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66 results on '"Elisei F"'

1. Baseline 18FDG-PET Metabolic Tumour Volume (MTV) as a Potential Predictive Factor of Response to Metronomic Chemotherapy (mCHT) in HR+/HER2- Metastatic Breast Cancer (MBC) Patients (pts). Preliminary Results of the Metro-pet Study

Author

Meazza Prina, M, Gotuzzo, I, Cazzaniga, M, De Bernardi, E, Cafaro, P, Capici, S, Cogliati, V, Fulvia Pepe, F, Cicchiello, F, Riva, F, Cordani, N, Cerrito, M, Turolla, E, Landoni, C, Elisei, F, Crivellaro, C, Virdone, L, Monaco, L, Guidi, A, Guerra, L, Meazza Prina, M, Gotuzzo, I, Cazzaniga, M, De Bernardi, E, Cafaro, P, Capici, S, Cogliati, V, Fulvia Pepe, F, Cicchiello, F, Riva, F, Cordani, N, Cerrito, M, Turolla, E, Landoni, C, Elisei, F, Crivellaro, C, Virdone, L, Monaco, L, Guidi, A, and Guerra, L

Subjects
mCHT, 18FDG-PET, MBC
Published
2023

2. Study of phenylxylylethane (PXE) as scintillator for low energy neutrino experiments

Author

Back, H. O., Balata, M, DE BARIC, A, Beaud, T, DE BELLEFOND, A, Bellini, G, Benziger, J, Bonetti, S, Brigatti, A, Buck, C, Caccianiga, B, Cadonati, L, Calaprice, F, Cecchet, G, Chen, M, DI CREDICO, A, Dadound, O, Dangelo, D, Derbin, A, Deutschk, M, Elisei, F, Etenko, A, VON FEILITZSCHI, F, Fernholzf, R, Ford, R, Franco, D, Freudigerg, B, Galbiati, C, Gatti, Flavio, Gazzana, S, Giammarchie, M. G., Giugni, D, GÖGER NEFF, M, Goretti, A, Grieb, C, DE HAASF, E, Hagneri, C, Hampelg, W, Harding, E, Hartmann, F. X., Hertrich, T, Hess, H, Heusserg, G, Ianni, A, Ianni, A. M., DE KERRET, H, Kiko, J, Kirsten, T, Korga, G, Korschinek, G, Kozlov, Y, Kryn, D, Laubenstein, M, Lendvai, C, Loeser, F, Lombardi, P, Malvezzi, S, Maneira, J, Manno, I, Manuzio, Daniela, Manuzio, Giulio, Masetti, F, Martemianov, A, Mazzucato, U, Mccarty, K, Meroni, E, Miramonti, L, Monzani, M. E., Musico, P, Niedermeier, L, Oberauer, L, Obolensky, M, Ortica, F, Pallavicini, Marco, Papp, L, Parmeggiano, S, Perasso, L, Pocar, A, Raghavan, R. S., Ranucci, G, Rau, W, Razeto, A, Resconi, E, Sabelnikov, A, Salvo, C, Scardaoni, R, Schimizzi, D, Schönert, S, MAIL THE CORRESPONDING AUTHOR, E., Schuhbecki, K. H., Seitzi, E., Simgeng, H., Shuttf, T., Skorokhvatovm, M., Smirnovj, O., Sonnenschein, A, Sotnikov, A, Sukhoti, S, Tarasenkov, V, Tartaglia, R, Testera, G, Vignaud, D, Vogelaar, R. B., Vyrodov, V, Wojcik, M, Zaimidoroga, O, and Zuzel, G.

Subjects
Physics, Nuclear and High Energy Physics, Scintillation, Silica gel, Solar neutrino, Analytical chemistry, Scintillator, Solvent, Nuclear physics, chemistry.chemical_compound, chemistry, Impurity, Neutrino, Instrumentation, Borexino
Abstract

We report on the study of a new liquid scintillator target for neutrino interactions in the framework of the research and development program of the Borexino solar neutrino experiment. The scintillator consists of 1,2-dimethyl-4-(1-phenylethyl)-benzene (phenyl-o-xylylethane, PXE) as solvent and 1,4-diphenylbenzene (para-Terphenyl, p-Tp) as primary and 1,4-bis(2-methylstyryl)benzene (bis-MSB) as secondary solute. The density close to that of water and the high flash point makes it an attractive option for large scintillation detectors in general. The study focused on optical properties, radioactive trace impurities and novel purification techniques of the scintillator. Attenuation lengths of the scintillator mixture of 12 m at 430 nm were achieved after purification with an alumina column. A radiocarbon isotopic ratio of C 14 / C 12 = 9.1 × 10 - 18 has been measured in the scintillator. Initial trace impurities, e.g. 238U at 3.2 × 10 - 14 g / g could be purified to levels below 1 × 10 - 17 g / g by silica gel solid column purification.

Published
2008
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3. Assessment of nodal status by 18F-FDG PET/CT in early stage ovarian cancer

Author

CRIVELLARO, CINZIA, GUERRA, LUCA, Signorelli, M, DE PONTI, ELENA, DOLCI, CARLOTTA, Pirovano, C, Elisei, F, CEPPI, LORENZO, FRUSCIO, ROBERT, MESSA, MARIA CRISTINA, Crivellaro, C, Guerra, L, Signorelli, M, DE PONTI, E, Dolci, C, Pirovano, C, Elisei, F, Ceppi, L, Fruscio, R, and Messa, M

Subjects
Ovarian cancer
Published
2013

4. New limits on nucleon decays into invisible channels with the BOREXINO counting test facility

Author

Back, H. O., Balata, DE BARI, A., Beau, T., DE BELLEFON, A., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., DE HAAS, E., DI CREDICO, A., Dadoun, O., D'Angelo, D., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., VON FEILITZSCH, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, Flavio, Gazzana, S., Giammarchi, M. G., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, T., Hagner, C., Hampel, W., Harding, E., Hartmann, F., G. HEUSSER G., Ianni, A., Ianni, A. M., DE KERRET, H., Kiko, J., Kirsten, T., Kohler, M., Korga, G., Korschinek, G., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, Giulio, Masetti, F., Martemiamov, A., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M. E., Musico, P., Neder, H., Neff, M., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, Marco, Papp, L., Perasso, L., Pocar, A., Raghavan, R. S., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Sabelnikov, A., Salvo, C., Scardaoni, R., Schoenert, S., Seidel, H., Simgen, H., Shutt, T., Skorokhvatov, M., Smirnov, O., Sonnenschein, A., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vitale, Sandro, Vogelaar, R. B., Vyrodov, V., Woijcik, M., Zaimidoroga, O., Zuzel, G., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Borexino, and Lantz, Simone

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Test facility, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, FOS: Physical sciences, 01 natural sciences, High Energy Physics - Experiment, 3. Good health, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Underground laboratory, High Energy Physics::Experiment, Nuclide, Neutrino, 010306 general physics, Nucleon, Borexino
Abstract

The results of background measurements with the second version of the BOREXINO Counting Test Facility (CTF-II), installed in the Gran Sasso Underground Laboratory, were used to obtain limits on the instability of nucleons, bounded in nuclei, for decays into invisible channels ($inv$): disappearance, decays to neutrinos, etc. The approach consisted of a search for decays of unstable nuclides resulting from $N$ and $NN$ decays of parents $^{12}$C, $^{13}$C and $^{16}$O nuclei in the liquid scintillator and the water shield of the CTF. Due to the extremely low background and the large mass (4.2 ton) of the CTF detector, the most stringent (or competitive) up-to-date experimental bounds have been established: $��(n \to inv) > 1.8 \cdot 10^{25}$ y, $��(p \to inv) > 1.1 \cdot 10^{26}$ y, $��(nn \to inv) > 4.9 \cdot 10^{25}$ y and $��(pp \to inv) > 5.0 \cdot 10^{25}$ y, all at 90% C.L., 22 pages, 3 figures,submitted to Phys.Lett. B

Published
2003
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5. Science and technology of Borexino: a real-time detector for low energy solar neutrinos

Author

Alimonti, G., Arpesella, C., Beck, H. O., Balata, Beau, T., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Caccianiga, B., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Debari, A., DE HAAS, E., Donghi, O., Deutsch, M., Elisei, F., VON FEILITZSCH, F., Fernholz, R., Ford, R., Freudiger, B., Garagiola, A., Gatti, Flavio, Gazzana, S., Giammarchi, M. G., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, T., Hagner, C., Hampel, W., Harding, E., Hartmann, F., VON HENTIG, R., Hess, H., G. HEUSSER G., Ianni, A., Inzani, P., DE KERRET, H., Kidner, S., Kiko, J., Kirsten, Korga, G., Korshinek, Krin, D., Lagomarsino, Vittorio, Laubenstein, M., Loeser, F., Lombardi, P., Magni, S., Malvezzi, S., Maneira, J., Manno, I., Manuzio, Giulio, Masetti, F., Mazzucato, U., Meroni, E., Musico, P., Neder, H., Neff, M., Nisi, S., Nostro, A., Oberauer, L., Obolensky, M., Pallavicini, Marco, Papp, L., Perasso, L., Pocar, A., Raghavan, R. S., Ranucci, G., Rau, W., Resconi, E., Riedel, Sabelnikov, A., Saggese, P., Salvo, C., Scardaoni, R., Schoenert, S., Shuubeck, K. H., Seidel, H., Shutt, Sonnenschein, Smirnov, O., Sotnikov, A., Skorokhvatov, M., Sukhotin, S., Tartaglia, R., Testera, G., Vogelaar, R. B., Vitale, Sandro, Woijcik, M., Zaimidoroga, O., and Zakharov, Y.

Subjects
Physics, Scintillation, Particle physics, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Solar neutrino, Detector, Astronomy and Astrophysics, Solar neutrino problem, 01 natural sciences, 7. Clean energy, Physics::Geophysics, Low energy, 0103 physical sciences, Background suppression, High Energy Physics::Experiment, Neutrino, 010306 general physics, Borexino
Abstract

BOREXINO, a real-time device for low energy neutrino spectroscopy is nearing completion of construction in the underground laboratories at Gran Sasso, Italy (LNGS). The experiment's goal is the direct measurement of the flux of 7Be solar neutrinos of all flavors via neutrino-electron scattering in an ultra-pure scintillation liquid. Seeded by a series of innovations which were brought to fruition by large scale operation of a 4-ton test detector at LNGS, a new technology has been developed for BOREXINO. It enables sub-MeV solar neutrino spectroscopy for the first time. This paper describes the design of BOREXINO, the various facilities essential to its operation, its spectroscopic and background suppression capabilities and a prognosis of the impact of its results towards resolving the solar neutrino problem. BOREXINO will also address several other frontier questions in particle physics, astrophysics and geophysics.

Published
2002
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6. Search for electron decay mode e→γ+ν with prototype of Borexino detector

Author

Back, H. O., Balata, DE BARI, A., Beau, T., DE BELLEFON, A., Bellini, G., Benziger, J., Bonetti, S., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., DE HAAS, E., DI CREDICO, A., Dadoun, ., D'Angelo, D., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., VON FEILITZSCH, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, Flavio, Gazzana, S., Giammarchi, M. G., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, T., Hagner, C., Hampel, W., Harding, E., Hartmann, F., G. HEUSSER G., Ianni, A., Ianni, A. M., DE KERRET, H., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, Giulio, Masetti, F., Martemiamov, A., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M. E., Musico, P., Neder, H., Neff, M., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, Marco, Papp, L., Perasso, L., Pocar, A., Raghavan, R. S., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Sabelnikov, A., Salvo, C., Scardaoni, R., Schoenert, S., Seidel, H., Simgen, H., Shutt, T., Skorokhvatov, M., Smirnov, O., Sonnenschein, A., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vitale, Sandro, Vogelaar, R. B., Vyrodov, V., Woijcik, M., Zaimidoroga, O., and Zuzel, G. .

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Test facility, Electron lifetime, Detector, Electron, Lower limit, Borexino
Abstract

The prototype of the Borexino detector Counting Test Facility, located in the Gran-Sasso laboratory, has been used to obtain a bound on the stability of the electron. The new lower limit on the mean lifetime defined on 32.1 days of data set is τ ( e − → ν e + γ )⩾4.6×10 26 yr (90% c.l.).

Published
2002
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12. Intervento

Author

Elisei, F.

Subjects
lcsh:Industries. Land use. Labor, lcsh:HD28-9999
Abstract

Aestimum, Atti del V Incontro di Studio (1975)

Published
2009

13. Introduzione

Author

Elisei, F.

Subjects
lcsh:Industries. Land use. Labor, lcsh:HD28-9999
Abstract

Aestimum, Atti del II Incontro di Studio (1974)

Published
2009

14. Intervento

Author

Elisei, F.

Subjects
lcsh:Industries. Land use. Labor, lcsh:HD28-9999
Abstract

Aestimum, Atti del VIII Incontro di Studio (1977)

Published
2009

15. Quantum chemical modelling and preparation of a biomimetic photochemical switch

Author

Lumento, F., Zanirato, V., Fusi, S., Busi, E., Latterini, L., Elisei, F., Sinicropi, A., Andruniów, T., Ferré, N., Basosi And M. Olivucci, R., Chimie, biologie et radicaux libres - UMR 6517 (CBRL), Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), and Nouguier, Colette

Subjects
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

18. ARTUS: synthesis and audiovisual watermarking of the movements of a virtual agent interpreting subtitling using cued speech for deaf televiewers

Author

Bailly, G., Attira, V., Baras, C., Bas, P., Baudry, S., Beautemps, D., Brun, R., Chassery, J. -M, Franck Davoine, Elisei, F., Gibert, G., Girin, L., Grison, D., Léoni, J. -P, Liénard, J., Moreau, N., Nguyen, P., Bailly, Gérard, Institut de la communication parlée (ICP), Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3, Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des images et des signaux (LIS), Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] (Heudiasyc), and Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SCCO.COMP] Cognitive science/Computer science, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SCCO.COMP]Cognitive science/Computer science, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

AMSE - ISSN: 1259-5977; International audience; The ARTUS project provides deaf televiewers with an alternative substitute for subtitles using Cued Speech: an animated agent can be superimposed - on demand and at the reception - to the original broadcast. The hand and face gestures of the agent are generated automatically by a text-to-cued speech synthesizer and watermarked in the broadcasted audiovisual signals. We describe here the technological blocks of our demonstrator. First evaluation of the complete system by end-users is presented.

Published
2006

20. Phenylxylylethane (PXE): a high-density, high-flashpoint organic liquid scintillator for applications in low-energy particle and astrophysics experiments

Author

Back, H. O., Balata, M., Bari, A., Beau, T., Bellefon, A., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., Di Credico, A., Dadoun, O., D Angelo, D., Haas, H., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., Feilitzsch, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gartner, N., Gatti, F., Gazzana, S., Giammarchi, M. G., Giugni, D., Goeger-Neff, M., Goretti, A., Grieb, C., Hagner, C., Hampel, W., Harding, E., Hartmann, F. X., Hertrich, T., Hess, H., Heusser, G., Ianni, A., Ianni, A. M., Kerret, H., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kozlov, Y., Kryn, D., Laubenstein, M., Lendvai, C., Loeser, F., Lombardi, P., Malvezzi, S., Maneira, J., Manno, I., Manuzio, D., Manuzio, G., Masetti, F., Martemianov, A., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M. E., Musico, P., Niedermeier, L., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, M., Papp, L., Parmeggiano, S., Perasso, L., Pocar, A., Raghavan, R. S., Gioacchino Ranucci, Rau, W., Razeto, A., Resconi, E., Sabelnikov, A., Salvo, C., Scardaoni, R., Schimizzi, D., Schonert, Stefan, Schuhbeck, K. H., Seitz, E., Simgen, H., Shutt, T., Skorokhvatov, M., Smirnov, O., Sonnenschein, A., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vogelaar, R. B., Vyrodov, V., Wojcik, M., Zaimidoroga, O., Zuzel, G., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Borexino, and Lantz, Simone

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

We report on the study of a new liquid scintillator target for neutrino interactions in the framework of the research and development program of the BOREXINO solar neutrino experiment. The scintillator consists of 1,2-dimethyl-4-(1-phenylethyl)-benzene (phenyl-o-xylylethane, PXE) as solvent and 1,4-diphenylbenzene (para-Terphenyl, p-Tp) as primary and 1,4-bis(2-methylstyryl)benzene (bis-MSB) as secondary solute. The density close to that of water and the high flash point makes it an attractive option for large scintillation detectors in general. The study focused on optical properties, radioactive trace impurities and novel purification techniques of the scintillator. Attenuation lengths of the scintillator mixture of 12 m at 430 nm were achieved after purification with an alumina column. A radio carbon isotopic ratio of C-14/C-12 = 9.1 * 10^{-18}$ has been measured in the scintillator. Initial trace impurities, e.g. U-238 at 3.2 * 10^{-14} g/g could be purified to levels below 10^{-17} g/g by silica gel solid column purification.

Published
2004

22. Study of the neutrino electromagnetic properties with prototype of BOREXINO detector

Author

Back, H.O., Balata, M., de Bari, A., Beau, T., de Bellefon, A., Bellini, G., Benziger, J., Bonetti, S., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., Di Credico, A., Dadoun, O., d'Angelo, D., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., von Feilitzsch, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M.G., Giugni, D., Goger-Neff, M., Golubchikov, A., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F.X., Heusser, G., Ianni, A., Ianni, A.M., de Kerret, H., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kozlov, Yu., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Martemyanov, A., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M.E., Musico, P., Neder, H., Niedermeier, L., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R.S., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Sabelnikov, A., Salvo, C., Scardaoni, R., Schonert, S., Seidel, H., Simgen, H., Shutt, T., Skorokhvatov, M., Smirnov, O., Sonnenschein, A., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vitale, S., Vogelaar, R.B., Vyrodov, V., Wojcik, M., Zaimidoroga, O., Zuzel, G., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Borexino, and Lantz, Simone

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]
Published
2003

23. Study of neutrino electromagnetic properties with the prototype of the Borexino detector

Author

Back, H. O., Balata, DE BARI, A., Beau, T., DE BELLEFON, A., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., DE HAAS, E., DI CREDICO, A., Dadoun, O., D'Angelo, D., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., VON FEILITZSCH, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, Flavio, Gazzana, S., Giammarchi, M. G., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, T., Hagner, C., Hampel, W., Harding, E., Hartmann, F., G. HEUSSER G., Ianni, A., Ianni, A. M., DE KERRET, H., Kiko, J., Kirsten, T., Kohler, M., Korga, G., Korschinek, G., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, Giulio, Masetti, F., Martemiamov, A., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M. E., Musico, P., Neder, H., Neff, M., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, Marco, Papp, L., Perasso, L., Pocar, A., Raghavan, R. S., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Sabelnikov, A., Salvo, C., Scardaoni, R., Schoenert, S., Seidel, H., Simgen, H., Shutt, T., Skorokhvatov, M., Smirnov, O., Sonnenschein, A., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vitale, Sandro, Vogelaar, R. B., Vyrodov, V., Woijcik, M., Zaimidoroga, O., and Zuzel, G.

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Standard solar model, Physics::Instrumentation and Detectors, Solar neutrino, High Energy Physics::Phenomenology, Solar neutrino problem, Nuclear physics, Neutrino detector, Measurements of neutrino speed, High Energy Physics::Experiment, Neutrino, Neutrino oscillation, Borexino
Abstract

The results of background measurements with the prototype of the Borexino detector (CTF) have been used to obtain an upper bound on the neutrino magnetic moment, μ ν . The new upper limit for μ ν from pp and 7 Be solar neutrinos is (5.5×10 −10 ) μ B (90% c.l.) in the Standard Solar Model scenario. This is the first limit on μ ν obtained using sub-MeV neutrinos. The sensitivity of the prototype to the neutrino charge radius and the neutrino radiative decay are also presented.

Published
2003

24. New experimental limits on heavy neutrino mixing in 8B- decay obtained with the BOREXINO counting test facility

Author

Back, H. O., Balata, M, DE BARIC, A, Beaud, T, DE BELLEFOND, A, Bellini, G, Benziger, J, Bonetti, S, Brigatti, A, Buck, C, Caccianiga, B, Cadonati, L, Calaprice, F, Cecchet, G, Chen, M, DI CREDICO, A, Dadound, O, Dangelo, D, Derbin, A, Deutschk, M, Elisei, F, Etenko, A, VON FEILITZSCHI, F, Fernholzf, R, Ford, R, Franco, D, Freudigerg, B, Galbiati, C, Gatti, Flavio, Gazzana, S, Giammarchie, M. G., Giugni, D, GÖGER NEFF, M, Goretti, A, Grieb, C, DE HAASF, E, Hagneri, C, Hampelg, W, Harding, E, Hartmann, F. X., Hertrich, T, Hess, H, Heusserg, G, Ianni, A, Ianni, A. M., DE KERRET, H, Kiko, J, Kirsten, T, Korga, G, Korschinek, G, Kozlov, Y, Kryn, D, Laubenstein, M, Lendvai, C, Loeser, F, Lombardi, P, Malvezzi, S, Maneira, J, Manno, I, Manuzio, D, Manuzio, G, Masetti, F, Martemianov, A, Mazzucato, U, Mccarty, K, Meroni, E, Miramonti, L, Monzani, M. E., Musico, P, Niedermeier, L, Oberauer, L, Obolensky, M, Ortica, F, Pallavicini, Marco, Papp, L, Parmeggiano, S, Perasso, L, Pocar, A, Raghavan, R. S., Ranucci, G, Rau, W, Razeto, A, Resconi, E, Sabelnikov, A, Salvo, C, Scardaoni, R, Schimizzi, D, Schönert, S, MAIL THE CORRESPONDING AUTHOR, E., Schuhbecki, K. H., Seitzi, E., Simgeng, H., Shuttf, T., Skorokhvatovm, M., Smirnovj, O., Sonnenschein, A, Sotnikov, A, Sukhoti, S, Tarasenkov, V, Tartaglia, R, Testera, G, Vignaud, D, Vogelaar, R. B., Vyrodov, V, Wojcik, M, Zaimidoroga, O, Zuzel, G., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Borexino, and Lantz, Simone

Subjects
Physics, Particle physics, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Coupling (probability), 7. Clean energy, 01 natural sciences, Nuclear physics, Massless particle, Particle decay, Neutrino detector, 13. Climate action, Antimatter, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Neutrino, 010306 general physics, Borexino, Lepton
Abstract

If heavy neutrinos with mass $$\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\smile}$}}{l} $$ are emitted in the decays of 8B in the Sun, then νH→νL+e ++e − decays should be observed. In the present work, the results of background measurements with the Borexino Counting Test Facility have been used to obtain bounds on the number of these decays. As a result, new limits on the coupling |U eH|2of a massive neutrino in the range of 1.1 MeV to 12 MeV have been derived (|U eH|2≤10−3−10−5). The obtained limits on the mixing parameter are stronger than obtained in previous experiments using nuclear reactors and accelerators.

Published
2003

25. Electron transfer and singlet oxygen mechanisms in the photooxygenation of dibutyl sulfide and thioanisole in MeCN sensitized by N-methylquinolinium tetrafluoborate and 9,10-dicyanoanthracene. The probable involvement of a thiadioxirane intermediate in el

Author

Baciocchi E, Del Giacco T, Elisei F, Gerini MF, Guerra M, Lapi A, and Liberali P

Abstract

Photooxygenations of PhSMe and Bu2S sensitized by N-methylquinolinium (NMQ(+)) and 9,10-dicyano-anthracene (DCA) in O-2-saturated MeCN have been investigated by laser and steady-state photolysis. Laser photolysis experiments showed that excited NMQ(+) promotes the efficient formation of sulfide radical cations with both substrates either in the presence or in absence of a cosensitizer (toluene). In contrast, excited DCA promotes the formation of radical ions with PhSMe, but not with Bu2S. To observe radical ions with the latter substrate, the presence of a cosensitizer (biphenyl) was necessary. With Bu2S, only the dimeric form of the radical cation, (Bu2S)(2)(+.), was observed, while the absorptions of both PhSMe+. and (PhSMe)(2)(+.) were present in the PhSMe time-resolved spectra. The decay of the radical cations followed second-order kinetics, which in the presence of O-2, was attributed to the reaction of the radical cation (presumably in the monomeric form) with O-2(-.) generated in the reaction between NMQ(.) or DCA(-.) and O-2. The fluorescence quenching of both NMQ(+) and DCA was also investigated, and it was found that the fluorescence of the two sensitizers is efficiently quenched by both sulfides (rates controlled by diffusion) as well by O-2 (k(q) = 5.9 x 10(9) M-1 s(-1) with NMQ(+) and 6.8 x 10(9) M-1 s(-1) with DCA). It was also found that quenching of (1)NMQ(*) by O-2 led to the production of O-1(2) in significant yield (phi(Delta) = 0.86 in O-2-saturated solutions) as already observed for (1)DCA(*). The steady-state photolysis experiments showed that the NMQ(+)- and DCA-sensitized photooxygenation of PhSMe afford exclusively the corresponding sulfoxide. A different situation holds for Bu2S: with NMQ(+), the formation of Bu2SO2 was accompanied by that of small amounts of Bu2S2; with DCA, the formation of Bu2SO2 was also observed. It was conclusively shown that with both sensitizers, the photooxygenations of PhSMe occur by an electron transfer (ET) mechanism, as no sulfoxidation was observed in the presence of benzoquinone (BQ), which is a trap for O-2(-.) NMQ(.), and DCA(-.). BQ also suppressed the NMQ(+)-sensitized photooxygenation of Bu2S, but not that sensitized by DCA, indicating that the former is an ET process, whereas the second proceeds via singlet oxygen. In agreement with the latter conclusion, it was also found that the relative rate of the DCA-induced photooxygenation of Bu2S decreases by increasing the initial concentration of the substrate and is slowed by DABCO (an efficient singlet oxygen quencher). To shed light on the actual role of a persulfoxide intermediate also in ET photooxygenations, experiments in the presence of Ph2SO (a trap for the persulfoxide) were carried out. Cooxidation of Ph2SO to form Ph2SO2 was, however, observed only in the DCA-induced photooxygenation of Bu2S, in line with the singlet oxygen mechanism suggested for this reaction. No detectable amounts of Ph2SO2 were formed in the ET photooxygenations of PhSMe with both DCA and NMQ(+) and of BusS with NMQ(+). This finding, coupled with the observation that O-1(2) and ET photooxygenations lead to different product distributions, makes it unlikely that, as currently believed, the two processes involve the same intermediate, i.e., a nucleophilic persulfoxide. Furthermore, the cooxidation of Ph2SO observed in the DCA-induced photooxygenation of Bu2S was drastically reduced when the reaction was performed in the presence of 0.5 M biphenyl as a cosensitizer, that is, under conditions where an (indirect) ET mechanism should operate. This observation confirms that a persulfoxide is formed in singlet oxygen but not in ET photosulfoxidations. The latter conclusion was further supported by the observation that also the intermediate formed in the reaction of thianthrene radical cation with KO2, a reaction which mimics step d (Scheme 2) in the ET mechanism of photooxygenation, is an electrophilic species, being able to oxidize Ph2S but not Ph2SO. It is thus proposed that the intermediate involved in ET sulfoxidations is a thiadioxirane, whose properties (it is an electrophilic species) seem more in line with the observed chemistry. Theoretical calculations concerning the reaction of a sulfide radical cation with O-2(-.) provide a rationale for this proposal.

Published
2003

26. Measurement of extremely low radioactivity levels in BOREXINO

Author

Arpesella, C., Back, H.O., Balata, M., Beau, T., Bellini, G., Benzinger, J., Brigatti, A., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., Dadoun, O., D'Angelo, D., De Bari, A., De Bellefon, A., De Haas, E., De Kerret, H., Derbin, A., Deutsch, M., Di Credico, Alessandra., Elisei, F., Etenko, A., Von Feilitzsch, V., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M.G., Giugni, D., Goger-Neff, M., Goldbrunner, T., Golubchikov, A., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F.X., Von Hentig, R., Heusser, G., Hult, M., Ianni, A., Ianni, A.M., Kiko, J., Kirsten, T., Kohler, M., Korga, G., Korschinek, G., Kozlov, Y., Kryn, D., LaMarche, P., Laubenstein, M., Lendvai, C., Loeser, F., Lombardi, P., McCarty, K., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Martemianov, A., Masetti, F., Mazzucato, U., Meroni, E., Miramonti, L., Monzani, M.E., Musico, P., Neder, H., Niedermeier, L., Nisi, S., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R.S., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Riedel, T., Sabelnikov, A., Salvo, C., Scardaoni, R., Schonert, S., Schuhbeck, K.H., Shutt, T., Simgen, H., Sonnenschein, A., Smirnov, O., Sotnikov, A., Skorokhvatov, M., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Trincherini, P.R., Vyrodov, V., Vogelaar, R.B., Vignaud, D., Vitale, S., Wojcik, M., Zaimidoroga, O., Zuzel, G., Lantz, Simone, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Borexino

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]
Published
2002

27. Science and Technology of BOREXINO : A Real Time Detector for Low Energy Solar Neutrinos

Author

Alimonti, G., Arpesella, C., Back, H., Balata, M., Beau, T., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., de Bari, A., de Haas, E., de Kerret, H., Donghi, O., Deutsch, M., Elisei, F., Etenko, A., von Feilitzsch, F., Fernholz, R., Ford, R., Freudiger, B., Garagiola, A., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M G., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F., von Hentig, R., Hess, H., Heusser, G., Ianni, A., Inzani, P., Kidner, S., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kryn, D., Lagomarsino, V., La Marche, P., Laubenstein, M., Loser, F., Lombardi, P., Magni, S., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Musico, P., Neder, H., Neff, M., Nisi, S., Oberauer, L., Obolensky, M., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Riedel, T., Sabelnikov, A., Saggese, P., Salvo, C., Scardaoni, R., Schonert, S., Schuhbeck, K., Seidel, H., Shutt, T., Simgen, H., Sonnenschein, A., Smirnov, O., Sotnikov, A., Skorokhvatov, M., Sukhotin, S., Tartaglia, R., Testera, G., Vitale, S., Vogelaar, R., Wojcik, M., Zaimidoroga, O., Zakharov, Y., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Borexino, and Lantz, Simone

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]
Published
2002

28. Borexino

Author

Beck, H. O., Balata, M., Beau, T., Bellini, G., Benzinger, J., Bonetti, S., Brigatti, A., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Dadoun, O., D'Angelo, D., de Bari, A., de Bellefon, A., De Haas, E., de Kerret, H., Derbin, A., Deutsch, M., Di Credico, A., Elisei, F., Etenko, A., von Feilitzsch, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, Flavio, Gazzana, S., Giammarchi, M. G., Giugni, D., Goger Neff, M., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F. X., Hess, H., Heusser, G., Ianni, A., Ianni, A. M., Inzani, P., Kidner, S., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kozlov, Y. u., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, Giulio, Martemyanov, A., Masetti, F., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M. E., Musico, P., Niedermeier, L., Nisi, S., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, Marco, Papp, L., Parmeggiano, S., Perasso, L., Pocar, A., Raghavan, R. S., Ranucci, G., Razeto, A., Resconi, E., Riedel, T., Sabelnikov, A., Saggese, P., Salvo, C., Scardaoni, R., Schnert, S., Shutt, T., Simgen, H., Sonnenschein, A., Smirnov, O., Sotnikov, A., Skorokhvatov, M., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vyrodov, V., Vogelaar, R. B., Vitale, Sandro, Wojcik, M., Zaimidoroga, O., and Zuzel, G.

Published
2002

29. Search for electron decay mode $e \rightarrow \gamma^+\nu$ with prototype of Borexino detector

Author

Back, H., Balata, M., de Bari, A., Beau, T., de Bellefon, A., Bellini, G., Benziger, J., Bonetti, S., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., Di, Credico, Dadoun, O., d'Angelo, D., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., von Feilitzsch, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M G., Giugni, D., Goeger-Neff, M., Golubchikov, A., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F., Heusser, G., Ianni, A., Ianni, A.M., de Kerret, H., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kozlov, Y., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Martemianov, A., Mazzucato, U., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M.E., Musico, P., Neder, H., Niedermeier, L., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R., Ranucci, G., Rau, W., Razeto, A., Resconi, E., Sabelnikov, A., Salvo, C., Scardaoni, R., Schoenert, S., Seidel, H., Shutt, T., Simgen, H., Sonnenschein, A., Smirnov, O., Skorokhvatov, M., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vitale, S., Vogelaar, R., Vyrodov, V., Wojcik, M., Zaimidoroga, O., Zuzel, G., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Borexino, and Lantz, Simone

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]
Published
2002

30. Borexino

Author

Ranucci, G., Alimonti, G., Arpesella, C., Back, H., Balata, M., Beau, T., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., Debari, A., Dehaas, E., de Kerret, H., Donghi, O., Deutsch, M., Elisei, F., Etenko, A., von Feilitzsch, F., Fernholz, R., Ford, R., Freudiger, B., Garagiola, A., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F., von Hentig, R., Hess, H., Heusser, G., Ianni, A., Inzani, P., Kidner, S., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kryn, D., Lagomarsino, V., Lamarche, P., Laubenstein, M., Loeser, F., Lombardi, P., Magni, S., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Musico, P., Neder, H., Neff, M., Nisi, S., Oberauer, L., Obolensky, M., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R., Rau, W., Razeto, A., Resconi, E., Riedel, T., Sabelnikov, A., Saggese, P., Salvo, C., Scardaoni, R., Schoenert, S., Schuhbeck, K., Seidel, H., Shutt, T., Simgen, H., Sonnenschein, A., Smirnov, O., Sotnikov, A., Skorokhvatov, M., Sukhotin, S., Tartaglia, R., Testera, G., Vogelaar, R., Vitale, S., Wojcik, M., and Lantz, Simone

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex]
Published
2001

31. Science and technology of BOREXINO: A Real time detector for low-energy solar neutrinos: A Real Time Detector for Low Energy Solar Neutrinos

Author

Alimonti, G, Arpesella, C, Back, H, Balata, M, Beau, T, Bellini, G, Benziger, J, Bonetti, S, Brigatti, A, Caccianiga, B, Cadonati, L, Calaprice, F, Cecchet, G, Chen, M, DeBari, A, DeHaas, E, de Kerret, H, Donghi, O, Deutsch, M, Elisei, F, Etenko, A, von Feilitzsch, F, Fernholz, R, Ford, R, Freudiger, B, Garagiola, A, Galbiati, C, Gatti, F, Gazzana, S, Giammarchi, M, Giugni, D, Golubchikov, A, Goretti, A, Grieb, C, Hagner, C, Hagner, T, Hampel, W, Harding, E, Hartmann, F, von Hentig, R, Hess, H, Heusser, G, Ianni, A, Inzani, P, Kidner, S, Kiko, J, Kirsten, T, Korga, G, Korschinek, G, Kryn, D, Lagomarsino, V, LaMarche, P, Laubenstein, M, Loeser, F, Lombardi, P, Magni, S, Malvezzi, S, Maniera, J, Manno, I, Manuzio, G, Masetti, F, Mazzucato, U, Meroni, E, Musico, P, Neder, H, Neff, M, Nisi, S, Oberauer, L, Obolensky, M, Pallavicini, M, Papp, L, Perasso, L, Pocar, A, Raghavan, R, Ranucci, G, Rau, W, Razeto, A, Resconi, E, Riedel, T, Sabelnikov, A, Saggese, P, Salvo, C, Scardaoni, R, Schoenert, S, Schuhbeck, K, Seidel, H, Shutt, T, Simgen, H, Sonnenschein, A, Smirnov, O, Sotnikov, A, Skorokhvatov, M, Sukhotin, S, Tartaglia, R, Testera, G, Vogelaar, R, Vitale, S, Wojcik, M, Zaimidoroga, O, and Zakharov, Y

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment, Particle Physics - Experiment, Physics::Geophysics
Abstract

BOREXINO, a real-time device for low energy neutrino spectroscopy is nearing completion of construction in the underground laboratories at Gran Sasso, Italy (LNGS). The experiment's goal is the direct measurement of the flux of 7Be solar neutrinos of all flavors via neutrino-electron scattering in an ultra-pure scintillation liquid. Seeded by a series of innovations which were brought to fruition by large scale operation of a 4-ton test detector at LNGS, a new technology has been developed for BOREXINO. It enables sub-MeV solar neutrino spectroscopy for the first time. This paper describes the design of BOREXINO, the various facilities essential to its operation, its spectroscopic and background suppression capabilities and a prognosis of the impact of its results towards resolving the solar neutrino problem. BOREXINO will also address several other frontier questions in particle physics, astrophysics and geophysics.

Published
2000

32. Borexino

Author

Ranucci, G., Alimonti, G., Arpesella, C., Back, H., Balata, M., Beau, T., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., DeBari, A., DeHaas, E., De Kerret, H., Donghi, O., Deutsch, M., Elisei, F., Etenko, A., Von Feilitzsch, F., Fernholz, R., Ford, R., Freudiger, B., Garagiola, A., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M., Giugni, D., Golubchikov, A., Goretti, A., Grieb, C., Hagner, C., Hagner, T., Hampel, W., Harding, E., Hartmann, F., Von Hentig, R., Hess, H., Heusser, G., Ianni, A., Inzani, P., Kidner, S., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kryn, D., Lagomarsino, V., LaMarche, P., Laubenstein, M., Loeser, F., Lombardi, P., Magni, S., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Musico, P., Neder, H., Neff, M., Nisi, S., Oberauer, L., Obolensky, M., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R., Rau, W., Razeto, A., Resconi, E., Riedel, T., Sabelnikov, A., Saggese, P., Salvo, C., Scardaoni, R., Schoenert, S., Schuhbeck, K., Seidel, H., Shutt, T., Simgen, H., Sonnenschein, A., Smirnov, O., Sotnikov, A., Skorokhvatov, M., Sukhotin, S., Tartaglia, R., Testera, G., Vogelaar, R., Vitale, S., Wojcik, M., Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Borexino

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]
Published
2000

33. Ultra-low background measurements in a large volume underground detector

Author

Alimonti, G., Anghloher, G., Arpesella, C., Balata, M., Bellini, G., Benziger, J., Bonetti, S., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Darnton, M., Debari, A., Deutsch, M., Elisei, F., VON FEILITZSCH, F., Galbiati, C., Gatti, Flavio, Giammarchi, M. G., Giugni, D., Goldbrunne, T., Golubchikov, A., Goretti, A., Hagner, T., Hartmann, F., VON HENTIG, R., Heusser, G., Ianni, A., Jochum, J., Johnson, M., Laubenstein, M., Lombardi, P., Magni, S., Malvezzi, S., Manno, I., Manuzio, Giulio, Masetti, F., Mazzucato, U., Meroni, E., Neff, M., Nisi, S., Nostro, A., Oberauer, L., Perotti, A., Preda, A., Raghavan, P., Raghavan, R. S., Ranucci, G., Resconi, E., Ruscitti, P., Scardaoni, R., Schoenert, S., Smirnov, O., Tartaglia, R., Testera, G., Ullucci, P., Vogelaar, R. B., Vitale, Sandro, Wpjcik, M., and Zaimidoroga, O.

Subjects
Nuclear physics, Physics, Scintillation, Volume (thermodynamics), Solar neutrino, Detector, Astronomy and Astrophysics, Natural abundance, Neutrino, Scintillator, Borexino
Abstract

A large volume (4.8 m3) liquid scintillator detector has been running in Hall C of the Gran Sasso Underground Laboratory since February 1995. This detector is called the “Counting Test Facility” (CTF). The main goal of the detector facility is the measurement of ultralow background levels in scintillators and the development of processes able to purify them at this level. The detector has been designed to have exceptional sensitivity using a variety of methods to identify backgrounds. With the CTF, records were achieved in the domain of low background large volume detectors. Limits of 3.5 ± 1.3 × 10−16 g/g and 4.4−1.2+1.5 × 10−16 g/g for the 238U and 232Th daughters, respectively, and 1.85 ± 0.13 ± 0.01 × 10−18 for the isotopic abundance of 14C relative to 12C were obtained. These results are very encouraging and point towards the feasibility of low energy, real time scintillation detectors for solar neutrinos, such as Borexino.

Published
1998

36. Borexino: The detector and the physics program

Author

Alimonti, G., Arpesella, C., Balata, M., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Caccianiga, B., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Bari, A., Deutsch, M., Dossi, R., Elisei, F., Feilitzsch, F., Fernholz, R., Galbiati, C., Garagiola, A., Gatti, F., Giammarchi, M. G., Giugni, D., Golubchikov, A., Goretti, A., Hagner, C., Hagner, T., Hampel, W., Handt, J., Hartmann, F., Hentig, R., Heusser, G., Ianni, A., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Laubenstein, M., Loeser, F., Lombardi, P., Magni, S., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Neder, H., Neff, M., Nisi, S., Nostro, A., Oberauer, L., Papp, L., Perotti, A., Pieri, G., Raghavan, P., Raghavan, R. S., Gioacchino Ranucci, Rau, W., Resconi, E., Saggese, P., Scardaoni, R., Schonert, Stefan, Schuhbeck, K. H., Smirnov, O., Sotnikov, A., Tartaglia, R., Testera, G., Vogelaar, B., Vitale, S., Wojcik, M., and Zaimidoroga, O.

37. Status report of solar neutrino experiments at Gran Sasso

Author

Alimonti, G., Anghloher, G., Arpesella, C., Balata, M., Bellini, G., Benziger, J., Bonetti, S., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Darnton, N., Bari, A., Deutsch, M., Elisei, F., Feilitzsch, F., Galbiati, C., Gatti, F., Giammarchi, M. G., Goldbrunner, T., Golubchikov, A., Goretti, A., Hagner, T., Hartmann, F., Hentig, R., Heusser, G., Ianni, A., Jochum, J., Johnson, M., Laubenstein, M., Lombardi, P., Magni, S., Malvezzi, S., Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Neff, M., Oberauer, L., Preda, A., Raghavan, R. S., Gioacchino Ranucci, Resconi, E., Scardaoni, R., Schonert, Stefan, Smirnov, O., Tartaglia, R., Testera, G., Ullucci, P., Vogelaar, B., Vitale, S., and Zaimidoroga, O.

38. Response to the critics of Borexino result in 'A New experimental limit for the stability of the electron' by H.V. Klapdor-Kleingrothaus, I.V. Krivosheina and I.V. Titkova

Author

Back, H. O., Balata, M., Bari, A., Beau, T., Bellefon, A., Bellini, G., Benziger, J., Bonetti, S., Buck, C., Caccianiga, B., Cadonati, L., Calaprice, F., Cecchet, G., Chen, M., Di Credico, A., Dadoun, O., D Angelo, D., Derbin, A., Deutsch, M., Elisei, F., Etenko, A., Feilitzsch, F., Fernholz, R., Ford, R., Franco, D., Freudiger, B., Galbiati, C., Gatti, F., Gazzana, S., Giammarchi, M. G., Goeger-Neff, M., Goretti, A., Grieb, C., Hagner, T., Harding, B., Hartmann, F. X., Heusser, G., Ianni, A., Ianni, A. M., Kerret, H., Kiko, J., Kirsten, T., Korga, G., Korschinek, G., Kozlov, Y., Kryn, D., Laubenstein, M., Lendvai, C., Lombardi, P., Machulin, I., Malvezzi, S., Maneira, J., Manno, I., Manuzio, G., Masetti, F., Martemianov, A., Mccarty, K., Meroni, E., Miramonti, L., Monzani, M. E., Musico, P., Neder, H., Niedermeier, L., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, M., Papp, L., Perasso, L., Pocar, A., Raghavan, R. S., Ranucci, G., Rau, W., Razeto, A., Elisa Resconi, Sabelnikov, A., Salvo, C., Scardaoni, R., Schoenert, S., Seidel, H., Simgen, H., Skorokhvatov, M., Smirnov, O., Sotnikov, A., Sukhotin, S., Tarasenkov, V., Tartaglia, R., Testera, G., Vignaud, D., Vitale, S., Vogelaar, R. B., Vyrodov, V., Wojcik, M., Zaimidoroga, O., and Zuzel, G.

39. Ultra-low background measurements in a large volume underground detector: Borexino Collaboration

Author

Alimonti, G., Anghloher, G., Arpesella, C., Balata, M., Bellini, G., Benziger, J., Bonetti, S., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Darnton, N., Bari, A., Deutsch, M., Elisei, F., Feilitzsch, F., Galbiati, C., Gatti, F., Giammarchi, M. G., Giugni, D., Goldbrunner, T., Golubchikov, A., Goretti, A., Hagner, T., Hartmann, F. X., Hentig, R., Heusser, G., Ianni, A., Jochum, J., Johnson, M., Laubenstein, M., Lombardi, P., Magni, S., Malvezzi, S., Manno, I., Manuzio, G., Masetti, F., Ugo Mazzucato, Meroni, E., Neff, M., Nostro, A., Oberauer, L., Perotti, A., Preda, A., Raghavan, R. S., Ranucci, G., Resconi, E., Ruscitti, M., Scardaoni, R., Schönert, S., Smirnov, O., Tartaglia, R., Testera, G., Ullucci, P., Vogelaar, R. B., Vitale, S., Wojcik, M., and Zaimidoroga, O.

41. Performances of the CTF experiment in prospect of Borexino

Author

Ranucci, G., Alimonti, G., Anghloher, G., Arpesella, C., Balata, M., Bellini, G., Benziger, J., Bonetti, S., Brigatti, A., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Darnton, N., Antonio de Bari, Deutsch, M., Dossi, R., Elisei, F., Feilitzsch, F., Galbiati, C., Garagiola, A., Gatti, F., Giammarchi, M. G., Giugni, D., Goldbrunner, T., Golubchikov, A., Goretti, A., Hagner, T., Hartmann, F., Hentig, R., Heusser, G., Ianni, A., Jochum, J., Johnson, M., Korga, G., Laubenstein, M., Loeser, F., Lombardi, P., Magni, S., Malvezzi, S., Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Neff, M., Nisi, S., Nostro, A., Oberauer, L., Perotti, A., Raghavan, P., Raghavan, R. S., Resconi, E., Ruscitti, M., Sacchetti, F., Scardaoni, R., Schönert, S., Smirnov, O., Sotnikov, A., Tartaglia, R., Testera, G., Vogelaar, B., Vitale, S., Wojcik, M., and Zaimidoroga, O.

43. Measurement of the14C abundance in a low-background liquid scintillator

Author

Alimonti, G., Angloher, G., Arpesella, C., Balata, M., Bellini, G., Benziger, J., Bonetti, S., Cadonati, L., Calaprice, F. P., Cecchet, G., Chen, M., Darnton, N., Bari, A., Deutsch, M., Elisei, F., Feilitzsch, F., Galbiati, C., Gatti, F., Giammarchi, M. G., Giugni, D., Goldbrunner, T., Golubchikov, A., Goretti, A., Hagner, T., Hartmann, F. X., Hentig, R., Heusser, G., Ianni, A., Jochum, J., Johnson, M., Laubenstein, M., Lombardi, P., Magni, S., Sandra Malvezzi, Manno, I., Manuzio, G., Masetti, F., Mazzucato, U., Meroni, E., Neff, M., Nostro, A., Oberauer, L., Perotti, A., Preda, A., Raghavan, R. S., Ranucci, G., Resconi, E., Ruscitti, M., Scardaoni, R., Schönert, S., Smirnov, O., Tartaglia, R., Testera, G., Ullucci, P., Vogelaar, R. B., Vitale, S., and Zaimidoroga, O.

44. The 'digital biopsy' in non-small cell lung cancer (NSCLC): a pilot study to predict the PD-L1 status from radiomics features of [18F]FDG PET/CT

Author

Lavinia Monaco, Elisabetta De Bernardi, Francesca Bono, Diego Cortinovis, Cinzia Crivellaro, Federica Elisei, Vincenzo L’Imperio, Claudio Landoni, Gregory Mathoux, Monica Musarra, Fabio Pagni, Elia Anna Turolla, Cristina Messa, Luca Guerra, Monaco, L, De Bernardi, E, Bono, F, Cortinovis, D, Crivellaro, C, Elisei, F, L'Imperio, V, Landoni, C, Mathoux, G, Musarra, M, Pagni, F, Turolla, E, Messa, C, and Guerra, L

Subjects
PD-L1, Lung Neoplasms, PET/CT, Biopsy, Pilot Projects, General Medicine, B7-H1 Antigen, Fluorodeoxyglucose F18, Carcinoma, Non-Small-Cell Lung, Positron Emission Tomography Computed Tomography, Humans, Radiology, Nuclear Medicine and imaging, Lung cancer, Radiomic, Tomography, X-Ray Computed, Retrospective Studies
Abstract

Purpose: The present pilot study investigates the putative role of radiomics from [18F]FDG PET/CT scans to predict PD-L1 expression status in non-small cell lung cancer (NSCLC) patients. Methods: In a retrospective cohort of 265 patients with biopsy-proven NSCLC, 86 with available PD-L1 immunohistochemical (IHC) assessment and [18F]FDG PET/CT scans have been selected to find putative metabolic markers that predict PD-L1 status (< 1%, 1–49%, and ≥ 50% as per tumor proportion score, clone 22C3). Metabolic parameters have been extracted from three different PET/CT scanners (Discovery 600, Discovery IQ, and Discovery MI) and radiomics features were computed with IBSI compliant algorithms on the original image and on images filtered with LLL and HHH coif1 wavelet, obtaining 527 features per tumor. Univariate and multivariate analysis have been performed to compare PD-L1 expression status and selected radiomic features. Results: Of the 86 analyzed cases, 46 (53%) were negative for PD-L1 IHC, 13 (15%) showed low PD-L1 expression (1–49%), and 27 (31%) were strong expressors (≥ 50%). Maximum standardized uptake value (SUVmax) demonstrated a significant ability to discriminate strong expressor cases at univariate analysis (p = 0.032), but failed to discriminate PD-L1 positive patients (PD-L1 ≥ 1%). Three radiomics features appeared the ablest to discriminate strong expressors: (1) a feature representing the average high frequency lesion content in a spherical VOI (p = 0.009); (2) a feature assessing the correlation between adjacent voxels on the high frequency lesion content (p = 0.004); (3) a feature that emphasizes the presence of small zones with similar grey levels inside the lesion (p = 0.003). The tri-variate linear discriminant model combining the three features achieved a sensitivity of 81% and a specificity of 82% in the test. The ability of radiomics to predict PD-L1 positive patients was instead scarce. Conclusions: Our data indicate a possible role of the [18F]FDG PET radiomics in predicting strong PD-L1 expression; these preliminary data need to be confirmed on larger or single-scanner series.

Published
2022
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45. Combining positron emission tomography/computed tomography, radiomics, and sentinel lymph node mapping for nodal staging of endometrial cancer patients

Author

Luca Guerra, Tommaso Grassi, Giampaolo Di Martino, Cristina Messa, Elisabetta De Bernardi, Fabio Landoni, Robert Fruscio, Claudio Landoni, Alessandro Buda, Federica Elisei, Manuela Bonacina, Martina Delle Marchette, Lavinia Monaco, Irene Gotuzzo, Cinzia Crivellaro, Sonia Magni, Daniela Giuliani, Crivellaro, C, Landoni, C, Elisei, F, Buda, A, Bonacina, M, Grassi, T, Monaco, L, Giuliani, D, Gotuzzo, I, Magni, S, Di Martino, G, Delle Marchette, M, Guerra, L, Landoni, F, Fruscio, R, Messa, C, and De Bernardi, E

Subjects
Sentinel lymph node, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, sentinel lymph node, 0302 clinical medicine, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Biopsy, medicine, Carcinoma, Humans, Lymph node, Neoplasm Staging, MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Receiver operating characteristic, medicine.diagnostic_test, Sentinel Lymph Node Biopsy, business.industry, Endometrial cancer, Obstetrics and Gynecology, Middle Aged, medicine.disease, Primary tumor, Endometrial Neoplasms, medicine.anatomical_structure, Oncology, Positron emission tomography, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, endometrial neoplasm, Lymph Nodes, Radiopharmaceuticals, business, Nuclear medicine
Abstract

ObjectiveTo evaluate the combination of positron emission tomography/computed tomography (PET/CT) and sentinel lymph node (SLN) biopsy in women with apparent early-stage endometrial carcinoma. The correlation between radiomics features extracted from PET images of the primary tumor and the presence of nodal metastases was also analyzed.MethodsFrom November 2006 to March 2019, 167 patients with endometrial cancer were included. All women underwent PET/CT and surgical staging: 60/167 underwent systematic lymphadenectomy (Group 1) while, more recently, 107/167 underwent SLN biopsy (Group 2) with technetium-99m +blue dye or indocyanine green. Histology was used as standard reference. PET endometrial lesions were segmented (n=98); 167 radiomics features were computed inside tumor contours using standard Image Biomarker Standardization Initiative (IBSI) methods. Radiomics features associated with lymph node metastases were identified (Mann-Whitney test) in the training group (A); receiver operating characteristic (ROC) curves, area under the curve (AUC) values were computed and optimal cut-off (Youden index) were assessed in the test group (B).ResultsIn Group 1, eight patients had nodal metastases (13%): seven correctly ridentified by PET/CT true-positive with one false-negative case. In Group 2, 27 patients (25%) had nodal metastases: 13 true-positive and 14 false-negative. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of PET/CT for pelvic nodal metastases were 87%, 94%, 93%, 70%, and 98% in Group 1 and 48%, 97%, 85%, 87%, and 85% in Group 2, respectively. On radiomics analysis a significant association was found between the presence of lymph node metastases and 64 features. Volume-density, a measurement of shape irregularity, was the most predictive feature (p=0001, AUC=0,77, cut-off 0.35). When testing cut-off in Group B to discriminate metastatic tumors, PET false-negative findings were reduced from 14 to 8 (-43%).ConclusionsPET/CT demonstrated high specificity in detecting nodal metastases. SLN and histologic ultrastaging increased false-negative PET/CT findings, reducing the sensitivity of the technique. PET radiomics features of the primary tumor seem promising for predicting the presence of nodal metastases not detected by visual analysis.

Published
2020
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46. Clinical Application of a High Sensitivity BGO PET/CT Scanner: Effects of Acquisition Protocols and Reconstruction Parameters on Lesions Quantification

Author

Lavinia Monaco, Elena De Ponti, Cinzia Crivellaro, Sabrina Morzenti, Sergio Todde, Claudio Landoni, Federica Elisei, Monica Musarra, Luca Guerra, De Ponti, E, Crivellaro, C, Morzenti, S, Monaco, L, Todde, S, Landoni, C, Elisei, F, Musarra, M, and Guerra, L

Subjects
Pharmacology, Bayes Theorem, quantification, lesion, standard osem algorithm plus PSF option, regularized reconstruction algo-rithm, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Image Processing, Computer-Assisted, Humans, Radiology, Nuclear Medicine and imaging, beta factor, Radiopharmaceuticals, Lesion detectability, Retrospective Studies
Abstract

Aims: The aim of this retrospective study was to investigate SUVs variability with respect to lesion size, administered dose, and reconstruction algorithm. Background: SUVmax and SUVpeak are influenced by technical factors as count statistics and reconstruction algorithms. Objective: To fulfill the aim, we evaluated the SUVs variability with respect to lesion size, administered dose, and reconstruction algorithm (ordered - subset expectation maximization plus point spread function option - OSEM+PSF, regularized Bayesian Penalized Likelihood - BPL) in a 5 - rings BGO PET/CT scanner. Method: Discovery IQ scanner (GE Healthcare, Milwaukee, Wisconsin, US) was used for list mode acquisition of 25 FDG patients, 12 injected with 3.7 MBq/kg (Standard Dose protocol - SD) and 13 injected with 1.8 MBq/kg (Low Dose protocol - LD). Each acquisition was reconstructed at different time/FOV with both OSEM+PSF algorithm and BPL using seven different beta factors. SUVs were calculated in 70 lesions and analysed in function of time/FOV and Beta. Image quality was evaluated as a coefficient of variation of the liver (CV - liver). Result: SUVs were not considerably affected by time/FOV. However, SUVs were influenced by beta: differences were higher in small lesions (37% for SUVmax, 15% for SUVpeak) compared to larger ones (14% and 6%). CV - liver ranged from 6% with Beta-500 (LD and SD) to 13% with Beta- 200 (LD). CV - liver of BPL with Beta-350 (optimized for clinical practice in our institution) in LD was lower than CV - liver of OSEM+PSF in SD. Conclusion: When a high sensitivity 5 - rings BGO PET/CT scanner is used with the same reconstruction algorithm, quantification by means of SUVmax and SUVpeak is a robust standard compared to the activity and scan duration. However, both SUVs and image quality are influenced by reconstruction algorithms and the related parameters should be considered to obtain the best compromise between detectability, quantification, and noise.

Published
2022

47. Motion Management in PET/CT: Technological Solutions

Author

Cinzia Crivellaro, Sabrina Morzenti, Elena De Ponti, Andrea Crespi, Federica Elisei, Luca Guerra, De Ponti, E, Morzenti, S, Crivellaro, C, Elisei, F, Crespi, A, and Guerra, L

Subjects
PET/CT imaging, Computer science, Image quality, Movement, Field of view, End expiration, PET field, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Organ Motion, Match moving, RG protocol, Region of interest, Positron Emission Tomography Computed Tomography, Humans, Radiology, Nuclear Medicine and imaging, Computer vision, Data driven gating, Pharmacology, PET-CT, Respiratory gated, business.industry, Respiration, Banana artefact management, 030220 oncology & carcinogenesis, Breathing, Artificial intelligence, Motion free, business, Correction for attenuation, Human
Abstract

Background and objective Motion due to patient's breathing can introduce heavy bias in PET/CT, both in image quality and quantitation. This paper is a review of the main technical solutions available to manage movement in PET/CT studies: a) Respiratory Gated (RG), b) Motion Free (MF), c) End Expiration (EE), d) Banana Artefact Management (BAM) and e) Data Driven Gating (DDG). Methods The most diffused solutions (RG, MF and EE) are based on LIST mode acquisition of a PET Field of View (4D FOV), centered on the anatomical region of interest; to link PET data not only to time and to spatial position but also to the corresponding breathing phase, the synchronized acquisition of the patient's breathing curve is performed by an external tracking device. Different commercial tools to track and to record patient breathing cycle are available to associate the internal organ motion with a measurable external parameter; for example these systems can measure the pressure on a chest elastic belt, the air flow trough patient nose, the breath-in and breath-out air temperature or the markers movement on the thorax/ abdominal region. Recently DDG techniques are developed to correct respiratory motion without the help of external motion tracking devices and to obtain a comparable result to that based on standard RG protocols. Results The final result of an RG or DDG protocol is a sequence of 3D images showing organs and lesions movement; using the other motion management options a single 3D motion-free image is obtained without motion artefacts and degradation. Compared to the previously described options the BAM solution is not a real motion management protocol but just a Banana Artefact correction technique obtained using an Attenuation Correction Map calculated merging the Whole Body Helical CT with a Cine CT on the diaphragm area. Conclusion The motion management in PET/CT imaging shows benefits in terms of image quality, quantification and lesion detectability and it is useful both in diagnostic and radiotherapy planning.

Published
2018
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48. Role of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in malignant ovarian germ cell tumors: a single-center experience with long term follow-up

Author

Cinzia Crivellaro, Robert Fruscio, Cristina Bonazzi, Federica Sina, Luca Guerra, Federica Elisei, Carlotta Dolci, Marco Adorni, Cristina Messa, Maria Lamanna, Lorenzo Ceppi, Dolci, C, Ceppi, L, Guerra, L, Crivellaro, C, Lamanna, M, Adorni, M, Elisei, F, Bonazzi, C, Sina, F, Fruscio, R, and Messa, C

Subjects
medicine.medical_specialty, Disease Response, medicine.medical_treatment, 030232 urology & nephrology, malignant ovarian germ cell tumors, Single Center, Malignancy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, clinical management, Laparoscopy, Chemotherapy, medicine.diagnostic_test, business.industry, 18F-FDG PET/CT, Obstetrics and Gynecology, medicine.disease, Oncology, Positron emission tomography, Histopathology, diagnostic accuracy, Radiology, Germ cell tumors, business
Abstract

Introduction18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a diagnostic tool widely used in oncology, but to date there are no established recommendations for its use in malignant ovarian germ cell tumors. The aim of this study was to evaluate the role of 18F-FDG PET/CT in the clinical management of patients with malignant ovarian germ cell tumors.MethodsThis was a retrospective review of 18F-FDG PET/CT scans performed in patients diagnosed with malignant ovarian germ cell tumors treated at the gynecology department of San Gerardo Hospital (Monza, Italy) from June 2006 to December 2016. Data collected included clinical history, radiological, biochemical and pathological evaluation, treatment, follow-up, outcome, and clinical indication for the PET/CT scan. PET/CT findings were categorized as negative/normal (no abnormal FDG uptake or physiological uptake), positive/abnormal (FDG uptake considered to indicate active germ cell malignancy), or equivocal (FDG uptake of uncertain significance, not clearly correlated to neoplastic disease).ResultsA total of 69 PET/CT scans in 37 patients were evaluated. The mean age at diagnosis was 25 years (range 20–48). The majority of patients had International Federation of Gynecology and Obstetrics (FIGO) stage I (22/37) disease and had a diagnosis of dysgerminomas (18/37). Imaging indications were initial staging before treatment (4/69, 6%), staging after inadequate staging surgery (24/69, 35%), restaging after adjuvant chemotherapy (17/69, 25%), relapse suspect (9/69, 13%), and follow-up (15/69, 21%). Pathology confirmation of PET/CT results was available in 28/69 (40.5%) studies. All negative PET/CT (15/28) cases were confirmed with laparoscopy as true negative; among 13/28 positive PET cases, histopathology confirmed 7 (54%) as true positive and 6 (46%) as false positive (5 inflammatory and 1 mature teratoma implants). Patient-based analysis showed 100% sensitivity, 71% specificity, 54% positive predictive value, 100% negative predictive value, and 79% accuracy. Clinical follow-up was available in 41 (59.4%) of 69 PET/CT images: 28/41 studies were negative and 13/41 positive. A mean follow-up of 28 months (median 15, range 5–102) confirmed negative PET/CT studies. A total of 13 positive PET/CT patients underwent chemotherapy with subsequent evidence of disease response.DiscussionPET/CT in malignant ovarian germ cell tumors was mainly performed for staging after inadequate staging surgery or for restaging after adjuvant chemotherapy. PET/CT was associated with high sensitivity and negative predictive value.

Published
2019

49. 18F-FDG PET/CT in a Case of Metastatic Breast Cancer to the Vulva

Author

Claudio Landoni, Federica Elisei, Mariachiara Paderno, Cinzia Crivellaro, Alessandro Buda, Priscilla Guglielmo, Luca Guerra, Guglielmo, P, Paderno, M, Elisei, F, Guerra, L, Landoni, C, Buda, A, and Crivellaro, C

Subjects
medicine.medical_specialty, Breast Neoplasms, Vulva, Metastasis, Breast cancer, breast cancer, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Biopsy, medicine, Humans, Radiology, Nuclear Medicine and imaging, nuclear medicine, Stage (cooking), skin and connective tissue diseases, vulvar lesion, Aged, Vulvar neoplasm, Vulvar Neoplasms, integumentary system, medicine.diagnostic_test, urogenital system, business.industry, Vulvar Neoplasm, General Medicine, Vulvar cancer, Middle Aged, medicine.disease, Metastatic breast cancer, female genital diseases and pregnancy complications, FDG PET/CT, medicine.anatomical_structure, Radiopharmaceutical, metastasi, Female, Radiology, Radiopharmaceuticals, business, Breast Neoplasm, Human
Abstract

A 56-year-old woman, previously treated for breast cancer, presented to gynecologists with a lump of the left labium major of the vulva. The FDG pattern resembled as a cIV stage vulvar cancer, whereas biopsy indicated metastases from breast cancer. Metastatic disease to the vulva is particularly uncommon, representing 5% to 8% of all vulvar cancer lesions. However, gynecological uptakes, including vulvar site, have to be kept in mind as a possible site of metastatic lesions from breast cancer.

Published
2019

50. Radiomics of the primary tumour as a tool to improve 18F-FDG-PET sensitivity in detecting nodal metastases in endometrial cancer

Author

Federica Elisei, Elisabetta De Bernardi, Robert Fruscio, Luca Guerra, Alessandro Buda, Cinzia Crivellaro, Claudio Landoni, Cristina Messa, Debora Vicini, De Bernardi, E, Buda, A, Guerra, L, Vicini, D, Elisei, F, Landoni, C, Fruscio, R, Messa, C, and Crivellaro, C

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, Multivariate statistics, medicine.medical_specialty, lcsh:R895-920, 030218 nuclear medicine & medical imaging, 18f fdg pet, 03 medical and health sciences, 0302 clinical medicine, Endometrial cancer, Nodal stage assessment, Medicine, Radiology, Nuclear Medicine and imaging, Sensitivity (control systems), Texture analysi, Cardiac imaging, Original Research, business.industry, Univariate, medicine.disease, PET radiomic, Texture analysis, Feature (computer vision), 030220 oncology & carcinogenesis, Radiology, PET radiomics, business, NODAL, 18F-FDG PET
Abstract

Background A radiomic approach was applied in 18F-FDG PET endometrial cancer, to investigate if imaging features computed on the primary tumour could improve sensitivity in nodal metastases detection. One hundred fifteen women with histologically proven endometrial cancer who underwent preoperative 18F-FDG PET/CT were retrospectively considered. SUV, MTV, TLG, geometrical shape, histograms and texture features were computed inside tumour contours. On a first group of 86 patients (DB1), univariate association with LN metastases was computed by Mann-Whitney test and a neural network multivariate model was developed. Univariate and multivariate models were assessed with leave one out on 20 training sessions and on a second group of 29 patients (DB2). A unified framework combining LN metastases visual detection results and radiomic analysis was also assessed. Results Sensitivity and specificity of LN visual detection were 50% and 99% on DB1 and 33% and 95% on DB2, respectively. A unique heterogeneity feature computed on the primary tumour (the zone percentage of the grey level size zone matrix, GLSZM ZP) was able to predict LN metastases better than any other feature or multivariate model (sensitivity and specificity of 75% and 81% on DB1 and of 89% and 80% on DB2). Tumours with LN metastases are in fact generally characterized by a lower GLSZM ZP value, i.e. by the co-presence of high-uptake and low-uptake areas. The combination of visual detection and GLSZM ZP values in a unified framework obtained sensitivity and specificity of 94% and 67% on DB1 and of 89% and 75% on DB2, respectively. Conclusions The computation of imaging features on the primary tumour increases nodal staging detection sensitivity in 18F-FDG PET and can be considered for a better patient stratification for treatment selection. Results need a confirmation on larger cohort studies.

Published
2018
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