروس التهاب الكبد D (الانتشار المصلي 5.3٪). وكان العمر الوسيط للمرضى الإيجابيين لالتهاب الكبد D أكبر بكثير منه للمرضى السلبيين لالتهاب الكبد D (القيمة الاحتمالية = 0.001). وعند معظم المرضى المصابين بالتهاب الكبد D، كان الحمل الفيروسي لفيروس التهاب الكبد B أقل من 2000 وحدة دولية/ ميلِِّّي لتر (53.6٪) وكانت نتائجهم سلبية لمستضد e لالتهاب الكبد (93.6٪). وعند المقارنة بين المرضى الإيجابيين لالتهاب الكبد D والمرضى السلبيين له، كانت نسبة الإصابة أكبر بكثير بين المرضى الإيجابيين، وذلك لفيروس التهاب الكبد C (القيمة الاحتمالية0.001)، وتشمُّع الكبد (القيمة الاحتمالية0.001)، والورم الكبدي الخبيث (القيمة الاحتمالية = 0.006).ترتبط الإصابة بفيروس التهاب الكبد D بانخفاض انتقال فيروس التهاب الكبد B عبر مجرى الدم والإصابة بمرض الكبد الأكثر تقدمًا لدى الفئة الخاضعة للدراسة.Séroprévalence et issue clinique de l'infection par le virus de l'hépatite D au Qatar.À l'échelle mondiale, 5 à 10 % des personnes atteintes d'une hépatite B chronique sont co-infectées par le virus de l'hépatite D. Au Qatar, on ne dispose d'aucune donnée sur l'infection par le virus de l'hépatite D chez les patients positifs pour l'antigène de surface du virus de l'hépatite B (HBsAg).Déterminer la séroprévalence de l'infection par le virus de l'hépatite D chez les patients atteints d'hépatite B chronique au Qatar et évaluer les caractéristiques de ces patients.Il s'agissait d'une étude de cohorte rétrospective de toutes les personnes positives pour l'antigène de surface du virus de l'hépatite B ayant subi un test de dépistage du virus de l'hépatite D entre le 1Sur les 2348 patients positifs pour l'HBsAg, 125 étaient positifs pour le virus de l'hépatite D (séroprévalence de 5,3 %). L'âge médian des patients positifs au virus de l'hépatite D était significativement plus élevé que celui des patients négatifs à ce même virus (p = 0,001). La plupart des patients atteints d'hépatite D avaient une charge virale pour l'hépatite B inférieure à 2000 UI/mL (53,6 %) et étaient négatifs pour l'antigène e du virus de l'hépatite B (93,6 %). Une proportion significativement plus importante de patients positifs au virus de l'hépatite D par rapport aux patients négatifs à ce même virus étaient infectés par le virus de l'hépatite C (p0,001) et présentaient une cirrhose (p0,001) et un carcinome hépatocellulaire (p = 0,006).L'infection par le virus de l'hépatite D est associée à une virémie plus faible du virus de l'hépatite B et à une maladie hépatique plus avancée dans la population de l'étude.

Published
2022

49. A case series of pediatric neurobrucellosis: a rare complication to a common disease

Author

Rayan Abdelwahab Osman Mohammed, Ahmed Mohamed Ayesh Ezzatly, Neema Siddiq Banaga Siddiq, Thnaa Alagraa, Maha Abdalla Yahia Elhassan, Roua Mohammedali Hussain Idres, Baraa Mohamed salaheldin Mohamed Elhassan, Khabab Abbasher Hussien Mohamed Ahmed, and Mohammed Mahmmoud Fadelallah Eljack

Subjects
Surgery, General Medicine
Published
2023

50. Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degenerations

Author

Ashraf Yahia, Ahlam A. A. Hamed, Inaam N. Mohamed, Maha A. Elseed, Mustafa A. Salih, Sarah M. El-sadig, Hassab Elrasoul Siddig, Ali Elsir Musa Nasreldien, Mohamed Ahmed Abdullah, Maha Elzubair, Farouk Yassen Omer, Aisha Motwakil Bakhiet, Rayan Abubaker, Fatima Abozar, Rawaa Adil, Sara Emad, Mhammed Alhassan Musallam, Isra Z. M. Eltazi, Zulfa Omer, Hiba Malik, Mayada O. E. Mohamed, Ali A. Elhassan, Eman O. E. Mohamed, Ahmed K. M. A. Ahmed, Elhami A. A. Ahmed, Esraa Eltaraifee, Bidour K. Hussein, Amal S. I. Abd Allah, Lina Salah, Mohamed Nimir, Omnia M. Tag Elseed, Tasneem E. A. Elhassan, Abubakr Elbashier, Esraa S. A. Alfadul, Moneeb Fadul, Khalil F. Ali, Shaimaa Omer M. A. Taha, Elfatih E. Bushara, Mutaz Amin, Mahmoud Koko, Muntaser E. Ibrahim, Ammar E. Ahmed, Liena E. O. Elsayed, and Giovanni Stevanin

Subjects
Genetics, Genetics (clinical)
Abstract

Hereditary spinocerebellar degenerations (SCDs) is an umbrella term that covers a group of monogenic conditions that share common pathogenic mechanisms and include hereditary spastic paraplegia (HSP), cerebellar ataxia, and spinocerebellar ataxia. They are often complicated with axonal neuropathy and/or intellectual impairment and overlap with many neurological conditions, including neurodevelopmental disorders. More than 200 genes and loci inherited through all modes of Mendelian inheritance are known. Autosomal recessive inheritance predominates in consanguineous communities; however, autosomal dominant and X-linked inheritance can also occur. Sudan is inhabited by genetically diverse populations, yet it has high consanguinity rates. We used next-generation sequencing, genotyping, bioinformatics analysis, and candidate gene approaches to study 90 affected patients from 38 unrelated Sudanese families segregating multiple forms of SCDs. The age-at-onset in our cohort ranged from birth to 35 years; however, most patients manifested childhood-onset diseases (the mean and median ages at onset were 7.5 and 3 years, respectively). We reached the genetic diagnosis in 63% and possibly up to 73% of the studied families when considering variants of unknown significance. Combining the present data with our previous analysis of 25 Sudanese HSP families, the success rate reached 52–59% (31–35/59 families). In this article we report candidate variants in genes previously known to be associated with SCDs or other phenotypically related monogenic disorders. We also highlight the genetic and clinical heterogeneity of SCDs in Sudan, as we did not identify a major causative gene in our cohort, and the potential for discovering novel SCD genes in this population.

Published
2023

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